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Article ; Online: sPLA2GIB Promotes PGD2 and IL-13 Production in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps.

Kang, Yi-Fan / Liu, Jin-Xin / Xu, Kai / Li, Xue-Li / Lu, Xiang

2023 Volume 134, Issue 3, Page(s) 1107–1117

Abstract: Objective: Secreted phospholipase A2 Group IB (sPLA2GIB) regulates the release of arachidonic acid, prostaglandins, and other inflammatory lipid mediators. Although it has been well involved in extensive inflammatory diseases, its specific mechanism in ... ...

Abstract	Objective: Secreted phospholipase A2 Group IB (sPLA2GIB) regulates the release of arachidonic acid, prostaglandins, and other inflammatory lipid mediators. Although it has been well involved in extensive inflammatory diseases, its specific mechanism in chronic rhinosinusitis with nasal polyps (CRSwNP) remains unclear. In this study, we investigated the role of sPLA2GIB in the pathophysiology of CRSwNP. Methods: Quantitative PCR, immunofluorescence staining, western blotting, and enzyme-linked immunosorbent assay (ELISA) were used to analyze the expression of sPLA2s, phospholipase A2 receptor (PLA2R), and prostaglandin D2 (PGD2) in nasal samples. Human nasal epithelial cells (HNECs) were cultured at an air-liquid interface (ALI) and stimulated with various cytokines. The human mast cell line HMC-1 was stimulated with sPLA2GIB, and the expression of PGD2 and cytokines in the culture supernatant was detected by ELISA. Results: The mRNA and protein levels of sPLA2GIB were significantly higher in eosinophilic CRSwNP than in control tissues. sPLA2GIB was predominantly expressed in the nasal epithelial cells. PLA2R mRNA and protein levels were upregulated in both eosinophilic and non-eosinophilic CRSwNP compared with the control groups. IL-4, IL-13, TNF-α, and IL-1β upregulated the expression of sPLA2GIB in ALI-cultured HNECs. sPLA2GIB induced PGD2 and IL-13 production in HMC-1 cells in a hydrolytic activity-independent manner. PGD2 protein expression was elevated in tissue homogenates of eosinophilic CRSwNP, and PGD2 upregulated the expression of IL-13 in HMC-1 cells. Conclusion: Increased secretion of sPLA2GIB by epithelial cells may promote eosinophilic inflammation in CRSwNP by enhancing PGD2 and IL-13 production in mast cells via binding to PLA2R. Level of evidence: N/A Laryngoscope, 134:1107-1117, 2024.
MeSH term(s)	Humans ; Nasal Polyps/complications ; Prostaglandin D2 ; Interleukin-13 ; Rhinitis/complications ; Rhinitis/genetics ; Rhinosinusitis ; Sinusitis/complications ; Sinusitis/genetics ; Cytokines/metabolism ; RNA, Messenger/metabolism ; Chronic Disease
Chemical Substances	Prostaglandin D2 (RXY07S6CZ2) ; Interleukin-13 ; Cytokines ; RNA, Messenger
Language	English
Publishing date	2023-08-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.30977
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Article ; Online: Bves maintains vascular smooth muscle cell contractile phenotype and protects against transplant vasculopathy via Dusp1-dependent p38MAPK and ERK1/2 signaling.

Liu, Jin-Xin / Huang, Tong / Xie, Dawei / Yu, Qihong

Atherosclerosis

2022 Volume 357, Page(s) 20–32

Abstract: Background and aims: Vascular smooth muscle cell (VSMC) plasticity is tightly associated with the pathological process of vasculopathy. Blood vessel epicardial substance (Bves) has emerged as an important regulator of intracardiac vasculogenesis and ... ...

Abstract	Background and aims: Vascular smooth muscle cell (VSMC) plasticity is tightly associated with the pathological process of vasculopathy. Blood vessel epicardial substance (Bves) has emerged as an important regulator of intracardiac vasculogenesis and organ homeostasis. However, the involvement and role of Bves in VSMC plasticity and neointimal lesion development remain unclear. Methods: We used an in vivo rat model of graft arteriosclerosis and in vitro PDGF-treated VSMCs and identified the novel VSMC contractile phenotype-related gene Bves using a transcriptomic analysis and literature search. In vitro knockdown and overexpression approaches were used to investigate the mechanisms underlying VSMC phenotypic plasticity. In vivo, VSMC-specific Bves overexpression in rat aortic grafts was generated to assess the physiological function of Bves in neointimal lesion development. Results: Here, we found that Bves expression was negatively regulated in aortic allografts in vivo and PDGF-treated VSMCs in vitro. The genetic knockdown of Bves dramatically inhibited, whereas Bves overexpression markedly promoted, the VSMC contractile phenotype. Furthermore, RNA sequencing unraveled a positive correlation between Bves and dual-specificity protein phosphatase 1 (Dusp1) expression in VSMCs. We found that Bves knockdown restrained Dusp1 expression, but enhanced p38MAPK and ERK1/2 activation, resulting in the loss of the VSMC contractile phenotype. In vivo, an analysis of a rat graft model confirmed that VSMC-specific Bves and Dusp1 overexpression in aortic allografts significantly attenuated neointimal lesion formation. Conclusions: Bves maintains the VSMC contractile phenotype through Dusp1-dependent p38MAPK and ERK1/2 signaling, and protects against neointimal formation, underscoring the important role of Bves in preventing transplant vasculopathy.
MeSH term(s)	Animals ; Cell Proliferation ; Cells, Cultured ; Dual Specificity Phosphatase 1 ; MAP Kinase Signaling System ; Muscle, Smooth, Vascular/pathology ; Myocytes, Smooth Muscle/pathology ; Neointima/pathology ; Phenotype ; Rats ; p38 Mitogen-Activated Protein Kinases/metabolism
Chemical Substances	p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Dual Specificity Phosphatase 1 (EC 3.1.3.48) ; Dusp1 protein, rat (EC 3.1.3.48)
Language	English
Publishing date	2022-08-14
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80061-2
ISSN	1879-1484 ; 0021-9150
ISSN (online)	1879-1484
ISSN	0021-9150
DOI	10.1016/j.atherosclerosis.2022.08.010
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Article ; Online: The complete chloroplast genome and phylogenetic analysis of

Zhang, Zhao-Lei / Zhao, Hong-Ye / Tian, Yu / Li, Xin-Yi / Liu, Jin-Xin / Shi, Lin-Chun

Mitochondrial DNA. Part B, Resources

2023 Volume 8, Issue 6, Page(s) 635–638

Abstract: Lemmaphyllum ... ...

Abstract	Lemmaphyllum carnosum
Language	English
Publishing date	2023-06-09
Publishing country	England
Document type	Journal Article
ISSN	2380-2359
ISSN (online)	2380-2359
DOI	10.1080/23802359.2023.2220426
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Article: A new species of spider in the genus Meotipa Simon, 1895 (Araneae: Theridiidae) from southern China

Li, Chao-Min / Liu, Jin-Xin / Xu, Xiang / Yin, Hai-Qiang

Pan-Pacific entomologist. 2020 Sept. 30, v. 96, no. 3

2020

Abstract: A new species, Meotipa capacifabasp. nov., is described from the Nonggang National Nature Reserve, Guangxi Zhuang Autonomous Region, China. This new species is diagnosed, described and illustrated with photographs and ink drawings, and a distribution map ...

Abstract	A new species, Meotipa capacifabasp. nov., is described from the Nonggang National Nature Reserve, Guangxi Zhuang Autonomous Region, China. This new species is diagnosed, described and illustrated with photographs and ink drawings, and a distribution map of all known Meotipa species in China is provided. This increases the number of Meotipa species in China to five.
Keywords	Theridiidae ; conservation areas ; entomologists ; new species ; spiders ; China
Language	English
Dates of publication	2020-0930
Size	p. 177-184.
Publishing place	Pacific Coast Entomological Society
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2486610-6
ISSN	0031-0603
ISSN	0031-0603
DOI	10.3956/2020-96.3.177
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Sox9 mediates autophagy-dependent vascular smooth muscle cell phenotypic modulation and transplant arteriosclerosis.

Yu, Qihong / Liu, Jin-Xin / Zheng, Xichuan / Yan, Xueke / Zhao, Peng / Yin, Chuanzheng / Li, Wei / Song, Zifang

iScience

2022 Volume 25, Issue 10, Page(s) 105161

Abstract: Vascular smooth muscle cell (vSMC) phenotypic modulation is a dynamic pathogenesis process implicated in neointimal formation and transplant arteriosclerosis (TA). Transcription factor Sox9 functions to establish cell type and wound healing, but little ... ...

Abstract	Vascular smooth muscle cell (vSMC) phenotypic modulation is a dynamic pathogenesis process implicated in neointimal formation and transplant arteriosclerosis (TA). Transcription factor Sox9 functions to establish cell type and wound healing, but little is known about its transcriptional regulation in vSMCs and its roles in the development of TA. Here, we found an increased Sox9 expression in aortic allografts and in HMGB1-treated vSMCs
Language	English
Publishing date	2022-09-21
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2022.105161
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Article ; Online: Application of 3D printing technique in pedicle screw placement for the lumbar isthmic spondylolisthesis

Zhu Nai-Qiang / Hou Jing-Yi / Ma Gui-Yun / Liu Jin-Xin / Chen Bin

Journal of Hainan Medical University, Vol 25, Iss 18, Pp 29-

2019 Volume 34

Abstract: Objective: To investigate the application value of 3D printing technique in the operation of the lumbar isthmic spondylolisthesis. Methods Totally 48 patients with lumbar isthmic spondylolisthesis treated in our department from January 2015 to April 2017 ...

Abstract	Objective: To investigate the application value of 3D printing technique in the operation of the lumbar isthmic spondylolisthesis. Methods Totally 48 patients with lumbar isthmic spondylolisthesis treated in our department from January 2015 to April 2017 were selected in the research plan. According to the random digital table method, they were divided into the observation group and the control group, with 25 cases in the observation group and 23 cases in control group. All patients were treated with transforaminal lumbar interbody fusion（TLIF）. The control group made the observation group made the operation plan with 3D printing technology, and the operation plan according to the 3D CT reconstruction image. The clinical and imaging results were compared between the two groups、including operation time、 intraoperative blood loss and X-ray exposure、complications、preoperative and postoperative ODI and JOA score. Results The accuracy of the screw placement in the observation group was 95.33%，which was significantly higher than those of 84.06% in the control group， the differences were statistically significant（P＜0.05）. Operation time and X-ray exposure and intraoperative blood loss in observation group were less than those in the control group，the differences were statistically significant（P＜0.05）. There were no significant differences spondylolisthesis reduction degree、ODI and JOA scores at postoperative different point between groups（P＞0.05）. Conclusions 3D printing technology is helpful to the development of the lumbar isthmic spondylolisthesis surgical plan, with the advantages of shortening the operation time and X-ray exposure，reducing the blood loss，improving the accuracy of the screw placement.
Keywords	3d printing ; spondylolysis ; spondylolisthesis ; pedicel screw ; Medicine ; R
Subject code	630
Language	English
Publishing date	2019-09-01T00:00:00Z
Publisher	Editorial Board of Journal of Hainan Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical and radiologic features of the first cured Coronavirus disease 2019 (COVID-19) patient in Guangzhou City, China.

Gan, Qing-Xin / Wang, Guan-Nan / Li, Mei-Yu / Feng, Guo-Kai / Liu, Jin-Xin

Chinese journal of academic radiology

2020 Volume 3, Issue 3, Page(s) 169–173

Abstract: To determine changes in clinical and radiologic findings associated with Coronavirus disease 2019 (COVID-19) from diagnosis to recovery, we retrospectively reviewed the diagnosis and treatment records of the first patient cured of COVID-19 in Guangzhou. ... ...

Abstract	To determine changes in clinical and radiologic findings associated with Coronavirus disease 2019 (COVID-19) from diagnosis to recovery, we retrospectively reviewed the diagnosis and treatment records of the first patient cured of COVID-19 in Guangzhou. A 55-year-old woman from Wuhan was admitted to the hospital isolation ward with the chief complaint of "cough for 11 days and once fever 8 days ago" on January 22, 2020. COVID-19 was laboratory confirmed by reverse transcription polymerase chain reaction (RT-PCR) assay, and she received conventional antiviral therapy, such as moxifloxacin, traditional Chinese medicine, and arbidol. Repeat chest-computed tomography (CT) scans were performed on days 13 and 19 of her illness. The former showed radiologic findings, including ground-glass opacities (GGOs), which revealed viral pneumonia; the latter revealed that the previous lesions had been significantly absorbed. The lesions on CT scans were consistent with the changes in the course of disease. Some drugs, such as traditional Chinese medicine and arbidol, might play an important role in the recovery of COVID-19 patients. This study provides some new insights into the formulation of a timely and effective diagnostic and therapeutic strategy to cure patients with COVID-19.
Keywords	covid19
Language	English
Publishing date	2020-08-25
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2967251-X
ISSN	2520-8993 ; 2520-8985
ISSN (online)	2520-8993
ISSN	2520-8985
DOI	10.1007/s42058-020-00045-z
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Article ; Online: B Cell-Activating Factor Promotes B Cell Survival in Ectopic Lymphoid Tissues in Nasal Polyps.

Wang, Zhe-Zheng / Song, Jia / Wang, Hai / Li, Jing-Xian / Xiao, Qiao / Yu, Ze / Liu, Jin-Xin / Liu, Zheng

Frontiers in immunology

2021 Volume 11, Page(s) 625630

Abstract: Ectopic lymphoid tissues (eLTs) characterized by B cell aggregation contribute to the local immunoglobulin production in nasal polyps (NPs). B cell-activating factor (BAFF) is vital for B cell survival, proliferation, and maturation. The purpose of this ... ...

Abstract	Ectopic lymphoid tissues (eLTs) characterized by B cell aggregation contribute to the local immunoglobulin production in nasal polyps (NPs). B cell-activating factor (BAFF) is vital for B cell survival, proliferation, and maturation. The purpose of this study is to investigate whether BAFF is involved in the B cell survival and eLT formation in NPs. The mRNA and protein levels of BAFF in NP tissues with and without eLTs were detected by PCR and ELISA assay, respectively. The cellular sources of BAFF and active caspase-3-positive B cells in NPs were studied by immunofluorescence staining. B cells purified from NP tissues were stimulated with BAFF and were analyzed by flow cytometry. Stromal cells purified from NP tissues were stimulated with lymphotoxin (LT) α
MeSH term(s)	Apoptosis/immunology ; B-Cell Activating Factor/immunology ; B-Lymphocytes/immunology ; B-Lymphocytes/pathology ; Caspase 3/immunology ; Cell Survival ; Female ; Humans ; Lymphotoxin alpha1, beta2 Heterotrimer/immunology ; Male ; Nasal Polyps/immunology ; Nasal Polyps/pathology ; Tertiary Lymphoid Structures/immunology ; Tertiary Lymphoid Structures/pathology
Chemical Substances	B-Cell Activating Factor ; Lymphotoxin alpha1, beta2 Heterotrimer ; TNFSF13B protein, human ; CASP3 protein, human (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-)
Language	English
Publishing date	2021-01-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.625630
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Article ; Online: A panel of clinical and biological markers predict difficult-to-treat chronic rhinosinusitis.

Liao, Bo / Liu, Jin-Xin / Guo, Cui-Lian / Li, Zhi-Yong / Pan, Li / Liu, Zheng

Allergy

2019 Volume 75, Issue 4, Page(s) 946–949

MeSH term(s)	Biomarkers ; Chronic Disease ; Humans ; Nasal Polyps ; Rhinitis/diagnosis ; Sinusitis/diagnosis
Chemical Substances	Biomarkers
Language	English
Publishing date	2019-10-03
Publishing country	Denmark
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.14049
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Article ; Online: MEX3B inhibits collagen production in eosinophilic nasal polyps by downregulating epithelial cell TGFBR3 mRNA stability.

Liu, Jin-Xin / Chen, Ao-Nan / Yu, Qihong / Shi, Ke-Tai / Liu, Yi-Bo / Guo, Cui-Lian / Wang, Zhe-Zheng / Yao, Yin / Pan, Li / Lu, Xiang / Xu, Kai / Wang, Heng / Zeng, Ming / Liu, Chaohong / Schleimer, Robert P / Wu, Ning / Liao, Bo / Liu, Zheng

JCI insight

2023 Volume 8, Issue 9

Abstract: Although the expression of Mex3 RNA-binding family member B (MEX3B) is upregulated in human nasal epithelial cells (HNECs) predominately in the eosinophilic chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) subtype, its functions as an RNA binding ... ...

Abstract	Although the expression of Mex3 RNA-binding family member B (MEX3B) is upregulated in human nasal epithelial cells (HNECs) predominately in the eosinophilic chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) subtype, its functions as an RNA binding protein in airway epithelial cells remain unknown. Here, we revealed the role of MEX3B based on different subtypes of CRS and demonstrated that MEX3B decreased the TGF-β receptor III (TGFBR3) mRNA level by binding to its 3' UTR and reducing its stability in HNECs. TGF-βR3 was found to be a TGF-β2-specific coreceptor in HNECs. Knocking down or overexpressing MEX3B promoted or inhibited TGF-β2-induced phosphorylation of SMAD2 in HNECs, respectively. TGF-βR3 and phosphorylated SMAD2 levels were downregulated in CRSwNP compared with controls and CRS without nasal polyps with a more prominent downregulation in the eosinophilic CRSwNP. TGF-β2 promoted collagen production in HNECs. Collagen abundance decreased and edema scores increased in CRSwNP compared with control, again more prominently in the eosinophilic type. Collagen expression in eosinophilic CRSwNP was negatively correlated with MEX3B but positively correlated with TGF-βR3. These results suggest that MEX3B inhibits tissue fibrosis in eosinophilic CRSwNP by downregulating epithelial cell TGFBR3 expression; consequently, MEX3B might be a valuable therapeutic target against eosinophilic CRSwNP.
MeSH term(s)	Humans ; Rhinitis/complications ; Rhinitis/metabolism ; Nasal Polyps/genetics ; Nasal Polyps/metabolism ; Transforming Growth Factor beta2/metabolism ; Sinusitis/genetics ; Sinusitis/metabolism ; Receptors, Transforming Growth Factor beta/genetics ; Receptors, Transforming Growth Factor beta/metabolism ; Epithelial Cells/metabolism ; RNA-Binding Proteins/genetics
Chemical Substances	betaglycan (145170-29-2) ; Transforming Growth Factor beta2 ; Receptors, Transforming Growth Factor beta ; MEX3B protein, human ; RNA-Binding Proteins
Language	English
Publishing date	2023-05-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2379-3708
ISSN (online)	2379-3708
DOI	10.1172/jci.insight.159058
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