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  1. Article ; Online: Combination of trimethoprim-sulfamethoxazole and clindamycin in the treatment of relapsing toxoplasmic encephalitis.

    Ting, Shih-Wen / Liu, Jien-Wei

    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

    2024  

    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Letter
    ZDB-ID 1497590-7
    ISSN 1995-9133 ; 1684-1182 ; 0253-2662
    ISSN (online) 1995-9133
    ISSN 1684-1182 ; 0253-2662
    DOI 10.1016/j.jmii.2024.02.008
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  2. Article ; Online: Increasing trend of healthcare-associated infections due to vancomycin-resistant Enterococcus faecium (VRE-fm) paralleling escalating community-acquired VRE-fm infections in a medical center implementing strict contact precautions: An epidemiologic and pathogenic genotype analysis and its implications.

    Tang, Ya-Fen / Lin, Yin-Shiou / Su, Li-Hsiang / Liu, Jien-Wei

    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

    2023  Volume 56, Issue 5, Page(s) 1045–1053

    Abstract: Objective: To clarify whether there were clandestine intra-hospital spreads of vancomycin-resistant Enterococcus faecium (VRE-fm) isolates that led to specific strain of VRE lingering in the hospital and/or developing outbreaks that rendered a ... ...

    Abstract Objective: To clarify whether there were clandestine intra-hospital spreads of vancomycin-resistant Enterococcus faecium (VRE-fm) isolates that led to specific strain of VRE lingering in the hospital and/or developing outbreaks that rendered a progressively increasing trend of healthcare-associated infections due to VRE-fm (VRE-fm-HAIs).
    Setting: Despite implementing strict contact precautions for hospitalized patients with VRE-fm-infection/colonization, number of VRE-fm-HAIs in a medical centre in southern Taiwan were escalating in 2009-2019, paralleling an increasing trend of community-acquired VRE-fm- infections.
    Methods: We analyzed epidemiologic data and genotypes of non-duplicate VRE-fm isolates each grown from a normally sterile site of 89 patients between December 2016 and October 2018; multilocus sequence typing (MLST) and pulse-field gel electrophoresis (PFGE) typing were performed.
    Results: Totally 13 sequence types (STs) were found, and the 3 leading STs were ST17 (44％), ST78 (37％), and ST18 (6％); 66 pulsotypes were generated by PFGE. Four VRE-fm isolates grouped as ST17/pulsotype S, 2 as ST17/pulsotype AS, 2 as ST17/pulsotype AU, and 3 as ST78/pulsotype V grew from clinical specimens sampled less than one week apart from patients staying at different wards/departments and/or on different floors of the hospital.
    Conclusions: Despite possible small transitory clusters of intra-hospital VRE-fm spreads, there was no specific VRE-fm strain lingering in the hospital leading to increasing trend of VRE-fm-HAIs during the study period. Strict contact precautions were able to curb intra-hospital VRE-fm spreads, but unable to curb the increasing trend of VRE-fm-HAIs with the backdrop of progressively increasing VRE-fm-infections/colorizations in the community.
    Language English
    Publishing date 2023-08-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1497590-7
    ISSN 1995-9133 ; 1684-1182 ; 0253-2662
    ISSN (online) 1995-9133
    ISSN 1684-1182 ; 0253-2662
    DOI 10.1016/j.jmii.2023.07.015
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  3. Article ; Online: Efficacy of cefoperazone/sulbactam for ESBL-producing Escherichia coli and Klebsiella pneumoniae bacteraemia and the factors associated with poor outcomes.

    Chen, Rou-Zhen / Lu, Po-Liang / Yang, Tsung-Ying / Lin, Shang-Yi / Tang, Hung-Jen / Chang, Feng-Yee / Yang, Ya-Sung / Chiang, Tsung-Ta / Wang, Fu-Der / Wu, Ting-Shu / Shie, Shian-Sen / Ho, Mao-Wang / Liu, Jien-Wei / Shi, Zhi-Yuan / Chou, Chia-Hui / Chuang, Yin-Ching

    The Journal of antimicrobial chemotherapy

    2024  Volume 79, Issue 3, Page(s) 648–655

    Abstract: Objective: We aimed to assess the efficacy of cefoperazone/sulbactam (CPZ/SUL) in extended-spectrum β-lactamase (ESBL)-producing Enterobacterales infections and identify factors influencing outcomes.: Methods: This retrospective multicentre study was ...

    Abstract Objective: We aimed to assess the efficacy of cefoperazone/sulbactam (CPZ/SUL) in extended-spectrum β-lactamase (ESBL)-producing Enterobacterales infections and identify factors influencing outcomes.
    Methods: This retrospective multicentre study was conducted in Taiwan (January 2015 to December 2020) and examined the efficacy of CPZ/SUL treatment in ESBL-producing Enterobacterales bacteraemia. The minimum inhibitory concentrations (MICs) were determined using agar dilution; ESBL/AmpC genes were detected using polymerase chain reaction. The primary outcome was clinical success, whereas the secondary outcome was 30-day mortality. Clinical success was defined as the complete resolution of clinical signs and symptoms of K. pneumoniae or E. coli infection, with no evidence of persistent or recurrent bacteraemia. The factors influencing outcomes were identified using a multivariate analysis.
    Results: CPZ/SUL demonstrated a clinical success rate of 82.7% (91/110) in treating ESBL-producing Enterobacterales bacteraemia, with a 30-day mortality rate of 9.1% (10/110). Among 110 ESBL-producing isolates, a high clinical success rate was observed at an MIC of ≤32/32 mg/L. Multivariate analysis revealed that a Charlson comorbidity index (CCI) of ≥6 was associated with lower clinical success [odds ratio (OR): 5.80, 95% confidence interval (CI): 1.15-29.14, P = 0.033]. High Sequential Organ Failure Assessment scores (≥6) were significantly associated with increased 30-day mortality (OR: 14.34, 95% CI: 1.45-141.82, P = 0.023).
    Discussion: CPZ/SUL demonstrated a clinical success rate of 82.7% (91/110) in treating ESBL-producing Enterobacterales bacteraemia. Treatment success was evident when the CPZ and SUL MIC was ≤32/32 mg/L. Comorbidities (CCI ≥6) were associated with lower clinical success, while disease severity (Sequential Organ Failure Assessment score ≥6) correlated with higher mortality.
    MeSH term(s) Humans ; Escherichia coli ; Cefoperazone/therapeutic use ; Sulbactam/therapeutic use ; Klebsiella pneumoniae ; Escherichia coli Infections/drug therapy ; Bacteremia/drug therapy ; Gammaproteobacteria
    Chemical Substances Cefoperazone (7U75I1278D) ; Sulbactam (S4TF6I2330)
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkae022
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  4. Article ; Online: Increased financial burdens and lengths of stay in patients with healthcare-associated infections due to multidrug-resistant bacteria in intensive care units: A propensity-matched case-control study.

    Su, Li-Hsiang / Chen, I-Ling / Tang, Ya-Fen / Lee, Jen-Sin / Liu, Jien-Wei

    PloS one

    2020  Volume 15, Issue 5, Page(s) e0233265

    Abstract: Background and objectives: Incidence rates of healthcare-associated infections (HAIs) depend upon infection control policy and practices, and the effectiveness of the implementation of antibiotic stewardship. Amongst intensive care unit (ICU) patients ... ...

    Abstract Background and objectives: Incidence rates of healthcare-associated infections (HAIs) depend upon infection control policy and practices, and the effectiveness of the implementation of antibiotic stewardship. Amongst intensive care unit (ICU) patients with HAIs, a substantial number of pathogens were reported to be multidrug-resistant bacteria (MDRB). However, impacts of ICU HAIs due to MDRB (MDRB-HAIs) remain understudied. Our study aimed to evaluate the negative impacts of MRDB-HAIs versus HAIs due to non-MDRB (non-MRDB-HAIs).
    Methods: Among 60,317 adult patients admitted at ICUs of a 2680-bed medical centre in Taiwan between January 2010 and December 2017, 279 pairs of propensity-score matched MRDB-HAI and non-MRDB-HAI were analyzed.
    Principal findings: Between the MDRB-HAI group and the non-MDRB-HAI group, significant differences were found in overall hospital costs, costs of medical and nursing services, medication, and rooms/beds, and in ICU length-of-stay (LOS). As compared with the non-MDRB-HAI group, the mean of the overall hospital costs of patients in the MDRB-HAI group was increased by 26%; for categorized expenditures, the mean of costs of medical and nursing services of patients in the MDRB-HAI group was increased by 8%, of medication by 26.9%, of rooms/beds by 10.3%. The mean ICU LOS in the MDRB-HAI group was increased by 13%. Mortality rates in both groups did not significantly differ.
    Conclusions: These data clearly demonstrate more negative impacts of MDRB-HAIs in ICUs. The quantified financial burdens will be helpful for hospital/government policymakers in allocating resources to mitigate MDRB-HAIs in ICUs; in case of need for clarification/verification of the medico-economic burdens of MDRB-HAIs in different healthcare systems, this study provides a model to facilitate the evaluations.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Catheter-Related Infections/epidemiology ; Critical Care ; Cross Infection/economics ; Cross Infection/epidemiology ; Drug Resistance, Multiple, Bacterial/drug effects ; Female ; Hospital Costs ; Hospitalization/economics ; Hospitals ; Humans ; Incidence ; Infection Control/economics ; Infection Control/methods ; Intensive Care Units/economics ; Intensive Care Units/trends ; Length of Stay/economics ; Male ; Methicillin-Resistant Staphylococcus aureus/metabolism ; Middle Aged ; Propensity Score ; Staphylococcal Infections/economics ; Staphylococcal Infections/epidemiology ; Taiwan
    Language English
    Publishing date 2020-05-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0233265
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  5. Article ; Online: Risk factors and outcomes for the acquisition of carbapenem-resistant Gram-negative bacillus bacteremia: A retrospective propensity-matched case control study.

    Ting, Shih-Wen / Lee, Chen-Hsiang / Liu, Jien-Wei

    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

    2017  Volume 51, Issue 5, Page(s) 621–628

    Abstract: Background/purpose: A substantial number of carbapenem-resistant Gram-negative bacilli (CR GNB) have been identified among the etiologic multidrug-resistant GNB in healthcare-associated infections. For achieving a better therapeutic outcome by ... ...

    Abstract Background/purpose: A substantial number of carbapenem-resistant Gram-negative bacilli (CR GNB) have been identified among the etiologic multidrug-resistant GNB in healthcare-associated infections. For achieving a better therapeutic outcome by minimizing inappropriate empirical antibiotic treatment before blood culture and susceptibility testing results are available, it is very important to identify patients who are at risk for the development of CR GNB bacteremia.
    Methods: Retrospective analysis of propensity-score matched (PSM) adult patients with CR GNB bacteremia (PSM-group 1 [n = 95]) and those with non-CR GNB bacteremia (PSM-group 2 [n = 190]).
    Results: PSM-group 1 was found to a significantly longer length of hospital stay (27 vs. 18 days; p < 0.001) after emerging GNB bacteremia and a higher 30-day all-cause mortality rate (27.4% vs. 5.8%; p < 0.001), when compared with PSM-2 group. Independent risk factors for the acquisition of CR GNB bacteremia were previous exposure to an antipseudomonal penicillin (odds ratio [OR] = 3.58; 95% confidence interval [CI] = 1.30-9.90), an antipseudomonal cephalosporin (OR = 3.49; 95% CI = 1.09-11.24), and a carbapenem (OR = 3.60; 95% CI = 1.37-9.47), and longer length of hospital stay before the development of GNB bacteremia (OR = 1.03; 95% CI = 1.01-1.05).
    Conclusion: Risk factors for acquisition of CR GNB bacteremia identified in this study each may serve as a reminder alerting clinicians to hospitalized patients at risk for CR GNB bacteremia requiring appropriate antibiotic coverage, and in these circumstances, combined antibiotics may be used until antimicrobial de-escalation/adjustment is clearly indicated by the subsequently identified pathogenic GNB and its susceptibility profile.
    MeSH term(s) Aged ; Aged, 80 and over ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacteremia/drug therapy ; Bacteremia/microbiology ; Bacteremia/mortality ; Carbapenems/pharmacology ; Carbapenems/therapeutic use ; Case-Control Studies ; Cross Infection/drug therapy ; Cross Infection/microbiology ; Cross Infection/mortality ; Drug Resistance, Bacterial/drug effects ; Female ; Gram-Negative Bacteria/classification ; Gram-Negative Bacteria/drug effects ; Gram-Negative Bacteria/physiology ; Gram-Negative Bacterial Infections/drug therapy ; Gram-Negative Bacterial Infections/microbiology ; Gram-Negative Bacterial Infections/mortality ; Humans ; Male ; Middle Aged ; Propensity Score ; Retrospective Studies ; Risk Factors ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents ; Carbapenems
    Language English
    Publishing date 2017-06-23
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 1497590-7
    ISSN 1995-9133 ; 1684-1182 ; 0253-2662
    ISSN (online) 1995-9133
    ISSN 1684-1182 ; 0253-2662
    DOI 10.1016/j.jmii.2016.08.022
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  6. Article ; Online: Analyses of clinical and laboratory characteristics of dengue adults at their hospital presentations based on the World Health Organization clinical-phase framework: Emphasizing risk of severe dengue in the elderly.

    Kuo, Hong-Jie / Lee, Ing-Kit / Liu, Jien-Wei

    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

    2017  Volume 51, Issue 6, Page(s) 740–748

    Abstract: Background/purpose: Dengue clinically dynamically changes over time; the World Health Organization (WHO) dengue classification framework proposed 3 dengue clinical phases-febrile (days 1-3), critical (days 4-6) and recovery (days ≥7) phases. This study ... ...

    Abstract Background/purpose: Dengue clinically dynamically changes over time; the World Health Organization (WHO) dengue classification framework proposed 3 dengue clinical phases-febrile (days 1-3), critical (days 4-6) and recovery (days ≥7) phases. This study aimed to better understand clinical and laboratory characteristics in adults (≥18 years) suffering dengue in different clinical phases at their hospital presentations.
    Methods: A retrospective analysis of adults suffering dengue between 2008 and 2014.
    Results: Of the 669 included dengue adults, 146 (21.8%) were elderly (≥65 years), and 27 (4%) suffered severe dengue. When compared with those in febrile phase, significantly higher incidence of ascites, mucosal bleeding, and/or gastrointestinal bleeding; lower white blood cell (WBC) and platelet counts; higher hematocrit, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values were found in critical phase. When compared with their younger counterparts, elderly at febrile phase had significantly lower frequencies of bone pain, myalgia, headache and rash; higher frequencies of vomiting, pleural effusion and mucosal bleeding; higher WBC count, AST and ALT levels, and lower platelet count; in critical phase, elderly had significantly higher frequencies of pleural effusion, mucosal bleeding and gum bleeding. Four (0.6%) patients experienced severe dengue in recovery phase. Significantly higher proportions of elderly developed severe dengue in both febrile and critical phases as compared with younger adults.
    Conclusions: Elderly had lower frequency of classical dengue symptoms, yet were at higher risk of development of severe dengue during their early dengue course. A small number of patients developed severe dengue at the WHO-proposed recovery phase.
    MeSH term(s) Adult ; Age Factors ; Aged ; Clinical Medicine/methods ; Clinical Medicine/standards ; Dengue/epidemiology ; Dengue/pathology ; Dengue/physiopathology ; Female ; Hospitals ; Humans ; Incidence ; Male ; Middle Aged ; Retrospective Studies ; Risk ; Severe Dengue/epidemiology ; Severe Dengue/pathology ; Severe Dengue/physiopathology ; Severity of Illness Index ; Taiwan/epidemiology ; World Health Organization ; Young Adult
    Language English
    Publishing date 2017-06-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1497590-7
    ISSN 1995-9133 ; 1684-1182 ; 0253-2662
    ISSN (online) 1995-9133
    ISSN 1684-1182 ; 0253-2662
    DOI 10.1016/j.jmii.2016.08.024
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  7. Article ; Online: Antifungal therapy did not improve outcomes including 30-day all-cause mortality in patients suffering community-acquired perforated peptic ulcer-associated peritonitis with Candida species isolated from their peritoneal fluid.

    Li, Wei-Sin / Lee, Chen-Hsiang / Liu, Jien-Wei

    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

    2017  Volume 50, Issue 3, Page(s) 370–376

    Abstract: Background/purpose: Although patients suffering community-acquired perforated peptic ulcer (PPU)-associated peritonitis with Candida species isolated from their peritoneal fluid have higher chances of mortality and experiencing a complicated ... ...

    Abstract Background/purpose: Although patients suffering community-acquired perforated peptic ulcer (PPU)-associated peritonitis with Candida species isolated from their peritoneal fluid have higher chances of mortality and experiencing a complicated postoperative clinical course, universal antifungal therapy for these patients remains controversial.
    Methods: This is a retrospective analysis of the impacts of antifungal therapy on outcomes of patients suffering community-acquired PPU-associated peritonitis with Candida species isolated from their ascites at a medical center in Taiwan. All included patients received source control and antibiotic treatment, with or without additional postoperative antifungal therapy with fluconazole or an echinocandin for at least 3 days.
    Results: Among the 133 included patients, 76 did not receive (Group 1) and 57 did receive (Group 2) antifungal therapy. Sixteen (12%) of the overall included patients died within 30 days. Shock [odds ratio (OR), 5.6; 95% confidence interval (CI), 1.9-16.5; p = 0.002] and higher Acute Physiology and Chronic Health Evaluation II score (>20; OR, 9.5; 95% CI, 1.1-80.7; p = 0.04) were independently associated with 30-day mortality. Among the 80 matched patients from Groups 1 and 2 (1:1 matched) with the closest propensity score, no significant difference was found in 30-day all-cause mortality, time to mortality, the need for reoperation/abscess formation/anastomotic leakage, prolonged intensive care unit stay, and prolonged mechanical ventilator dependence between patients with and without antifungal therapy.
    Conclusion: Our study provides solid evidence supporting the notions that antifungal therapies do not benefit patients suffering PPU peritonitis with Candida species isolated from their ascites in general, and antifungal therapy could be reserved for patients who are critically ill and/or severely immunocompromised.
    Language English
    Publishing date 2017-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1497590-7
    ISSN 1995-9133 ; 1684-1182 ; 0253-2662
    ISSN (online) 1995-9133
    ISSN 1684-1182 ; 0253-2662
    DOI 10.1016/j.jmii.2015.07.004
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  8. Article ; Online: Diabetic patients suffering dengue are at risk for development of dengue shock syndrome/severe dengue: Emphasizing the impacts of co-existing comorbidity(ies) and glycemic control on dengue severity.

    Lee, Ing-Kit / Hsieh, Ching-Jung / Lee, Chien-Te / Liu, Jien-Wei

    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

    2018  Volume 53, Issue 1, Page(s) 69–78

    Abstract: Background/purpose: The impact of type 2 diabetes mellitus (DM2) on clinical severity of dengue has not been fully understood. We aimed to assess risk factors for dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) and severe dengue (SD) (defined ...

    Abstract Background/purpose: The impact of type 2 diabetes mellitus (DM2) on clinical severity of dengue has not been fully understood. We aimed to assess risk factors for dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) and severe dengue (SD) (defined based on the World Health Organization 1997 and 2009 dengue classifications), and additionally identify, among DM2 patients, who are at risk for developing DHF/DSS and severe dengue.
    Methods: A retrospective analysis of dengue patients diagnosed between 2002 and 2010. Risk factors for development of DHF/DSS/SD were identified using multivariate analysis. To elucidate the impacts of coexisting comorbidity(ies) (i.e., hypertension, chronic kidney disease, old stroke, and/or ischemic heart disease) and glycemic control on clinical outcomes of dengue in DM2 patients, the overall DM2 patients and stratified DM2 patients (HbA1c < 7% vs. HbA1c ≧ 7%), with or without comorbidity(ies), were separately compared to controls (patients without any morbidity).
    Results: Of 767 (146 DM2 and 621 controls) included patients, 1.4% suffered DSS and 3.3% SD. While DM2 was an independent risk factor for DSS (adjusted odds ratio [AOR] = 7.473; 95% confidence interval [CI] = 2.221-25.146) and SD (AOR = 6.207; 95% CI = 2.464-15.636), only DM2 patients with additional comorbidity(ies) and suboptimal glycemic control (HbA1c ≧ 7%) had significantly higher incidences of non-shock DHF (60.8% vs. 29%), DSS (8.7% vs. 0.8%) and SD (34.8% vs. 1.1%).
    Conclusions: These data could help narrow down the number of targets in the triage for risky DM2 dengue patients to those with suboptimal glycemic control and co-existing comorbidity(ies).
    MeSH term(s) Adult ; Aged ; Blood Glucose/analysis ; Comorbidity ; Diabetes Mellitus, Type 2/complications ; Female ; Glycemic Index ; Humans ; Incidence ; Male ; Middle Aged ; Odds Ratio ; Retrospective Studies ; Risk Factors ; Severe Dengue/complications ; Severity of Illness Index
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2018-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 1497590-7
    ISSN 1995-9133 ; 1684-1182 ; 0253-2662
    ISSN (online) 1995-9133
    ISSN 1684-1182 ; 0253-2662
    DOI 10.1016/j.jmii.2017.12.005
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  9. Article ; Online: Epidemiological Correlation of Pulmonary

    Liu, Jien-Wei / Ku, Yee-Huang / Chao, Chien-Ming / Ou, Hsuan-Fu / Ho, Chung-Han / Chan, Khee-Siang / Yu, Wen-Liang

    Journal of fungi (Basel, Switzerland)

    2021  Volume 7, Issue 3

    Abstract: An increase in fungal spores in ambient air is reported during a spike in particulate matter ( ... ...

    Abstract An increase in fungal spores in ambient air is reported during a spike in particulate matter (PM
    Language English
    Publishing date 2021-03-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof7030227
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  10. Article: An observational study on prevalence of latent tuberculosis infection and outcome of 3HP treatment in patients under hemodialysis in Taiwan.

    Wu, Chien-Hsing / Su, Hsuan-An / Chou, Chia-An / Liu, Jien-Wei / Lee, Chien-Te / Dai, Lo-Hsin / Yang, Chih-Chao

    Journal of the Formosan Medical Association = Taiwan yi zhi

    2020  Volume 120, Issue 6, Page(s) 1350–1360

    Abstract: Background: Identification and treatment for latent tuberculosis infection (LTBI) are of great epidemiological importance of controlling tuberculosis (TB) worldwide. Identification in high-risk population on dialysis and treatment with 12-week weekly ... ...

    Abstract Background: Identification and treatment for latent tuberculosis infection (LTBI) are of great epidemiological importance of controlling tuberculosis (TB) worldwide. Identification in high-risk population on dialysis and treatment with 12-week weekly rifapentine plus isoniazid (3HP) help improve prevention outcomes effectively.
    Methods: We conducted a single-center, nonrandomized follow-up study on end-stage renal disease patients on hemodialysis. The interferon-gamma release assay (IGRA) was used for the diagnosis of LTBI. Participants were treated with 3HP, and treatment responses were recorded and analyzed.
    Results: A total of 123 of the 641 patients showed positive IGRA results. The male sex, age >60 years, low serum albumin level (<4.0 g/dL), and hypercalcemia (serum calcium level > 10.2 mg/dL) were associated with IGRA positivity. Seventy-five patients were treated with 3HP, with a completion rate of 66.67%. The male sex, albumin level >4.0 g/dL, and absence of adverse drug reaction were associated with increased completion rates. Adverse drug reactions included dizziness, fatigue, nausea and vomiting, fever, and hypertension.
    Conclusion: Risk factors for LTBI in dialysis patients were identified to prioritize LTBI screening and initiate early treatment. The completion rate in dialysis patients were approximately 2 of 3 patients with mild adverse drug reaction, leading to discontinuation of the treatment.
    MeSH term(s) Antitubercular Agents/therapeutic use ; Drug Therapy, Combination ; Follow-Up Studies ; Humans ; Isoniazid/therapeutic use ; Latent Tuberculosis/diagnosis ; Latent Tuberculosis/drug therapy ; Latent Tuberculosis/epidemiology ; Male ; Middle Aged ; Prevalence ; Renal Dialysis ; Taiwan/epidemiology
    Chemical Substances Antitubercular Agents ; Isoniazid (V83O1VOZ8L)
    Language English
    Publishing date 2020-10-23
    Publishing country Singapore
    Document type Journal Article ; Observational Study
    ZDB-ID 2096659-3
    ISSN 1876-0821 ; 0929-6646
    ISSN (online) 1876-0821
    ISSN 0929-6646
    DOI 10.1016/j.jfma.2020.10.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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