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Article ; Online: SerpinA3N Regulates the Secretory Phenotype of Mouse Senescent Astrocytes Contributing to Neurodegeneration.

Han, Xiaojuan / Lei, Qing / Liu, Huanhuan / Zhang, Tianying / Gou, Xingchun

The journals of gerontology. Series A, Biological sciences and medical sciences

2024 Volume 79, Issue 4

Abstract: Senescent astrocyte accumulation in the brain during normal aging is a driver of age-related neurodegenerative diseases such as Alzheimer's disease. However, the molecular events underlying astrocyte senescence in Alzheimer's disease are not fully ... ...

Abstract	Senescent astrocyte accumulation in the brain during normal aging is a driver of age-related neurodegenerative diseases such as Alzheimer's disease. However, the molecular events underlying astrocyte senescence in Alzheimer's disease are not fully understood. In this study, we demonstrated that senescent astrocytes display a secretory phenotype known as the senescence-associated secretory phenotype (SASP), which is associated with the upregulation of various proinflammatory factors and the downregulation of neurotrophic growth factors (eg, NGF and BDNF), resulting in a decrease in astrocyte-mediated neuroprotection and increased risk of neurodegeneration. We found that SerpinA3N is upregulated in senescent primary mouse astrocytes after serial passaging in vitro or by H2O2 treatment. Further exploration of the underlying mechanism revealed that SerpinA3N deficiency protects against senescent astrocyte-induced neurodegeneration by suppressing SASP-related factors and inducing neurotrophic growth factors. Brain tissues from Alzheimer's disease model mice possessed increased numbers of senescent astrocytes. Moreover, senescent astrocytes exhibited upregulated SerpinA3N expression in vitro and in vivo, confirming that our cell model recapitulated the in vivo pathology of these neurodegenerative diseases. Altogether, our study reveals a novel molecular strategy to regulate the secretory phenotype of senescent astrocytes and implies that SerpinA3N and its regulatory mechanisms may be potential targets for delaying brain aging and aging-related neurodegenerative diseases.
MeSH term(s)	Animals ; Mice ; Alzheimer Disease/metabolism ; Astrocytes/metabolism ; Astrocytes/pathology ; Cellular Senescence/physiology ; Hydrogen Peroxide/metabolism ; Neurodegenerative Diseases/metabolism ; Phenotype
Chemical Substances	Hydrogen Peroxide (BBX060AN9V) ; Serpina3n protein, mouse
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1223643-3
ISSN	1758-535X ; 1079-5006
ISSN (online)	1758-535X
ISSN	1079-5006
DOI	10.1093/gerona/glad278
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Article ; Online: Influence of Addition of Ti Particles and Processing Condition on Microstructure and Properties of Selectively Laser-Melted Invar 36 Alloy.

Liu, Huanhuan / Pan, Xingyu / Sun, Pengyue / Liu, Yanjun / Qiu, Chunlei

3D printing and additive manufacturing

2024 Volume 11, Issue 1, Page(s) 24–39

Abstract: Invar 36 exhibits extremely low thermal expansion coefficients at low temperatures but also low yield strength (YS), which greatly restricts its application as a structural material. In this study, a small fraction of pure titanium powder particles was ... ...

Abstract	Invar 36 exhibits extremely low thermal expansion coefficients at low temperatures but also low yield strength (YS), which greatly restricts its application as a structural material. In this study, a small fraction of pure titanium powder particles was added into Invar 36 by powder mixing and selective laser melting (SLM) with the aim of further improving tensile strengths of Invar 36. It was found that increased laser power led to increased grain size and to slight decrease in YS in Invar 36. During SLM, amorphous SiO
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ISSN	2329-7670
ISSN (online)	2329-7670
DOI	10.1089/3dp.2022.0016
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Article ; Online: Dual fluorescence images, transport pathway, and blood-brain barrier penetration of B-Met-W/O/W SE.

Fang, Liang / Li, Junying / Cheng, Hongyan / Liu, Huanhuan / Zhang, Caiyun

International journal of pharmaceutics

2024 Volume 652, Page(s) 123854

Abstract: Borneol is an aromatic traditional Chinese medicine that can improve the permeability of the blood-brain barrier (BBB), enter the brain, and promote the brain tissue distribution of many other drugs. In our previous study, borneol-metformin hydrochloride ...

Abstract	Borneol is an aromatic traditional Chinese medicine that can improve the permeability of the blood-brain barrier (BBB), enter the brain, and promote the brain tissue distribution of many other drugs. In our previous study, borneol-metformin hydrochloride water/oil/water composite submicron emulsion (B-Met-W/O/W SE) was prepared using borneol and SE to promote BBB penetration, which significantly increased the brain distribution of Met. However, the dynamic images, transport pathway (uptake and efflux), promotion of BBB permeability, and mechanisms of B-Met-W/O/W SE before and after entering cells have not been clarified. In this study, rhodamine B and coumarin-6 were selected as water-soluble and oil-soluble fluorescent probes to prepare B-Met-W/O/W dual-fluorescent SE (B-Met-W/O/W DFSE) with concentric circle imaging. B-Met-W/O/W SE can be well taken up by brain microvascular endothelial cells (BMECs). The addition of three inhibitors (chlorpromazine hydrochloride, methyl-β-cyclodextrin, and amiloride hydrochloride) indicated that its main pathway may be clathrin-mediated and fossa protein-mediated endocytosis. Meanwhile, B-Met-W/O/W SE was obviously shown to inhibit the efflux of BMECs. Next, BMECs were cultured in the Transwell chamber to establish a BBB model, and Western blot was employed to detect the protein expressions of Occludin, Zona Occludens 1 (ZO-1), and p-glycoprotein (P-gp) after B-Met-W/O/W SE treatment. The results showed that B-Met-W/O/W SE significantly down-regulated the expression of Occludin, ZO-1, and P-gp, which increased the permeability of BBB, promoted drug entry into the brain through BBB, and inhibited BBB efflux. Furthermore, 11 differentially expressed genes (DEGs) and 7 related signaling pathways in BMECs treated with B-W/O/W SE were detected by transcriptome sequencing and verified by quantitative real-time polymerase chain reaction (qRT-PCR). These results provide a scientific experimental basis for the dynamic monitoring, transmembrane transport mode, and permeation-promoting mechanism of B-Met-W/O/W SE as a new brain-targeting drug delivery system.
MeSH term(s)	Blood-Brain Barrier/metabolism ; Occludin/metabolism ; Endothelial Cells/metabolism ; Fluorescence ; Camphanes
Chemical Substances	isoborneol (L88RA8N5EG) ; Occludin ; Camphanes
Language	English
Publishing date	2024-01-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2024.123854
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Zs.A 1409: Show issues

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Article ; Online: fMRI reveals overlapping and non-overlapping neural bases of domain-general and emotional conflict control.

Guo, Tingting / Schwieter, John W / Liu, Huanhuan

Psychophysiology

2023 Volume 60, Issue 10, Page(s) e14355

Abstract: The present study uses functional magnetic resonance image (fMRI) to examine the overlapping and specific neural correlates of contextualized emotional conflict control and domain-general conflict control. During a performance on emotional and domain- ... ...

Abstract	The present study uses functional magnetic resonance image (fMRI) to examine the overlapping and specific neural correlates of contextualized emotional conflict control and domain-general conflict control. During a performance on emotional and domain-general conflict tasks, conjunction analyses showed that neural areas distributed in the frontoparietal network were engaged in both processes, supporting the notion that similar neural mechanisms are implemented in these two types of control. Importantly, disjunction analyses revealed a broader neural recruitment of emotional conflict control compared to domain-general conflict control as shown by the possible lateralization of the lateral prefrontal cortex (lPFC), such that emotional conflict control significantly involved the left lPFC while domain-general conflict control seemly involved the right lPFC. Results of generalized psychophysiological interaction (gPPI) analyses further demonstrated that emotional conflict control, compared to domain-general conflict control, elicited broader synergistic activities in individuals' brain networks. Together, these findings offer novel and compelling neural evidence that furthers our understanding of the complex relationship between domain-general and emotional conflict control.
MeSH term(s)	Humans ; Magnetic Resonance Imaging ; Brain Mapping ; Conflict, Psychological ; Emotions/physiology ; Brain/diagnostic imaging ; Brain/physiology ; Prefrontal Cortex/diagnostic imaging
Language	English
Publishing date	2023-05-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209486-1
ISSN	1540-5958 ; 0048-5772
ISSN (online)	1540-5958
ISSN	0048-5772
DOI	10.1111/psyp.14355
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Zs.A 502: Show issues

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Article ; Online: Roles of single gene in plant hypoxia and pathogen responses.

Tang, Hu / Liu, Huanhuan

Plant signaling & behavior

2021 Volume 16, Issue 10, Page(s) 1934295

Abstract: Hypoxia stress can be caused by submergence or pathogen infection. These two stresses often occur sequentially or at the same time in nature. Therefore, plants have evolved economical and efficient strategies to deal with them, such as "single-gene multi- ...

Abstract	Hypoxia stress can be caused by submergence or pathogen infection. These two stresses often occur sequentially or at the same time in nature. Therefore, plants have evolved economical and efficient strategies to deal with them, such as "single-gene multi-functions", that is, one gene could play roles in hypoxia or pathogen responses at the corresponding stress. This review mainly introduces the ERF-VII (ethylene response factor VII) and WRKYs (WRKY transcription factors) that can play roles in these two stresses. Meanwhile, the relationship between hypoxia and pathology has certain similarities in animals and plants, so we can learn from their related studies and develop new ideas for disease therapy and breeding.
MeSH term(s)	Animals ; Arabidopsis/genetics ; Arabidopsis/microbiology ; Arabidopsis Proteins/metabolism ; Arabidopsis Proteins/physiology ; DNA-Binding Proteins/physiology ; Gene Expression Regulation, Plant ; Genes, Plant ; Hordeum/genetics ; Hordeum/microbiology ; Oryza/genetics ; Oryza/microbiology ; Oxygen/metabolism ; Plant Diseases/genetics ; Plant Diseases/microbiology ; Stress, Physiological/genetics ; Transcription Factors/physiology
Chemical Substances	Arabidopsis Proteins ; DNA-Binding Proteins ; ERF-VII transcription factors, Arabidopsis ; Transcription Factors ; Oxygen (S88TT14065)
Language	English
Publishing date	2021-06-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1559-2324
ISSN (online)	1559-2324
DOI	10.1080/15592324.2021.1934295
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Article ; Online: A digital workflow for tooth-supported complete overdentures with a composite resin injection technique to manage the treatment of a child with ectodermal dysplasia.

Liu, Huanhuan / Wu, Jiacheng / Zhang, Na / Rao, Sihan / Tan, Ying / Yu, Haiyang

The Journal of prosthetic dentistry

2024

Abstract: This clinical report describes a digital workflow for the rehabilitation of an 8-year-old patient diagnosed with ectodermal dysplasia. Based on the patient's digital primary casts, small custom trays and an arch tracer were designed and 3-dimensionally ... ...

Abstract	This clinical report describes a digital workflow for the rehabilitation of an 8-year-old patient diagnosed with ectodermal dysplasia. Based on the patient's digital primary casts, small custom trays and an arch tracer were designed and 3-dimensionally printed. The mandibular custom tray and retention plate with a tracing screw were assembled with tracing plate, forming an individual assembled mini-arch tracer system to record the jaw relationship together with a conventional facebow and a digital articulator. In addition, composite resin injection guides were designed and fabricated to form the predesigned targeted shape of the abutment teeth and provide a buffer. By following this workflow, complete overdentures with good fit, occlusion, and acceptable esthetics were delivered.
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	218157-5
ISSN	1097-6841 ; 0022-3913
ISSN (online)	1097-6841
ISSN	0022-3913
DOI	10.1016/j.prosdent.2023.11.036
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Ul III Zs.145: Show issues

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Article ; Online: Ultrasmall Gold Nanoparticles Radiolabeled with Iodine-125 as Potential New Radiopharmaceutical.

Wang, Runze / Liu, Huanhuan / Antal, Bas / Wolterbeek, Hubert Th / Denkova, Antonia G

ACS applied bio materials

2024 Volume 7, Issue 2, Page(s) 1240–1249

Abstract: The relatively high linear energy transfer of Auger electrons, which can cause clustered DNA damage and hence efficient cell death, makes Auger emitters excellent candidates for attacking metastasized tumors. Moreover, gammas or positrons are usually ... ...

Abstract	The relatively high linear energy transfer of Auger electrons, which can cause clustered DNA damage and hence efficient cell death, makes Auger emitters excellent candidates for attacking metastasized tumors. Moreover, gammas or positrons are usually emitted along with the Auger electrons, providing the possibility of theragnostic applications. Despite the promising properties of Auger electrons, only a few radiopharmaceuticals employing Auger emitters have been developed so far. This is most likely explained by the short ranges of these electrons, requiring the delivery of the Auger emitters to crucial cell parts such as the cell nucleus. In this work, we combined the Auger emitter
MeSH term(s)	Humans ; Radiopharmaceuticals/therapeutic use ; Gold ; Metal Nanoparticles/therapeutic use ; Iodine Radioisotopes ; Neoplasms
Chemical Substances	Iodine-125 (GVO776611R) ; Radiopharmaceuticals ; Gold (7440-57-5) ; Iodine Radioisotopes
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ISSN	2576-6422
ISSN (online)	2576-6422
DOI	10.1021/acsabm.3c01158
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Article: Bio-functional hydroxyapatite-coated 3D porous polyetherketoneketone scaffold for enhanced osteogenesis and osteointegration in orthopedic applications.

Liu, Huanhuan / Liu, Taiqing / Yin, Zhicheng / Liu, Xiaoyin / Tan, Ying / Zhao, Yuwei / Yu, Haiyang

Regenerative biomaterials

2024 Volume 11, Page(s) rbae023

Abstract: Polyetherketoneketone (PEKK), a high-performance thermoplastic special engineering material, maintains bone-like mechanical properties and has received considerable attention in the biomedical field. The 3D printing technique enables the production of ... ...

Abstract	Polyetherketoneketone (PEKK), a high-performance thermoplastic special engineering material, maintains bone-like mechanical properties and has received considerable attention in the biomedical field. The 3D printing technique enables the production of porous scaffolds with a honeycomb structure featuring precisely controlled pore size, porosity and interconnectivity, which holds significant potential for applications in tissue engineering. The ideal pore architecture of porous PEKK scaffolds has yet to be elucidated. Porous PEKK scaffolds with five pore sizes P200 (225 ± 9.8 μm), P400 (411 ± 22.1 μm), P600 (596 ± 23.4 μm), P800 (786 ± 24.2 μm) and P1000 (993 ± 26.0 μm) were produced by a 3D printer. Subsequently, the optimum pore size, the P600, for mechanical properties and osteogenesis was selected based on
Language	English
Publishing date	2024-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2799042-4
ISSN	2056-3426 ; 2056-3418
ISSN (online)	2056-3426
ISSN	2056-3418
DOI	10.1093/rb/rbae023
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Article ; Online: Post translational modifications of connexin 43 in ventricular arrhythmias after myocardial infarction.

Yang, Fan / Zhang, Xiao-Lu / Liu, Huan-Huan / Qian, Ling-Ling / Wang, Ru-Xing

Molecular biology reports

2024 Volume 51, Issue 1, Page(s) 329

Abstract: Ventricular arrhythmias are the leading cause of sudden cardiac death in patients after myocardial infarction (MI). Connexin43 (Cx43) is the most important gap junction channel-forming protein in cardiomyocytes. Dysfunction of Cx43 contributes to ... ...

Abstract	Ventricular arrhythmias are the leading cause of sudden cardiac death in patients after myocardial infarction (MI). Connexin43 (Cx43) is the most important gap junction channel-forming protein in cardiomyocytes. Dysfunction of Cx43 contributes to impaired myocardial conduction and the development of ventricular arrhythmias. Following an MI, Cx43 undergoes structural remodeling, including expression abnormalities, and redistribution. These alterations detrimentally affect intercellular communication and electrical conduction within the myocardium, thereby increasing the susceptibility to post-infarction ventricular arrhythmias. Emerging evidence suggests that post-translational modifications play essential roles in Cx43 regulation after MI. Therefore, Cx43-targeted management has the potential to be a promising protective strategy for the prevention and treatment of post infarction ventricular arrhythmias. In this article, we primarily reviewed the regulatory mechanisms of Cx43 mediated post-translational modifications on post-infarction ventricular arrhythmias. Furthermore, Cx43-targeted therapy have also been discussed, providing insights into an innovative treatment strategy for ventricular arrhythmias after MI.
MeSH term(s)	Humans ; Arrhythmias, Cardiac/metabolism ; Connexin 43/genetics ; Connexin 43/metabolism ; Myocardial Infarction/complications ; Myocardial Infarction/metabolism ; Myocardium/metabolism ; Protein Processing, Post-Translational
Chemical Substances	Connexin 43 ; GJA1 protein, human
Language	English
Publishing date	2024-02-23
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-024-09290-2
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Zs.A 1140: Show issues

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Article: Effect of Yoga Intervention on Problem Behavior and Motor Coordination in Children with Autism.

Ju, Xingda / Liu, Huanhuan / Xu, Jing / Hu, Bo / Jin, Yunlei / Lu, Chang

Behavioral sciences (Basel, Switzerland)

2024 Volume 14, Issue 2

Abstract: Children with autism exhibit more pronounced symptoms of both problem behaviors and motor coordination difficulties. Yoga, recognized as an effective intervention modality, can be valuable after assessing its efficacy in addressing problem behaviors and ... ...

Abstract	Children with autism exhibit more pronounced symptoms of both problem behaviors and motor coordination difficulties. Yoga, recognized as an effective intervention modality, can be valuable after assessing its efficacy in addressing problem behaviors and motor coordination challenges, ultimately contributing to symptom alleviation in autism. The randomized controlled trial (RCT) was used to divide 17 children with autism into an intervention group (
Language	English
Publishing date	2024-02-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651997-5
ISSN	2076-328X
ISSN	2076-328X
DOI	10.3390/bs14020116
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