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Article ; Online: FANCD2 inhibits ferroptosis by regulating the JAK2/STAT3 pathway in osteosarcoma.

Li, Xujun / Liu, Jiangyi

2023 Volume 23, Issue 1, Page(s) 179

Abstract: Background: This research aimed to investigate the roles of fanconi anemia complementation group D2 (FANCD2) on the regulation of ferroptosis in osteosarcoma progression.: Methods: The function of FANCD2 on cell viability, invasion, migration, and ... ...

Abstract	Background: This research aimed to investigate the roles of fanconi anemia complementation group D2 (FANCD2) on the regulation of ferroptosis in osteosarcoma progression. Methods: The function of FANCD2 on cell viability, invasion, migration, and tumor growth were explored. FANCD2 and pathway-related genes were determined by western blot. Ferroptosis-associated markers were determined, including lipid peroxidation, labile iron pool (LIP), ferrous iron (Fe Results: FANCD2 expression was increased in osteosarcoma cells. FANCD2 knockdown reduced cell viability, invasion, and migration of osteosarcoma cells. FANCD2 knockdown regulated ferroptosis-related gene expression, and distinctly increased the levels of LIP, Fe Conclusion: These findings suggested that FANCD2 silencing could suppress osteosarcoma cell viability, migration, invasion, and tumor growth, and induced ferroptosis by regulating the JAK2/STAT3 axis. These findings may provide novel therapeutic ideas for clinical treatment of osteosarcoma.
MeSH term(s)	Humans ; Bone Neoplasms/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Fanconi Anemia Complementation Group D2 Protein/metabolism ; Ferroptosis ; Iron/pharmacology ; Janus Kinase 2/metabolism ; Osteosarcoma/metabolism ; STAT3 Transcription Factor/metabolism
Chemical Substances	FANCD2 protein, human ; Fanconi Anemia Complementation Group D2 Protein ; Iron (E1UOL152H7) ; JAK2 protein, human (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2) ; STAT3 protein, human ; STAT3 Transcription Factor
Language	English
Publishing date	2023-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-023-10626-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A single cell atlas of circulating immune cells involved in diabetic retinopathy.

Liao, Dan / Fan, Wei / Li, Na / Li, Ruonan / Wang, Xiaotang / Liu, Jiangyi / Wang, Hong / Hou, Shengping

iScience

2024 Volume 27, Issue 2, Page(s) 109003

Abstract: This study focused on examining the exact role of circulating immune cells in the development of diabetic retinopathy (DR). ...

Abstract	This study focused on examining the exact role of circulating immune cells in the development of diabetic retinopathy (DR).
Language	English
Publishing date	2024-01-26
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2024.109003
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Article ; Online: [No title information]

Liu, Jiangyi / Liao, Xingyun / Li, Na / Xu, Zongren / Yang, Wang / Zhou, Hongxiu / Liu, Yusen / Zhang, Zhi / Wang, Guoqing / Hou, Shengping

MedComm

2024 Volume 5, Issue 4, Page(s) e534

Abstract: Autoimmune uveitis (AU) is a kind of immune-mediated disease resulting in irreversible ocular damage and even permanent vision loss. However, the precise mechanism underlying dynamic immune changes contributing to disease initiation and progression of AU ...

Title translation	Single‐cell RNA sequencing reveals inflammatory retinal microglia in experimental autoimmune uveitis.
Abstract	Autoimmune uveitis (AU) is a kind of immune-mediated disease resulting in irreversible ocular damage and even permanent vision loss. However, the precise mechanism underlying dynamic immune changes contributing to disease initiation and progression of AU remains unclear. Here, we induced an experimental AU (EAU) model with IRBP
Language	Italian
Publishing date	2024-04-07
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	2688-2663
ISSN (online)	2688-2663
DOI	10.1002/mco2.534
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Book ; Online: Lay-it-out

Zhu, Fengmin / Liu, Jiangyi / He, Fei

Interactive Design of Layout-Sensitive Grammars

2022

Abstract: Layout-sensitive grammars have been adopted in many modern programming languages. However, tool support for this kind of grammars still remains limited and immature. In this paper, we present Lay-it-out, an interactive framework for layout-sensitive ... ...

Abstract	Layout-sensitive grammars have been adopted in many modern programming languages. However, tool support for this kind of grammars still remains limited and immature. In this paper, we present Lay-it-out, an interactive framework for layout-sensitive grammar design. Beginning with a user-defined ambiguous grammar, our framework refines it by synthesizing layout constraints through user interaction. For ease of interaction, a shortest nonempty ambiguous sentence (if exists) is automatically generated by our bounded ambiguity checker via SMT solving. The soundness and completeness of our SMT encoding are mechanized in the Coq proof assistant. Case studies on real grammars, including a full grammar, demonstrate the practicality and scalability of our approach.
Keywords	Computer Science - Programming Languages
Publishing date	2022-03-30
Publishing country	us
Document type	Book ; Online
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Article: [The role of epithelial cells in the formation and development of nasal polyps].

Chen, Zhuo / Liu, Jiangyi / Chen, Jie / Ma, Yiyou / Liao, Min / Li, Shuang / Yang, Yucheng

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

2022 Volume 34, Issue 11, Page(s) 1053–1056

Abstract: Nasal polyps, as a subtype of chronic sinusitis, is prone to clinical recurrence and seriously affects the quality of life of patients, but its pathogenesis is unclear. It is considered to be a chronic inflammation of the nasal-sinus mucosa under the ... ...

Abstract	Nasal polyps, as a subtype of chronic sinusitis, is prone to clinical recurrence and seriously affects the quality of life of patients, but its pathogenesis is unclear. It is considered to be a chronic inflammation of the nasal-sinus mucosa under the combined action of multiple factors. Among them, nasal mucosal epithelial injury and shedding are the main pathological features. Nasal-sinus epithelial separated nasal sinuses with the outside world, is the complex natural biological barrier to resist external stimuli and the key to maintaining homeostasis in the nasal sinuses. At present, the epithelium is considered not only as a "target organ" but also as an "effector" and a central regulator of the inflammatory response. This paper reviews the role of epithelial cells in the formation and development of nasal polyps, including the epithelial cell layer were stimulated not only leads to tissue remodeling, changes in mucociliary clearance, abnormal ion channels, and proliferation and apoptosis imbalance, but also produce a series of bioactive substances in response to various internal and external stimuli.Therefore, maintaining the integrity of the structure and function of airway mucosal epithelial cells may be a new approach for clinical prevention and treatment of nasal polyps.
MeSH term(s)	Cell Count ; Chronic Disease ; Epithelial Cells ; Humans ; Nasal Mucosa ; Nasal Polyps ; Paranasal Sinuses ; Quality of Life ; Rhinitis
Language	Chinese
Publishing date	2022-03-29
Publishing country	China
Document type	Journal Article ; Review
ISSN	2096-7993
ISSN	2096-7993
DOI	10.13201/j.issn.2096-7993.2020.11.024
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Article ; Online: YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes.

Huang, Jiaxing / Wang, Xiaotang / Li, Na / Fan, Wei / Li, Xingran / Zhou, Qian / Liu, Jiangyi / Li, Wanqian / Zhang, Zhi / Liu, Xiaoyan / Zeng, Shuhao / Yang, Hui / Tian, Meng / Yang, Peizeng / Hou, Shengping

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2024 , Page(s) e2308031

Abstract: Activated microglia in the retina are essential for the development of autoimmune uveitis. Yin-Yang 1 (YY1) is an important transcription factor that participates in multiple inflammatory and immune-mediated diseases. Here, an increased YY1 lactylation ... ...

Abstract	Activated microglia in the retina are essential for the development of autoimmune uveitis. Yin-Yang 1 (YY1) is an important transcription factor that participates in multiple inflammatory and immune-mediated diseases. Here, an increased YY1 lactylation in retinal microglia within in the experimental autoimmune uveitis (EAU) group is observed. YY1 lactylation contributed to boosting microglial activation and promoting their proliferation and migration abilities. Inhibition of lactylation suppressed microglial activation and attenuated inflammation in EAU. Mechanistically, cleavage under targets & tagmentation （CUT&Tag） analysis revealed that YY1 lactylation promoted microglial activation by regulating the transcription of a set of inflammatory genes, including STAT3, CCL5, IRF1, IDO1, and SEMA4D. In addition, p300 is identified as the writer of YY1 lactylation. Inhibition of p300 decreased YY1 lactylation and suppressed microglial inflammation in vivo and in vitro. Collectively, the results showed that YY1 lactylation promoted microglial dysfunction in autoimmune uveitis by upregulating inflammatory cytokine secretion and boosting cell migration and proliferation. Therapeutic effects can be achieved by targeting the lactate/p300/YY1 lactylation/inflammatory genes axis.
Language	English
Publishing date	2024-03-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2808093-2
ISSN	2198-3844 ; 2198-3844
ISSN (online)	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202308031
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Article ; Online: DNA methylation data-based molecular subtype classification related to the prognosis of patients with cervical cancer.

Li, Chunxiao / Ke, Jinxiu / Liu, Jiangyi / Su, Jingjing

Journal of cellular biochemistry

2019 Volume 121, Issue 3, Page(s) 2713–2724

Abstract: Cervical cancer is one of the leading female health-killers among all types of malignancies globally. Human papillomavirus infection combined with genetic and epigenetic alterations have been indicated to be closely associated with the pathogenesis, ... ...

Abstract	Cervical cancer is one of the leading female health-killers among all types of malignancies globally. Human papillomavirus infection combined with genetic and epigenetic alterations have been indicated to be closely associated with the pathogenesis, progression, and malignant transformation of cervical cancer. Notably, during the complex tumorigenesis process, a series of DNA methylations occurs early and is the most frequent molecular behavior. In this study, to exploit the specific DNA methylation sites influencing the prognosis of patients with cervical cancer, 275 samples were downloaded from The Cancer Genome Atlas database and further analyzed. As a result, 1253 CpGs were found to have a significant correlation with patient prognosis and were further selected for the consistent clustering of samples into six subgroups. Specifically, the samples in every subgroup were different regarding the following: race, age, tumor stage, receptor status, histological type, metastasis status, and patient prognosis. In addition, we calculated the levels of methylation sites in all subgroups, with 79 methylation sites (corresponding to 81 genes) screened as the intrasubgroup-specific methylation sites. Moreover, signaling pathway enrichment analysis was conducted on the genes of the corresponding promoter regions of the above-described specific methylation sites, revealing that these genes were enriched in biological pathways closely associated with tumors, such as the cyclic guanosine monophosphate-dependent protein kinase and focal adhesion signaling pathways. Finally, the least absolute shrinkage and selection operator algorithm was employed to establish a prognostic prediction model for cervical cancer patients, with training and test sets used for testing and validation, respectively. In summary, the specific DNA methylation site-based classification is able to reflect the heterogeneity of cervical cancer tissue, contributing to the development of personalized therapy and the accurate prediction of patient prognosis.
MeSH term(s)	Biomarkers, Tumor/genetics ; DNA Methylation ; Disease Progression ; Epigenesis, Genetic ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Prognosis ; Promoter Regions, Genetic ; Survival Rate ; Uterine Cervical Neoplasms/classification ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/pathology
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2019-11-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	392402-6
ISSN	1097-4644 ; 0730-2312
ISSN (online)	1097-4644
ISSN	0730-2312
DOI	10.1002/jcb.29491
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization.

Wang, Guoqing / Li, Xingran / Li, Na / Wang, Xiaotang / He, Siyuan / Li, Wanqian / Fan, Wei / Li, Ruonan / Liu, Jiangyi / Hou, Shengping

Redox biology

2022 Volume 52, Page(s) 102297

Abstract: Uveitis causes blindness and critical visual impairment in people of all ages, and retinal microglia participate in uveitis progression. Unfortunately, effective treatment is deficient. Icariin (ICA) is a bioactive monomer derived from Epimedium. However, ...

Abstract	Uveitis causes blindness and critical visual impairment in people of all ages, and retinal microglia participate in uveitis progression. Unfortunately, effective treatment is deficient. Icariin (ICA) is a bioactive monomer derived from Epimedium. However, the role of ICA in uveitis remains elusive. Our study indicated that ICA alleviated intraocular inflammation in vivo. Further results showed the proinflammatory M1 microglia could be transferred to anti-inflammatory M2 microglia by ICA in the retina and HMC3 cells. However, the direct pharmacological target of ICA is unknown, to this end, proteome microarrays and molecular simulations were used to identify the molecular targets of ICA. Data showed that ICA binds to peroxiredoxin-3 (PRDX3), increasing PRDX3 protein expression in both a time- and a concentration-dependent manner and promoting the subsequent elimination of H
MeSH term(s)	Animals ; Flavonoids ; Humans ; Hydrogen Peroxide/metabolism ; Inflammation/drug therapy ; Inflammation/metabolism ; Mice ; Microglia/metabolism ; Peroxiredoxin III/metabolism ; Uveitis/drug therapy ; Uveitis/metabolism
Chemical Substances	Flavonoids ; Hydrogen Peroxide (BBX060AN9V) ; Peroxiredoxin III (EC 1.11.1.15) ; icariin (VNM47R2QSQ)
Language	English
Publishing date	2022-03-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2701011-9
ISSN	2213-2317 ; 2213-2317
ISSN (online)	2213-2317
ISSN	2213-2317
DOI	10.1016/j.redox.2022.102297
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Article ; Online: Global lactylome reveals lactylation-dependent mechanisms underlying T

Fan, Wei / Wang, Xiaotang / Zeng, Shuhao / Li, Na / Wang, Guoqing / Li, Ruonan / He, Siyuan / Li, Wanqian / Huang, Jiaxing / Li, Xingran / Liu, Jiangyi / Hou, Shengping

Science advances

2023 Volume 9, Issue 42, Page(s) eadh4655

Abstract: Dysregulation of ... ...

Abstract	Dysregulation of CD4
MeSH term(s)	Mice ; Animals ; Th17 Cells ; Uveitis/genetics ; Uveitis/drug therapy ; Autoimmune Diseases/genetics ; Cell Differentiation ; Lactates ; Disease Models, Animal ; Mice, Inbred C57BL
Chemical Substances	Lactates
Language	English
Publishing date	2023-10-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adh4655
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Article: Plasma YKL-40: a Potential Biomarker for Tumor Invasion in Esophageal Cancer.

Huang, Rongfu / Yao, Jianfeng / Ding, Xin / Liu, Jiangyi / Fan, Chunmei / Duan, Hongbin / Ye, Huiming

Clinical laboratory

2020 Volume 66, Issue 3

Abstract: Background: YKL-40, a chitinase-like glycoprotein has been identified as a candidate tumor marker. The current study evaluated the clinical significance of plasma YKL-40 in esophageal cancer patients.: Methods: We enrolled 127 esophageal cancer ... ...

Abstract	Background: YKL-40, a chitinase-like glycoprotein has been identified as a candidate tumor marker. The current study evaluated the clinical significance of plasma YKL-40 in esophageal cancer patients. Methods: We enrolled 127 esophageal cancer patients, 29 healthy controls. Plasma YKL-40 levels were measured through enzyme linked immunosorbent assay. Receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic efficiency of plasma YKL-40 in esophageal cancer patients. The correlations between plasma YKL-40 and clinicopathological characteristics of esophageal were analyzed. Results: Plasma YKL-40 levels were significantly higher in patients with lymph node metastasis than those that were non-metastatic (p = 0.005). Patients with tumor thrombus formation presented with significantly higher YKL-40 levels than those without thrombus formation (160.3 vs. 74.7 ng/mL, p = 0.012). YKL-40 levels in patients with advanced stage (III and IV) were significantly higher than those in the early stages (I and II, p = 0.016). ROC curve analysis showed that the area under curve was 0.909, and the best diagnostic threshold of YKL-40 for esophageal cancer was 80.6 ng/mL with 68.9% sensitivity and 96.6% specificity. Conclusions: This study indicated that YKL-40 may be a biomarker for esophageal cancer and potential biomarker for identification of invasive esophageal cancer.
MeSH term(s)	Adult ; Aged ; Biomarkers, Tumor/blood ; Chitinase-3-Like Protein 1/blood ; Esophageal Neoplasms/blood ; Esophageal Neoplasms/epidemiology ; Esophageal Neoplasms/pathology ; Female ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Invasiveness ; Retrospective Studies ; Sensitivity and Specificity ; Young Adult
Chemical Substances	Biomarkers, Tumor ; CHI3L1 protein, human ; Chitinase-3-Like Protein 1
Language	English
Publishing date	2020-03-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2019.190528
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