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  1. Article: Emergence of

    Liu, Guoye / Qian, Huimin / Lv, Jingwen / Tian, Benshun / Bao, Changjun / Yan, Hong / Gu, Bing

    Frontiers in microbiology

    2021  Volume 12, Page(s) 723697

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-09-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2021.723697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Significance of LncRNA CASC8 genetic polymorphisms on the tuberculosis susceptibility in Chinese population.

    Liu, Guoye / Xia, Rui / Wang, Qian / Wang, Zhiqiang / Ying, Binwu / Yan, Hong

    Journal of clinical laboratory analysis

    2020  Volume 34, Issue 6, Page(s) e23234

    Abstract: Background: Tuberculosis remains an important disease threatening the security of public health, and no effective targets have been found for the immunological diagnosis or therapy of tuberculosis. The aim of this study was to explore the associations ... ...

    Abstract Background: Tuberculosis remains an important disease threatening the security of public health, and no effective targets have been found for the immunological diagnosis or therapy of tuberculosis. The aim of this study was to explore the associations between lncRNA CASC8 genetic polymorphism and tuberculosis risk.
    Method: A total of 900 tuberculosis patients and 1534 healthy individuals in the Western Chinese Han population were recruited for our study. Candidate SNPs of CASC8 were initially filtered by importing the 1000 genomes database into Haploview, and subsequently genotyped using modified multiplex ligation detection reactions.
    Results: The lncRNA CASC8 genetic variant rs7836840 was associated with an increased tuberculosis risk with a P-value of .034, but .134 after Bonferroni correction. Using subtype analysis, the C allele in rs7836840 showed a significant association with tuberculosis susceptibility (OR = 1.196, 95% CI = 1.05-1.362, P = .02739 after Bonferroni correction). Patients carrying genotype AG and GG of rs7825118 and rs9297758 exhibited lower Hb concentrations (P = .006) and neutrophil counts (P = .015), respectively, while genotype AG and AA in rs6981424 demonstrated higher levels of ALT (P = .005) and AST (P = .033) in a dominant model, which were consistent with a tendency toward increased TB risk.
    Conclusions: This study was the first to explore the association between lncRNA CASC8 polymorphisms and TB infection risk and clinical manifestations. Our results provide evidence that CASC8 may act as a biomarker for the progression of clinical tuberculosis.
    MeSH term(s) Adult ; Asian Continental Ancestry Group/genetics ; Case-Control Studies ; Female ; Genetic Association Studies ; Genetic Linkage ; Genetic Predisposition to Disease ; Haplotypes ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; RNA, Long Noncoding/genetics ; Tuberculosis/genetics
    Chemical Substances CASC8 lncRNA, human ; RNA, Long Noncoding
    Language English
    Publishing date 2020-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645095-7
    ISSN 1098-2825 ; 0887-8013
    ISSN (online) 1098-2825
    ISSN 0887-8013
    DOI 10.1002/jcla.23234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Discovery of seven novel mutations of gyrB, parC and parE in Salmonella Typhi and Paratyphi strains from Jiangsu Province of China.

    Qian, Huimin / Cheng, Siyun / Liu, Guoye / Tan, Zhongming / Dong, Chen / Bao, Jinfeng / Hong, Jie / Jin, Dazhi / Bao, Changjun / Gu, Bing

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 7359

    Abstract: Objective: To investigate the prevalence of Salmonella Typhi and Paratyphi resistance to quinolones and characterize the underlying mechanism in Jiangsu Province of China.: Methods: Antimicrobial susceptibility testing was performed using Kirby-Bauer ...

    Abstract Objective: To investigate the prevalence of Salmonella Typhi and Paratyphi resistance to quinolones and characterize the underlying mechanism in Jiangsu Province of China.
    Methods: Antimicrobial susceptibility testing was performed using Kirby-Bauer disc diffusion system. Quinolone resistance-determining region (QRDR), plasmid-mediated quinolone resistance (PMQR) determinant genes were detected by PCR and sequencing.
    Results: Out of 239 Salmonella isolates, 164 were S. Typhi and 75 were S. Paratyphi. 128 (53.6%) Salmonella isolates were resistant to nalidixic acid; 11 (4.6%) isolates to ciprofloxacin and 66 (27.6%) isolates were intermediate to ciprofloxacin. QRDR were present in 69 S. Typhi isolates, among which mutation at codon 83 (n = 45) and 133 (n = 61) predominated. In S. Paratyphi, the most common mutations were detected in gyrA at codon 83(n = 24) and parC: T57S (n = 8). Seven mutations were first reported in Salmonella isolates including gyrB: S426G, parC: D79G and parE: [S498T, E543K, V560G, I444S, Y434S]. PMQR genes including qnrD1, qnrA1, qnrB4, aac (6')-Ib-cr4 and qnrS1 were detected in 1, 2, 3, 7 and 9 isolates, relatively.
    Conclusions: High resistance to quinolones in Salmonella remains a serious problem in Jiangsu, China. The presence of the novel mutations increases the complexity of quinolone-resistant genotypes and poses a threat to public health. Subject terms: Salmonella Typhi, Salmonella Paratyphi, antimicrobial resistance, QRDR, PMQR.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; China ; Ciprofloxacin/pharmacology ; DNA Gyrase/genetics ; Drug Resistance, Bacterial/genetics ; Microbial Sensitivity Tests ; Mutation/genetics ; Nalidixic Acid/pharmacology ; Quinolones/pharmacology ; Salmonella paratyphi A/drug effects ; Salmonella paratyphi A/genetics ; Salmonella typhi/drug effects ; Salmonella typhi/genetics
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; Quinolones ; Nalidixic Acid (3B91HWA56M) ; Ciprofloxacin (5E8K9I0O4U) ; DNA Gyrase (EC 5.99.1.3)
    Language English
    Publishing date 2020-04-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-64346-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Up-regulated long noncoding RNA AC007128.1 and its genetic polymorphisms associated with Tuberculosis susceptibility.

    Yan, Hong / Liu, Guoye / Liang, Yuan / Wu, Wei / Xia, Rui / Jiao, Lin / Shen, Han / Jia, Zhijun / Wang, Qian / Wang, Zhiqiang / Kong, Yi / Ying, Binwu / Wang, Hualiang / Wang, Chengbin

    Annals of translational medicine

    2021  Volume 9, Issue 12, Page(s) 1018

    Abstract: Background: Tuberculosis (TB) remains a major public health problem. Long non-coding RNAs (lncRNAs) are important regulators of gene expression. In this study, we explored the association between the expression of lncRNA AC007128.1 and TB susceptibility. ...

    Abstract Background: Tuberculosis (TB) remains a major public health problem. Long non-coding RNAs (lncRNAs) are important regulators of gene expression. In this study, we explored the association between the expression of lncRNA AC007128.1 and TB susceptibility.
    Methods: Three single-nucleotide polymorphisms (SNPs) (rs12333784, rs6463794, and rs720964) of lncRNA AC007128.1 were selected using the 1000 Genomes Project database and offline software Haploview V4.2, and were genotyped by a customized 2×48-Plex SNPscan™ Kit.
    Results: We identified two differentially expressed lncRNA including AC007128.1 and AP001065.3 in comparisons of expression profiles between ATB
    Conclusions: Our findings show lncRNA AC007128.1 can be regarded as biomarkers discriminating between ATB and LTBI and may also be a diagnostic biomarker for LBTI. These findings may aid clinical decision making in the management of TB.
    Language English
    Publishing date 2021-06-30
    Publishing country China
    Document type Journal Article
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-21-2724
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Increasing clinical resistance rate of

    Qian, Huimin / Liu, Guoye / Chen, Yin / Ma, Ping / Kong, Xiaoxiao / Zhou, Lu / Hong, Jie / Bao, Changjun / Gu, Bing

    Annals of translational medicine

    2018  Volume 6, Issue 11, Page(s) 207

    Abstract: Background: The objective of this study is to evaluate the prevalence of : Methods: We investigated the drug resistance in 95 isolates of : Results: Over a 4-year period, the resistance rate of : Conclusions: The antimicrobial resistance rate ... ...

    Abstract Background: The objective of this study is to evaluate the prevalence of
    Methods: We investigated the drug resistance in 95 isolates of
    Results: Over a 4-year period, the resistance rate of
    Conclusions: The antimicrobial resistance rate of
    Language English
    Publishing date 2018-06-05
    Publishing country China
    Document type Journal Article
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2018.05.43
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Prevalence and characterisation of third-generation cephalosporin-resistant Shigella flexneri isolates from Jiangsu Province, China, 2013-2015.

    Liu, Guoye / Qian, Huimin / Tang, Bo / Chen, Yin / Kang, Haiquan / Jiang, Fei / Ma, Ping / Gu, Bing / Huo, Xiang

    Journal of global antimicrobial resistance

    2018  Volume 15, Page(s) 283–287

    Abstract: Objectives: The aim of this study was to assess the prevalence of Shigella flexneri resistance to third-generation cephalosporins (3GCs) and to characterise the underlying resistance mechanisms.: Methods: A total of 282 S. flexneri strains isolated ... ...

    Abstract Objectives: The aim of this study was to assess the prevalence of Shigella flexneri resistance to third-generation cephalosporins (3GCs) and to characterise the underlying resistance mechanisms.
    Methods: A total of 282 S. flexneri strains isolated in 2013-2015 in Jiangsu Province, China, were identified, serotyped and analysed for their susceptibility to 3GCs. The bla
    Results: Of the 282 S. flexneri strains, 97 (34.4%) were resistant to cefotaxime, from which 68 (24.1%) were also resistant to ceftazidime. ESBL genes were detected in 73/97 isolates (75.3%), of which 66/73 (90.4%) showed resistance to 3GCs. Of the 73 ESBL-positive isolates, 32 (43.8%) were positive for CTX-M-1 group (17 for CTX-M-55, 4 for CTX-M-3, 1 for CTX-M-15, 3 for CTX-M-79 and 7 for CTX-M-123), 31 (42.5%) were positive for CTX-M-9 group (29 for CTX-M-14, 1 for CTX-M-24 and 1 for CTX-M-27), 25 (34.2%) were positive for TEM-types (21 for TEM-1 and 4 for TEM-1b) and 1 (1.4%) was positive for SHV-type (SHV-12); none were positive for CTX-M-2 group, CTX-M-8 group and OXA-type.
    Conclusion: ESBLs play an important role in Shigella resistance to 3GCs. CTX-M-14 and CTX-M-55 appeared to be the dominant ESBLs in 13 cities of Jiangsu Province. Therefore, it is time to regularly monitor resistance of S. flexneri to 3GCs and to take appropriate measures to manage this problem.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Cephalosporins/pharmacology ; China/epidemiology ; Drug Resistance, Bacterial ; Dysentery, Bacillary/epidemiology ; Dysentery, Bacillary/microbiology ; Female ; Humans ; Male ; Prevalence ; Shigella flexneri/classification ; Shigella flexneri/drug effects ; Shigella flexneri/genetics ; Shigella flexneri/isolation & purification ; beta-Lactamases/genetics ; beta-Lactamases/metabolism
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; Cephalosporins ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2018-08-23
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7165
    ISSN (online) 2213-7173
    ISSN 2213-7165
    DOI 10.1016/j.jgar.2018.08.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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