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Article ; Online: Unique regulatory roles of ncRNAs changed by PM

He, Bo / Xu, Hai-Ming / Liu, Hao-Wen / Zhang, Yin-Feng

2023 Volume 255, Page(s) 114812

Abstract: ... ...

Abstract	PM
MeSH term(s)	Humans ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; RNA, Circular/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Inflammation ; Biomarkers ; Particulate Matter/toxicity
Chemical Substances	RNA, Long Noncoding ; RNA, Circular ; MicroRNAs ; Biomarkers ; Particulate Matter
Language	English
Publishing date	2023-03-22
Publishing country	Netherlands
Document type	Meta-Analysis ; Journal Article ; Review
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2023.114812
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Zs.A 1418: Show issues

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Article: Ovo-lactovegetarian diet as a possible protective factor against gallbladder polyps in Taiwan: A cross-sectional study.

Liu, Hao-Wen / Chen, Cheng-Yu

Ci ji yi xue za zhi = Tzu-chi medical journal

2019 Volume 31, Issue 1, Page(s) 29–34

Abstract: Objective: Gallbladder polyps (GBPs) are an increasingly common incidental finding and 3% to 8% of GBPs become malignant. A poor prognosis is expected in patients with gallbladder cancer. No studies have considered the relationship between diet and the ... ...

Abstract	Objective: Gallbladder polyps (GBPs) are an increasingly common incidental finding and 3% to 8% of GBPs become malignant. A poor prognosis is expected in patients with gallbladder cancer. No studies have considered the relationship between diet and the development of GBPs in the Taiwanese population. The objective of this study was to investigate whether a vegetarian diet protects against GBP development. Materials and methods: This cross-sectional study included 11,717 individuals who received a health checkup at Taipei Tzu Chi Hospital (New Taipei City, Taiwan) between October 2011 and October 2016. All individuals completed questionnaires that collected data about their characteristics, dietary patterns, and lifestyle. Physical examinations were conducted, and blood chemistry tests were performed. The presence of GBPs was determined using ultrasonography. We subsequently evaluated the association between diet and GBP prevalence using multivariate analysis. Results: The prevalence of GBPs for the entire group was 8.3%. GBPs were significantly less common in the vegetarian groups (vegans 9.0%, ovo-lacto vegetarians 7.5%, and semi-vegetarians 7.2%) compared with the omnivore group (9.6%) ( Conclusions: The study findings showed a strong negative association between an ovo-lacto vegetarian diet and GBP occurrence.
Language	English
Publishing date	2019-01-16
Publishing country	China (Republic : 1949- )
Document type	Journal Article
DOI	10.4103/tcmj.tcmj_16_18
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Article ; Online: Dissecting the risk factors for hyperuricemia in vegetarians in Taiwan.

Chang, Kai-Chieh / Huang, Sin-Yi / Tsai, Wen-Hsin / Liu, Hao-Wen / Liu, Jia-Sin / Wu, Chia-Lin / Kuo, Ko-Lin

Journal of the Chinese Medical Association : JCMA

2024 Volume 87, Issue 4, Page(s) 393–399

Abstract: Background: Vegetarian diets have been shown to lower the risks of hyperuricemia and gout. Little is known about the risk factors of hyperuricemia in vegetarians.: Methods: This community-based retrospective case-control study was conducted to ... ...

Abstract	Background: Vegetarian diets have been shown to lower the risks of hyperuricemia and gout. Little is known about the risk factors of hyperuricemia in vegetarians. Methods: This community-based retrospective case-control study was conducted to establish prediction models for hyperuricemia. From September 5, 2005, to December 31, 2016, 7331 adult vegetarians were recruited at Taipei Tzu Chi Hospital. Hyperuricemia was defined as a serum uric acid concentration greater than 7 mg/dL. Results: There were 593 (8.1%) vegetarians with hyperuricemia and 6738 (91.9%) without hyperuricemia. We stepwise built up three models for predicting hyperuricemia in vegetarians. The full model (model 3) has the highest area under the receiver operating characteristic curve (AUROC, 85.52%). Additionally, the AUROC of model 3 is 77.97% and 84.85% in vegetarians with or without prior gout history, respectively. Moreover, male gender, hyperlipidemia, body mass index, and serum albumin are independent risk factors for hyperuricemia in vegetarians. In contrast, estimated glomerular filtration rate and proteinuria are independently associated with lower risks of hyperuricemia in vegetarians. Conclusion: Our study revealed that risk factors for hyperuricemia, which includes clinical characteristics, account for more than 85% of discriminatory performance in Taiwanese vegetarians. This model may be helpful for monitoring and preventing hyperuricemia in the population.
MeSH term(s)	Adult ; Male ; Humans ; Hyperuricemia/epidemiology ; Hyperuricemia/etiology ; Uric Acid ; Retrospective Studies ; Case-Control Studies ; Taiwan/epidemiology ; Risk Factors ; Gout/epidemiology ; Vegetarians
Chemical Substances	Uric Acid (268B43MJ25)
Language	English
Publishing date	2024-02-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2107283-8
ISSN	1728-7731 ; 1726-4901
ISSN (online)	1728-7731
ISSN	1726-4901
DOI	10.1097/JCMA.0000000000001074
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Zs.A 2699: Show issues

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Article ; Online: Vegan Diet Is Associated with a Lower Risk of Chronic Kidney Disease in Patients with Hyperuricemia.

Wu, Chia-Lin / Tsai, Wen-Hsin / Liu, Jia-Sin / Liu, Hao-Wen / Huang, Sin-Yi / Kuo, Ko-Lin

Nutrients

2023 Volume 15, Issue 6

Abstract: Hyperuricemia is a well-known risk factor for chronic kidney disease (CKD). Little is known about whether a vegetarian diet is associated with a lower risk of CKD in patients with hyperuricemia. From 5 September 2005, to 31 December 2016, we ... ...

Abstract	Hyperuricemia is a well-known risk factor for chronic kidney disease (CKD). Little is known about whether a vegetarian diet is associated with a lower risk of CKD in patients with hyperuricemia. From 5 September 2005, to 31 December 2016, we retrospectively included clinically stable patients with hyperuricemia who received health check-ups at Taipei Tzu Chi Hospital. All participants completed a dietary habits questionnaire to determine whether they were omnivorous, lacto-ovo vegetarian, or vegan. CKD was defined as an estimated glomerular filtration rate <60 mL/min/1.73 m
MeSH term(s)	Humans ; Diet, Vegan ; Hyperuricemia/complications ; Hyperuricemia/epidemiology ; Cross-Sectional Studies ; Retrospective Studies ; Diet, Vegetarian ; Vegetarians ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/etiology ; Diet
Language	English
Publishing date	2023-03-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15061444
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Article: Association of nonalcoholic fatty liver and chronic kidney disease: An analysis of 37,825 cases from health checkup center in Taiwan.

Liu, Hao-Wen / Liu, Jia-Sin / Kuo, Ko-Lin

Ci ji yi xue za zhi = Tzu-chi medical journal

2019 Volume 32, Issue 1, Page(s) 65–69

Abstract: Objective: Nonalcoholic fatty liver (NAFLD) and chronic kidney disease (CKD) share common pathogenic mechanisms and risk factors. The relationship between in NAFLD and CKD remains controversial. We aim to assess the association between NAFLD and CKD.: ...

Abstract	Objective: Nonalcoholic fatty liver (NAFLD) and chronic kidney disease (CKD) share common pathogenic mechanisms and risk factors. The relationship between in NAFLD and CKD remains controversial. We aim to assess the association between NAFLD and CKD. Materials and methods: A cross-sectional study was based on individuals who received physical checkups at the Taipei Tzu Chi Hospital from September 5, 2005, to December 31, 2016. Demographic and clinical characteristics of the study population were collected. NAFLD was defined by abdominal ultrasonography and excluded other liver disease. CKD was defined as estimated glomerular filtration rate ≤60 mL/min/1.73 m Results: In univariate analysis, individuals with mild NAFLD and moderate-to-severe NAFLD were both significantly associated with CKD (odds ratio [OR], 1.23; 95% confidence interval [CI], 1.13-1.33; OR, 1.66; CI, 1.49-1.85) when compared to individuals without NAFLD. After multivariate adjustment, individuals with moderate-to-severe NAFLD were still significantly more likely to have CKD (OR, 1.17, 95% CI, 1.03-1.33). Conclusions: Our finding showed that the presence and severity of NAFLD was positively associated with CKD in unadjusted and adjusted analysis. Further follow-up studies may be needed to validate these associations.
Language	English
Publishing date	2019-04-23
Publishing country	China (Republic : 1949- )
Document type	Journal Article
DOI	10.4103/tcmj.tcmj_233_18
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Article: Emerging Functions and Clinical Applications of Exosomal ncRNAs in Ovarian Cancer.

Zhang, Yu / Wei, Yi-Jing / Zhang, Yi-Fei / Liu, Hao-Wen / Zhang, Yin-Feng

Frontiers in oncology

2021 Volume 11, Page(s) 765458

Abstract: Ovarian cancer (OC) is one of the deadliest gynecological malignancies worldwide and has a high mortality rate. Its dismal prognosis is closely related to late diagnosis and drug resistance. Exosomes are a novel means of intercellular communication that ... ...

Abstract	Ovarian cancer (OC) is one of the deadliest gynecological malignancies worldwide and has a high mortality rate. Its dismal prognosis is closely related to late diagnosis and drug resistance. Exosomes are a novel means of intercellular communication that are involved in the genesis and development of tumors by delivering a variety of biologically active molecules, including proteins, lipids, and nucleic acids. As an important component, noncoding RNAs (ncRNAs) are selectively enriched in exosomes and participate in the regulation of specific aspects of OC development, such as proliferation, invasion, metastasis, angiogenesis, immune escape, and treatment resistance. Therefore, strategies that specifically target exosomal ncRNAs may be attractive therapeutic options. Exosomes are readily available in almost all types of human biological fluids and are biocompatible, making them promising biomarkers of OC as well as targets for therapeutic applications. In this review, we briefly summarize the biology of exosomes, the function of exosomal ncRNAs in OC development, and their potential clinical applications as biomarkers and therapeutic tools. Ideally, exosomal ncRNAs will become increasingly valuable in the diagnosis and treatment of OC in the near future.
Language	English
Publishing date	2021-11-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2021.765458
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Article: Vegetarian diet and blood pressure in a hospital-base study.

Liu, Hao-Wen / Liu, Jia-Sin / Kuo, Ko-Lin

Ci ji yi xue za zhi = Tzu-chi medical journal

2018 Volume 30, Issue 3, Page(s) 176–180

Abstract: Objective: Previous studies have reported that a vegetarian diet may lower blood pressure (BP), but the effect of diet on BP in asymptomatic participants with proteinuria is unknown. We examined the association of diet and BP in individuals with or ... ...

Abstract	Objective: Previous studies have reported that a vegetarian diet may lower blood pressure (BP), but the effect of diet on BP in asymptomatic participants with proteinuria is unknown. We examined the association of diet and BP in individuals with or without proteinuria. Materials and methods: This cross-sectional study analyzed data from participants who were more than 40 years old and received physical checkups at Taipei Tzu Chi Hospital from September 5, 2005, to December 31, 2016. Diets were assessed at baseline by a self-reported questionnaire and categorized as vegan, lacto-ovo vegetarian, or omnivore. There were 2818 (7.7%) vegans, 5616 (15.3%) lacto-ovo vegetarians, and 28,183 (77.0%) omnivores. The effect of different parameters on BP was determined using a multivariate multiple linear regression model with no intercept, with control for important characteristics and lifestyle confounders. Results: The vegan group had a lower mean systolic BP (-3.87 mmHg, Conclusions: A vegan diet was associated with lower BP in asymptomatic participants with proteinuria. This diet could be a nonpharmacologic method to reduce BP.
Language	English
Publishing date	2018-07-30
Publishing country	China (Republic : 1949- )
Document type	Journal Article
DOI	10.4103/tcmj.tcmj_91_17
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Article: Vegetarian Diet Was Associated With a Lower Risk of Chronic Kidney Disease in Diabetic Patients.

Hou, Yi-Chou / Huang, Hui-Fen / Tsai, Wen-Hsin / Huang, Sin-Yi / Liu, Hao-Wen / Liu, Jia-Sin / Kuo, Ko-Lin

Frontiers in nutrition

2022 Volume 9, Page(s) 843357

Abstract: Introduction: Diabetes mellitus (DM) is a pathological hyperglycemic state related to the dysregulation of insulin. Chronic kidney disease (CKD) is a common chronic complication in diabetic patients. A vegetarian diet could be one of the preventive ... ...

Abstract	Introduction: Diabetes mellitus (DM) is a pathological hyperglycemic state related to the dysregulation of insulin. Chronic kidney disease (CKD) is a common chronic complication in diabetic patients. A vegetarian diet could be one of the preventive strategies for the occurrence of CKD in patients with diabetes mellitus. However, it is still unknown whether a vegetarian diet lowers the occurrence of CKD in DM patients. Research design and methods: This retrospective study was conducted at Taipei Tzu Chi Hospital from 5 September 2005 to 31 December 2016. Subjects with an HbA1c level > 6.5% or previous history of diabetes mellitus elder than 40 years were grouped based on self-reported dietary habits (vegetarians, lacto-ovo vegetarians and omnivores) in the structured questionnaire. Structural equation modeling (SEM) was applied to estimate the direct and indirect effects of variables on the occurrence of chronic kidney disease. Results: Among these 2,797 subjects, the participants were grouped into dietary habits as vegans ( Conclusion: Vegetarian dietary habits were associated with a lower occurrence of CKD in DM patients.
Language	English
Publishing date	2022-04-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.843357
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Article ; Online: Unifying the order and disorder dynamics in photoexcited VO

Liu, Hao-Wen / Liu, Wen-Hao / Suo, Zhao-Jun / Wang, Zhi / Luo, Jun-Wei / Li, Shu-Shen / Wang, Lin-Wang

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 28, Page(s) e2122534119

Abstract: Photoinduced phase transition (PIPT) is always treated as a coherent process, but ultrafast disordering in PIPT is observed in recent experiments. Utilizing the real-time time-dependent density functional theory method, here we track the motion of ... ...

Abstract	Photoinduced phase transition (PIPT) is always treated as a coherent process, but ultrafast disordering in PIPT is observed in recent experiments. Utilizing the real-time time-dependent density functional theory method, here we track the motion of individual vanadium (V) ions during PIPT in VO
Language	English
Publishing date	2022-07-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2122534119
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Zs.A 1148: Show issues

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Article ; Online: Association of Vegetarian Diet with Chronic Kidney Disease.

Liu, Hao-Wen / Tsai, Wen-Hsin / Liu, Jia-Sin / Kuo, Ko-Lin

Nutrients

2019 Volume 11, Issue 2

Abstract: Chronic kidney disease (CKD) and its complications are major global public health issues. Vegetarian diets are associated with a more favorable profile of metabolic risk factors and lower blood pressure, but the protective effect in CKD is still unknown. ...

Abstract	Chronic kidney disease (CKD) and its complications are major global public health issues. Vegetarian diets are associated with a more favorable profile of metabolic risk factors and lower blood pressure, but the protective effect in CKD is still unknown. We aim to assess the association between vegetarian diets and CKD. A cross-sectional study was based on subjects who received physical checkups at the Taipei Tzu Chi Hospital from 5 September 2005, to 31 December 2016. All subjects completed a questionnaire to assess their demographics, medical history, diet pattern, and lifestyles. The diet patterns were categorized into vegan, ovo-lacto vegetarian, or omnivore. CKD was defined as an estimated GFR <60 mL/min/1.73 m² or the presence of proteinuria. We evaluated the association between vegetarian diets and CKD prevalence by using multivariate analysis. Our study recruited 55,113 subjects. CKD was significantly less common in the vegan group compared with the omnivore group (vegan 14.8%, ovo-lacto vegetarians 20%, and omnivores 16.2%,
MeSH term(s)	Adult ; Aged ; Cross-Sectional Studies ; Diet, Vegetarian/statistics & numerical data ; Humans ; Middle Aged ; Renal Insufficiency, Chronic/epidemiology ; Risk Factors
Language	English
Publishing date	2019-01-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu11020279
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