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Artikel: Update on dyslipidemia in hypothyroidism: the mechanism of dyslipidemia in hypothyroidism.

Liu, Huixing / Peng, Daoquan

2022 Band 11, Heft 2

Abstract: Hypothyroidism is often associated with elevated serum levels of total cholesterol, LDL-C and triglycerides. Thyroid hormone (TH) affects the production, clearance and transformation of cholesterol, but current research shows that thyroid-stimulating ... ...

Abstract	Hypothyroidism is often associated with elevated serum levels of total cholesterol, LDL-C and triglycerides. Thyroid hormone (TH) affects the production, clearance and transformation of cholesterol, but current research shows that thyroid-stimulating hormone (TSH) also participates in lipid metabolism independently of TH. Therefore, the mechanism of hypothyroidism-related dyslipidemia is associated with the decrease of TH and the increase of TSH levels. Some newly identified regulatory factors, such as proprotein convertase subtilisin/kexin type 9, angiogenin-like proteins and fibroblast growth factors are the underlying causes of dyslipidemia in hypothyroidism. HDL serum concentration changes were not consistent, and its function was reportedly impaired. The current review focuses on the updated understanding of the mechanism of hypothyroidism-related dyslipidemia.
Sprache	Englisch
Erscheinungsdatum	2022-02-07
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review
ZDB-ID	2668428-7
ISSN	2049-3614
ISSN	2049-3614
DOI	10.1530/EC-21-0002
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Independent association of PCSK9 with platelet reactivity in subjects without statin or antiplatelet agents.

Wang, Shuai / Fu, Di / Liu, Huixing / Peng, Daoquan

Frontiers in cardiovascular medicine

2022 Band 9, Seite(n) 934914

Abstract: Background and aims: Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels could predict cardiovascular event in patients with well-controlled LDL-C levels, suggesting an LDL-independent mechanism of PCSK9 on the cardiovascular system. ... ...

Abstract	Background and aims: Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels could predict cardiovascular event in patients with well-controlled LDL-C levels, suggesting an LDL-independent mechanism of PCSK9 on the cardiovascular system. Accumulating evidence suggests PCSK9 might be associated with increased platelet reactivity. This study aimed to assess the relationship between PCSK9 levels and platelet reactivity in subjects not taking statins or antiplatelet agents. Methods: A cross-sectional study was conducted to investigate the independent contribution of PCSK9 to platelet activity by controlling for the potential confounding factors. The study population included 89 subjects from a health examination centre who underwent routine annual health check-ups or had an examination before a selective operation. Subjects taking statins or antiplatelet agents were excluded. Adenosine diphosphate (ADP)-induced platelet aggregation was determined by PL-11 platelet analyzer using impedance aggregometry and plasma PCSK9 levels were determined using an ELISA. Serum Lipid profile was assessed by measuring the concentration of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG), with low-density lipoprotein cholesterol (LDL-C) being directly measured using enzymatic techniques. The association between PCSK9 and platelet reactivity was investigated. Results: The study subjects were composed of 53 males and 36 females with an average age of 55 (±11) years old. The univariate correlation analysis showed significant correlation between ADP-induced maximal aggregation rate (MAR) and PCSK9 ( Conclusions: PCSK9 is positively associated with platelet reactivity, which may partly account for the beneficial effect of PCSK9 inhibition in reducing the risk of major adverse cardiovascular events after acute coronary syndrome (ACS).
Sprache	Englisch
Erscheinungsdatum	2022-10-17
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.934914
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Independent association of Lp(a) with platelet reactivity in subjects without statins or antiplatelet agents.

Liu, Huixing / Fu, Di / Luo, Yonghong / Peng, Daoquan

Scientific reports

2022 Band 12, Heft 1, Seite(n) 16609

Abstract: The physiological effect of Lp(a) on platelet activity is unclear. Previous studies explored the relationship between Lp(a) and platelet aggregation in patients taking statins and antiplatelet agents, but few was conducted in individuals without the bias ...

Abstract	The physiological effect of Lp(a) on platelet activity is unclear. Previous studies explored the relationship between Lp(a) and platelet aggregation in patients taking statins and antiplatelet agents, but few was conducted in individuals without the bias of those drugs that either influence Lp(a) or platelet activity. The aim of this study was to assess the relationship between Lp(a) levels and platelet aggregation in subjects not taking statins or antiplatelet drugs. A hospital-based cross-sectional study was conducted to investigate the independent contribution of Lp(a) to platelet activity by controlling the effects of potential confounding factors including lipoprotein-associated phospholipase A2 [Lp-PLA2]. Blood samples were collected from 92 subjects without statins or antiplatelet agents from the Second Xiangya Hospital. The univariate correlation analysis showed a significant correlation between AA-induced average aggregation rate [AAR] and ApoB (r = 0.324, P = 0.002), ApoA1 (r = 0.252, P = 0.015), Lp(a) (r = 0.370, P < 0.001), Lp-PLA2 (r = 0.233, P = 0.025) and platelet counts [PLT] (r = 0.389, P < 0.001). Multivariate regression analysis suggested that Lp(a) contributed independently to AA-induced average aggregation rate (β = 0.023, P = 0.027) after controlling for the effects of ApoB, Lp-PLA2 and platelet counts. Lp(a) is positively associated with platelet aggregation independent of Lp-PLA2, which may partly account for the atherothrombotic effect of Lp(a).
Mesh-Begriff(e)	1-Alkyl-2-acetylglycerophosphocholine Esterase ; Biomarkers ; Cross-Sectional Studies ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Platelet Aggregation ; Platelet Aggregation Inhibitors/pharmacology ; Risk Factors
Chemische Substanzen	Biomarkers ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Platelet Aggregation Inhibitors ; 1-Alkyl-2-acetylglycerophosphocholine Esterase (EC 3.1.1.47)
Sprache	Englisch
Erscheinungsdatum	2022-10-05
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-21121-7
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The Median Effective Dose of Intrathecal Hyperbaric Bupivacaine for Cesarean Section at Moderately High-Altitude.

Yang, Chen / Dong, Wangjun / Luo, Jianbo / Ma, Mengzhao / Gao, Yeyue / Ni, Lijie / Liu, Huixing / Cha, Chengjun / Xiao, Yangli / Huang, Shaoqiang

Drug design, development and therapy

2024 Band 18, Seite(n) 1313–1319

Abstract: Objective: Alterations in altitude can lead to an augmented requirement for local anesthesia among patients. Nevertheless, the necessity for an elevated dosage of local anesthetic for parturients at moderately high altitudes during spinal anesthesia for ...

Abstract	Objective: Alterations in altitude can lead to an augmented requirement for local anesthesia among patients. Nevertheless, the necessity for an elevated dosage of local anesthetic for parturients at moderately high altitudes during spinal anesthesia for cesarean section remains uninvestigated. This up-down sequential study endeavors to determine the ED Methods: Thirty singleton parturients at moderately high altitude underwent elective cesarean section under combined spinal-epidural anesthesia. The up-and-down sequential method was employed, starting with an initial dose of 12mg (1.6mL) of 0.75% hyperbaric bupivacaine for the first participant. The dose for the next case was adjusted up or down by 0.75mg based on the effectiveness of the previous participant. Effectiveness was defined as the bilateral sensory block reaching T6 within 15 minutes after spinal anesthesia injection, without the need for additional epidural anesthesia before fetal delivery. The ED Results: The ED Conclusion: The ED
Mesh-Begriff(e)	Adult ; Female ; Humans ; Pregnancy ; Young Adult ; Altitude ; Anesthesia, Epidural ; Anesthesia, Obstetrical ; Anesthesia, Spinal ; Anesthetics, Local/administration & dosage ; Bupivacaine/administration & dosage ; Cesarean Section ; Dose-Response Relationship, Drug ; Injections, Spinal
Chemische Substanzen	Anesthetics, Local ; Bupivacaine (Y8335394RO)
Sprache	Englisch
Erscheinungsdatum	2024-04-22
Erscheinungsland	New Zealand
Dokumenttyp	Clinical Trial ; Journal Article
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S455844
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Associations of Serum Pepsinogens and Helicobacter Pylori Infection with High-Sensitivity C-Reactive Protein in Medical Examination Population.

Liu, Huixing / Fei, Chunrong / Zhang, Jun

Laboratory medicine

2020 Band 52, Heft 1, Seite(n) 57–63

Abstract: Objective: This study aimed to clarify the distribution characteristics of serum pepsinogen (PG) and Helicobacter pylori in the medical examination population and to explore the relationships of PG level and H. pylori infection status with the high- ... ...

Abstract	Objective: This study aimed to clarify the distribution characteristics of serum pepsinogen (PG) and Helicobacter pylori in the medical examination population and to explore the relationships of PG level and H. pylori infection status with the high-sensitivity C-reactive protein (hsCRP) level and their significance in health examination. Methods: We detected H. pylori infection by C13 urea breath test, the serum pepsinogen I (PGI) and pepsinogen II (PGII) contents were measured by chemiluminescence microparticle immunoassay, and the PGI/PGII ratio was calculated. In addition, the serum hsCRP level was determined by the Abbott C16000 automatic biochemical analyzer. Results: The PGI and hsCRP levels were significantly higher in men than in women, and the PGII level was slightly higher in men than in women (both P <.05). The PGI, PGII, and hsCRP levels were positively correlated with age (r = 0.210, 0.287, and 0.133, respectively; P <.05), whereas the PGI/PGII ratio was negatively correlated with age (r = -0.190; P <.05). The positive H. pylori infection rate was 30.2% among the patients in this study; H. pylori infection was not related to sex (P >.05), and the difference in age stratification was not statistically significant (P >.05). The abnormal PGI/PGII ratio in the medical examination population was not correlated with sex (P >.05). In the H. pylori positive infection group, the proportion of PGI/PGII ratio <3, the PGI and PGII levels were significantly higher than those in the H. pylori negative infection group, and the PGI/PGII ratio was significantly lower than that in the negative group (both P <.05). The hsCRP level was not associated with H. pylori infection (P >.05), and it was significantly higher in the PGI/PGII ratio <3 group than in the PGI/PGII ratio ≥3 group (P <.05). Conclusion: The PGI and PGII levels and the PGI/PGII ratio are correlated with H. pylori infection. The abnormal PGI/PGII ratio is closely related to H. pylori infection and hsCRP level. Therefore, H. pylori infection status and hsCRP level should be considered when determining atrophic gastritis by the PGI/PGII ratio.
Mesh-Begriff(e)	Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; C-Reactive Protein/metabolism ; China/epidemiology ; Female ; Helicobacter Infections/blood ; Helicobacter Infections/epidemiology ; Helicobacter pylori ; Humans ; Male ; Middle Aged ; Pepsinogen A/blood ; Pepsinogen C/blood ; Reference Values ; Sex Factors ; Young Adult
Chemische Substanzen	Pepsinogen C (61536-72-9) ; Pepsinogen A (9001-10-9) ; C-Reactive Protein (9007-41-4)
Sprache	Englisch
Erscheinungsdatum	2020-07-17
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	391758-7
ISSN	1943-7730 ; 0007-5027
ISSN (online)	1943-7730
ISSN	0007-5027
DOI	10.1093/labmed/lmaa042
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Case report: A homozygous

Li, Mojiang / Li, Yingshu / Liu, Huixing / Zhou, Haiyan / Xie, Wanqin / Peng, Qinghua

Frontiers in genetics

2022 Band 13, Seite(n) 1014188

Abstract: Background: ...

Abstract	Background:
Sprache	Englisch
Erscheinungsdatum	2022-09-28
Erscheinungsland	Switzerland
Dokumenttyp	Case Reports
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2022.1014188
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Lipoaspirate fluid derived factors and extracellular vesicles accelerate wound healing in a rat burn model.

Wu, Yue / Hong, Pengyu / Liu, Pan / Zhang, Qi / Zhang, Yue / Yang, Baohua / Liu, Huixing / Liu, Lei / Tian, Weidong / Yu, Mei

Frontiers in bioengineering and biotechnology

2023 Band 11, Seite(n) 1185251

Abstract: Background: ...

Abstract	Background:
Sprache	Englisch
Erscheinungsdatum	2023-06-22
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.1185251
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The effects of psychiatric disorders on the risk of chronic heart failure: a univariable and multivariable Mendelian randomization study.

Chen, Yang / Peng, Wenke / Pang, Min / Zhu, Botao / Liu, Huixing / Hu, Die / Luo, Yonghong / Wang, Shuai / Wu, Sha / He, Jia / Yang, Yang / Peng, Daoquan

Frontiers in public health

2024 Band 12, Seite(n) 1306150

Abstract: Background: Substantial evidence suggests an association between psychiatric disorders and chronic heart failure. However, further investigation is needed to confirm the causal relationship between these psychiatric disorders and chronic heart failure. ... ...

Abstract	Background: Substantial evidence suggests an association between psychiatric disorders and chronic heart failure. However, further investigation is needed to confirm the causal relationship between these psychiatric disorders and chronic heart failure. To address this, we evaluated the potential effects of five psychiatric disorders on chronic heart failure using two-sample Mendelian Randomization (MR). Methods: We selected single nucleotide polymorphisms (SNPs) associated with chronic heart failure and five psychiatric disorders (Attention-Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), Major Depression, Bipolar Disorder and Schizophrenia (SCZ)). Univariable (UVMR) and multivariable two-sample Mendelian Randomization (MVMR) were employed to assess causality between these conditions. Ever smoked and alcohol consumption were controlled for mediating effects in the multivariable MR. The inverse variance weighting (IVW) and Wald ratio estimator methods served as the primary analytical methods for estimating potential causal effects. MR-Egger and weighted median analyses were also conducted to validate the results. Sensitivity analyses included the funnel plot, leave-one-out, and MR-Egger intercept tests. Additionally, potential mediators were investigated through risk factor analyses. Results: Genetically predicted heart failure was significantly associated with ADHD (odds ratio (OR), 1.12; 95% CI, 1.04-1.20; Conclusion: Our study demonstrated ADHD, ASD, SCZ and major depression may have a causal relationship with an increased risk of heart failure. In contrast, bipolar disorder was associated with a reduced risk of heart failure, which could potentially be mediated by ever smoked and alcohol consumption. Therefore, prevention strategies for heart failure should also incorporate mental health considerations, and vice versa.
Mesh-Begriff(e)	Humans ; Autism Spectrum Disorder ; Mendelian Randomization Analysis ; Mental Disorders/epidemiology ; Mental Disorders/genetics ; Mental Health ; Chronic Disease ; Heart Failure/epidemiology ; Heart Failure/genetics
Sprache	Englisch
Erscheinungsdatum	2024-01-17
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2024.1306150
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Influence of sugammadex versus neostigmine for neuromuscular block reversal on the incidence of postoperative pulmonary complications: a meta-analysis of randomized controlled trials.

Wang, Jia-Feng / Zhao, Zhen-Zhen / Jiang, Zheng-Yu / Liu, Hui-Xing / Deng, Xiao-Ming

Perioperative medicine (London, England)

2021 Band 10, Heft 1, Seite(n) 32

Abstract: Background: The influence of sugammadex for reversal of neuromuscular block (NMB) on postoperative pulmonary complications (PPCs), compared with neostigmine, remains to be determined. We performed a meta-analysis of randomized controlled trials (RCTs) ... ...

Abstract	Background: The influence of sugammadex for reversal of neuromuscular block (NMB) on postoperative pulmonary complications (PPCs), compared with neostigmine, remains to be determined. We performed a meta-analysis of randomized controlled trials (RCTs) to compare the incidence of PPCs between patients who received sugammadex versus neostigmine. Methods: Relevant studies were obtained by searching the PubMed, Embase, and Cochrane Library databases. A random effects model incorporating the potential heterogeneity was used to pool the results. Results: Fourteen RCTs including 1478 adult patients who underwent surgeries with general anesthesia were included, and of these, 753 received sugammadex and 725 received neostigmine for reversal of NMB. The pooled results showed that sugammadex was associated with a lower risk of overall PPCs compared to neostigmine (odds ratio [OR]: 0.62, 95% confidence interval [CI]: 0.43-0.89, p = 0.01; I Conclusions: Compared with neostigmine, the use of sugammadex for reversal of NMB was associated with a lower risk of PPCs, mainly due to a lower incidence of postoperative respiratory failure with the use of sugammadex.
Sprache	Englisch
Erscheinungsdatum	2021-09-20
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2683800-X
ISSN	2047-0525
ISSN	2047-0525
DOI	10.1186/s13741-021-00203-6
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Serum soluble TREM2 is an independent biomarker associated with coronary heart disease.

Liu, Wenwu / Weng, Shuwei / Liu, Huixing / Cao, Chenghui / Wang, Shuai / Wu, Sha / He, Jia / Yang, Yang / Hu, Die / Luo, Yonghong / Peng, Daoquan

Clinica chimica acta; international journal of clinical chemistry

2023 Band 548, Seite(n) 117499

Abstract: Background: Triggering receptor expressed on myeloid cells 2 (TREM2) is a unique receptor expressed by macrophages in atherosclerotic plaque and is involved in the progression of atherosclerosis. Whether serum soluble TREM2 (sTREM2) levels has a ... ...

Abstract	Background: Triggering receptor expressed on myeloid cells 2 (TREM2) is a unique receptor expressed by macrophages in atherosclerotic plaque and is involved in the progression of atherosclerosis. Whether serum soluble TREM2 (sTREM2) levels has a relationship with coronary heart disease (CHD) remains unclear. Methods: The cross-sectional study included 86 patients with CHD and 86 controls matched with age and sex. Demographic information, medication history, and laboratory data were collected. sTREM2 concentrations were detected by enzyme-linked immunosorbent assay. We compared the sTREM2 levels in two groups and constructed stepwise linear regression analysis for factors related to the sTREM2 level in patients with CHD; we further used the logistic regression model to evaluate the relationship between sTREM2 and CHD. The diagnostic value of sTREM2 and other biomarkers in CHD was evaluated by the receiver operating characteristic curve (ROC). Results: The serum level of sTREM2 in CHD patients is higher than that in controls. In CHD patients, the stepwise linear regression analysis found that sTREM2 levels were correlated with triglyceride (TG), high-density lipoprotein cholesterols (HDL-C), apolipoprotein B (ApoB) and smoking status. Logistic regression models showed that sTREM2 was associated independently with CHD after adjusted confounders. The ROC curve showed a sensitivity of 59.3% and specificity of 81.4% with an area under the curve of 0.781 (95% CI: 0.711-0.852) for the diagnosis of CHD with serum sTREM2 at a cut-off value of > 1104.894 pg/ml, indicating a higher diagnostic value than high sensitivity C reaction protein (hs-CRP) and apolipoprotein B (ApoB). Conclusion: In this study, we provide evidence that sTREM2 levels are elevated in CHD patients and are associated with various cardiovascular risk factors. Additionally, sTREM2 demonstrates better diagnostic performance compared to traditional indicators in identifying CHD. These findings suggest that sTREM2 may serve as a potential biomarker for coronary heart disease.
Mesh-Begriff(e)	Humans ; Cross-Sectional Studies ; Coronary Disease/diagnosis ; Biomarkers/analysis ; Atherosclerosis ; C-Reactive Protein/analysis ; Apolipoproteins B ; Membrane Glycoproteins ; Receptors, Immunologic
Chemische Substanzen	Biomarkers ; C-Reactive Protein (9007-41-4) ; Apolipoproteins B ; TREM2 protein, human ; Membrane Glycoproteins ; Receptors, Immunologic
Sprache	Englisch
Erscheinungsdatum	2023-08-01
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	80228-1
ISSN	1873-3492 ; 0009-8981
ISSN (online)	1873-3492
ISSN	0009-8981
DOI	10.1016/j.cca.2023.117499
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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