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Book ; Online: Antimicrobial Resistance and Anti-Biofilms

Liu, Junyan / Chen, Ding-Qiang / Tan, Yulong / Gan, Ren-You / Qu, Guanggang / Xu, Zhenbo

2023

Keywords	Research & information: general ; Biology, life sciences ; Microbiology (non-medical) ; carbapenem-resistant Enterobacteriaceae ; metallo-β-lactamases ; NDM producers ; complicated urinary tract infections ; outcomes ; costs ; burden of illness ; Medicare ; Serratia marcescens ; multidrug resistance ; mcr-9 ; blaIMP-26 ; megaplasmids IMP-26 ; evolutionary pathway ; Canarium patentinervium Miq. ; antibiofilm activity ; AcrAB-TolC efflux pump ; molecular docking ; Autodock Vina ; Staphylococcus aureus ; persisters ; biofilm ; antimicrobial activity ; drug combination ; Ralstonia mannitolilytica ; chronic obstructive pulmonary disease (COPD) ; catheter-related bloodstream infection (CRBSI) ; commensal ; pathogen ; chitosan ; nanoparticle ; antibiofilm ; cinnamaldehyde ; invasive plants ; natural products ; molecular networking ; Candida albicans ; betulinic acid ; biofilms ; extracellular matrix ; quorum sensing ; antibiotic resistance ; Streptococcus mutans ; dental caries ; Casearia sylvestris
Language	English
Size	1 electronic resource (164 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030722373
ISBN	9783036569505 ; 3036569502
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Editorial: Eicosanoids and cytokines: Resolution of inflammation.

Liu, Jun-Yan

Frontiers in pharmacology

2022 Volume 13, Page(s) 978331

Language	English
Publishing date	2022-08-11
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.978331
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Article ; Online: Pathological and pharmacological functions of the metabolites of polyunsaturated fatty acids mediated by cyclooxygenases, lipoxygenases, and cytochrome P450s in cancers.

Meng, Yi-Wen / Liu, Jun-Yan

Pharmacology & therapeutics

2024 Volume 256, Page(s) 108612

Abstract: Oxylipins have garnered increasing attention because they were consistently shown to play pathological and/or pharmacological roles in the development of multiple cancers. Oxylipins are the metabolites of polyunsaturated fatty acids via both enzymatic ... ...

Abstract	Oxylipins have garnered increasing attention because they were consistently shown to play pathological and/or pharmacological roles in the development of multiple cancers. Oxylipins are the metabolites of polyunsaturated fatty acids via both enzymatic and nonenzymatic pathways. The enzymes mediating the metabolism of PUFAs include but not limited to lipoxygenases (LOXs), cyclooxygenases (COXs), and cytochrome P450s (CYPs) pathways, as well as the down-stream enzymes. Here, we systematically summarized the pleiotropic effects of oxylipins in different cancers through pathological and pharmacological aspects, with specific reference to the enzyme-mediated oxylipins. We discussed the specific roles of oxylipins on cancer onset, growth, invasion, and metastasis, as well as the expression changes in the associated metabolic enzymes and the associated underlying mechanisms. In addition, we also discussed the clinical application and potential of oxylipins and related metabolic enzymes as the targets for cancer prevention and treatment. We found the specific function of most oxylipins in cancers, especially the underlying mechanisms and clinic applications, deserves and needs further investigation. We believe that research on oxylipins will provide not only more therapeutic targets for various cancers but also dietary guidance for both cancer patients and healthy humans.
MeSH term(s)	Humans ; Oxylipins/metabolism ; Lipoxygenases ; Prostaglandin-Endoperoxide Synthases/metabolism ; Fatty Acids, Unsaturated/metabolism ; Cytochromes ; Neoplasms/drug therapy ; Cytochrome P-450 Enzyme System/metabolism
Chemical Substances	Oxylipins ; Lipoxygenases (EC 1.13.11.-) ; Prostaglandin-Endoperoxide Synthases (EC 1.14.99.1) ; Fatty Acids, Unsaturated ; Cytochromes ; Cytochrome P-450 Enzyme System (9035-51-2)
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	194735-7
ISSN	1879-016X ; 0163-7258
ISSN (online)	1879-016X
ISSN	0163-7258
DOI	10.1016/j.pharmthera.2024.108612
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Zs.A 1183: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Research on Improved MOF Materials Modified by Functional Groups for Purification of Water.

Liu, Junyan / Wang, Yang

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 5

Abstract: With the rapid development of urbanization and industrialization, water contamination has gradually become a big problem. Relevant studies show that adsorption is an efficient strategy to treat pollutants in water. MOFs are a class of porous materials ... ...

Abstract	With the rapid development of urbanization and industrialization, water contamination has gradually become a big problem. Relevant studies show that adsorption is an efficient strategy to treat pollutants in water. MOFs are a class of porous materials with a three-dimensional frame structure shaped by the self-assembly of metal centers and organic ligands. Because of its unique performance advantages, it has become a promising adsorbent. At present, single MOFs cannot meet the needs, but the introduction of familiar functional groups on MOFs can promote the adsorption performance of MOFs on the target. In this review, the main advantages, adsorption mechanism, and specific applications of various functional MOF adsorbents for pollutants in water are reviewed. At the end of the article, we summarize and discuss the future development direction.
Language	English
Publishing date	2023-02-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28052141
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Zs.MO 81: Show issues

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Article ; Online: Green Human Resource Management, Employee Work Values, and Enterprise Environmental Performance.

Liu, Junyan / Wu, Yongli

Journal of environmental and public health

2022 Volume 2022, Page(s) 8129359

Abstract: China's economy is developing rapidly, and enterprises are paying more and more attention to environmental protection in the process of economic development. However, relatively speaking, the environmental awareness of enterprises and employees needs to ... ...

Abstract	China's economy is developing rapidly, and enterprises are paying more and more attention to environmental protection in the process of economic development. However, relatively speaking, the environmental awareness of enterprises and employees needs to be further improved. This paper investigates the impact of green human resource management on environmental performance by questionnaire survey. A total of 372 questionnaires were distributed to front-line employees and human resource supervisors, 357 of which were valid. Using descriptive statistics, correlation analysis, regression analysis, and mediating effect test, this paper studies the relationship between green human resource management and environmental performance, and tests the mediating role of employees' work values between green human resource management and enterprise environmental performance. The conclusion of the empirical study has some inspiration for the green human resource management of enterprises, provides some references for the development of relevant theories, and provides practical significance for the green development of enterprises.
MeSH term(s)	Humans ; Workforce
Language	English
Publishing date	2022-06-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2526611-1
ISSN	1687-9813 ; 1687-9813
ISSN (online)	1687-9813
ISSN	1687-9813
DOI	10.1155/2022/8129359
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Article: Inhibition of Soluble Epoxide Hydrolase for Renal Health.

Liu, Jun-Yan

Frontiers in pharmacology

2019 Volume 9, Page(s) 1551

Abstract: A soluble epoxide hydrolase (sEH) mediates the metabolism of epoxy fatty acids to form the corresponding vicinal diols, which are usually inactive or less active than the epoxide substrates. The sEH enzyme presents in many organs, including but not ... ...

Abstract	A soluble epoxide hydrolase (sEH) mediates the metabolism of epoxy fatty acids to form the corresponding vicinal diols, which are usually inactive or less active than the epoxide substrates. The sEH enzyme presents in many organs, including but not limited to the liver, heart, spleen, lung, and kidney. Here we summarized the changes in the expression and activity of sEH in multiple renal diseases, such as acute kidney injury (AKI), diabetic nephrology (DN), chronic kidney diseases (CKD), hypertension-mediated renal damage, and other renal dysfunctions. We also discussed the pharmacologic effects and the underlying mechanisms of sEH inhibition by using an inhibitor of sEH and/or the generic deletion of sEH on multiple renal diseases. We believe that sEH is a potential therapeutic target for renal dysfunction although the target disease needs further investigation.
Language	English
Publishing date	2019-01-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2018.01551
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Article ; Online: Saikosaponin D mitigate pilocarpine-induced astrocyte injury by regulating the NLRP3/caspase-1 signaling pathway.

Liu, Jun-Yan / Shen, Yu-Ling / Zhu, Jing-Yi / Yang, Dong-Dong

Chemical biology & drug design

2024 Volume 103, Issue 3, Page(s) e14481

Abstract: Studies have shown that saikosaponin D (SSD) has favorable neurotherapeutic effects. Therefore, the objective of this study was to explore the efficacy and possible molecular mechanisms of SSD on pilocarpine (PP)-induced astrocyte injury. Primary ... ...

Abstract	Studies have shown that saikosaponin D (SSD) has favorable neurotherapeutic effects. Therefore, the objective of this study was to explore the efficacy and possible molecular mechanisms of SSD on pilocarpine (PP)-induced astrocyte injury. Primary astrocytes were isolated from juvenile rats and identified using immunofluorescence. The cells were treated with PP and/or SSD for 6 h and 12 h, respectively, followed by measurement of their viability through 3-(4,5-dimethylthiazol)-2,5-diphenyl-tetrazolium bromide (MTT) assay. Next, quantitative real-time polymerase chain reaction (qRT-PCR) was used to measure the expression levels of Glial fibrillary acidic protein (GFAP), C3, S100 calcium binding protein A10 (S100a10), pentraxin 3 (Ptx3), toll-like receptor 4 (TLR4), and RAG in astrocytes after different treatments. Enzyme-linked immunosorbent assay and biochemical tests were utilized to evaluate the level of inflammatory factors [interleukin (IL)-1β, IL-6, and tumor necrosis factor alpha (TNF-α)] secreted by cells and the content of oxidative stress-related factors (malondialdehyde [MDA] and glutathione [GSH]) or enzyme activity (catalase [CAT] and glutathione peroxidase [GPX]) in cells. The JC-1 mitochondrial membrane potential (MMP) fluorescence probe was used to measure the MMP in astrocytes. Additionally, western blot was applied to test the expression of proteins related to the nod-like receptor protein 3 (NLRP3)/caspase-1 signaling pathway. PP treatment (1 mM) induced cell injury by significantly reducing the viability of astrocytes and expression of cellular markers. SSD treatment (4 μM) had no toxicity to astrocytes. Besides, SSD (4 μM) treatment could significantly up-regulate the cell viability and marker expression of PP-induced astrocytes. Furthermore, SSD could be employed to inhibit inflammation (reduce IL-1β, IL-6, and TNF-α levels) and oxidative stress (decrease MDA level, elevate GSH level, the activity of CAT and GPX), and ameliorate mitochondrial dysfunction (upregulate JC-1 ratio) in PP-induced astrocytes. Moreover, further mechanism exploration revealed that SSD treatment significantly reduced the activity of the NLRP3/caspase-1 signaling pathway activated by PP induction. SSD increased cell viability, inhibited inflammation and oxidative stress response, and ameliorated mitochondrial dysfunction in PP-induced astrocyte injury model, thus playing a neuroprotective role. The mechanism of SSD may be related to the inhibition of the NLRP3/caspase-1 inflammasome.
MeSH term(s)	Rats ; Animals ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Astrocytes/metabolism ; Astrocytes/pathology ; Pilocarpine/toxicity ; Tumor Necrosis Factor-alpha/genetics ; Caspases/metabolism ; Interleukin-6 ; Signal Transduction ; Inflammation/metabolism ; Mitochondrial Diseases ; Benzimidazoles ; Carbocyanines ; Oleanolic Acid/analogs & derivatives ; Saponins
Chemical Substances	NLR Family, Pyrin Domain-Containing 3 Protein ; saikosaponin D (UR635J3F00) ; Pilocarpine (01MI4Q9DI3) ; Tumor Necrosis Factor-alpha ; Caspases (EC 3.4.22.-) ; 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine (21527-78-6) ; Interleukin-6 ; Benzimidazoles ; Carbocyanines ; Oleanolic Acid (6SMK8R7TGJ) ; Saponins
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2216600-2
ISSN	1747-0285 ; 1747-0277
ISSN (online)	1747-0285
ISSN	1747-0277
DOI	10.1111/cbdd.14481
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Article ; Online: Robust Discriminant Subspace Clustering With Adaptive Local Structure Embedding.

Liu, Junyan / Li, Dapeng / Zhao, Haitao / Gao, Lin

IEEE transactions on neural networks and learning systems

2023 Volume 34, Issue 5, Page(s) 2466–2479

Abstract: Unsupervised dimension reduction and clustering are frequently used as two separate steps to conduct clustering tasks in subspace. However, the two-step clustering methods may not necessarily reflect the cluster structure in the subspace. In addition, ... ...

Abstract	Unsupervised dimension reduction and clustering are frequently used as two separate steps to conduct clustering tasks in subspace. However, the two-step clustering methods may not necessarily reflect the cluster structure in the subspace. In addition, the existing subspace clustering methods do not consider the relationship between the low-dimensional representation and local structure in the input space. To address the above issues, we propose a robust discriminant subspace (RDS) clustering model with adaptive local structure embedding. Specifically, unlike the existing methods which incorporate dimension reduction and clustering via regularizer, thereby introducing extra parameters, RDS first integrates them into a unified matrix factorization (MF) model through theoretical proof. Furthermore, a similarity graph is constructed to learn the local structure. A constraint is imposed on the graph to guarantee that it has the same connected components with low-dimensional representation. In this spirit, the similarity graph serves as a tradeoff that adaptively balances the learning process between the low-dimensional space and the original space. Finally, RDS adopts the l
Language	English
Publishing date	2023-05-02
Publishing country	United States
Document type	Journal Article
ISSN	2162-2388
ISSN (online)	2162-2388
DOI	10.1109/TNNLS.2021.3106702
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Article ; Online: Resolution improvement of photothermal microscopy by the modulated difference method.

Wang, Yonghui / Wang, Fei / Song, Peng / Liu, Junyan

Optics letters

2023 Volume 48, Issue 7, Page(s) 1750–1753

Abstract: Photothermal microscopy (PTM) was developed to image non-fluorescent objects. In the past two decades, PTM has reached single-particle and single-molecule sensitivity and has been used in the fields of material science and biology. However, PTM is a far- ... ...

Abstract	Photothermal microscopy (PTM) was developed to image non-fluorescent objects. In the past two decades, PTM has reached single-particle and single-molecule sensitivity and has been used in the fields of material science and biology. However, PTM is a far-field imaging method whose resolution is restricted by the diffraction limits. This Letter reports a resolution improvement approach for photothermal microscopy called modulated difference PTM (MD-PTM), which utilizes Gaussian and doughnut formalism heating beams that are modulated at the same frequency but are of opposite phase to generate the photothermal signal. Furthermore, the opposite phase characteristics of the photothermal signals are applied to determine the objective profile from the PTM magnitude, and this helps to improve the lateral resolution of PTM. The lateral resolution is related to the difference coefficient between the Gaussian and doughnut heating beams; an increase in the difference coefficient causes a larger sidelobe of the MD-PTM amplitude, which readily forms an artifact. A pulse-coupled neural network (PCNN) is employed for phase image segmentations of MD-PTM. We experimentally study the micro-imaging of gold nanoclusters and crossed nanotubes using MD-PTM, and the results indicate that MD-PTM has merit in terms of improving the lateral resolution.
Language	English
Publishing date	2023-05-23
Publishing country	United States
Document type	Journal Article
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.484969
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Article ; Online: Male larval experience of cues from adult rivals alters lifetime sperm investment patterns in a sperm heteromorphic moth, Ephestia kuehniella.

Liu, Junyan / He, Xiong Zhao / Wang, Qiao

Insect science

2023 Volume 30, Issue 6, Page(s) 1773–1783

Abstract: Male animals may adjust their resource allocations for reproduction and other fitness functions in response to cues from rivals. For instance, adult males increase their investment in sperm for a higher paternity share when they perceive sperm ... ...

Abstract	Male animals may adjust their resource allocations for reproduction and other fitness functions in response to cues from rivals. For instance, adult males increase their investment in sperm for a higher paternity share when they perceive sperm competition risk in their surroundings. In nature, both juveniles and adults may coexist spatially and temporally. Yet, it is not clear how juvenile males of different ages respond to cues from adult rivals and fine-tune their lifetime investment in sperm production and ejaculation in any insect. Here we used the Mediterranean flour moth, Ephestia kuehniella, which produces both fertile eupyrene and infertile apyrene sperm, to explore this question. We demonstrate that the late, but not early, instar larvae are sensitive to adult male cues. As a response, they produce more sperm before emergence and their resultant adults have shorter mating latency and ejaculate more sperm in the first few matings. When the juvenile stage produces more eupyrenes, the adult stops making these sperm, but regardless of the number of apyrenes produced during the juvenile stage, the adult continues to make them. These findings suggest that the number of spermatogonia for eupyrenes may be limited and that for apyrenes may be flexible. Our results show that the insect does not trade off survival, mating frequency, body size, or testis size for sperm production in response to adult males during the larval stage. Knowledge created in the present study offers insight into the stage-dependent sensitivity of juvenile males to cues from adult rivals and subsequent lifetime resource allocations.
MeSH term(s)	Male ; Animals ; Moths/physiology ; Larva ; Cues ; Semen ; Spermatozoa/physiology ; Sexual Behavior, Animal
Language	English
Publishing date	2023-05-10
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2179775-4
ISSN	1744-7917 ; 1672-9609
ISSN (online)	1744-7917
ISSN	1672-9609
DOI	10.1111/1744-7917.13204
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