LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 10

Search options

  1. Article ; Online: Hsa_circ_0015382 is involved in the pathogenesis of preeclampsia by mediating THBS2 expression.

    Wang, Yang / Liu, Lingfang / Wang, Jiayao / Gao, Yan

    American journal of reproductive immunology (New York, N.Y. : 1989)

    2023  Volume 90, Issue 3, Page(s) e13760

    Abstract: Background: Preeclampsia (PE) is a hypertensive disorder of pregnancy that causes significant maternal and perinatal morbidity and mortality. Circular RNA (circRNA) hsa_circ_0015382 is associated with the pathogenesis of PE, but its underlying ... ...

    Abstract Background: Preeclampsia (PE) is a hypertensive disorder of pregnancy that causes significant maternal and perinatal morbidity and mortality. Circular RNA (circRNA) hsa_circ_0015382 is associated with the pathogenesis of PE, but its underlying regulatory mechanism remains to be explored.
    Methods: Relative RNA levels of hsa_circ_0015382, microRNA-616-3p and thrombospondin-2 (THBS2) were detected by quantitative reverse transcription-polymerase chain reaction. In vitro regulatory effects of hsa_circ_0015382 on the proliferation, migration, invasion and angiogenesis of trophoblasts were evaluated by CCK-8, flow cytometry for cell cycle, EdU, transwell, wound healing and HUVEC tube formation assays, respectively. Targeting interaction was verified by dual-luciferase reporter and RNA immunoprecipitation assays.
    Results: Hsa_circ_0015382 was highly expressed in placental tissues from PE patients. Upregulation of hsa_circ_0015382 repressed trophoblast proliferation, migration, invasion and lowered trophoblast-induced HUVEC tube formation. Hsa_circ_0015382 was validated as a miR-616-3p sponge and miR-616-3p targeted THBS2. Hsa_circ_0015382 could mediate trophoblast proliferation, migration, invasion and regulate trophoblast-induced HUVEC tube formation by sponging miR-616-3p and regulating THBS2 expression.
    Conclusion: Hsa_circ_0015382 is associated with the pathogenesis of PPE by regulating the miR-616-3p/THBS2 axis.
    Highlights: Hsa_circ_0015382 is overexpressed in preeclampsia patients. Hsa_circ_0015382 inhibits trophoblast proliferation, migration, invasion and decreases trophoblast-induced HUVEC tube formation. Hsa_circ_0015382 interacts with miR-616-3p to regulate THBS2 expression.
    MeSH term(s) Female ; Pregnancy ; Humans ; Pre-Eclampsia/genetics ; Placenta ; Thrombospondins/genetics ; Hypertension ; MicroRNAs/genetics
    Chemical Substances Thrombospondins ; MicroRNAs ; MIRN616 microRNA, human
    Language English
    Publishing date 2023-08-29
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 604542-x
    ISSN 1600-0897 ; 0271-7352 ; 8755-8920 ; 1046-7408
    ISSN (online) 1600-0897
    ISSN 0271-7352 ; 8755-8920 ; 1046-7408
    DOI 10.1111/aji.13760
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1653: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Synergy of Bulk Defects and Surface Defects on TiO

    Fu, Cong / Liu, Lingfang / Li, Zhaorui / Wei, Yaxiong / Huang, Weixin / Zhang, Xiaojun

    The journal of physical chemistry letters

    2023  Volume 14, Issue 34, Page(s) 7690–7696

    Abstract: Artificial photosynthesis of ... ...

    Abstract Artificial photosynthesis of H
    Language English
    Publishing date 2023-08-22
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.3c01865
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Urban-Rural Differences in Physical Fitness and Out-of-School Physical Activity for Primary School Students: A County-Level Comparison in Western China.

    Tian, Yunxi / Liu, Lingfang / Wang, Xuhui / Zhang, Xue / Zhai, Yang / Wang, Kai / Liu, Jianjun

    International journal of environmental research and public health

    2021  Volume 18, Issue 20

    Abstract: Rapid urbanization of China has brought lifestyle changes resulting in a continuous decline in children's physical fitness (PF) and out-of-school physical activity (PA). To date, studies have been focused on correlates of PF and out-of-school PA, and ... ...

    Abstract Rapid urbanization of China has brought lifestyle changes resulting in a continuous decline in children's physical fitness (PF) and out-of-school physical activity (PA). To date, studies have been focused on correlates of PF and out-of-school PA, and patterns and trends based on geographic diversity and urban-rural contrasts. Western China, with a large rural population, has substantial urban-rural differences, but little work has been done to compare its children's physical fitness (PF) and out-of-school physical activity (PA) at a county level. A total of 715 primary school students (grades 3-6) were surveyed from one urban school (
    MeSH term(s) Child ; China ; Exercise ; Humans ; Physical Fitness ; Rural Population ; Schools ; Students
    Language English
    Publishing date 2021-10-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph182010813
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Diagnostic value of strain elastography for differentiating benign and malignant soft tissue masses.

    Li, Shilin / Liu, Lingfang / Lv, Guorong

    Oncology letters

    2017  Volume 14, Issue 2, Page(s) 2041–2044

    Abstract: The aim of the current study was to investigate the importance of strain elastography (SE) in the differential diagnosis of benign and malignant soft tissue masses. SE was adopted to examine 61 patients with superficial masses, classify their elastic ... ...

    Abstract The aim of the current study was to investigate the importance of strain elastography (SE) in the differential diagnosis of benign and malignant soft tissue masses. SE was adopted to examine 61 patients with superficial masses, classify their elastic scores and assess their strain ratios (SRs) between the masses and the surrounding structures. Significantly increased SR values and elastic scores were observed in the malignant masses compared with the benign masses (5.42±3.47 vs. 1.80±2.10, P<0.001; 3.13±0.34 vs. 2.03±0.99, P<0.001). Area under receiver operating characteristic curve values of the SRs and elastic scores were 0.87 (P<0.001) and 0.805 (P=0.001), respectively. With an SR of >2.295 as the optimal threshold value, the sensitivity, specificity and positive and negative predictive values for diagnosing a malignant mass were 93.8, 80.5, 65.2 and 97.1%, respectively; whilst using an elastic score of ≥3 as the optimal threshold value, the sensitivity, specificity and positive and negative predictive values for diagnosing a malignant mass were 100, 51.6, 51.6 and 100%, respectively. SR values and elastic scores were significantly different between the malignant and benign soft tissue masses. Therefore, SE may be used to effectively differentiate between malignant and benign soft tissue masses.
    Language English
    Publishing date 2017-06-15
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2573196-8
    ISSN 1792-1082 ; 1792-1074
    ISSN (online) 1792-1082
    ISSN 1792-1074
    DOI 10.3892/ol.2017.6385
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Ultrasmall Pt Clusters Reducing Radiation-Induced Injuries via Scavenging Free Radicals.

    Xu, Fujuan / Mu, Xiaoyu / Wang, Junying / Bian, Peixian / Liu, Lingfang / Liu, Haile / Jing, Yaqi / Long, Wei / Liu, Changlong / Zhang, Xiao-Dong

    Journal of biomedical nanotechnology

    2019  Volume 13, Issue 11, Page(s) 1512–1521

    Abstract: High energy ionizing radiation was widely used in medical diagnosis and cancer radiation therapy. The high dose of X ray ... ...

    Abstract High energy ionizing radiation was widely used in medical diagnosis and cancer radiation therapy. The high dose of X ray or
    Language English
    Publishing date 2019-06-26
    Publishing country United States
    Document type Journal Article
    ISSN 1550-7033
    ISSN 1550-7033
    DOI 10.1166/jbn.2017.2468
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Fluorescence enhancement of gold nanoclusters

    Qiao, Yanqing / Liu, Ying / Liu, Haixia / Li, Yonghui / Long, Wei / Wang, Junying / Mu, Xiaoyu / Chen, Jing / Liu, Haile / Bai, Xueting / Liu, Lingfang / Sun, Yuan-Ming / Liu, Qiang / Guo, Meili / Zhang, Xiao-Dong

    RSC advances

    2018  Volume 8, Issue 14, Page(s) 7396–7402

    Abstract: Gold nanoclusters (NCs) have been widely used in bioimaging and cancer therapy due to their unique electronic structures and tunable luminescence. However, their weak fluorescence prevents potential biomedical application, and thus it is necessary to ... ...

    Abstract Gold nanoclusters (NCs) have been widely used in bioimaging and cancer therapy due to their unique electronic structures and tunable luminescence. However, their weak fluorescence prevents potential biomedical application, and thus it is necessary to develop an effective route to enhance the fluorescence of gold NCs. In this work, we report the fluorescence enhancement of ultrasmall GSH-protected Au NCs by Zn atom doping. The fluorescence signal of Zn-doped Au NCs shows approximately 5-fold enhancement compared to pure Au NCs. Density functional theory (DFT) calculation shows that Zn doping can enhance the electronic states of the highest occupied molecular orbital (HOMO), leading to enhancement of visible optical transitions.
    Language English
    Publishing date 2018-02-15
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/c7ra13072d
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Ultrasmall WS

    Bai, Xueting / Wang, Junying / Mu, Xiaoyu / Yang, Jiang / Liu, Haixia / Xu, Fujuan / Jing, Yaqi / Liu, Lingfang / Xue, Xuhui / Dai, Haitao / Liu, Qiang / Sun, Yuan-Ming / Liu, Changlong / Zhang, Xiao-Dong

    ACS biomaterials science & engineering

    2017  Volume 3, Issue 3, Page(s) 460–470

    Abstract: Two-dimensional ... ...

    Abstract Two-dimensional WS
    Language English
    Publishing date 2017-02-09
    Publishing country United States
    Document type Journal Article
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.6b00714
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Black Phosphorus Quantum Dot Induced Oxidative Stress and Toxicity in Living Cells and Mice.

    Mu, Xiaoyu / Wang, Jun-Ying / Bai, Xueting / Xu, Fujuan / Liu, Haixia / Yang, Jiang / Jing, Yaqi / Liu, Lingfang / Xue, Xuhui / Dai, Haitao / Liu, Qiang / Sun, Yuan-Ming / Liu, Changlong / Zhang, Xiao-Dong

    ACS applied materials & interfaces

    2017  Volume 9, Issue 24, Page(s) 20399–20409

    Abstract: Black phosphorus (BP), as an emerging successor to layered two-dimensional materials, has attracted extensive interest in cancer therapy. Toxicological studies on BP are of great importance for potential biomedical applications, yet not systemically ... ...

    Abstract Black phosphorus (BP), as an emerging successor to layered two-dimensional materials, has attracted extensive interest in cancer therapy. Toxicological studies on BP are of great importance for potential biomedical applications, yet not systemically explored. Herein, toxicity and oxidative stress of BP quantum dots (BPQDs) at cellular, tissue, and whole-body levels are evaluated by performing the systemic in vivo and in vitro experiments. In vitro investigations show that BPQDs at high concentration (200 μg/mL) exhibit significant apoptotic effects on HeLa cells. In vivo investigations indicate that oxidative stress, including lipid peroxidation, reduction of catalase activity, DNA breaks, and bone marrow nucleated cells (BMNC) damage, can be induced by BPQDs transiently but recovered gradually to healthy levels. No apparent pathological damages are observed in all organs, especially in the spleen and kidneys, during the 30-day period. This work clearly shows that BPQDs can cause acute toxicities by oxidative stress responses, but the inflammatory reactions can be recovered gradually with time for up to 30 days. Thus, BPQDs do not give rise to long-term appreciable toxicological responses.
    MeSH term(s) Animals ; HeLa Cells ; Humans ; Lipid Peroxidation ; Mice ; Oxidative Stress ; Phosphorus ; Quantum Dots
    Chemical Substances Phosphorus (27YLU75U4W)
    Language English
    Publishing date 2017-06-06
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.7b02900
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article: Black Phosphorus Quantum Dot Induced Oxidative Stress and Toxicity in Living Cells and Mice

    Mu, Xiaoyu / Wang Jun-Ying / Bai Xueting / Xu Fujuan / Liu Haixia / Yang Jiang / Jing Yaqi / Liu Lingfang / Xue Xuhui / Dai Haitao / Liu Qiang / Sun Yuan-Ming / Liu Changlong / Zhang Xiao-Dong

    ACS applied materials . 2017 June 21, v. 9, no. 24

    2017  

    Abstract: Black phosphorus (BP), as an emerging successor to layered two-dimensional materials, has attracted extensive interest in cancer therapy. Toxicological studies on BP are of great importance for potential biomedical applications, yet not systemically ... ...

    Abstract Black phosphorus (BP), as an emerging successor to layered two-dimensional materials, has attracted extensive interest in cancer therapy. Toxicological studies on BP are of great importance for potential biomedical applications, yet not systemically explored. Herein, toxicity and oxidative stress of BP quantum dots (BPQDs) at cellular, tissue, and whole-body levels are evaluated by performing the systemic in vivo and in vitro experiments. In vitro investigations show that BPQDs at high concentration (200 μg/mL) exhibit significant apoptotic effects on HeLa cells. In vivo investigations indicate that oxidative stress, including lipid peroxidation, reduction of catalase activity, DNA breaks, and bone marrow nucleated cells (BMNC) damage, can be induced by BPQDs transiently but recovered gradually to healthy levels. No apparent pathological damages are observed in all organs, especially in the spleen and kidneys, during the 30-day period. This work clearly shows that BPQDs can cause acute toxicities by oxidative stress responses, but the inflammatory reactions can be recovered gradually with time for up to 30 days. Thus, BPQDs do not give rise to long-term appreciable toxicological responses.
    Keywords DNA damage ; apoptosis ; bone marrow ; catalase ; in vitro studies ; kidneys ; lipid peroxidation ; mice ; neoplasms ; oxidative stress ; phosphorus ; quantum dots ; spleen ; stress response ; therapeutics ; toxicity
    Language English
    Dates of publication 2017-0621
    Size p. 20399-20409.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1944-8252
    DOI 10.1021/acsami.7b02900
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Hollow PtPdRh Nanocubes with Enhanced Catalytic Activities for In Vivo Clearance of Radiation-Induced ROS via Surface-Mediated Bond Breaking.

    Wang, Jun-Ying / Mu, Xiaoyu / Li, Yonghui / Xu, Fujuan / Long, Wei / Yang, Jiang / Bian, Peixian / Chen, Junchi / Ouyang, Lufei / Liu, Haile / Jing, Yaqi / Wang, Jingya / Liu, Lingfang / Dai, Haitao / Sun, Yuanming / Liu, Changlong / Zhang, Xiao-Dong

    Small (Weinheim an der Bergstrasse, Germany)

    2018  Volume 14, Issue 13, Page(s) e1703736

    Abstract: Catalytic nanomaterials can be used extrinsically to combat diseases associated with a surplus of reactive oxygen species (ROS). Rational design of surface morphologies and appropriate doping can substantially improve the catalytic performances. In this ... ...

    Abstract Catalytic nanomaterials can be used extrinsically to combat diseases associated with a surplus of reactive oxygen species (ROS). Rational design of surface morphologies and appropriate doping can substantially improve the catalytic performances. In this work, a class of hollow polyvinyl pyrrolidone-protected PtPdRh nanocubes with enhanced catalytic activities for in vivo free radical scavenging is proposed. Compared with Pt and PtPd counterparts, ternary PtPdRh nanocubes show remarkable catalytic properties of decomposing H
    MeSH term(s) Catalase/metabolism ; Catalysis ; Hydrogen Peroxide/chemistry ; Hydrogen Peroxide/metabolism ; Nanostructures/chemistry ; Palladium/chemistry ; Peroxidase/metabolism ; Platinum/chemistry ; Reactive Oxygen Species/metabolism ; Superoxide Dismutase/metabolism
    Chemical Substances Reactive Oxygen Species ; Platinum (49DFR088MY) ; Palladium (5TWQ1V240M) ; Hydrogen Peroxide (BBX060AN9V) ; Catalase (EC 1.11.1.6) ; Peroxidase (EC 1.11.1.7) ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2018-02-09
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1613-6829
    ISSN (online) 1613-6829
    DOI 10.1002/smll.201703736
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top