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  1. Article: Stimulation Modeling on Three-Dimensional Anisotropic Diffusion of MRI Tracer in the Brain Interstitial Space.

    Wang, Wei / He, Qingyuan / Hou, Jin / Chui, Dehua / Gao, Mingyong / Wang, Aibo / Han, Hongbin / Liu, Huipo

    Frontiers in neuroinformatics

    2019  Volume 13, Page(s) 6

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2019-02-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452979-5
    ISSN 1662-5196
    ISSN 1662-5196
    DOI 10.3389/fninf.2019.00006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The Alteration of Brain Interstitial Fluid Drainage with Myelination Development.

    Wang, Rui / Han, Hongbin / Shi, Kuangyu / Alberts, Ian Leigh / Rominger, Axel / Yang, Chenlong / Yan, Junhao / Cui, Dehua / Peng, Yun / He, Qingyuan / Gao, Yajuan / Lian, Jingge / Yang, Shuangfeng / Liu, Huipo / Yang, Jun / Wong, Chaolan / Wei, Xunbin / Yin, Feng / Jia, Yanxing /
    Tong, Huaiyu / Liu, Bo / Lei, Jianbo

    Aging and disease

    2021  Volume 12, Issue 7, Page(s) 1729–1740

    Abstract: The integrity of myelination is crucial for maintaining brain interstitial fluid (ISF) drainage in adults; however, the mechanism of ISF drainage with immature myelin in the developing brain remains unknown. In the present study, the ISF drainage from ... ...

    Abstract The integrity of myelination is crucial for maintaining brain interstitial fluid (ISF) drainage in adults; however, the mechanism of ISF drainage with immature myelin in the developing brain remains unknown. In the present study, the ISF drainage from the caudate nucleus (Cn) to the ipsilateral cortex was studied at different developmental stages of the rat brain (P 10, 20, 30, 40, 60, 80, 10-80). The results show that the traced ISF drained to the cortex from Cn and to the thalamus in an opposite direction before P30. From P40, we found impeded drainage to the thalamus due to myelin maturation. This altered drainage was accompanied by enhanced cognitive and social functions, which were consistent with those in the adult rats. A significant difference in diffusion parameters was also demonstrated between the extracellular space (ECS) before and after P30. The present study revealed the alteration of ISF drainage regulated by myelin at different stages during development, indicating that a regional ISF homeostasis may be essential for mature psychological and cognitive functions.
    Language English
    Publishing date 2021-10-01
    Publishing country United States
    Document type Journal Article
    ISSN 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2021.0305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Transportation in the Interstitial Space of the Brain Can Be Regulated by Neuronal Excitation.

    Shi, Chunyan / Lei, Yiming / Han, Hongbin / Zuo, Long / Yan, Junhao / He, Qingyuan / Yuan, Lan / Liu, Huipo / Xu, Ge / Xu, Weiguo

    Scientific reports

    2015  Volume 5, Page(s) 17673

    Abstract: The transportation of substances in the interstitial space (ISS) is crucial for the maintenance of brain homeostasis, however its link to neuronal activity remains unclear. Here, we report a marked reduction in substance transportation in the ISS after ... ...

    Abstract The transportation of substances in the interstitial space (ISS) is crucial for the maintenance of brain homeostasis, however its link to neuronal activity remains unclear. Here, we report a marked reduction in substance transportation in the ISS after neuronal excitation. Using a tracer-based method, water molecules in the interstitial fluid (ISF) could be specifically visualized in magnetic resonance (MR) imaging. We first observed the flow of ISF in the thalamus and caudate nucleus of a rat. The ISF flow was then modulated using a painful stimulation model. We demonstrated that the flow of ISF slowed significantly following neuronal activity in the thalamus. This reduction in ISF flow continued for hours and was not accompanied by slow diffusion into the ISS. This observation suggests that the transportation of substances into the ISS can be regulated with a selective external stimulation.
    MeSH term(s) Animals ; Biological Transport/physiology ; Brain/physiology ; Caudate Nucleus/physiology ; Electric Stimulation ; Extracellular Fluid ; Gadolinium DTPA/pharmacokinetics ; Magnetic Resonance Imaging/methods ; Male ; Neurons/physiology ; Rats, Sprague-Dawley ; Thalamus/physiology
    Chemical Substances Gadolinium DTPA (K2I13DR72L)
    Language English
    Publishing date 2015-12-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep17673
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  4. Article: Bloodletting at Jing-well points decreases interstitial fluid flow in the thalamus of rats.

    Fu, Yu / Li, Yuliang / Guo, Jia / Liu, Bin / Liu, Huipo / Zhang, Weibo / Sun, Wanli / Gao, Yajuan / Ren, Qiushi / Han, Haojun

    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

    2015  Volume 36, Issue 1, Page(s) 107–112

    Abstract: Objective: To investigate the changes in the neuronal microenvironment of the middle cerebral artery (MCA) territory induced by Jing-well points bloodletting acupuncture (WPBA) and to explore the neuroprotective mechanism of WPBA in stroke.: Methods: ...

    Abstract Objective: To investigate the changes in the neuronal microenvironment of the middle cerebral artery (MCA) territory induced by Jing-well points bloodletting acupuncture (WPBA) and to explore the neuroprotective mechanism of WPBA in stroke.
    Methods: Adult male Sprague Dawley (n = 32) rats were randomly divided into four groups of eight animals each: WPBA-thalamus group (WT), WPBA-caudate nucleus group (WC), sham-control thalamus group (ST) and sham-control caudate nucleus group (SC). Animals in the WT and WC groups received 2 µL of the extracellular tracer gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) injected into the thalamus or caudate nucleus, respectively, and 12 Jing-well points in the distal ends of the rats' digits were used for WPBA. Although 2 µL of Gd-DTPA was injected into the thalamus or caudate nucleus, respectively, for animals in the two sham groups (ST and SC), no acupuncture or bloodletting was performed. Brain extracellular space and interstitial fluid flow parameters were measured using Gd-DTPA-enhanced magnetic resonance imaging.
    Results: The brain interstitial fluid flow speed was decreased in the thalamus after WPBA, with a significantly lower Gd-DTPA clearance rate and longer half-life of Gd-DTPA in the thalamus of treated rats than those in sham-control rats [WPBA-treated rats' clearance rate, (7.47 ± 3.15) x 10(-5)/s (P.= 0.009); half-life, (1.52 ± 0.13) h, P = 0.000]. By contrast, no significant changes in brain extracellular space and interstitial fluid flow parameters were detected in the caudate nucleus after WPBA (P = 0.649). In addition, no differences in the morphology of the brain extracellular space or the final distribution of the traced brain interstitial fluid were demonstrated between the WT and WC groups (P = 0.631, P = 0.970, respectively).
    Conclusion: The WPBA decreased the speed of the local thalamic ISF flow in rats, which is assumed to be a beneficial protection by down-modulated the metabolic rate of the attacked neurons under stroke.
    MeSH term(s) Acupuncture Points ; Animals ; Bloodletting ; Extracellular Fluid/metabolism ; Humans ; Male ; Rats ; Rats, Sprague-Dawley ; Stroke/metabolism ; Stroke/therapy ; Thalamus/blood supply ; Thalamus/metabolism
    Language English
    Publishing date 2015-09-02
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603186-9
    ISSN 0254-6272 ; 0255-2922
    ISSN (online) 0254-6272
    ISSN 0255-2922
    DOI 10.1016/s0254-6272(16)30016-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Design and preliminary application of regional control and prevention auxiliary information system under the attack of COVID-19 infectious disease

    HAN, Hongbin / CHENG, Yumeng / YANG, Mo / TANG, Zeqing / WANG, Hui / YANG, Shuya / MA, Qingbian / WANG, Daidai / BAI, Yi / HE, Qingyuan / GUO, Kaixin / LIU, Huipo / XUE, Xiaoqi / CHENG, Fangxiao / LI, Xiang / MA, Jun

    Chinese Journal of Medical Science Research Management

    Abstract: Objective To propose the concept of a novel regional control and prevention (RCP) system for the outbreak of COVID-19 infectious disease, design an emergency epidemic prevention information system based on the existing network architecture and ... ...

    Abstract Objective To propose the concept of a novel regional control and prevention (RCP) system for the outbreak of COVID-19 infectious disease, design an emergency epidemic prevention information system based on the existing network architecture and information system in the region, and a remote intelligent medical consultation and remote office platform, research and develop the technology of risk assessment and early warning for people in the region, and improve the regions’prevention and control ability facing emergency of major infectious diseases Methods Taking colleges, affiliated (teaching) hospitals, and cloud applications as typical RCP regional units, the existing local area network interaction methods between the cloud and universities and affiliated (teaching) hospitals are established to realize remote work in the network environment, remote medical imaging, psychological and ethical consultation and interaction;applying multi-agent propagation model based on complex network, combining Global Positioning System (GPS), Radio Frequency Identification (RFID), and electronic fence technology, to realize the risk classification and early warning of units and personnel in the area Results In the RCP, a system architecture combining campus network, affiliated (teaching) hospital intranet, and the Internet is used Dynamic connection is made using distributed technology and cloud storage The data buffer mechanism of the intermediary database in the network realized telemedicine consultation and telecommuting Relying on the platform, multi-agent propagation model based on complex network and cellular automaton model are used to realize the score and early warning of population exposure risk in the region by using GPS, RFID and electronic fence technology Conclusions In the epidemic phase of major infectious diseases, the construction of RCP can improve the response speed of wartime epidemic prevention, provide reasonable data-based warnings and risk ratings, and reduce the exposure risk of susceptible people The design and development of RCP is a systematic project that needs to combine regional structural and functional characteristics, and the foundation of the early informatization work in the region and the level of the emergency development team determine the development progress, maintenance, and actual application effects It is recommended to establish a peacetime and wartime combined RCP mode and incorporate it into the government's disease control system to improve the national and regional level of prevention and control of major infectious diseases
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #6282
    Database COVID19

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  6. Article: Design and preliminary application of regional control and prevention auxiliary information system under the attack of COVID-19 infectious disease/ 中华医学科研管理杂志

    HAN, Hongbin / CHENG, Yumeng / YANG, Mo / TANG, Zeqing / WANG, Hui / YANG, Shuya / Qingbian, MA / WANG, Daidai / BAI, Yi / Qingyuan, HE / GUO, Kaixin / LIU, Huipo / XUE, Xiaoqi / CHENG, Fangxiao / Xiang, LI / Jun, MA

    Chinese Journal of Medical Science Research Management

    Abstract: Objective@#To propose the concept of a novel regional control and prevention (RCP) system for the outbreak of COVID-19 infectious disease, design an emergency epidemic prevention information system based on the existing network architecture and ... ...

    Abstract Objective@#To propose the concept of a novel regional control and prevention (RCP) system for the outbreak of COVID-19 infectious disease, design an emergency epidemic prevention information system based on the existing network architecture and information system in the region, and a remote intelligent medical consultation and remote office platform, research and develop the technology of risk assessment and early warning for people in the region, and improve the regions’prevention and control ability facing emergency of major infectious diseases.@*Methods@#Taking colleges, affiliated (teaching) hospitals, and cloud applications as typical RCP regional units, the existing local area network interaction methods between the cloud and universities and affiliated (teaching) hospitals are established to realize remote work in the network environment, remote medical imaging, psychological and ethical consultation and interaction; applying multi-agent propagation model based on complex network, combining Global Positioning System (GPS), Radio Frequency Identification (RFID), and electronic fence technology, to realize the risk classification and early warning of units and personnel in the area.@*Results@#In the RCP, a system architecture combining campus network, affiliated (teaching) hospital intranet, and the Internet is used. Dynamic connection is made using distributed technology and cloud storage. The data buffer mechanism of the intermediary database in the network realized telemedicine consultation and telecommuting. Relying on the platform, multi-agent propagation model based on complex network and cellular automaton model are used to realize the score and early warning of population exposure risk in the region by using GPS, RFID and electronic fence technology.@*Conclusions@#In the epidemic phase of major infectious diseases, the construction of RCP can improve the response speed of wartime epidemic prevention, provide reasonable data-based warnings and risk ratings, and reduce the exposure risk of susceptible people. The design and development of RCP is a systematic project that needs to combine regional structural and functional characteristics, and the foundation of the early informatization work in the region and the level of the emergency development team determine the development progress, maintenance, and actual application effects. It is recommended to establish a peacetime and wartime combined RCP mode and incorporate it into the government's disease control system to improve the national and regional level of prevention and control of major infectious diseases.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #6282
    Database COVID19

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  7. Article: The Drainage of Interstitial Fluid in the Deep Brain is Controlled by the Integrity of Myelination.

    Wang, Aibo / Wang, Rui / Cui, Dehua / Huang, Xinrui / Yuan, Lan / Liu, Huipo / Fu, Yu / Liang, Lei / Wang, Wei / He, Qingyuan / Shi, Chunyan / Guan, Xiangping / Teng, Ze / Zhao, Guomei / Li, Yuanyuan / Gao, Yajuan / Han, Hongbin

    Aging and disease

    2019  Volume 10, Issue 5, Page(s) 937–948

    Abstract: In searching for the drainage route of the interstitial fluid (ISF) in the deep brain, we discovered a regionalized ISF drainage system as well as a new function of myelin in regulating the drainage. The traced ISF from the caudate nucleus drained to the ...

    Abstract In searching for the drainage route of the interstitial fluid (ISF) in the deep brain, we discovered a regionalized ISF drainage system as well as a new function of myelin in regulating the drainage. The traced ISF from the caudate nucleus drained to the ipsilateral cortex along myelin fiber tracts, while in the opposite direction, its movement to the adjacent thalamus was completely impeded by a barrier structure, which was identified as the converged, compact myelin fascicle. The regulating and the barrier effects of myelin were unchanged in AQP4-knockout rats but were impaired as the integrity of boundary structure of drainage system was destroyed in a demyelinated rat model. We thus proposed that the brain homeostasis was maintained within each ISF drainage division locally, rather than across the brain as a whole. A new brain division system and a new pathogenic mechanism of demyelination are therefore proposed.
    Language English
    Publishing date 2019-10-01
    Publishing country United States
    Document type Journal Article
    ISSN 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2018.1206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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