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Article: Low expression of RACK1 is associated with metastasis and worse prognosis in cholangiocarcinoma.

Gao, Zhihui / Sun, Wentao / Ni, Xiaojian / Wan, Wenze / Suo, Tao / Ni, Xiaoling / Liu, Han / Li, Na / Sheng Shen / Liu, Houbao

Heliyon

2024 Volume 10, Issue 6, Page(s) e27366

Abstract: Background: Cholangiocarcinoma is a poorly prognostic malignant tumor, and the metastatic stage of cancer is not an early stage when diagnosed. Lymph node metastasis is common in the early stage. Ribosomal receptor for activated C-kinase 1 (RACK1) has ... ...

Abstract	Background: Cholangiocarcinoma is a poorly prognostic malignant tumor, and the metastatic stage of cancer is not an early stage when diagnosed. Lymph node metastasis is common in the early stage. Ribosomal receptor for activated C-kinase 1 (RACK1) has found involved in the oncogenesis of various tumors and in the epithelial-mesenchymal transition (EMT). Nevertheless, its role in cholangiocarcinoma remains unknown. Material and methods: The possible correlation between RACK1 and tumor prognosis was analyzed in cholangiocarcinoma patients. The GEO and TCGA databases were used to evaluate the level of Results: The Kaplan-Meier analysis indicated that low expression of RACK1 was associated with poor prognosis and RACK1 was negatively related to lymph node metastasis, which were verified in databases TCGA and GEO; downregulation of RACK1 via RNA interference correlated with changes in the expression of EMT biomarkers and promoted the migration of cholangiocarcinoma cell lines. Conclusion: The protein expression of RACK1 is significantly higher in cholangiocarcinoma tissues than in peritumoral tissues, however, the high RACK1 expression indicates better overall survival and less risk for lymph node metastasis.
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e27366
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Article ; Online: Cystic duct carcinoma and type I/II perihilar cholangiocarcinoma: Clinicopathological features and a new differential diagnosis model.

Nan, Lingxi / Wang, Changcheng / Wang, Jie / Xu, Shijie / Bo, Xiaobo / Liu, Houbao / Wang, Yueqi

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2023 Volume 49, Issue 12, Page(s) 107099

MeSH term(s)	Humans ; Klatskin Tumor/diagnosis ; Klatskin Tumor/surgery ; Klatskin Tumor/pathology ; Diagnosis, Differential ; Cystic Duct ; Cholangiocarcinoma/surgery ; Bile Ducts, Intrahepatic/pathology ; Bile Duct Neoplasms/pathology
Language	English
Publishing date	2023-09-26
Publishing country	England
Document type	Journal Article
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2023.107099
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Zs.A 1149: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 549: Show issues

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Article: Publication Trends of Research on Gallbladder Cancer During 2001-2021: A 20-Year Bibliometric Analysis.

Sun, Wentao / Wan, Wenze / Gao, Zhihui / Suo, Tao / Shen, Sheng / Liu, Houbao

Frontiers in oncology

2022 Volume 12, Page(s) 932797

Abstract: Gallbladder cancer (GBC) is one of the lethal cancers with an extremely poor prognosis. In the recent 20 years, research on GBC has developed rapidly. Here we aim to perform a systematical bibliometric analysis on the current foci and status of GBC ... ...

Abstract	Gallbladder cancer (GBC) is one of the lethal cancers with an extremely poor prognosis. In the recent 20 years, research on GBC has developed rapidly. Here we aim to perform a systematical bibliometric analysis on the current foci and status of GBC research. This study analyzes trends in GBC research and compares contributions from different countries and regions, institutions, and authors. All publications in GBC research from 2001 to 2021 in the Web of Science Core Collection (WoSCC) database were collected. Microsoft Excel 2010 and GraphPad Prism 9 were used to analyze publication data and publication trends. VOSviewer 1.6.17 was adapted to generate a visual network of keywords in surgical training research. A total of 3,323 publications were included. China was the most productive country, with the highest number of publications (n = 900, 27.08%). Shanghai Jiaotong University and Roa JC were the most productive institution and authors, contributing 215 and 89 publications, respectively. Keywords were classified into five clusters, each representing a key topic. The main clusters of GBC are related to surgery therapy, mechanism research-related study, and non-surgery therapy, while migration is the current hotspot of GBC research. The scientific progression of GBC research over the past two decades was comprehensively analyzed by this bibliometric study. Finding deeper mechanisms in the migration of GBC cells, new biomarkers, and highly effective nomograms will be the major problems and directions in the future.
Language	English
Publishing date	2022-07-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.932797
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Article: ARID1A Downregulation Predicts High PD-L1 Expression and Worse Clinical Outcome in Patients With Gallbladder Cancer.

Nan, Lingxi / Wang, Changcheng / Wang, Jie / Zhang, Shulong / Bo, Xiaobo / Wang, Yueqi / Liu, Houbao

Frontiers in oncology

2022 Volume 12, Page(s) 787897

Abstract: Background: Recent studies have confirmed that AT-rich interactive domain-containing protein 1A (ARID1A) plays a critical role in tumorigenesis, but its role in gallbladder cancer (GBC) remains unclear.: Methods: In total, 224 patients from Zhongshan ...

Abstract	Background: Recent studies have confirmed that AT-rich interactive domain-containing protein 1A (ARID1A) plays a critical role in tumorigenesis, but its role in gallbladder cancer (GBC) remains unclear. Methods: In total, 224 patients from Zhongshan Hospital were recruited for this retrospective study. The clinicopathological and baseline characteristics of the patients were collected. Bioinformatics analysis was performed to reveal variations in genes and signaling pathways, and ARID1A and PD-L1 expression and the number of PD1+ tumor-infiltrating lymphocytes (TILs) were measured by immunohistochemical staining. Results: ARID1A expression was negatively correlated with overall survival in patients with GBC, and multivariate analysis identified ARID1A as an independent prognostic factor for overall survival. A heatmap and gene set enrichment analysis suggested that cytotoxic T lymphocyte signatures and immune-related signaling pathways were downregulated in ARID1A low tumors. Subsequent immunohistochemical staining confirmed that ARID1A expression was negatively correlated with PD-L1 expression and PD1+ TILs in the tumor microenvironment. The Kaplan-Meier analysis suggested that high ARID1A expression combined with low PD-L1 expression or low PD1+ TIL counts is associated with the best prognosis in patients with GBC. Conclusion: ARID1A inactivation can lead to a worse prognosis in patients with GBC, potentially by mediating immune evasion through the PD1/PD-L1 pathway.
Language	English
Publishing date	2022-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.787897
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Article ; Online: Comparison of

Pang, Lifang / Mao, Wujian / Zhang, Yiqiu / Liu, Guobing / Hu, Pengcheng / Chen, Shuguang / Gu, Yushen / Wang, Yueqi / Liu, Houbao / Shi, Hongcheng

Abdominal radiology (New York)

2023 Volume 48, Issue 8, Page(s) 2537–2546

Abstract: Purpose: 18: Methods: Fifty-eight patients with HCCA confirmed by pathology were retrospectively analyzed. : Results: There was no significant difference in SUV: Conclusions: The diagnostic accuracy ... ...

Abstract	Purpose: 18 Methods: Fifty-eight patients with HCCA confirmed by pathology were retrospectively analyzed. Results: There was no significant difference in SUV Conclusions: The diagnostic accuracy of
MeSH term(s)	Humans ; Positron Emission Tomography Computed Tomography ; Fluorodeoxyglucose F18 ; Klatskin Tumor/pathology ; Klatskin Tumor/surgery ; Neoplasm Staging ; Retrospective Studies ; Bismuth ; Bile Duct Neoplasms/pathology
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Bismuth (U015TT5I8H)
Language	English
Publishing date	2023-05-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2839786-1
ISSN	2366-0058 ; 2366-004X
ISSN (online)	2366-0058
ISSN	2366-004X
DOI	10.1007/s00261-023-03925-x
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Zs.A 1262: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Fasting-induced RNF152 resensitizes gallbladder cancer cells to gemcitabine by inhibiting mTORC1-mediated glycolysis.

Tao, Ying / Gong, Zijun / Shen, Sheng / Ding, Yaqi / Zan, Rui / Zheng, Bohao / Sun, Wentao / Ma, Chaolin / Shu, Mengxuan / Lu, Xiao / Liu, Han / Ni, Xiaoling / Liu, Houbao / Suo, Tao

iScience

2024 Volume 27, Issue 5, Page(s) 109659

Abstract: Abnormal mTORC1 activation by the lysosomal Ragulator complex has been implicated in cancer and glycolytic metabolism associated with drug resistance. Fasting upregulates RNF152 and mediates the metabolic status of cells. We report that RNF152 regulates ... ...

Abstract	Abnormal mTORC1 activation by the lysosomal Ragulator complex has been implicated in cancer and glycolytic metabolism associated with drug resistance. Fasting upregulates RNF152 and mediates the metabolic status of cells. We report that RNF152 regulates mTORC1 signaling by targeting a Ragulator subunit, p18, and attenuates gemcitabine resistance in gallbladder cancer (GBC). We detected levels of RNF152 and p18 in tissues and undertook mechanistic studies using activators, inhibitors, and lentivirus transfections. RNF152 levels were significantly lower in GBC than in adjacent non-cancer tissues. Fasting impairs glycolysis, induces gemcitabine sensitivity, and upregulates RNF152 expression. RNF152 overexpression increases the sensitivity of GBC cells to gemcitabine, whereas silencing RNF152 has the opposite effect. Fasting-induced RNF152 ubiquitinates p18, resulting in proteasomal degradation. RNF152 deficiency increases the lysosomal localization of p18 and increases mTORC1 activity, to promote glycolysis and decrease gemcitabine sensitivity. RNF152 suppresses mTORC1 activity to inhibit glycolysis and enhance gemcitabine sensitivity in GBC.
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2024.109659
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Article ; Online: Biomimicking covalent organic frameworks nanocomposite coating for integrated enhanced anticorrosion and antifouling properties of a biodegradable magnesium stent.

Zan, Rui / Wang, Hao / Shen, Sheng / Yang, Shi / Yu, Han / Zhang, Xiyue / Zhang, Xian / Chen, Xiang / Shu, Mengxuan / Lu, Xiao / Xia, Jiazeng / Gu, Yaqi / Liu, Houbao / Zhou, Yongping / Zhang, Xiaonong / Suo, Tao

Acta biomaterialia

2024 Volume 180, Page(s) 183–196

Abstract: The utilization of biodegradable magnesium (Mg) alloys in the fabrication of temporary non-vascular stents is an innovative trend in biomedical engineering. However, the heterogeneous degradation profiles of these biomaterials, together with potential ... ...

Abstract	The utilization of biodegradable magnesium (Mg) alloys in the fabrication of temporary non-vascular stents is an innovative trend in biomedical engineering. However, the heterogeneous degradation profiles of these biomaterials, together with potential bacterial colonization that could precipitate infectious or stenotic complications, are critical obstacles precluding their widespread clinical application. In pursuit of overcoming these limitations, this study applies the principles of biomimicry, particularly the hydrophobic and anti-fouling characteristics of lotus leaves, to pioneer the creation of nanocomposite coatings. These coatings integrate poly-trimethylene carbonate (PTMC) with covalent organic frameworks (COFs), to modify the stent's surface property. The strategic design of the coating's topography, porosity, and self-polishing capabilities collectively aims to decelerate degradation processes and minimize biological adhesion. The protective qualities of the coatings were substantiated through rigorous testing in both in vitro dynamic bile tests and in vivo New Zealand rabbit choledochal models. Empirical findings from these trials confirmed that the implementation of COF-based nanocomposite coatings robustly fortifies Mg implantations, conferring heightened resistance to both biocorrosion and biofouling as well as improved biocompatibility within bodily environments. The outcomes of this research elucidate a comprehensive framework for the multifaceted strategies against stent corrosion and fouling, thereby charting a visionary pathway toward the systematic conception of a new class of reliable COF-derived surface modifications poised to amplify the efficacy of Mg-based stents. STATEMENT OF SIGNIFICANCE: Biodegradable magnesium (Mg) alloys are widely utilized in temporary stents, though their rapid degradation and susceptibility to bacterial infection pose significant challenges. Our research has developed a nanocomposite coating inspired by the lotus, integrating poly-trimethylene carbonate with covalent organic frameworks (COF). The coating achieved self-polishing property and optimal surface energy on the Mg substrate, which decelerates stent degradation and reduces biofilm formation. Comprehensive evaluations utilizing dynamic bile simulations and implantation in New Zealand rabbit choledochal models reveal that the coating improves the durability and longevity of the stent. The implications of these findings suggest the potential COF-based Mg alloy stent surface treatments and a leap forward in advancing stent performance and endurance in clinical applications.
MeSH term(s)	Animals ; Rabbits ; Magnesium/chemistry ; Magnesium/pharmacology ; Nanocomposites/chemistry ; Corrosion ; Coated Materials, Biocompatible/chemistry ; Coated Materials, Biocompatible/pharmacology ; Absorbable Implants ; Stents ; Metal-Organic Frameworks/chemistry ; Metal-Organic Frameworks/pharmacology ; Biofouling/prevention & control ; Dioxanes/chemistry ; Biomimetic Materials/chemistry ; Biomimetic Materials/pharmacology ; Polymers/chemistry ; Polymers/pharmacology ; Alloys/chemistry ; Alloys/pharmacology
Chemical Substances	Magnesium (I38ZP9992A) ; Coated Materials, Biocompatible ; Metal-Organic Frameworks ; polytrimethylene carbonate (31852-84-3) ; Dioxanes ; Polymers ; Alloys
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2173841-5
ISSN	1878-7568 ; 1742-7061
ISSN (online)	1878-7568
ISSN	1742-7061
DOI	10.1016/j.actbio.2024.04.012
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Article ; Online: KRAS G12D mutation eliminates reactive oxygen species through the Nrf2/CSE/H

Fan, Kun / Zhang, Shulong / Ni, Xiaojian / Shen, Sheng / Wang, Jiwen / Sun, Wentao / Suo, Tao / Liu, Han / Ni, Xiaoling / Liu, Houbao

Acta biochimica et biophysica Sinica

2022 Volume 54, Issue 11, Page(s) 1731–1739

Abstract: In pancreatic cancer, KRAS G12D can trigger pancreatic cancer initiation and development. Rapid tumor growth is often accompanied by excess intracellular reactive oxygen species (ROS) production, which is unfavorable to tumor. However, the regulation of ... ...

Abstract	In pancreatic cancer, KRAS G12D can trigger pancreatic cancer initiation and development. Rapid tumor growth is often accompanied by excess intracellular reactive oxygen species (ROS) production, which is unfavorable to tumor. However, the regulation of intracellular ROS levels in KRAS mutant pancreatic cancer remains unclear. In this study, we establish BxPC3 stable cell strains expressing KRAS wild type (WT) and G12D mutation and find unchanged ROS levels despite higher glycolysis and proliferation viability in KRAS mutant cells than KRAS WT cells. The key hydrogen sulfide (H
MeSH term(s)	Humans ; Mutation ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Pancreatic Neoplasms/metabolism ; Proto-Oncogene Proteins p21(ras)/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism ; Reactive Oxygen Species/metabolism ; Cystathionine gamma-Lyase ; Pancreatic Neoplasms
Chemical Substances	KRAS protein, human ; NF-E2-Related Factor 2 ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; Reactive Oxygen Species ; NFE2L2 protein, human ; Cystathionine gamma-Lyase (EC 4.4.1.1)
Language	English
Publishing date	2022-12-13
Publishing country	China
Document type	Journal Article
ZDB-ID	2175256-4
ISSN	1745-7270 ; 0582-9879 ; 1672-9145
ISSN (online)	1745-7270
ISSN	0582-9879 ; 1672-9145
DOI	10.3724/abbs.2022173
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Article ; Online: The impact of preoperative biliary drainage on postoperative outcomes in patients with malignant obstructive jaundice: a retrospective analysis of 290 consecutive cases at a single medical center.

Gao, Zhihui / Wang, Jie / Shen, Sheng / Bo, Xiaobo / Suo, Tao / Ni, Xiaoling / Liu, Han / Huang, Lihong / Liu, Houbao

World journal of surgical oncology

2022 Volume 20, Issue 1, Page(s) 7

Abstract: Background: The efficacy of preoperative biliary drainage (PBD) has been debated for several decades, and yet indications for PBD remain controversial. The aim of this study was to compare the postoperative morbidity and mortality in patients with ... ...

Abstract	Background: The efficacy of preoperative biliary drainage (PBD) has been debated for several decades, and yet indications for PBD remain controversial. The aim of this study was to compare the postoperative morbidity and mortality in patients with malignant obstructive jaundice undergoing direct surgery versus surgery with PBD. Methods: All consecutive patients with malignant obstructive jaundice who underwent radical resection between June 2017 and December 2019 at Zhongshan Hospital were analyzed retrospectively. The study population was divided into two groups: PBD group (PG) and direct surgery group (DG). The subgroups were chosen based on the site of obstruction. Perioperative indicators and postoperative complications were compared and analyzed. Results: A total of 290 patients were analyzed. Postoperative complications occurred in 134 patients (46.4%). Patients in the PG group had a lower overall rate of postoperative complications compared with the DG group, with perioperative total bilirubin (TB) identified as an independent risk factor in multivariate analysis (hazard ratio = 1.004; 95% confidence interval 1.001-1.007; P = 0.017). Subgroup analysis showed that PBD reduced the complication rate in patients with proximal obstruction. In the proximal-obstruction subgroup, a preoperative TB level > 162 μmol/L predicted postoperative complications. Conclusions: PBD may reduce the overall rate of postoperative complications among patients with proximal malignant obstructive jaundice. Trial registration: ClinicalTrials.gov, 2018ZSLC 24 . Registered May 17, 2018, https://clinicaltrials.gov/ .
MeSH term(s)	Drainage ; Hospitals ; Humans ; Jaundice, Obstructive/etiology ; Jaundice, Obstructive/surgery ; Pancreaticoduodenectomy ; Postoperative Complications ; Preoperative Care ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2022-01-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2118383-1
ISSN	1477-7819 ; 1477-7819
ISSN (online)	1477-7819
ISSN	1477-7819
DOI	10.1186/s12957-021-02476-z
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Article: Pancreatobiliary and peripancreatobiliary tuberculosis: a rare cause of obstructive jaundice.

Shen, Zhenbin / Liu, Houbao

Archives of medical science : AMS

2013 Volume 9, Issue 6, Page(s) 1152–1157

Language	English
Publishing date	2013-12-26
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2203781-0
ISSN	1734-1922
ISSN	1734-1922
DOI	10.5114/aoms.2013.39799
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