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  1. Article ; Online: Mesenchymal stem cell-derived exosomes overexpressing SRC-3 protect mice from cerebral ischemia by inhibiting ferroptosis.

    Deng, Mingyang / Hou, Ying / Liu, Jianyang / He, Jialin / Lan, Ziwei / Xiao, Han

    Brain research bulletin

    2024  Volume 211, Page(s) 110948

    Abstract: Background: The treatment for cerebral ischemia remains limited, and new therapeutic strategies are urgently needed. Exosome has shown great promise for the treatment of cerebral ischemia. Steroid receptor coactivator-3 (SRC-3) was reported to be ... ...

    Abstract Background: The treatment for cerebral ischemia remains limited, and new therapeutic strategies are urgently needed. Exosome has shown great promise for the treatment of cerebral ischemia. Steroid receptor coactivator-3 (SRC-3) was reported to be involved in neurological performances. In this study, we aimed to investigate the protective effects of mesenchymal stem cell (MSC)-derived exosomes overexpressing SRC-3 on cerebral ischemia in mice.
    Methods: The mice were treated with an intracerebroventricular injection of GFP-overexpressed exosomes (GFP-exo) and SRC-3-overexpressed exosomes (SRC3-exo) in a middle cerebral artery occlusion (MCAO) model of cerebral ischemia.
    Results: The results showed that SRC3-exo treatment significantly inhibited lipid peroxidation and ferroptosis of the neurons subjected to oxygen-glucose deprivation. It further suppressed the activation of microglia and astrocytes, and decreased the production of pro-inflammatory cytokines in the brains of MCAO mice. Furthermore, SRC3-exo treatment reduced the water content of brain tissue and infarct size, which alleviated the neurological damage and improved neurological performances in the MCAO mice.
    Conclusions: Our results suggest that MSC-derived exosomes expressing SRC3 can be a therapeutic strategy for cerebral ischemia by inhibiting ferroptosis.
    MeSH term(s) Animals ; Exosomes/metabolism ; Exosomes/transplantation ; Mice ; Ferroptosis/physiology ; Mesenchymal Stem Cells/metabolism ; Male ; Brain Ischemia/metabolism ; Brain Ischemia/therapy ; Nuclear Receptor Coactivator 3/metabolism ; Nuclear Receptor Coactivator 3/genetics ; Infarction, Middle Cerebral Artery/metabolism ; Mice, Inbred C57BL ; Neurons/metabolism ; Disease Models, Animal ; Astrocytes/metabolism ; Brain/metabolism
    Chemical Substances Nuclear Receptor Coactivator 3 (EC 2.3.1.48) ; Ncoa3 protein, mouse (EC 2.3.1.48)
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 197620-5
    ISSN 1873-2747 ; 0361-9230
    ISSN (online) 1873-2747
    ISSN 0361-9230
    DOI 10.1016/j.brainresbull.2024.110948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1243: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: euAP2a, a key gene that regulates flowering time in peach (

    Liu, Jianyang / Bennett, Dennis / Demuth, Mark / Burchard, Erik / Artlip, Tim / Dardick, Chris / Liu, Zongrang

    Horticulture research

    2024  Volume 11, Issue 5, Page(s) uhae076

    Abstract: Frequent spring frost damage threatens temperate fruit production, and breeding of late-flowering cultivars is an effective strategy for preventing such damage. However, this effort is often hampered by the lack of specific genes and markers and a lack ... ...

    Abstract Frequent spring frost damage threatens temperate fruit production, and breeding of late-flowering cultivars is an effective strategy for preventing such damage. However, this effort is often hampered by the lack of specific genes and markers and a lack of understanding of the mechanisms. We examined a Late-Flowering Peach (
    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ISSN 2662-6810
    ISSN 2662-6810
    DOI 10.1093/hr/uhae076
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  3. Article ; Online: Effects of Aminoethoxyvinylglycine (AVG) and 1-Methylcyclopropene (1-MCP) on the Pre-Harvest Drop Rate, Fruit Quality, and Stem-End Splitting in ‘Gala’ Apples

    Liu, Jianyang / Islam, Md Tabibul / Sherif, Sherif M.

    Horticulturae. 2022 Nov. 24, v. 8, no. 12

    2022  

    Abstract: Preharvest fruit drop is a significant physiological problem that affects numerous commercially significant apple varieties, including ‘Gala.’ AVG and 1-MCP are two plant growth regulators commonly used to reduce fruit drop by reducing ethylene synthesis ...

    Abstract Preharvest fruit drop is a significant physiological problem that affects numerous commercially significant apple varieties, including ‘Gala.’ AVG and 1-MCP are two plant growth regulators commonly used to reduce fruit drop by reducing ethylene synthesis and perception, respectively. To optimize yield and market acceptance, a complete investigation of AVG and 1-MCP impacts on fruit drop and fruit quality of ‘Gala’ apples is required. In this study, four trials were conducted over the course of three years to determine the effects of AVG and 1-MCP on fruit drop and quality at harvest and after cold storage. Our results indicated that applications of AVG at the full-rate (130 mgL⁻¹) three weeks before harvest (WBAH) were more effective at minimizing fruit drop than applications at the half-rate (65 mgL⁻¹) and did not differ significantly from the double rate (260 mgL⁻¹). Additionally, a single application of AVG was as effective in preventing fruit drop as two applications of 1-MCP. We also demonstrated that AVG decreased fruit skin pigmentation when used alone or in conjunction with GA₄₊₇ or 1-MCP, while 1-MCP applications had no negative effect on fruit color. Finally, our data showed that when compared to 1-MCP and GA₄₊₇, AVG alone was more effective in preventing stem-end splitting in Gala apples.
    Keywords 1-methylcyclopropene ; aminoethoxyvinylglycine ; apples ; cold storage ; ethylene ; fruit color ; fruit drop ; fruit quality ; fruits ; markets ; pigmentation ; plant growth
    Language English
    Dates of publication 2022-1124
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2813983-5
    ISSN 2311-7524
    ISSN 2311-7524
    DOI 10.3390/horticulturae8121100
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Resveratrol has an Overall Neuroprotective Role in Ischemic Stroke: A Meta-Analysis in Rodents.

    Liu, Jianyang / He, Jialin / Huang, Yan / Hu, Zhiping

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 795409

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-12-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.795409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Ethephon-Mediated Bloom Delay in Peach Is Associated With Alterations in Reactive Oxygen Species, Antioxidants, and Carbohydrate Metabolism During Dormancy.

    Islam, Md Tabibul / Liu, Jianyang / Sherif, Sherif M

    Frontiers in plant science

    2021  Volume 12, Page(s) 765357

    Abstract: Ethephon (ET) is an ethylene-based plant growth regulator (PGR) that has demonstrated greater efficacy in delaying bloom in deciduous fruit species. However, the underlying mechanisms by which ET modulates dormancy and flowering time remain obscure. This ...

    Abstract Ethephon (ET) is an ethylene-based plant growth regulator (PGR) that has demonstrated greater efficacy in delaying bloom in deciduous fruit species. However, the underlying mechanisms by which ET modulates dormancy and flowering time remain obscure. This study aimed to delineate the ET-mediated modulations of reactive oxygen species (ROS), antioxidants, and carbohydrate metabolism in relation to chilling and heat requirements of "Redhaven" peach trees during dormancy. Peach trees were treated with ethephon (500ppm) in the fall (at 50% leaf fall), and floral buds were collected at regular intervals of chilling hours (CH) and growing degree hours (GDH). In the control trees, hydrogen peroxide (H
    Language English
    Publishing date 2021-10-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2021.765357
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  6. Article ; Online: L-3-n-butylphthalide promotes restoration after an experimental animal model of intracerebral hemorrhage.

    Pi, Zhendong / Liu, Jianyang / Xiao, Han / Hu, Zhiping

    International journal of medical sciences

    2021  Volume 18, Issue 12, Page(s) 2607–2614

    Abstract: Intracerebral hemorrhage (ICH) is a devastating type of stroke with high morbidity and mortality, and the effective therapies for ICH remain to be explored. L-3-n-butylphthalide (NBP) is widely used in the treatment of ischemic stroke. However, few ... ...

    Abstract Intracerebral hemorrhage (ICH) is a devastating type of stroke with high morbidity and mortality, and the effective therapies for ICH remain to be explored. L-3-n-butylphthalide (NBP) is widely used in the treatment of ischemic stroke. However, few studies evaluated the therapeutic effects of NBP on ICH. Therefore, the present study aims to evaluate the effects of NBP on ICH and its potential mechanism. The rats were randomly divided into sham-operated group, saline-treated (ICH + saline) group, and NBP-treated (ICH + NBP) group. The ICH model of SD rats induced by IV collagenase was established. The modified Garcia JH score was used to detect the neurological deficit in rats. Western Blot and immunohistochemistry analysis was applied to test the levels of UBIAD1 and caspase-3 expressions in the perihematomal region. The rates of apoptotic cells were detected by TUNEL staining. The results showed that NBP up-regulated the expression of UBIAD1, reduced the apoptotic cells in the perihematomal region, and improved the neurological deficit. Taken together, our study added some new evidence to the application of NBP in ICH treatment.
    MeSH term(s) Animals ; Benzofurans/administration & dosage ; Cerebral Hemorrhage/drug therapy ; Cerebral Hemorrhage/etiology ; Disease Models, Animal ; Hemorrhagic Stroke/drug therapy ; Hemorrhagic Stroke/etiology ; Humans ; Male ; Neuroprotective Agents/administration & dosage ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Benzofurans ; Neuroprotective Agents ; 3-n-butylphthalide (822Q956KGM)
    Language English
    Publishing date 2021-04-29
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2151424-0
    ISSN 1449-1907 ; 1449-1907
    ISSN (online) 1449-1907
    ISSN 1449-1907
    DOI 10.7150/ijms.60342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Research progress on circular RNA vaccines.

    Bai, Yu / Liu, Dong / He, Qian / Liu, Jianyang / Mao, Qunying / Liang, Zhenglun

    Frontiers in immunology

    2023  Volume 13, Page(s) 1091797

    Abstract: Owing to the success of linear mRNA coronavirus disease 2019 (COVID-19) vaccines, biopharmaceutical companies and research teams worldwide have attempted to develop more stable circular RNA (circRNA) vaccines and have achieved some preliminary results. ... ...

    Abstract Owing to the success of linear mRNA coronavirus disease 2019 (COVID-19) vaccines, biopharmaceutical companies and research teams worldwide have attempted to develop more stable circular RNA (circRNA) vaccines and have achieved some preliminary results. This review aims to summarize key findings and important progress made in circRNA research, the
    MeSH term(s) Humans ; RNA, Circular/genetics ; COVID-19/prevention & control ; RNA, Messenger ; Vaccines ; Biological Products ; COVID-19 Vaccines
    Chemical Substances RNA, Circular ; RNA, Messenger ; Vaccines ; Biological Products ; COVID-19 Vaccines
    Language English
    Publishing date 2023-01-12
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1091797
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Amplifying mRNA vaccines: potential versatile magicians for oncotherapy.

    Hu, Chaoying / Liu, Jianyang / Cheng, Feiran / Bai, Yu / Mao, Qunying / Xu, Miao / Liang, Zhenglun

    Frontiers in immunology

    2023  Volume 14, Page(s) 1261243

    Abstract: Cancer vaccines drive the activation and proliferation of tumor-reactive immune cells, thereby eliciting tumor-specific immunity that kills tumor cells. Accordingly, they possess immense potential in cancer treatment. However, such vaccines are also ... ...

    Abstract Cancer vaccines drive the activation and proliferation of tumor-reactive immune cells, thereby eliciting tumor-specific immunity that kills tumor cells. Accordingly, they possess immense potential in cancer treatment. However, such vaccines are also faced with challenges related to their design and considerable differences among individual tumors. The success of messenger RNA (mRNA) vaccines against coronavirus disease 2019 has prompted the application of mRNA vaccine technology platforms to the field of oncotherapy. These platforms include linear, circular, and amplifying mRNA vaccines. In particular, amplifying mRNA vaccines are characterized by high-level and prolonged antigen gene expression at low doses. They can also stimulate specific cellular immunity, making them highly promising in cancer vaccine research. In this review, we summarize the research progress in amplifying mRNA vaccines and provide an outlook of their prospects and future directions in oncotherapy.
    MeSH term(s) RNA, Messenger ; Immunity, Cellular ; Antigens/genetics ; Cancer Vaccines
    Chemical Substances RNA, Messenger ; Antigens ; Cancer Vaccines
    Language English
    Publishing date 2023-10-23
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1261243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Microsomal prostaglandin E synthase-1 inhibition promotes shunting in arachidonic acid metabolism during inflammatory responses in vitro.

    Liu, Jianyang / Peng, Bing / Steinmetz-Späh, Julia / Idborg, Helena / Korotkova, Marina / Jakobsson, Per-Johan

    Prostaglandins & other lipid mediators

    2023  Volume 167, Page(s) 106738

    Abstract: Microsomal Prostaglandin E Synthase 1 (mPGES-1) is the key enzyme for the generation of the pro-inflammatory lipid mediator prostaglandin ... ...

    Abstract Microsomal Prostaglandin E Synthase 1 (mPGES-1) is the key enzyme for the generation of the pro-inflammatory lipid mediator prostaglandin E
    MeSH term(s) Mice ; Animals ; Prostaglandin-E Synthases/metabolism ; Cyclooxygenase 2/metabolism ; Arachidonic Acid ; Prostaglandins ; Inflammation/drug therapy ; Inflammation/metabolism ; Dinoprostone/metabolism ; Eicosanoids
    Chemical Substances Prostaglandin-E Synthases (EC 5.3.99.3) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Arachidonic Acid (27YG812J1I) ; Prostaglandins ; Dinoprostone (K7Q1JQR04M) ; Eicosanoids
    Language English
    Publishing date 2023-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1426962-4
    ISSN 2212-196X ; 1098-8823 ; 0090-6980
    ISSN (online) 2212-196X
    ISSN 1098-8823 ; 0090-6980
    DOI 10.1016/j.prostaglandins.2023.106738
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 815: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Prediction of air pollutant concentrations based on the long short-term memory neural network.

    Wu, Zechuan / Tian, Yuping / Li, Mingze / Wang, Bin / Quan, Ying / Liu, Jianyang

    Journal of hazardous materials

    2023  Volume 465, Page(s) 133099

    Abstract: In recent years, environmental problems caused by air pollutants have received increasing attention. Effective prediction of air pollutant concentrations is an important way to protect the public from harm. Recently, due to extreme climate and social ... ...

    Abstract In recent years, environmental problems caused by air pollutants have received increasing attention. Effective prediction of air pollutant concentrations is an important way to protect the public from harm. Recently, due to extreme climate and social development, the forest fire frequency has increased. During the biomass combustion process caused by forest fires, the content of particulate matter (PM) in the atmosphere increases significantly. However, most existing air pollutant concentration prediction methods do not consider the considerable impact of forest fires, and effective long-term prediction models have not been established to provide early warnings for harmful gases. Therefore, in this paper, we collected a daily air quality data set (aerodynamic diameter smaller than 2.5 µm, PM
    MeSH term(s) Air Pollutants/analysis ; Memory, Short-Term ; Environmental Monitoring/methods ; Air Pollution/analysis ; Particulate Matter/analysis ; Neural Networks, Computer
    Chemical Substances Air Pollutants ; Particulate Matter
    Language English
    Publishing date 2023-11-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2023.133099
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