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Article ; Online: A novel polyamide thin-film nanocomposite reverse osmosis membrane constructed by a 3D multi-layer graphene oxide assembled with 1,3-diamino-2-propanol

Su, Ting / Li, Xun / Yang, Zhen-Miao / Liu, Li-Fen

Journal of Membrane Science. 2023 Sept., v. 681 p.121773-

2023

Abstract: Polyamide (PA) thin-film composite (TFC) reverse osmosis (RO) membrane has been widely used for desalination to produce fresh water. In order to further enhance the membrane’s water flux without sacrificing the salt rejection, in this study, a new kind ... ...

Abstract	Polyamide (PA) thin-film composite (TFC) reverse osmosis (RO) membrane has been widely used for desalination to produce fresh water. In order to further enhance the membrane’s water flux without sacrificing the salt rejection, in this study, a new kind of three-dimension (3D) multi-layer graphene oxide (mGO) was synthesized through the layer-by-layer (LbL) crosslinking between the sing-layer GO (sGO) nanosheet and 1,3-diamino-2-propanol (DAPL) molecule, and then was introduced into the aqueous phase solution to modify the conventional polyamide TFC RO membrane via interfacial polymerization (IP). The size and structure of mGO were regulated through the optimization of LbL crosslinking techniques, and the effect of mGO on the micro-structure and macro-property of thin-film nanocomposite (TFN) RO membrane was correspondingly investigated. It was found that the mGO made the PA layer surface of RO membrane smoother and more hydrophilic. Most importantly, it increased the water flux of RO membrane, improved the salt rejection above 99.3%, and endowed the RO membrane better long-term stability. Obviously, this is due to that mGO created a certain d-spacing through crosslinking DAPL molecules between sGO nanosheets, which provided channels for water transport across the PA layer and thus accelerated the migration of water molecules in the membrane, ultimately enhancing the water flux of TFN RO membrane. Meanwhile, the DAPL grafted on the outmost surface of mGO enhanced the compatibility between mGO(30) and PA polymeric matrix via the reaction with TMC during the IP, further improving the membrane’s salt rejection. Therefore, this study provides a facile way to improve the comprehensive separation performance of RO membrane.
Keywords	crosslinking ; desalination ; freshwater ; graphene oxide ; hydrophilicity ; microstructure ; nanocomposites ; nanosheets ; polyamides ; polymerization ; reverse osmosis ; 3D multi-layers graphene oxide (mGO) ; LbL crosslinking between sGO nanosheet and DAPL ; Thin-film nanocomposite (TFN) reverse osmosis membrane ; High water flux ; Better long-term stability
Language	English
Dates of publication	2023-09
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	194516-6
ISSN	0376-7388
ISSN	0376-7388
DOI	10.1016/j.memsci.2023.121773
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effects of Aloe Gel on Lactating Women with Nipple Trauma.

Wang, Rui-Hua / Gong, Jing-Ya / Liu, Peng-Cheng / Liu, Li-Fen / Zhang, Jin-Ting / Yao, Lan / Dong, Qin / Jia, Su-Hong

Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine

2024

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2234680-6
ISSN	1556-8342 ; 1556-8253
ISSN (online)	1556-8342
ISSN	1556-8253
DOI	10.1089/bfm.2023.0265
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Article: Neuroplastin 65 deficiency reduces amyloid plaque formation and cognitive deficits in an Alzheimer's disease mouse model.

Wu, Dan-Dan / Cheng, Jie / Zheng, Ya-Ni / Liu, Yu-Tong / Hou, Shuang-Xin / Liu, Li-Fen / Huang, Liang / Yuan, Qiong-Lan

Frontiers in cellular neuroscience

2023 Volume 17, Page(s) 1129773

Abstract: Introduction: Alzheimer's disease (AD) is characterized by increasing cognitive dysfunction, progressive cerebral amyloid beta (Aβ) deposition, and neurofibrillary tangle aggregation. However, the molecular mechanisms of AD pathologies have not been ... ...

Abstract	Introduction: Alzheimer's disease (AD) is characterized by increasing cognitive dysfunction, progressive cerebral amyloid beta (Aβ) deposition, and neurofibrillary tangle aggregation. However, the molecular mechanisms of AD pathologies have not been completely understood. As synaptic glycoprotein neuroplastin 65 (NP65) is related with synaptic plasticity and complex molecular events underlying learning and memory, we hypothesized that NP65 would be involved in cognitive dysfunction and Aβ plaque formation of AD. For this purpose, we examined the role of NP65 in the transgenic amyloid precursor protein (APP)/presenilin 1 (PS1) mouse model of AD. Methods: Neuroplastin 65-knockout (NP65 Results: We found that loss of NP65 alleviated the cognitive deficits of APP/PS1 mice. In addition, Aβ plaque burden and Aβ levels were significantly reduced in NP65-deficient APP/PS1 mice compared with control animals. NP65-loss in APP/PS1 mice resulted in a decrease in glial activation and the levels of pro- and anti-inflammatory cytokines (IL-1β, TNF-α, and IL-4) as well as protective matrix YM-1 and Arg-1, but had no effect on microglial phenotype. Moreover, NP65 deficiency significantly reversed the increase in 5-hydroxytryptamine (serotonin) receptor 3A (Htr3A) expression levels in the hippocampus of APP/PS1 mice. Discussion: These findings identify a previously unrecognized role of NP65 in cognitive deficits and Aβ formation of APP/PS1 mice, and suggest that NP65 may serve as a potential therapeutic target for AD.
Language	English
Publishing date	2023-05-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452963-1
ISSN	1662-5102
ISSN	1662-5102
DOI	10.3389/fncel.2023.1129773
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Article: Inhibiting 5-hydroxytryptamine receptor 3 alleviates pathological changes of a mouse model of Alzheimer's disease.

Liu, Li-Fen / Liu, Yu-Tong / Wu, Dan-Dan / Cheng, Jie / Li, Na-Na / Zheng, Ya-Ni / Huang, Liang / Yuan, Qiong-Lan

Neural regeneration research

2023 Volume 18, Issue 9, Page(s) 2019–2028

Abstract: Extracellular amyloid beta (Aβ) plaques are main pathological feature of Alzheimer's disease. However, the specific type of neurons that produce Aβ peptides in the initial stage of Alzheimer's disease are unknown. In this study, we found that 5- ... ...

Abstract	Extracellular amyloid beta (Aβ) plaques are main pathological feature of Alzheimer's disease. However, the specific type of neurons that produce Aβ peptides in the initial stage of Alzheimer's disease are unknown. In this study, we found that 5-hydroxytryptamin receptor 3A subunit (HTR3A) was highly expressed in the brain tissue of transgenic amyloid precursor protein and presenilin-1 mice (an Alzheimer's disease model) and patients with Alzheimer's disease. To investigate whether HTR3A-positive interneurons are associated with the production of Aβ plaques, we performed double immunostaining and found that HTR3A-positive interneurons were clustered around Aβ plaques in the mouse model. Some amyloid precursor protein-positive or β-site amyloid precursor protein cleaving enzyme-1-positive neurites near Aβ plaques were co-localized with HTR3A interneurons. These results suggest that HTR3A -positive interneurons may partially contribute to the generation of Aβ peptides. We treated 5.0-5.5-month-old model mice with tropisetron, a HTR3 antagonist, for 8 consecutive weeks. We found that the cognitive deficit of mice was partially reversed, Aβ plaques and neuroinflammation were remarkably reduced, the expression of HTR3 was remarkably decreased and the calcineurin/nuclear factor of activated T-cell 4 signaling pathway was inhibited in treated model mice. These findings suggest that HTR3A interneurons partly contribute to generation of Aβ peptide at the initial stage of Alzheimer's disease and inhibiting HTR3 partly reverses the pathological changes of Alzheimer's disease.
Language	English
Publishing date	2023-03-14
Publishing country	India
Document type	Journal Article
ZDB-ID	2388460-5
ISSN	1876-7958 ; 1673-5374
ISSN (online)	1876-7958
ISSN	1673-5374
DOI	10.4103/1673-5374.366492
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Article: A rigid-flexible interpenetrating polyamide reverse osmosis membrane with improved antifouling property fabricated via two step modifications

Chen, Fang-Fang / Su, Ting / Zhao, Xue-Ting / Pan, Jie-Feng / Liu, Li-Fen

Journal of membrane science. 2021 Nov. 01, v. 637

2021

Abstract: Polyamide thin-film composite reverse osmosis (RO) membranes usually suffer from fouling problem, which greatly limits the wide application of RO technology. In this study, a novel rigid-flexible interpenetrating polyamide RO membrane was fabricated via ... ...

Abstract	Polyamide thin-film composite reverse osmosis (RO) membranes usually suffer from fouling problem, which greatly limits the wide application of RO technology. In this study, a novel rigid-flexible interpenetrating polyamide RO membrane was fabricated via two step modifications to alleviate the membrane fouling during the RO process. The first step modification was carried out by incorporation a new aliphatic diamine of 1,3-diamino-2-propanol (DAPL) into the aromatic m-phenylenediamine (MPD) aqueous solution to react with trimesoyl chloride (TMC) to form a rigid-flexible interpenetration polyamide (PA) separation layer for enhancing its permeability. Then, the second modification was performed by grafting PVA on the top surface of the DAPL-based PA layer to tailor more hydrophilic, smoother and less negatively charged surface and endowed the modified membrane favorable antifouling property. Under the optimized condition, the permeability flux of the modified RO membrane reached 58.6 L/m²h with an about 58.8% increase than the pristine RO membrane (about 36.9 L/m²h), and the salt rejection was also maintained about 99.6% without any loss. At the same time, the modified RO membrane presented a favorable resistance to the dye foulants of methylene blue (MB) and crystal violet (CV) with flux recovery rate of 76.8% and 84.2% respectively. This study provides a facile and effective way to fabricate a novel antifouling reverse osmosis composite membrane with favorable comprehensive separation performance.
Keywords	antifouling activities ; aqueous solutions ; asymmetric membranes ; gentian violet ; hydrophilicity ; methylene blue ; permeability ; polyamides ; reverse osmosis ; trimesoyl chloride
Language	English
Dates of publication	2021-1101
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	194516-6
ISSN	0376-7388
ISSN	0376-7388
DOI	10.1016/j.memsci.2021.119625
Database	NAL-Catalogue (AGRICOLA)

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Article: [Fenton-like Catalytic Removal of Organic Pollutants in Water by Framework Cu in Cu-Al

Xu, Dan / Zhang, Li-Li / Liu, Li-Fen

Huan jing ke xue= Huanjing kexue

2018 Volume 38, Issue 3, Page(s) 1054–1060

Abstract: To address the problem of low activity for Fe-based Fenton-like catalysts at neutral pH, Cu- ... ...

Abstract	To address the problem of low activity for Fe-based Fenton-like catalysts at neutral pH, Cu-Al
Language	Chinese
Publishing date	2018-07-02
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.201608058
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effects of primary microglia and astrocytes on neural stem cells in

Wen, Sheng-Jun / Zheng, Xi-Min / Liu, Li-Fen / Li, Na-Na / Mao, Hai-An / Huang, Liang / Yuan, Qiong-Lan

Neural regeneration research

2021 Volume 16, Issue 9, Page(s) 1677–1685

Abstract: Transplantation of neural stem cells (NSCs) can protect neurons in animal stroke models; however, their low rates of survival and neuronal differentiation limit their clinical application. Glial niches, an important location of neural stem cells, ... ...

Abstract	Transplantation of neural stem cells (NSCs) can protect neurons in animal stroke models; however, their low rates of survival and neuronal differentiation limit their clinical application. Glial niches, an important location of neural stem cells, regulate survival, proliferation and differentiation of neural stem cells. However, the effects of activated glial cells on neural stem cells remain unclear. In the present study, we explored the effects of activated astrocytes and microglia on neural stem cells in vitro stroke models. We also investigated the effects of combined transplantation of neural stem cells and glial cells after stroke in rats. In a Transwell co-culture system, primary cultured astrocytes, microglia or mixed glial cells were exposed to glutamate or H
Language	English
Publishing date	2021-01-28
Publishing country	India
Document type	Journal Article
ZDB-ID	2388460-5
ISSN	1876-7958 ; 1673-5374
ISSN (online)	1876-7958
ISSN	1673-5374
DOI	10.4103/1673-5374.306093
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Article: Structure adjustment for enhancing the water permeability and separation selectivity of the thin film composite nanofiltration membrane based on a dendritic hyperbranched polymer

Zhang, Xiao / Chen, Tian-Hui / Chen, Fang-Fang / Wu, Hao / Yu, Chun-Yang / Liu, Li-Fen / Gao, Cong-Jie

Journal of membrane science. 2021 Jan. 15, v. 618

2021

Abstract: In this study, a dendritic amphiphilic hyperbranched polyester acyl chloride (HPE-COCl) with abundant terminal acyl chloride groups was proposed to incorporate into the polyamide skin layer via interfacial polymerization to adjust the structure and the ... ...

Abstract	In this study, a dendritic amphiphilic hyperbranched polyester acyl chloride (HPE-COCl) with abundant terminal acyl chloride groups was proposed to incorporate into the polyamide skin layer via interfacial polymerization to adjust the structure and the separation performance of the thin film composite (TFC) nanofiltration (NF) membranes. The modified NF membranes based on HPE-COCl exhibit looser, more hydrophilic and negatively charged surface, thereby endowing TFC membranes with relatively higher water permeability and selectivity of monovalent/divalent salts, heavy metals/common monovalent salts, and dyes/common monovalent salts. Especially, the TFC-H2 membrane containing 0.07% w/v HPE-COCl significantly increases the water flux by 145% compared to the pristine membrane. Furthermore, the corresponding selectivity of Fe³⁺/Na⁺ increase about 5.09 times. The hypothesis on the basis of experimental results is that the HPE-COCl with alternating hydrophilic and hydrophobic units is prone to form a plurality of hydrophilic channels based on PEG units and hydrophobic microdomains based on benzoate units, which enhances the water permeation through capillary forces. Moreover, the strong negatively charged surface formed by high-density terminal carboxyl groups in HPE-COCl facilitates the passage of monovalent salts and retains the lager-sized heavy metal salts and dyes, thereby improving the selectivity of membranes. Thus, this work provides a new idea and method for the development of high performance nanofiltration membranes.
Keywords	dyes ; films (materials) ; heavy metals ; hydrophilicity ; hydrophobicity ; iron ; moieties ; nanofiltration ; organochlorine compounds ; permeability ; polyamides ; polyesters ; polymerization ; salts ; sodium ; thin film composite membranes
Language	English
Dates of publication	2021-0115
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	194516-6
ISSN	0376-7388
ISSN	0376-7388
DOI	10.1016/j.memsci.2020.118455
Database	NAL-Catalogue (AGRICOLA)

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Article: [Isolation, Identification, and Biodegradation Behaviors of a Perfluorooctane Sulfonic Acid Precursor (PreFOSs) Degrading Bacterium from Contaminated Soil].

Zhao, Shu-Yan / Zhou, Tao / Wang, Bo-Hui / Liang, Tian-Kun / Liu, Li-Fen

Huan jing ke xue= Huanjing kexue

2018 Volume 39, Issue 7, Page(s) 3321–3328

Abstract: Transformation of perfluorooctane sulfonate (PFOS) precursors (PreFOSs) is considered an additional source of PFOS in the environment and biota. A PreFOSs-degrading bacterium PF1, which was able to utilize PreFOSs as the sole carbon and energy source for ...

Abstract	Transformation of perfluorooctane sulfonate (PFOS) precursors (PreFOSs) is considered an additional source of PFOS in the environment and biota. A PreFOSs-degrading bacterium PF1, which was able to utilize PreFOSs as the sole carbon and energy source for growth, was isolated from contaminated soil collected from the surroundings of a fluoride factory. According to its morphology and 16S rDNA gene sequence analysis, strain PF1 was identified as
MeSH term(s)	Alkanesulfonic Acids/metabolism ; Bacteria/classification ; Bacteria/metabolism ; Biodegradation, Environmental ; Fluorocarbons/metabolism ; Soil ; Soil Microbiology ; Soil Pollutants/metabolism
Chemical Substances	Alkanesulfonic Acids ; Fluorocarbons ; Soil ; Soil Pollutants ; perfluorooctane sulfonic acid (9H2MAI21CL)
Language	Chinese
Publishing date	2018-07-02
Publishing country	China
Document type	Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.201711269
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The GLP-1 receptor agonists exendin-4 and liraglutide alleviate oxidative stress and cognitive and micturition deficits induced by middle cerebral artery occlusion in diabetic mice.

Li, Ping-Chia / Liu, Li-Fen / Jou, Ming-Jia / Wang, Hao-Kuang

BMC neuroscience

2016 Volume 17, Issue 1, Page(s) 37

Abstract: Background: Glucagon-like peptide 1 (GLP-1) analogs protect a variety of cell types against oxidative damage and vascular and neuronal injury via binding to GLP-1 receptors. This study aimed to investigate the effects of the GLP-1 analogs exendin-4 and ... ...

Abstract	Background: Glucagon-like peptide 1 (GLP-1) analogs protect a variety of cell types against oxidative damage and vascular and neuronal injury via binding to GLP-1 receptors. This study aimed to investigate the effects of the GLP-1 analogs exendin-4 and liraglutide on cerebral blood flow, reactive oxygen species production, expression of oxidative stress-related proteins, cognition, and pelvic sympathetic nerve-mediated bladder contraction after middle cerebral artery occlusion (MCAO) injury in the db/db mouse model of diabetes. Results: Sixty minutes of MCAO increased blood and brain reactive oxygen species counts in male db/db mice, as revealed by dihydroethidium staining. MCAO also increased nuclear factor-κB and intercellular adhesion molecule-1 expression and decreased cerebral microcirculation. These effects were attenuated by treatment with exendin-4 or liraglutide. MCAO did not affect basal levels of phosphorylated Akt (p-Akt) or endothelial nitric oxide synthase (p-eNOS); however, exendin-4 and liraglutide treatments significantly enhanced p-Akt and p-eNOS levels, indicating activation of the p-Akt/p-eNOS signaling pathway. MCAO-induced motor and cognitive deficits and micturition dysfunction, indicated by reduced pelvic nerve-mediated voiding contractions and increased nonvoiding contractions, were also partially attenuated by exendin-4 treatment. Conclusions: The above data indicate that treatment with GLP-1 agonists exerts protective effects against oxidative, inflammatory, and apoptotic damage in brain areas that control parasympathetic/pelvic nerve-mediated voiding contractions and cognitive and motor behaviors in a diabetic mouse model.
MeSH term(s)	Animals ; Cerebrovascular Circulation/drug effects ; Cerebrovascular Circulation/physiology ; Cognition Disorders/drug therapy ; Cognition Disorders/etiology ; Cognition Disorders/physiopathology ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/physiopathology ; Glucagon-Like Peptide-1 Receptor/agonists ; Glucagon-Like Peptide-1 Receptor/metabolism ; Hypoglycemic Agents/pharmacology ; Infarction, Middle Cerebral Artery/complications ; Infarction, Middle Cerebral Artery/drug therapy ; Infarction, Middle Cerebral Artery/physiopathology ; Liraglutide/pharmacology ; Male ; Mice ; Movement Disorders/drug therapy ; Movement Disorders/etiology ; Movement Disorders/physiopathology ; Nootropic Agents/pharmacology ; Oxidative Stress/drug effects ; Oxidative Stress/physiology ; Peptides/pharmacology ; Protective Agents/pharmacology ; Urination Disorders/drug therapy ; Urination Disorders/etiology ; Urination Disorders/physiopathology ; Venoms/pharmacology
Chemical Substances	Glp1r protein, mouse ; Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents ; Nootropic Agents ; Peptides ; Protective Agents ; Venoms ; Liraglutide (839I73S42A) ; exenatide (9P1872D4OL)
Language	English
Publishing date	2016-06-13
Publishing country	England
Document type	Journal Article
ISSN	1471-2202
ISSN (online)	1471-2202
DOI	10.1186/s12868-016-0272-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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