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Article: Intratumor microbiome in cancer progression: current developments, challenges and future trends.

Liu, Jinyan / Zhang, Yi

2022 Volume 10, Issue 1, Page(s) 37

Abstract: Cancer is a complicated disease attributed to multifactorial changes, which causes difficulties with treatment strategies. Various factors have been regarded as the main contributors, and infectious etiological factors have recently attracted interest. ... ...

Abstract	Cancer is a complicated disease attributed to multifactorial changes, which causes difficulties with treatment strategies. Various factors have been regarded as the main contributors, and infectious etiological factors have recently attracted interest. Several microbiomes contribute to carcinogenesis, cancer progression, and modulating cancer treatment by inducing cancerous epithelial cells and chronic inflammation. Most of our knowledge on the role of microbiota in tumor oncogenesis and clinical efficiency is associated with the intestinal microbiome. However, compelling evidence has also confirmed the contribution of the intratumor microbiome in cancer. Indeed, the findings of clinical tumor samples, animal models, and studies in vitro have revealed that many intratumor microbiomes promote tumorigenesis and immune evasion. In addition, the intratumor microbiome participates in regulating the immune response and even affects the outcomes of cancer treatment. This review summarizes the interplay between the intratumor microbiota and cancer, focusing on the contribution and mechanism of intratumor microbiota in cancer initiation, progression, and potential applications to cancer therapy.
Language	English
Publishing date	2022-05-31
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2699926-2
ISSN	2050-7771
ISSN	2050-7771
DOI	10.1186/s40364-022-00381-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effect of stepwise psychological intervention on improving adverse mood and quality of life after colon cancer surgery.

Wang, Peng / Pang, Xin / He, Mingxuan / Liu, Jinyan

American journal of translational research

2023 Volume 15, Issue 6, Page(s) 4055–4064

Abstract: Objective: To explore the effect of stepwise psychological intervention on adverse mood and quality of life of patients after colon cancer surgery.: Methods: The clinical data from 102 patients with colon cancer admitted to the Second Hospital of ... ...

Abstract	Objective: To explore the effect of stepwise psychological intervention on adverse mood and quality of life of patients after colon cancer surgery. Methods: The clinical data from 102 patients with colon cancer admitted to the Second Hospital of Baoding from January 2018 to June 2022 were collected and analyzed retrospectively. Based on the intervention measures, 51 patients with the general intervention were regarded as the general group, and 51 patients with the stepwise psychological intervention were considered as the intervention group. Piper Fatigue Scale (PFS) was used to scale the degree of Cancer-related fatigue (CRF); Self-rating anxiety scale (SAS) and Self-rating depression scale (SDS) were applied to measure the negative emotion; Positive and negative emotion scale (PANAS) was used to evaluate the degree of positive negative emotions. In addition, Symptom Checklist 90 (SCL-90), Connor-Davidson Resilience Scale (CD-RISC) self-assessment scale, and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) were applied to evaluate the mental state, mental resilience, and quality of life, respectively. The adverse reactions, prognosis, and intervention satisfaction after intervention were compared between the two groups. Results: After intervention, the PFS scores, SAS score, SDS score, and PANAS score in the general group and intervention groups were decreased (all Conclusions: The stepwise psychological intervention can improve the psychological wellbeing and quality of life in the patients after colon cancer surgery.
Language	English
Publishing date	2023-06-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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Article ; Online: Current advances in bacteria-based cancer immunotherapy.

Guo, Caijuan / Liu, Jinyan / Zhang, Yi

European journal of immunology

2023 Volume 54, Issue 2, Page(s) e2350778

Abstract: As the understanding of the tumor microenvironment has deepened, immunotherapy has become a promising strategy for cancer treatment. In contrast to traditional therapies, immunotherapy is more precise and induces fewer adverse effects. In this field, ... ...

Abstract	As the understanding of the tumor microenvironment has deepened, immunotherapy has become a promising strategy for cancer treatment. In contrast to traditional therapies, immunotherapy is more precise and induces fewer adverse effects. In this field, some bacteria have attracted increased attention because of their natural ability to preferentially colonize and proliferate inside tumor sites and exert antitumor effects. Moreover, bacterial components may activate innate and adaptive immunity to resist tumor progression. However, the application of bacteria-based cancer immunotherapy is hampered by potential infection-associated toxicity and unpredictable behavior in vivo. Owing to modern developments in genetic engineering, bacteria can be modified to weaken their toxicity and enhance their ability to eliminate tumor cells or activate the antitumor immune response. This review summarizes the roles of bacteria in the tumor microenvironment, current strategies for bacterial engineering, and the synergistic efficiency of bacteria with other immunotherapies. In addition, the prospects and challenges of the clinical translation of engineered bacteria are summarized.
MeSH term(s)	Humans ; Neoplasms/therapy ; Immunotherapy ; Bacteria ; Tumor Microenvironment ; Genetic Engineering
Language	English
Publishing date	2023-12-17
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.202350778
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Book ; Online: A Coarse to Fine Framework for Object Detection in High Resolution Image

Liu, Jinyan / Chen, Jie

2023

Abstract: Object detection is a fundamental problem in computer vision, aiming at locating and classifying objects in image. Although current devices can easily take very high-resolution images, current approaches of object detection seldom consider detecting tiny ...

Abstract	Object detection is a fundamental problem in computer vision, aiming at locating and classifying objects in image. Although current devices can easily take very high-resolution images, current approaches of object detection seldom consider detecting tiny object or the large scale variance problem in high resolution images. In this paper, we introduce a simple yet efficient approach that improves accuracy of object detection especially for small objects and large scale variance scene while reducing the computational cost in high resolution image. Inspired by observing that overall detection accuracy is reduced if the image is properly down-sampled but the recall rate is not significantly reduced. Besides, small objects can be better detected by inputting high-resolution images even if using lightweight detector. We propose a cluster-based coarse-to-fine object detection framework to enhance the performance for detecting small objects while ensure the accuracy of large objects in high-resolution images. For the first stage, we perform coarse detection on the down-sampled image and center localization of small objects by lightweight detector on high-resolution image, and then obtains image chips based on cluster region generation method by coarse detection and center localization results, and further sends chips to the second stage detector for fine detection. Finally, we merge the coarse detection and fine detection results. Our approach can make good use of the sparsity of the objects and the information in high-resolution image, thereby making the detection more efficient. Experiment results show that our proposed approach achieves promising performance compared with other state-of-the-art detectors.
Keywords	Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Artificial Intelligence
Subject code	006 ; 004
Publishing date	2023-03-02
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Regulatory role of Mss11 in

Wang, Lu-Ling / Huang, Si-Jia / Zhao, Jun-Tao / Liu, Jin-Yan / Xiang, Ming-Jie

Frontiers in cellular and infection microbiology

2024 Volume 13, Page(s) 1321094

Abstract: Introduction: Candida glabrata: Methods: In this work, a : Results: In : Conclusion: Mss11 plays a crucial role ... ...

Abstract	Introduction: Candida glabrata Methods: In this work, a Results: In Conclusion: Mss11 plays a crucial role in
MeSH term(s)	Candida glabrata/genetics ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Virulence/genetics ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Saccharomyces cerevisiae/metabolism ; Cell Adhesion ; Biofilms ; Virulence Factors/genetics ; Virulence Factors/metabolism ; Repressor Proteins/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Telomere-Binding Proteins/metabolism
Chemical Substances	Fungal Proteins ; Transcription Factors ; Virulence Factors ; RIF1 protein, S cerevisiae (146589-82-4) ; Repressor Proteins ; Saccharomyces cerevisiae Proteins ; Telomere-Binding Proteins
Language	English
Publishing date	2024-01-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1321094
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A novel CD8+ T cell-related gene signature as a prognostic biomarker in hepatocellular carcinoma.

Peng, Xiaozhen / Lu, Xingjun / Yang, Daqing / Liu, Jinyan / Wu, Honglin / Peng, Hong / Zhang, Yiya

Medicine

2024 Volume 103, Issue 11, Page(s) e37496

Abstract: CD8+ T cells have great roles in tumor suppression and elimination of various tumors including hepatocellular carcinoma (HCC). Nonetheless, potential prognostic roles of CD8+ T cell-related genes (CD8Gs) in HCC remains unknown. In our study, 416 CD8Gs ... ...

Abstract	CD8+ T cells have great roles in tumor suppression and elimination of various tumors including hepatocellular carcinoma (HCC). Nonetheless, potential prognostic roles of CD8+ T cell-related genes (CD8Gs) in HCC remains unknown. In our study, 416 CD8Gs were identified in HCC, which were enriched in inflammatory and immune signaling pathways. Using The Cancer Genome Atlas dataset, a 5-CD8Gs risk model (KLRB1, FYN, IL2RG, FCER1G, and DGKZ) was constructed, which was verified in International Cancer Genome Consortium and gene expression omnibus datasets. Furthermore, we found that overall survival was independently correlated with the CD8Gs signature, and it was associated with immune- and cancer-related signaling pathways and immune cells infiltration. Finally, drug sensitivity data indicated that 10 chemotherapeutic drugs held promise as therapeutics for HCC patients with high-risk. In conclusion, multi-databases analysis showed that 5-CD8Gs and their signature could be an indicator to predict candidate drugs for HCC therapy.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/genetics ; Prognosis ; Liver Neoplasms/genetics ; CD8-Positive T-Lymphocytes ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037496
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Article: Corrosion inhibition performance of synergistic inhibitors on Q235 steel in methanol/formic acid medium

Wang, Jia / Liu, Jinyan / Liu, Qian / Chong, Yao

Journal of materials science. 2022 Sept., v. 57, no. 33

2022

Abstract: The corrosion inhibition behaviors of dodecylpyridinium chloride (DPC), hexadecylpyridinium chloride monohydrate (HDPC), and the rosin amino acid surfactants dehydroabietic acylamino sodium (6-DAS) and compounds (6-DAS/DPC and 6-DAS/HDPC) were ... ...

Abstract	The corrosion inhibition behaviors of dodecylpyridinium chloride (DPC), hexadecylpyridinium chloride monohydrate (HDPC), and the rosin amino acid surfactants dehydroabietic acylamino sodium (6-DAS) and compounds (6-DAS/DPC and 6-DAS/HDPC) were investigated by weight loss measurements and electrochemical testing. Besides, corrosion inhibition performance was further verified by combining a series of surface properties analyses and theoretical calculations. The weight loss results showed that the increase in inhibition efficiency was mainly attributed to its high concentration and revealed that the inhibition efficiency of compound inhibitors was higher than that of single inhibitor 6-DAS (92.23%), which was up to 95.86% and 96.72% of 6-DAS/DPC and 6-DAS/HDPC at 1:8 concentration ratio, respectively. The potential polarization curve potential demonstrated that single inhibitor 6-DAS and compound inhibitors (6-DAS/DPC and 6-DAS/HDPC) were both mixed-type corrosion inhibitors dominated by the anode. Thus, among the three, 6-DAS/HDPC had the best corrosion inhibition performance, and the average inhibition efficiency was 96.90%. Surface studies presented the adsorption of inhibitor molecules adhered on the Fe surface, while the adsorption performance of compound inhibitors appeared to be superior to single inhibitor 6-DAS. Moreover, it was found that there were a few excellent data from molecular dynamics simulation about the adsorption energies of inhibitors that could also explain the corrosion inhibitor performance, the results of which had good agreement with the experimental data, which provided strong evidence for the close relationship between the molecular structure of inhibitor and its inhibition efficiency.
Keywords	adsorption ; amino acids ; anodes ; chemical structure ; chlorides ; corrosion ; electrochemistry ; formic acid ; methanol ; molecular dynamics ; rosin ; sodium ; steel ; weight loss
Language	English
Dates of publication	2022-09
Size	p. 16025-16047.
Publishing place	Springer US
Document type	Article
ZDB-ID	2015305-3
ISSN	1573-4803 ; 0022-2461
ISSN (online)	1573-4803
ISSN	0022-2461
DOI	10.1007/s10853-022-07629-3
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Pachymic acid inhibits proliferation of human colon cancer cell line HT-29

FENG Naxin, WANG Peng, HE Mingxuan, LIU Jinyan

Jichu yixue yu linchuang, Vol 43, Iss 11, Pp 1673-

2023 Volume 1679

Abstract: Objective To investigate the impacts of pachymic acid (PA) on proliferation and apoptosis of human colon cancer cell line (HT-29) and its potential mechanism. Methods The cells were divided into blank group, 20, 40 and 80 μmol/L PA groups. The ... ...

Abstract	Objective To investigate the impacts of pachymic acid (PA) on proliferation and apoptosis of human colon cancer cell line (HT-29) and its potential mechanism. Methods The cells were divided into blank group, 20, 40 and 80 μmol/L PA groups. The proliferation of HT-29 cells was detected by MTT method; The cell cycle and apoptosis of HT-29 cells were detected by flow cytometry; The expression of cell cycle, apoptosis and Akt/MDM2/p53 signal pathway related proteins in HT-29 cells were detected by Western blot. The tumor xeno-transplantation model with HT-29 cells was constructed, and then the tumorigenic nude mice were randomly divided into control group, intra-peritoneal injection of 10, 30 and 60 mg/kg PA groups(6 in each group), the tumor volume and weight were measured; The expression of Ki-67 and of cleared caspase-3 proteins in tumor tissue was detected by immuno-histochemistry; The expression of Akt/MDM2/p53 signal pathway related protein in tumor tissue was detected by Western blot. Results PA of all doses obviously inhibited proliferation of HT-29 cells, the proportion of cells in S phase and in G2/M phase was deceased and the expression of B cell lymphoma gene-2(Bcl-2), cyclin D1, cycle protein dependent activating enzyme 2(CDK2) proteins all decreased, The ratios of p-Akt/Akt and p-MDM2/MDM2 in a concentration-dependent manner increased(P＜0.05).The apoptosis rate, the ratio of cells in G0/G1 phase and the protein expression of Bax, cleaved caspase-3 and p53 also increased(P＜0.05). PA in all dose groups obviously reduced the tumor volume, weight, the expression of Ki-67 protein and the ratios of p-Akt/Akt, p-MDM2/MDM2 in tumor tissue of nude mice (P＜0.05), and increased the protein expression of cleaved caspase-3 and p53 in tumor tissue(P＜0.05). Conclusions PA can induce apoptosis and cell cycle arrest of colon cancer cells and inhibit cell proliferation. Its mechanism may be related to the regulation of Akt/MDM2/p53 signal pathway.
Keywords	colon cancer\|pachymic acid\|apoptosis\|cell cycle\|akt/mdm2/p53 signal pathway ; Medicine ; R
Language	Chinese
Publishing date	2023-11-01T00:00:00Z
Publisher	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Comprehensive Evaluation of Clinical Application of Balanced Compound Amino Acid Injection.

Shi, Yingqin / Song, Hai / Liu, Jinyan / Lin, Jie / Fang, Lingzhi

Frontiers in nutrition

2022 Volume 9, Page(s) 880256

Abstract: Background: To provide a reference for hospital drug selection and rational clinical drug selection based on the evaluation of the safety, nutritional quality, and economy of 27 manufacturers of five varieties (18AA, 18AA-I, 18AA-II, 18AA-IV, 18AA-V) of ...

Abstract	Background: To provide a reference for hospital drug selection and rational clinical drug selection based on the evaluation of the safety, nutritional quality, and economy of 27 manufacturers of five varieties (18AA, 18AA-I, 18AA-II, 18AA-IV, 18AA-V) of balanced compound amino acids for injection and (18AA-II Methods: The safety of compound amino acids for injection was evaluated by comparing the antioxidant sulfite contents. Based on the amino acid scoring standard mode and the whole egg protein mode as proposed by the Food and Agriculture Organization of the United Nations/World Health Organization (FAO/WHO) in 1973, we compared the formula. The first limiting amino acid content and the comprehensive quality of the total essential amino acid (EAA) contents of the six formulations were studied. The price/content ratio was used to evaluate their economy. Results: Similar variety produced by different manufacturers have the same formula and contents of balanced compound amino acids for injection. Safety: 18AA-II Conclusion: Through its security, effectiveness, and economy of the comprehensive research, we recommended 18AA-II and 18AA-IIoriginal research with high safety, efficacy, and reasonable price as the first choice. 18AA and 18AA-I with better safety and reasonable price, secondary recommendation. 18AA-IV or 18AA-V with poor safety, efficacy, and economy are not recommended.
Language	English
Publishing date	2022-06-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.880256
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Article: Value of

Liu, Jinyan / Li, Xinhui / Deng, Haoyu

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

2021 Volume 46, Issue 9, Page(s) 1018–1023

Abstract: Objectives: Hyperfunctioning parathyroid lesions require surgical resection. : Methods: This study was a retrospective analysis. A total of 68 patients who were diagnosed as parathyroid lesions by : Results: The : Conclusions: The degree ... ...

Title translation	99m
Abstract	Objectives: Hyperfunctioning parathyroid lesions require surgical resection. Methods: This study was a retrospective analysis. A total of 68 patients who were diagnosed as parathyroid lesions by Results: The Conclusions: The degree of
MeSH term(s)	Goiter, Nodular/diagnostic imaging ; Humans ; Parathyroid Glands ; Radiopharmaceuticals ; Retrospective Studies ; Single Photon Emission Computed Tomography Computed Tomography ; Technetium Tc 99m Sestamibi ; Tomography, Emission-Computed, Single-Photon
Chemical Substances	Radiopharmaceuticals ; Technetium Tc 99m Sestamibi (971Z4W1S09)
Language	Chinese
Publishing date	2021-11-05
Publishing country	China
Document type	Journal Article
ZDB-ID	2168533-2
ISSN	1672-7347
ISSN	1672-7347
DOI	10.11817/j.issn.1672-7347.2021.190641
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