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Article ; Online: Hepatocytes: A key role in liver inflammation.

Gong, Jin / Tu, Wei / Liu, Jingmei / Tian, Dean

2023 Volume 13, Page(s) 1083780

Abstract: Hepatocytes, the major parenchymal cells in the liver, are responsible for a variety of cellular functions including carbohydrate, lipid and protein metabolism, detoxification and immune cell activation to maintain liver homeotasis. Recent studies show ... ...

Abstract	Hepatocytes, the major parenchymal cells in the liver, are responsible for a variety of cellular functions including carbohydrate, lipid and protein metabolism, detoxification and immune cell activation to maintain liver homeotasis. Recent studies show hepatocytes play a pivotal role in liver inflammation. After receiving liver insults and inflammatory signals, hepatocytes may undergo organelle damage, and further respond by releasing mediators and expressing molecules that can act in the microenvironment as well as initiate a robust inflammatory response. In this review, we summarize how the hepatic organelle damage link to liver inflammation and introduce numerous hepatocyte-derived pro-inflammatory factors in response to chronic liver injury.
MeSH term(s)	Humans ; Inflammation ; Hepatocytes/metabolism ; Hepatitis/metabolism ; Liver Diseases/etiology ; Liver Diseases/metabolism
Language	English
Publishing date	2023-01-18
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1083780
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Article ; Online: Influence of using collagen on the soft and hard tissue outcomes of immediate dental implant placement: A systematic review and meta-analysis.

Liu, Jingmei / Hua, Fang / Zhang, Haiwen / Hu, Jian

Journal of stomatology, oral and maxillofacial surgery

2023 Volume 124, Issue 1S, Page(s) 101385

Abstract: Objective: To compare the effects of bone grafting materials, collagen-infused grafting materials, and no grafting materials on the soft and hard tissue outcomes when an immediate implant is placed.: Materials and methods: In addition to hand ... ...

Abstract	Objective: To compare the effects of bone grafting materials, collagen-infused grafting materials, and no grafting materials on the soft and hard tissue outcomes when an immediate implant is placed. Materials and methods: In addition to hand searching, electronic searches were performed in Pubmed, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL). Only RCTs were included in our review. The Cochrane ROB 2.0 tool was used to assess the risk of bias (ROB). Two subgroups were used to evaluate implant failure rate, buccal bone resorption, soft tissue thickness, and esthetic scores. In the meta-analysis, both the fixed-effects model and the random-effects model were employed. Result: 7 RCTs were selected after screening 580 studies, and 205 patients were included in the review, with 279 implants. Two RCTs were at low bias of risk, three were at moderate bias, and two were deemed at high risk of bias. The failure rate (95% CI: 0.17 to 11.84) and soft tissue thickness were not significantly different between collagen with bone grafting materials and without bone grafting materials. On the basis of the failure rate and buccal bone thickness, there was no significant difference between collagen with bone grafting materials and bone grafting materials. While we found collagen with bone grafting materials could have a significant advantage on the buccal bone thickness (MD: -0.43,95% CI -0.72 to -0.41) and esthetic outcome (MD: -1.23,95% CI -1.90 to -0.55). Conclusion: In the statement of immediate implant implantation, the thickness of the buccal bone and esthetic outcomes did significantly benefit from bone grafting materials with collagen inserted in the "jumping gap".
MeSH term(s)	Humans ; Dental Implantation, Endosseous ; Dental Implants ; Collagen/therapeutic use
Chemical Substances	Dental Implants ; Collagen (9007-34-5)
Language	English
Publishing date	2023-01-13
Publishing country	France
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2916276-2
ISSN	2468-7855 ; 2468-8509
ISSN (online)	2468-7855
ISSN	2468-8509
DOI	10.1016/j.jormas.2023.101385
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Article ; Online: Over-the-scope clip as a rescue treatment for massive bleeding due to Dieulafoy lesion at the colorectal anastomosis: A case report.

Han, Ping / Li, Demin / Guo, Qiaozhen / Lei, Yu / Liu, Jingmei / Tian, Dean / Yan, Wei

Medicine

2024 Volume 103, Issue 16, Page(s) e37871

Abstract: Rationale: The bleeding of Dieulafoy lesion predominantly involves the proximal stomach and leads to severe gastrointestinal bleeding. However, these lesions have also been reported in the whole gastrointestinal tract. Bleeding of Dieulafoy lesions at ... ...

Abstract	Rationale: The bleeding of Dieulafoy lesion predominantly involves the proximal stomach and leads to severe gastrointestinal bleeding. However, these lesions have also been reported in the whole gastrointestinal tract. Bleeding of Dieulafoy lesions at the anastomosis was seldomly reported and was very easy to be ignored clinically. Patient concerns: We describe a 72-year-old woman with a past history of surgery for rectal carcinoma hospitalized with chief complaint of massive rectal bleeding. No gross bleeding lesion was found during the first emergency colonoscopy. Despite multiple blood transfusions, her hemoglobin rapidly dropped to 5.8 g/dL. Diagnosis: She was diagnosed with Dieulafoy lesion at the colorectal anastomosis during the second emergency colonoscopy. Interventions: Primary hemostasis was achieved by endoscopic hemostatic clipping. However, she experienced another large volume hematochezia 3 days later, and then received another endoscopic hemostatic clipping. She was improved and discharged. However, this patient underwent hematochezia again 1 month later. Bleeding was arrested successfully after the over-the-scope clip (OTSC) was placed during the fourth emergency colonoscopy. Outcomes: This patient underwent 4 endoscopic examinations and treatments during 2 hospitalizations. The lesion was overlooked during the first emergency colonoscopy. The second and third endoscopes revealed Dieulafoy lesion at the colorectal anastomosis and performed endoscopic hemostatic clippings, but delayed rebleeding occurred. The bleeding was stopped after the fourth emergency colonoscopy using OTSC. There was no further rebleeding during hospitalization and after 2-year of follow-up. Lessons: As far as we know, there is no reported case of lower gastrointestinal bleeding caused by Dieulafoy lesion at the colorectal anastomosis, OTSC is a safe and effective rescue treatment for Dieulafoy lesions.
MeSH term(s)	Humans ; Female ; Aged ; Hemostasis, Endoscopic/adverse effects ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/surgery ; Vascular Diseases/complications ; Anastomosis, Surgical/adverse effects ; Hemostatics ; Colorectal Neoplasms/therapy
Chemical Substances	Hemostatics
Language	English
Publishing date	2024-04-19
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037871
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Article: Colon Metastasis from Pancreatic Cancer: A Case Report.

Meng, Nan / Han, Ping / Liu, Liwei / Liu, Jiqiao / Liu, Jingmei

OncoTargets and therapy

2023 Volume 16, Page(s) 739–744

Abstract: Pancreatic cancer commonly metastasizes to the liver, lung or adrenal glands, but rarely spreads to the colon. We describe a case of a 65-year-old man with operation history of endoscopic submucosal dissection for rectal adenoma, who visited our ... ...

Abstract	Pancreatic cancer commonly metastasizes to the liver, lung or adrenal glands, but rarely spreads to the colon. We describe a case of a 65-year-old man with operation history of endoscopic submucosal dissection for rectal adenoma, who visited our department with a lesion in the sigmoid colon. A biopsy of the sigmoid pathologic lesion found heterologous cells in the muscularis mucosa, which indicated that this lesion did not originate in the colon. Abdominal enhanced CT results revealed a soft tissue mass in pancreatic tail and several masses in the liver and rectovesical pouch. 18-FDG PET-scan results showed pancreatic neoplastic mass. Biopsy result of pancreatic pathologic area was positive for ductal pancreatic adenocarcinoma. Immunohistochemical staining confirmed that the sigmoid lesion was a metastasis from a primary pancreatic adenocarcinoma-an unusual pattern of spread. The patient accepted chemotherapy after an oncologic evaluation. To our knowledge, there were only nine reported cases of metastatic pancreatic cancer spreading to the colon. This was a rare route of metastasis for pancreatic cancer. It is important to keep this possibility in mind when patients present with a colon lesion. Furthermore, our case highlights the importance of considering metastases when a colon mass is found in patients with a history of colon cancer, although primary colon cancer is still more likely.
Language	English
Publishing date	2023-09-07
Publishing country	New Zealand
Document type	Case Reports
ZDB-ID	2495130-4
ISSN	1178-6930
ISSN	1178-6930
DOI	10.2147/OTT.S419493
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Article ; Online: Staphylococcus cohnii

Lei, Yu / Guo, Qiaozhen / Liu, Jingmei / Huang, Huanjun / Han, Ping

Frontiers in cellular and infection microbiology

2023 Volume 13, Page(s) 1240283

Abstract: Background: Patients with spontaneous bacterial peritonitis (SBP) often just receive empirical antibiotic therapy, as pathogens can be identified in only few patients using the techniques of conventional culture. Metagenomic next generation sequencing ( ... ...

Abstract	Background: Patients with spontaneous bacterial peritonitis (SBP) often just receive empirical antibiotic therapy, as pathogens can be identified in only few patients using the techniques of conventional culture. Metagenomic next generation sequencing (mNGS) is a useful tool for diagnosis of infectious diseases. However, clinical application of mNGS in diagnosis of infected ascites of cirrhotic patients is rarely reported. Case presentation: A 53-year-old male with cirrhosis on regular hemodialysis presented with continuous abdominal pain. After treatment with empiric antibiotics, his inflammatory parameters decreased without significant relief of abdominal pain. Finally, based on ascites mNGS detection, he was diagnosed as infection of Conclusions: When conventional laboratory diagnostic methods and empirical antibiotic therapy fail, proper application of mNGS can help identify pathogens and significantly improve prognosis and patients' symptoms.
MeSH term(s)	Male ; Humans ; Middle Aged ; Ascites/diagnosis ; Ascites/microbiology ; High-Throughput Nucleotide Sequencing/methods ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis ; Peritonitis/diagnosis ; Peritonitis/microbiology ; Abdominal Pain/drug therapy ; Metagenomics/methods ; Sensitivity and Specificity
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-09-22
Publishing country	Switzerland
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1240283
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Article ; Online: Curcumin Enhances the Efficacy of Docetaxel by Promoting Anti-Tumor Immune Response in Head and Neck Squamous Cell Carcinoma.

Sun, Lili / Yao, Xingmei / Liu, Jingmei / Zhang, Yu / Hu, Jian

Cancer investigation

2023 Volume 41, Issue 5, Page(s) 524–533

Abstract: This study evaluated the feasibility of curcumin and docetaxel (DTX) combination therapy for head and neck squamous cell carcinoma (HNSCC). Animal assay demonstrated DTX has certain limitations in improving immunosuppressive microenvironment. Treatment ... ...

Abstract	This study evaluated the feasibility of curcumin and docetaxel (DTX) combination therapy for head and neck squamous cell carcinoma (HNSCC). Animal assay demonstrated DTX has certain limitations in improving immunosuppressive microenvironment. Treatment with curcumin overcame this inhibition and reduced tumor progression. Curcumin synergized DTX showed significantly greater reduction in tumor burden than either treatment alone via down-regulation of MDSCs, M2 macrophages and up-regulation of CD8
MeSH term(s)	Animals ; Humans ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Docetaxel/pharmacology ; Curcumin/pharmacology ; Curcumin/therapeutic use ; Head and Neck Neoplasms/drug therapy ; CD8-Positive T-Lymphocytes ; Immunity ; Tumor Microenvironment
Chemical Substances	Docetaxel (15H5577CQD) ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2023-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	604942-4
ISSN	1532-4192 ; 0735-7907
ISSN (online)	1532-4192
ISSN	0735-7907
DOI	10.1080/07357907.2023.2194420
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Article: Perirenal Perivascular Epithelioid Cell Tumor (PEcoma) with Pulmonary Micro Invasive Adenocarcinoma: A Case Report and Literature Review.

Li, Zhaoxun / Hu, Nan / Liao, Yan / Liu, Jingmei

OncoTargets and therapy

2021 Volume 14, Page(s) 4255–4260

Abstract: Perivascular epithelioid cell tumor (PEComa) is a rare type of mesenchymal neoplasm, which occurs most commonly in uterus and gastrointestinal tract. PEComa with perirenal manifestation is an extremely rare entity. To the best of our knowledge, only four ...

Abstract	Perivascular epithelioid cell tumor (PEComa) is a rare type of mesenchymal neoplasm, which occurs most commonly in uterus and gastrointestinal tract. PEComa with perirenal manifestation is an extremely rare entity. To the best of our knowledge, only four cases have been reported up to now. In this case, we reported a patient with both a pulmonary mass and a perirenal mass. Two resections were performed successively and postoperative pathology suggested pulmonary micro invasive adenocarcinoma (MIA) and perirenal PEComa. This is the first case of perirenal PEComa with pulmonary MIA. Combining the present case and prior literature, we summarized the crucial role of immunohistochemistry in the diagnosis and consider that complete operation might be conducive to patients with perirenal PEComa that presents a benign phenotype, regardless of complications with other tumors.
Language	English
Publishing date	2021-07-21
Publishing country	New Zealand
Document type	Case Reports
ZDB-ID	2495130-4
ISSN	1178-6930
ISSN	1178-6930
DOI	10.2147/OTT.S317777
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Article ; Online: Catalytic Hydroconversion of Model Compounds over Ni/NiO@NC Nanoparticles.

Liu, Ting / Ma, Yanxi / Tang, Yakun / Zhang, Yue / Liu, Jingmei / Zhou, Xiaodong / Li, Xiaohui / Liu, Lang

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 4

Abstract: The conversion of lignite into aromatic compounds by highly active catalysts is a key strategy for lignite valorization. In this study, Ni/NiO@NC nanocomposites with a high specific surface area and a vesicular structure were successfully prepared via a ... ...

Abstract	The conversion of lignite into aromatic compounds by highly active catalysts is a key strategy for lignite valorization. In this study, Ni/NiO@NC nanocomposites with a high specific surface area and a vesicular structure were successfully prepared via a facile sol-gel method. The Ni/NiO@NC catalysts exhibited excellent catalytic activity for the catalytic hydroconversion (CHC) of benzyloxybenzene (as lignite-related modeling compounds) under mild conditions (120 °C, 1.5 MPa H
Language	English
Publishing date	2024-02-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29040755
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Article ; Online: The Effect of Using Premedication of Simethicone/Pronase With or Without Postural Change on Visualization of the Mucosa Before Endoscopy: A Prospective, Double Blinded, Randomized Controlled Trial.

Cao, Li / Zheng, Fangqin / Wang, Deqiong / Chen, Li / Feng, Xinxia / Zhou, Zhenzhen / Liu, Jingmei / Wang, Mi / Guo, Qiaozhen / Liu, Mei

Clinical and translational gastroenterology

2024 Volume 15, Issue 2, Page(s) e00625

Abstract: Introduction: To investigate the efficacy and safety of preprocedural simethicone (S) and pronase (P) for optimal mucosal visualization during esophagogastroduodenoscopy with sedation. The effect of postural change combined with premedication on mucosal ...

Abstract	Introduction: To investigate the efficacy and safety of preprocedural simethicone (S) and pronase (P) for optimal mucosal visualization during esophagogastroduodenoscopy with sedation. The effect of postural change combined with premedication on mucosal visibility was also examined. Methods: The study randomized 496 patients into 8 groups based on the type of premedication provided and whether a postural change occurred. The premedication in the control group was 100 mL of normal saline solution (NS). The remaining 3 intervention groups were administered 100 mL of simethicone alone (S), pronase solution alone (P), and simethicone plus pronase solution (S + P). Each group was classified into subgroups according to whether there was a postural change (PC). The mucosal visibility score (MVS), total mucosal visibility score (TVS), procedure time, water consumption for mucosal cleansing, and proportion of patients with diminutive lesions <5 mm were recorded. Results: The P and S groups had a significantly better TVS than the NS group (11.86 ± 3.36 in group P vs 14.52 ± 2.57 in group NS, P < 0.001; 12.36 ± 2.93 in group S vs 14.52 ± 2.57 in group NS, P = 0.006). The TVS was better in the P group than in the S group (11.86 ± 3.36 vs 12.36 ± 2.93, P = 0.037). The MVS was significantly better in the esophagus and duodenum and worse in the upper and lower gastric body in the S group than in the P group. The P + S group had a significantly better TVS than the P and S groups (9.81 ± 2.90 in group P + S vs 11.86 ± 3.36 in group P and 12.36 ± 2.93 in group S, respectively, P < 0.001),\ and had a reduced amount of flushing water during the procedure (0 [interquartile range [IQR]: 0-33] mL in group P + S vs 40 [IQR: 0-70] mL in group P, P < 0.01; 0 [IQR: 0-33] mL in group P + S vs 50 [IQR: 20-98] mL in group S, P < 0.001). The TVS was significantly better in the P + S + PC group than in the P + S group (8.44 ± 2.10 vs 9.81 ± 2.90, P = 0.003). The MVS was significantly better in the gastric antrum, fundus, and upper and lower gastric body in the P + S + PC group than in the P + S group. There was no significant difference in the detection rate of diminutive lesions among the different groups during an endoscopic examination ( P > 0.05). Discussion: The combination of preprocedural administration with simethicone and pronase achieved superior mucosal visualization compared with saline, simethicone, or pronase alone in patients receiving upper endoscopy. Postural change maneuvers performed before endoscopy further improved the mucosal visibility in most parts of the stomach when used with preprocedural simethicone and pronase.
MeSH term(s)	Humans ; Simethicone ; Pronase ; Prospective Studies ; Endoscopy, Gastrointestinal/methods ; Mucous Membrane ; Premedication/methods
Chemical Substances	Simethicone (8050-81-5) ; Pronase (EC 3.4.24.-)
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2581516-7
ISSN	2155-384X ; 2155-384X
ISSN (online)	2155-384X
ISSN	2155-384X
DOI	10.14309/ctg.0000000000000625
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Article ; Online: The emerging role of KIAA1199 in cancer development and therapy.

Liu, Jingmei / Yan, Wei / Han, Ping / Tian, Dean

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2021 Volume 138, Page(s) 111507

Abstract: KIAA1199, also known as CEMIP or HYBID, is an important member of the Human Unidentified Gene-Encoded (HUGE) database. Accumulated evidence has revealed that KIAA1199 is associated with tumor progression and metastasis in numerous malignancies, including ...

Abstract	KIAA1199, also known as CEMIP or HYBID, is an important member of the Human Unidentified Gene-Encoded (HUGE) database. Accumulated evidence has revealed that KIAA1199 is associated with tumor progression and metastasis in numerous malignancies, including colorectal, liver, gastric, pancreatic, breast, lung, prostate, ovarian and papillary thyroid cancers. As an oncogene, it plays crucial role in the proliferation, apoptosis, invasion and migration of various tumor cells. In addition, KIAA1199 is also involved in the regulation of multiple signal pathways such as epithelial-mesenchymal transition (EMT), Wnt/ β-catenin, MEK/ERK and PI3K/Akt. In this review, we summarized up to date advancement on the role of KIAA1199 in human cancer development, progression, and metastasis. We also addressed KIAA1199 as a potential therapeutic target for cancer therapy.
MeSH term(s)	Databases, Genetic ; Epithelial-Mesenchymal Transition/physiology ; Gene Expression Regulation, Neoplastic/physiology ; Humans ; Hyaluronoglucosaminidase/biosynthesis ; Hyaluronoglucosaminidase/genetics ; MicroRNAs/biosynthesis ; MicroRNAs/genetics ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Phosphatidylinositol 3-Kinases/biosynthesis ; Phosphatidylinositol 3-Kinases/genetics ; Signal Transduction/physiology
Chemical Substances	MicroRNAs ; CEMIP protein, human (EC 3.2.1.35) ; Hyaluronoglucosaminidase (EC 3.2.1.35)
Language	English
Publishing date	2021-03-24
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2021.111507
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