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Article: [Genetic analysis of a child with Hemoglobin Santa Ana].

Liu, Jianghua / Yu, Jie

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

2023 Volume 40, Issue 3, Page(s) 287–290

Abstract: Objective: To explore the genetic basis for a child with Hemoglobin Santa Ana (Hb Santa Ana).: Methods: The child was admitted to the Children's Hospital of Chongqing Medical University on August 4, 2013 due to anemia, splenomegaly and deepening ... ...

Abstract	Objective: To explore the genetic basis for a child with Hemoglobin Santa Ana (Hb Santa Ana). Methods: The child was admitted to the Children's Hospital of Chongqing Medical University on August 4, 2013 due to anemia, splenomegaly and deepening urine color for 5 years. His clinical data were collected. Peripheral blood samples of the child and his parents were collected for routine blood test. The erythrocyte parameters of the child and his parents were determined with an automatic hemocyte analyzer. The hemoglobin components of the child and his parents were detected by high-performance liquid chromatography (HPLC). Common mutations associated with thalassemia were detected by Gap-PCR and PCR-reverse dot blotting (PCR-RDB). Rare variants of the globin genes were detected by next generation sequencing (NGS), and the result was verified by Sanger sequencing. Results: The child has shown mild to moderate hemolytic anemia. Routine blood test showed that he had lower hemoglobin (90 g/L) and mean corpuscular hemoglobin concentration (267 g/L) but a higher reticulocyte ratio (0.141), which indicated hypopigmented hyperplastic anemia. Analysis of hemoglobin component showed that his hemoglobin F was elevated to 10.7%, which indicated abnormal synthesis of β globin peptide chain. HPLC analysis showed an abnormal peak accounting for 4.5% of the total area. Neither of his parents was found to have abnormal results for routine blood test and hemoglobin component analysis. No common globin gene variant was detected in the child. Gene sequencing revealed that the child has harbored a heterozygous variant of HBB: c.266T>C, which was de novo in origin. Based on the guidelines of American College of Medical Genetics and Genomics, the variant was predicted to be pathogenic. Conclusion: The heterozygous HBB: c.266T>C variant probably underlay the hemolytic anemia associated with Hb Santa Ana in this patient.
MeSH term(s)	Child ; Humans ; Male ; Chromatography, High Pressure Liquid ; Hemoglobins, Abnormal/genetics
Chemical Substances	hemoglobin Santa Ana (37359-24-3) ; Hemoglobins, Abnormal
Language	Chinese
Publishing date	2023-02-26
Publishing country	China
Document type	Case Reports ; English Abstract ; Journal Article
ISSN	1003-9406
ISSN	1003-9406
DOI	10.3760/cma.j.cn511374-20220923-00619
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Article: Locking plate versus K-wires and cast fixation in lateral closing-wedge osteotomy for cubitus varus deformity.

Liu, Jianghua / He, Youzhi / Shi, Qiang / Wang, Yongfu

Frontiers in pediatrics

2024 Volume 12, Page(s) 1344283

Abstract: Background: The aim of this study was to assess the clinical and radiographic outcomes of cubitus varus treatments based on different fixation methods: Locking plate vs. Kirschner-wires (K-wires) and cast fixation.: Methods: This retrospective study ... ...

Abstract	Background: The aim of this study was to assess the clinical and radiographic outcomes of cubitus varus treatments based on different fixation methods: Locking plate vs. Kirschner-wires (K-wires) and cast fixation. Methods: This retrospective study of 28 patients was performed in lateral-wedge osteotomy for cubitus varus deformity in our hospital from July 2018 to July 2020. 14 patients in group A were treated by locking plate after lateral closing-wedge osteotomy, whereas other 14 patients were treated by K-wires in group B. We measured the bony union and carrying angle. The clinical and radiographic outcomes were assessed according to the Bellemore criteria. Results: No nonunion, neurovascular injury or myositis ossificans was noted at follow-up. In group A, 1 patient with lateral condylar prominence was found. In group B, 2 patients with pinning site infection were treated successfully with oral antibiotics and 2 patients needed revision surgery for residual varus. According to the Bellemore criteria, statistically significant difference was noted between the two groups Conclusions: Compared with K-wires and cast fixation, we recommend the wedge osteotomy with lateral locking plate to treat the cubitus varus deformity because locking plate could achieve better functional and cosmetic results and stabilize the distal humerus rigidly.
Language	English
Publishing date	2024-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2024.1344283
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Article ; Online: Value of serum iron and urine neutrophil gelatinase-associated lipocalin in predicting the mortality of critically ill patients with sepsis.

Zhao, Rui / Liu, Jiang-Hua / Qiu, Ze-Liang

Clinical and investigative medicine. Medecine clinique et experimentale

2024 Volume 47, Issue 1, Page(s) 4–12

Abstract: Introduction: We aimed to investigate the association of iron metabolism-related parameters with 60-day mortality in critically ill patients with sepsis.: Methods: Serum or urine concentrations of iron metabolism-related parameters on intensive care ... ...

Abstract	Introduction: We aimed to investigate the association of iron metabolism-related parameters with 60-day mortality in critically ill patients with sepsis. Methods: Serum or urine concentrations of iron metabolism-related parameters on intensive care unit admission were measured in a prospective cohort of 133 eligible patients with sepsis according to the Sepsis-3 criteria, and these values were compared between survivors and nonsurvivors, categorized according to their 60-day survival status. Cox regression analyses were performed to examine the association between iron parameters and 60-day mortality. Kaplan-Meier methods were used to illustrate the differences in survival between different iron parameters. Results: Of the 133 patients included in the study, 61 (45.8%) had died by day 60. After adjusting for confounding variables, higher concentrations of serum iron (cut-off 9.5 μmol/mL) and higher concentrations of urine neutrophil gelatinase-associated lipocalin (uNGAL; cut-off 169.3 ng/mL) were associated with a significantly greater risk of death in the Cox regression analysis. These two biomarkers combined with Sequential Organ Failure Assessment (SOFA) scores increased the area under the receiver operating characteristic (AUROC) curve to 0.85. Discussion: These findings suggest that higher concentrations of serum iron and uNGAL are each associated with higher 60-day mortality, and they add significant accuracy to this prediction in combination with SOFA.
MeSH term(s)	Humans ; Critical Illness/mortality ; Iron/blood ; Lipocalin-2/urine ; Prospective Studies ; Sepsis/mortality
Chemical Substances	Iron (E1UOL152H7) ; Lipocalin-2
Language	English
Publishing date	2024-03-28
Publishing country	Canada
Document type	Journal Article
ZDB-ID	434004-8
ISSN	1488-2353 ; 0147-958X
ISSN (online)	1488-2353
ISSN	0147-958X
DOI	10.3138/cim-2024-2672
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Zs.A 1389: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Exponential super-twisting control for nonlinear systems with unknown polynomial perturbations.

Liu, Jianghua / Zhu, Jiang / Khayati, Karim / Zhong, Dong / Jiang, Jinguang

Scientific reports

2024 Volume 14, Issue 1, Page(s) 3457

Abstract: The study focuses on the control of nonlinear dynamic systems in the presence of parameter uncertainties, unmodeled dynamics, and external disturbances. The lumped perturbation is assumed to be bounded within a polynomial in the system state with the ... ...

Abstract	The study focuses on the control of nonlinear dynamic systems in the presence of parameter uncertainties, unmodeled dynamics, and external disturbances. The lumped perturbation is assumed to be bounded within a polynomial in the system state with the polynomial parameters and degrees unknown a priori such that it accommodates a quite wider range dynamic systems. Based on the studies in recent super-twisting algorithm designs and the idea from adaptive sliding mode control for nonlinear systems with uncertainties, we propose a novel adaptive super-twisting algorithm with exponential reaching law, or exponential super-twisting algorithm (ESTA), for the high-stability and acceptable accuracy control of the aimed nonlinear dynamics. The stability analysis and practical finite-time (PFT) convergence are proven using Lyapunov theory and an intuitive analysis of the control behaviour. Simulations are performed to compare the proposed ESTA with the existing super-twisting method and the traditional proportional integral differential control. The simulation results demonstrate the effectiveness of the proposed ESTA in terms of the fastest settling time and the smallest overshoot.
Language	English
Publishing date	2024-02-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53761-2
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Article: [Comparative Analysis of Primary and Reactivated EB Virus Infection Associated Hemophagocytic Lymphohistiocytosis].

Liu, Jiang-Hua / Liu, Wei / Li, Yan-Ge

Zhongguo shi yan xue ye xue za zhi

2023 Volume 31, Issue 2, Page(s) 575–580

Abstract: Objective: To compare the clinical characteristics of children with hemophagocytic lymphocytosis (HLH) associated with primary Epstein-Barr virus (EBV) infection and EBV reactivation, and explore the effects of different EBV infection status on the ... ...

Abstract	Objective: To compare the clinical characteristics of children with hemophagocytic lymphocytosis (HLH) associated with primary Epstein-Barr virus (EBV) infection and EBV reactivation, and explore the effects of different EBV infection status on the clinical indexes and prognosis of HLH. Methods: The clinical data of 51 children with EBV associated HLH treated in Henan Children's Hospital from June 2016 to June 2021 were collected. According to the detection results of plasma EBV antibody spectrum, they were divided into EBV primary infection-associated HLH group (18 cases) and EBV reactivation-associated HLH group (33 cases). The clinical features, laboratory indexes and prognosis of the two groups were analyzed and compared. Results: There were no significant differences in age, gender, hepatomegaly, splenomegaly, lymphadenopathy, neutrophil count in peripheral blood, hemoglobin content, platelet count, plasma EBV-DNA load, lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, albumin, fibrinogen, triglyceride, ferritin, hemophagocytosis in bone marrow, NK cell activity and sCD25 between the two groups( Conclusion: EBV reactivation-associated HLH is more likely to cause central nervous system involvement and the prognosis is worser than EBV primary infection-associated HLH, which requires intensive treatment.
MeSH term(s)	Child ; Humans ; Epstein-Barr Virus Infections/complications ; Lymphohistiocytosis, Hemophagocytic/complications ; Herpesvirus 4, Human ; Retrospective Studies ; Prognosis
Language	Chinese
Publishing date	2023-04-25
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2023.02.038
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Article ; Online: Fertility intention-based birth forecasting in the context of China's universal two-child policy: an algorithm and empirical study in Xi'an City.

Liu, Jianghua / Zhang, Lianchao

Journal of biosocial science

2021 , Page(s) 1–17

Abstract: After a universal two-child policy was introduced in China in 2016, studies have been published using women's fertility intentions to forecast future births; however, the recommended algorithms need to be improved. In this study, an algorithm based on ... ...

Abstract	After a universal two-child policy was introduced in China in 2016, studies have been published using women's fertility intentions to forecast future births; however, the recommended algorithms need to be improved. In this study, an algorithm based on the method of limiting factors is developed to retrospectively forecast annual births in Xi'an City in the first three years of policy implementation, i.e. 2016-2018. The 2015 Xi'an Fertility Survey (sample: 560 one-child mothers) showed that 17% of mothers intended to have a second child, 30% were undecided and 53% did not intend to do so at the end of 2015. The low forecast variant based on the updated algorithm indicates that there would be a baby boom in 2016-2018, but the annual births would increase by 13% at most. The forecasting results are basically consistent with the official reports on annual births. This study emphasizes the importance of appropriately adjusting all fertility intentions in birth forecasting, helps to understand women's fertility behaviour and evaluate the effects of implementing the universal two-child policy, and has important implications for China's population and family planning work.
Language	English
Publishing date	2021-05-20
Publishing country	England
Document type	Journal Article
ZDB-ID	390961-x
ISSN	1469-7599 ; 0021-9320
ISSN (online)	1469-7599
ISSN	0021-9320
DOI	10.1017/S0021932021000201
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Article ; Online: Potential Effects of Akkermansia Muciniphila in Aging and Aging-Related Diseases: Current Evidence and Perspectives.

Zeng, Shi-Yu / Liu, Yi-Fu / Liu, Jiang-Hua / Zeng, Zhao-Lin / Xie, Hui / Liu, Jiang-Hua

Aging and disease

2023 Volume 14, Issue 6, Page(s) 2015–2027

Abstract: Akkermansia muciniphila (A. muciniphila) is an anaerobic bacterium that widely colonizes the mucus layer of the human and animal gut. The role of this symbiotic bacterium in host metabolism, inflammation, and cancer immunotherapy has been extensively ... ...

Abstract	Akkermansia muciniphila (A. muciniphila) is an anaerobic bacterium that widely colonizes the mucus layer of the human and animal gut. The role of this symbiotic bacterium in host metabolism, inflammation, and cancer immunotherapy has been extensively investigated over the past 20 years. Recently, a growing number of studies have revealed a link between A. muciniphila, and aging and aging-related diseases (ARDs). Research in this area is gradually shifting from correlation analysis to exploration of causal relationships. Here, we systematically reviewed the association of A. muciniphila with aging and ARDs (including vascular degeneration, neurodegenerative diseases, osteoporosis, chronic kidney disease, and type 2 diabetes). Furthermore, we summarize the potential mechanisms of action of A. muciniphila and offer perspectives for future studies.
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2625789-0
ISSN	2152-5250 ; 2152-5250
ISSN (online)	2152-5250
ISSN	2152-5250
DOI	10.14336/AD.2023.0325
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Article: How would the carbon tax on energy commodities affect consumer welfare? Evidence from China's household energy consumption system

Liu, Jianghua / Gong, Nianjiao / Qin, Jiahong

Journal of environmental management. 2022 Sept. 01, v. 317

2022

Abstract: Although carbon tax policies can effectively restrain energy consumption and reduce pollution, they will also affect the welfare of residents through a price mechanism. We explore the impact of energy price increases that are caused by possible carbon ... ...

Abstract	Although carbon tax policies can effectively restrain energy consumption and reduce pollution, they will also affect the welfare of residents through a price mechanism. We explore the impact of energy price increases that are caused by possible carbon tax policies on the welfare of residents in China with a quadratic almost ideal demand system (QUAIDS) model. The estimated elasticities show that the income elasticity of coal demand is −0.741 for urban residents, compared to 0.392 for rural residents. The cross-price elasticity shows that China's residential energy consumption has moved up the clean energy ladder. Based on the above reliable elasticity estimates, the welfare effects are analyzed in the residential consumption system. The overall welfare loss for residents increases with the level of carbon tax. A carbon tax on all energy sources is a regressive policy for China, and when the carbon tax rate reaches the world average, of 30 USD/tCO₂e, the welfare loss for low-income and high-income residents is 1.55% and 0.62% respectively. However, the separate imposition of carbon taxes on different energy sources shows the heterogeneity of the welfare impacts of carbon taxes. At the national and urban levels, the distribution effects of carbon taxes are regressive for coal, LPG, and electricity, progressive for gasoline, and distributional neutral for natural gas. In rural areas, however, the welfare distribution effect of the carbon tax on diesel, LPG, and natural gas are progressive, and the welfare effects of carbon taxes on electricity show an inverted U-shaped distribution. Our findings are conducive to the development of a differentiated carbon tax policy by the Chinese government.
Keywords	Almost Ideal Demand System ; carbon ; carbon markets ; clean energy ; coal ; electricity ; energy ; energy costs ; gasoline ; income elasticities ; issues and policy ; natural gas ; pollution ; prices ; taxes ; China
Language	English
Dates of publication	2022-0901
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2022.115466
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Article ; Online: Primary energy consumption structure and the influencing factors in China: an income decomposition and post-economic crisis era perspective

Wang, Ting / Liu, Jianghua / Xu, Yongqiang

Environ Sci Pollut Res. 2022 Nov., v. 29, no. 51 p.77908-77926

2022

Abstract: China’s coal-based energy structure makes its carbon peak and neutrality goals very challenging. As a result, optimizing the energy structure has become an important means, and researching its influencing factors and trends has become the foundation and ... ...

Abstract	China’s coal-based energy structure makes its carbon peak and neutrality goals very challenging. As a result, optimizing the energy structure has become an important means, and researching its influencing factors and trends has become the foundation and prerequisite for policy formulation related to energy structure optimization. Especially after the severe economic crisis, the economic structure has undergone profound changes, and the impact of related factors on the energy structure has also changed. This study adopts regression methods considering heteroskedasticity and cross-section correlation to study the panel data of 30 provinces in China and obtains the changes in the relationship between fossil and non-fossil fuel consumption in different regions and their influencing factors after two global financial crises. Research results show that China’s energy consumption tends to decouple from GDP. Income structure changes, especially trade changes, are important factors in influencing energy consumption and energy structure. The deviation between energy resource distribution and consumption distribution tends to increase. Regional heteroskedasticity is evident in the impact of urbanization development models, energy prices, and efficiency.
Keywords	carbon ; economic crises ; economic structure ; energy use and consumption ; heteroskedasticity ; income ; issues and policy ; primary energy ; urbanization ; China
Language	English
Dates of publication	2022-11
Size	p. 77908-77926.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-21202-0
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Article: Comprehensive binary interaction mapping of τ phosphotyrosine sites with SH2 domains in the human genome: Implications for the rational design of self-inhibitory phosphopeptides to target τ hyperphosphorylation signaling in Alzheimer’s Disease

Bao, Zhonglei / Liu, Jianghua / Fu, Jin

Amino acids. 2022 June, v. 54, no. 6

2022

Abstract: Human microtubule-associated protein Tau (τ) is abundant in the axons of neurons where it stabilizes microtubule bundles; abnormally hyperphosphorylated τ is a hallmark of Alzheimer’s disease (AD) and related tauopathies. The hyperphosphorylation events ... ...

Abstract	Human microtubule-associated protein Tau (τ) is abundant in the axons of neurons where it stabilizes microtubule bundles; abnormally hyperphosphorylated τ is a hallmark of Alzheimer’s disease (AD) and related tauopathies. The hyperphosphorylation events can be recognized by phosphotyrosine-recognition domain SH2 (Src homology 2) to elicit downstream τ signaling in AD pathology. In this study, a comprehensive binary interaction map (CBIM) of all the 6 τ phosphotyrosine sites with 120 SH2 domains in the human genome was systematically created at structural level using computational analyses and binding assays, from which we were able to identify those of strong and moderate binding pairs of sites to domains. It is found that the SH2-recognition specificity of different τ phosphotyrosine sites has been evolutionally optimized to become roughly orthogonal to each other, and thus these site phosphorylations would regulate different but probably partially overlapped biological functions in τ signaling. Some SH2 groups such as SRC, RIN, PLCG, SOCS and SH2D were revealed to have effective binding potency as compared to others; they could be regarded as potential τ-associated proteins to transduce the downstream signaling. We further determined the systematic binding affinities of 6 τ-phosphopeptides to the 11 SH2 domains in SRC group, from which the FYN-τ¹⁸ and YES-τ²⁹ pairs were identified as strong binders. Subsequently, rational molecular design was performed on τ¹⁸ and τ²⁹ to derive a number of τ-phosphopeptide mutants with increased affinity; they are self-inhibitory candidates to competitively target τ hyperphosphorylation events in AD. In addition, it is revealed that the primary anchor pY₀ and secondary anchor X₊₃ of τ-phosphopeptides play an important role in SRC-group SH2 recognition, which confer stability and specificity to the SH2–phosphopeptide binding, respectively.
Keywords	genome ; humans ; microtubules ; phosphopeptides
Language	English
Dates of publication	2022-06
Size	p. 859-875.
Publishing place	Springer Vienna
Document type	Article
ZDB-ID	1121341-3
ISSN	1438-2199 ; 0939-4451
ISSN (online)	1438-2199
ISSN	0939-4451
DOI	10.1007/s00726-022-03171-3
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