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  1. Article ; Online: Risk Factors and Prognosis of Early Neurological Deterioration after Bridging Therapy.

    Xie, Yiju / Li, Shengyu / Liu, Liuyu / Tang, Shiting / Liu, Yayuan / Tan, Shuangquan / Liang, Zhijian

    Current neurovascular research

    2024  

    Abstract: Background: Early neurological deterioration (END) after bridging therapy (BT) of acute ischemic stroke (AIS) patients is associated with poor outcomes.: Objective: We aimed to study the incidence, risk factors and prognosis of END after BT.: ... ...

    Abstract Background: Early neurological deterioration (END) after bridging therapy (BT) of acute ischemic stroke (AIS) patients is associated with poor outcomes.
    Objective: We aimed to study the incidence, risk factors and prognosis of END after BT.
    Methods: From January to December 2021, the clinical data of AIS patients treated by BT (intravenous thrombolysis with alteplase prior to mechanical thrombectomy) from three comprehensive stroke centers were analyzed. Patients were divided into non-END group and END group according to whether they developed END within 72 hours of symptom onset. Modified Rankin scale (mRS) was used to assess the patient's prognosis at 90 days, and favorable outcomes were defined as mRS≤2. The incidence of END was investigated, and binary logistic regression analysis was used to explore its associated factors.
    Results: The incidence of END after BT was 33.67%. The eligible 90 patients included 29 cases in the END group and 61 cases in the non-END group. Multivariate Logistic regression analysis showed that increase of systolic blood pressure (SBP) (OR=1.026, 95%CI:1.001-1.051, p =0.043), higher level of blood glucose at admission (OR=1.389, 95%CI:1.092-1.176, p =0.007) and large artery atherosclerosis (LAA) subtype (OR=8.009, 95%CI:2.357-27.223, p =0.001) were independent risk factors of END. Compared with the non-END group, the END group had significantly lower rates of good outcomes (6.90% versus 65.57%, p =0.001) while higher rates of mortality (44.83% versus 4.92%, p =0.001).
    Conclusion: It was found that the incidence of END after BT in AIS patients was 33.67%. An increase in SBP, higher glucose levels at admission, and LAA were independent risk factors of END that predicted a poor prognosis.
    Language English
    Publishing date 2024-01-17
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2296350-9
    ISSN 1875-5739 ; 1567-2026
    ISSN (online) 1875-5739
    ISSN 1567-2026
    DOI 10.2174/0115672026287986240104074006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Weighted Gene Co-Expression Network Analysis to Identify Potential Biological Processes and Key Genes in COVID-19-Related Stroke.

    Cen, Gengyu / Liu, Liuyu / Wang, Jun / Wang, Xue / Chen, Shijian / Song, Yiting / Liang, Zhijian

    Oxidative medicine and cellular longevity

    2022  Volume 2022, Page(s) 4526022

    Abstract: The purpose of this research was to explore the underlying biological processes causing coronavirus disease 2019- (COVID-19-) related stroke. The Gene Expression Omnibus (GEO) database was utilized to obtain four COVID-19 datasets and two stroke datasets. ...

    Abstract The purpose of this research was to explore the underlying biological processes causing coronavirus disease 2019- (COVID-19-) related stroke. The Gene Expression Omnibus (GEO) database was utilized to obtain four COVID-19 datasets and two stroke datasets. Thereafter, we identified key modules via weighted gene co-expression network analysis, following which COVID-19- and stroke-related crucial modules were crossed to identify the common genes of COVID-19-related stroke. The common genes were intersected with the stroke-related hub genes screened via Cytoscape software to discover the critical genes associated with COVID-19-related stroke. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis for common genes associated with COVID-19-related stroke, and the Reactome database was used to annotate and visualize the pathways involved in the key genes. Two COVID-19-related crucial modules and one stroke-related crucial module were identified. Subsequently, the top five genes were screened as hub genes after visualizing the genes of stroke-related critical module using Cytoscape. By intersecting the COVID-19- and stroke-related crucial modules, 28 common genes for COVID-19-related stroke were identified. ITGA2B and ITGB3 have been further identified as crucial genes of COVID-19-related stroke. Functional enrichment analysis indicated that both ITGA2B and ITGB3 were involved in integrin signaling and the response to elevated platelet cytosolic Ca
    MeSH term(s) COVID-19/complications ; COVID-19/genetics ; Computational Biology ; Gene Expression Profiling ; Gene Ontology ; Gene Regulatory Networks ; Humans ; Integrin alpha2/genetics ; Integrin beta3/genetics ; Stroke/genetics ; Stroke/virology
    Chemical Substances ITGA2B protein, human ; ITGB3 protein, human ; Integrin alpha2 ; Integrin beta3
    Language English
    Publishing date 2022-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2455981-7
    ISSN 1942-0994 ; 1942-0994
    ISSN (online) 1942-0994
    ISSN 1942-0994
    DOI 10.1155/2022/4526022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Acute Ischemic Stroke in Tubercular Meningitis Patients Without Conventional Vascular Risk Factors: A Retrospective Case Control Study.

    Tang, Shiting / Liu, Liuyu / Xie, Zhouhua / He, Yaoqin / Zhang, Yunli / Xie, Yiju / Chen, Shijian / Liu, Yayuan / Wei, Yunfei / Liang, Zhijian

    Journal of inflammation research

    2022  Volume 15, Page(s) 6617–6627

    Abstract: Objective: Ischemic stroke is a common complication in patients with tubercular meningitis (TBM). However, the risk factors for Ischemic stroke in TBM patients are not fully understood, especially in those patients without conventional vascular risk ... ...

    Abstract Objective: Ischemic stroke is a common complication in patients with tubercular meningitis (TBM). However, the risk factors for Ischemic stroke in TBM patients are not fully understood, especially in those patients without conventional vascular risk factors. The aim of the present study was to explore the clinical features and independent risk factors for tubercular meningitis-related Ischemic stroke (TBMRIS).
    Methods: Tubercular meningitis patients with acute Ischemic stroke without conventional vascular risk factors were recruited between July 2010 and July 2020 as the TBMRIS group. Patients who solely had tubercular meningitis were recruited as the control group (TMB group). Demographic characteristics, clinical presentations, and cerebrospinal fluid (CSF) examinations were collected, and multiple logistic regression analysis was applied to analyse the independent risk factors for TBMRIS.
    Results: A total of 70 TBMRIS patients and 70 TMB patients were enrolled. Most (82.86%) of the TBMRIS patients experienced Ischemic stroke events within 3 months after the diagnosis of tubercular meningitis. The multiple logistic regression analysis revealed that variation in red blood cell distribution width (RDW-CV), mean platelet volume (MVP), C-reactive protein (CRP), CSF glucose and Modified Research Council Grade II (MRC Grade II) were independent risk factors for TBRIS. The AUC of the identification model was 0.808, with a sensitivity of 68.60% and a specificity of 84.30%.
    Conclusion: This study revealed that RDW-CV, MVP, CRP, CSF glucose and MRC Grade II are potential independent risk factors for TBMRIS. The identification model established in this study may help monitor TBM patients who are at high risk of developing TBMRIS.
    Language English
    Publishing date 2022-12-07
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494878-0
    ISSN 1178-7031
    ISSN 1178-7031
    DOI 10.2147/JIR.S392040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Pulmonary Tuberculosis-Related Ischemic Stroke: A Retrospective Case Control Study.

    Wei, Yunfei / Tang, Shiting / Xie, Zhouhua / He, Yaoqin / Zhang, Yunli / Xie, Yiju / Chen, Shijian / Liu, Liuyu / Liu, Yayuan / Liang, Zhijian

    Journal of inflammation research

    2022  Volume 15, Page(s) 4239–4249

    Abstract: Objective: There have been only a few studies of ischemic stroke in patients with pulmonary tuberculosis (pTB). This study aimed to explore the clinical features and the underlying pathogenesis of pulmonary tuberculosis-related ischemic stroke (TBRIS).!# ...

    Abstract Objective: There have been only a few studies of ischemic stroke in patients with pulmonary tuberculosis (pTB). This study aimed to explore the clinical features and the underlying pathogenesis of pulmonary tuberculosis-related ischemic stroke (TBRIS).
    Methods: Active pulmonary tuberculosis patients with acute ischemic stroke (without conventional vascular risk factors) were recruited as the TBRIS group. Patients who solely had active pulmonary tuberculosis were recruited as the control group (pTB group). Clinical data were collected, and multiple logistic regression analysis was applied to analyze the independent risk factors for TBRIS.
    Results: A total of 179 TBRIS patients and 179 pTB patients were enrolled. Most (56.42%) of the TBRIS patients experienced the ischemic stroke events within 3 months after the diagnosis of tuberculosis. The multiple logistic regression analysis revealed that an increased mean platelet volume; elevated plasma D-dimer, C-reactive protein, and serum ferritin levels; and an increased monocyte percentage were independent risk factors for TBRIS. The AUC of the identification model was 0.778, with a sensitivity of 70.30% and a specificity of 78.90%.
    Conclusion: The findings in the present study suggested that most of the TBRIS patients experienced ischemic stroke within 3 months after the diagnosis of tuberculosis. And the more intensive immune response to the tuberculosis infection in the TBRIS group contributed to the initiation of platelet activation and to the development of a hypercoagulable state, which were attributed to the pathogenesis of TBRIS. Index of TBRIS equaling to 0.3234 facilitates clinicians to identify the pTB patients who were at higher risk for TBRIS, and allow physicians to take further effective measures to prevent ischemic stroke in patients with pTB. However, our findings will need to be confirmed by further studies.
    Language English
    Publishing date 2022-07-26
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494878-0
    ISSN 1178-7031
    ISSN 1178-7031
    DOI 10.2147/JIR.S368183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The investigation on the hypercoagulability of hepatocellular carcinoma-related cerebral infarction with thromboelastography.

    Cen, Gengyu / Song, Yiting / Chen, Shijian / Liu, Liuyu / Wang, Jun / Zhang, Jian / Li, Jing / Li, Guohui / Li, Haihua / Liang, Hongbin / Liang, Zhijian

    Brain and behavior

    2023  Volume 13, Issue 4, Page(s) e2961

    Abstract: Aim: To investigate the hypercoagulability of hepatocellular carcinoma (HCC)-related cerebral infarction (HCRCI) with thromboelastography (TEG).: Methods: A multicenter prospective study was conducted in HCRCI patients, HCC patients without cerebral ... ...

    Abstract Aim: To investigate the hypercoagulability of hepatocellular carcinoma (HCC)-related cerebral infarction (HCRCI) with thromboelastography (TEG).
    Methods: A multicenter prospective study was conducted in HCRCI patients, HCC patients without cerebral infarction, and acute cerebral infarction (ACI) patients without HCC between January 2016 and December 2019. TEG parameters and laboratory and clinical data were collected and compared among the three groups. To confirm the independent risk factors of HCRCI, multivariate analyses were conducted. Receiver operating characteristic (ROC) curves were utilized to evaluate the area under the curve (AUC) plotted by each independent risk factor.
    Results: There were 38 patients recruited in the HCRCI group, and 152 patients were recruited to the HCC group and the ACI group. The levels of plasma neutrophil count, D-dimer, α-fetoprotein (AFP), carcinoembryonic antigen, and maximum amplitude (MA)-a parameter of TEG-were significantly higher in the HCRCI group than HCC and ACI groups. Multivariate logistic regression analysis showed that increased neutrophile count, D-dimer, AFP, and MA were independently associated with HCRCI. ROC curve analysis showed first that AUC of MA for HCRCI was .875, which was larger than the other risk factors, and second that the optimal cutoff value for MA was 61.35, with a sensitivity of 89.50% and specificity of 66.40%.
    Conclusion: It was suggested that TEG disclosed that the pathogenesis of HCRIC is exactly related to the hypercoagulability. And with a cutoff value of MA equaling to 61.35, TEG facilitates clinicians to identify HCC patients at high risk of HCRIC.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/pathology ; Thrombelastography ; alpha-Fetoproteins ; Liver Neoplasms/complications ; Liver Neoplasms/pathology ; Prospective Studies ; Cerebral Infarction/etiology ; ROC Curve ; Stroke ; Thrombophilia/diagnosis ; Thrombophilia/etiology ; Brain Ischemia ; Acute Disease
    Chemical Substances alpha-Fetoproteins
    Language English
    Publishing date 2023-03-16
    Publishing country United States
    Document type Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2623587-0
    ISSN 2162-3279 ; 2162-3279
    ISSN (online) 2162-3279
    ISSN 2162-3279
    DOI 10.1002/brb3.2961
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and the Risk of Leukoaraiosis in a South Chinese Han Population: A Case-Control Study.

    Mo, Dong-Can / Wu, Xiao-Ju / Li, Xiao-Ling / Liu, Liu-Yu / Jiang, Yi-Ying / Zhou, Guo-Qiu / Chen, Li-Jie / Li, Jiao-Xing / Luo, Man

    Biochemical genetics

    2023  

    Abstract: Leukoaraiosis (LA) appears as white matter hyperintensities on T2-weighted brain magnetic resonance imaging scans. Age and hypertension are considered the primary risk factors for LA, but its pathogenesis remains uncertain. This study aims to investigate ...

    Abstract Leukoaraiosis (LA) appears as white matter hyperintensities on T2-weighted brain magnetic resonance imaging scans. Age and hypertension are considered the primary risk factors for LA, but its pathogenesis remains uncertain. This study aims to investigate the correlation between the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and LA. A total of 140 patients with LA and 136 neuroimaging alteration-free controls were recruited in a case-control study. ACE I/D polymorphism was determined using the polymerase chain reaction method. The allele and genotype distributions of the ACE I/D polymorphism were significantly different between subjects with and without LA. Significant difference was observed in the genotypic distribution between LA patients and controls for recessive and additive models. A statistically significant association remained apparent after adjusting for potential risk factors (D/D vs. I/D + I/I: adjusted OR 3.251, 95% CI 1.185-8.918; D/D vs. I/I: adjusted OR 3.277, 95% CI 1.187-9.047). Our results indicate that the D/D genotype and D allele are important risk factors for LA. Future studies with larger populations are needed to validate our results.
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2168-4
    ISSN 1573-4927 ; 0006-2928
    ISSN (online) 1573-4927
    ISSN 0006-2928
    DOI 10.1007/s10528-023-10505-7
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  7. Article ; Online: Neuronal intranuclear inclusion disease with cortical involvement in left hemisphere: a case report.

    Wu, Xiao-Ju / Jiang, Yi-Ying / Chen, Li-Jie / Zhou, Guo-Qiu / Mo, Dong-Can / Liu, Liu-Yu / Li, Jian-Li / Li, Xiao-Ling / Tang, Yu-Lan / Luo, Man

    Wiener klinische Wochenschrift

    2023  Volume 136, Issue 1-2, Page(s) 67–72

    Abstract: Background: Neuronal intranuclear inclusion disease (NIID) is a rare highly heterogeneous disease. In this paper, we present a case of NIID featured in cortical involvement in left hemisphere of brain and the imaging changes in the process of the ... ...

    Abstract Background: Neuronal intranuclear inclusion disease (NIID) is a rare highly heterogeneous disease. In this paper, we present a case of NIID featured in cortical involvement in left hemisphere of brain and the imaging changes in the process of the disease.
    Case presentation: A 57-year-old female was hospitalized due to recurrent attacks of headache with cognitive impairment and tremor for 2 years. The symptoms of headache episodes were reversible. The characteristic radiologic change was high intensity signal involving the grey matter-white matter junction on the brain diffusion-weighted imaging (DWI), which existed in the frontal lobe and then extended backwards. Atypical features on fluid-attenuated inversion recovery (FLAIR) sequences showing small patchy high signals in the cerebellar vermis. High signals and edema were detected on FLAIR images along the cortex of the left occipito-parieto-temporal lobes, expanding and gradually shrinking in the follow-up visit. Besides, cerebral atrophy and bilateral symmetrical leukoencephalopathy were also detected. Skin biopsy and genetic testing confirmed the diagnosis of NIID.
    Conclusion: Except for typical radiological change strongly suggesting NIID, it is also necessary to notice the insidious symptoms of NIID combining with some atypical imaging features to make an early diagnosis. Skin biopsies or genetic testing should be carried out early in patients with highly suspected NIID.
    MeSH term(s) Female ; Humans ; Middle Aged ; Neurodegenerative Diseases/complications ; Neurodegenerative Diseases/diagnosis ; Neurodegenerative Diseases/pathology ; Magnetic Resonance Imaging ; Diffusion Magnetic Resonance Imaging ; Headache
    Language English
    Publishing date 2023-06-30
    Publishing country Austria
    Document type Case Reports ; Journal Article
    ZDB-ID 200462-8
    ISSN 1613-7671 ; 0043-5325 ; 0300-5178
    ISSN (online) 1613-7671
    ISSN 0043-5325 ; 0300-5178
    DOI 10.1007/s00508-023-02232-1
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    Zs.A 902: Show issues Location:
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  8. Article ; Online: Loss of Gucy1a3 causes poor post-stroke recovery by reducing angiogenesis via the HIF-1α/VEGFA signaling pathway in mice.

    Luo, Man / Mo, Dongcan / Liu, LiuYu / Li, Jianli / Lin, Jing / Liang, Jie / Ye, Fei / Wu, Xiaoju / Li, Xiaoling / Li, Jiaoxing / Sheng, Wenli

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2023  Volume 33, Issue 2, Page(s) 107484

    Abstract: Objectives: Ischemic stroke is a common and debilitating disease that can cause permanent neurological damage. Gucy1a3, which encodes the α1 subunit of soluble guanylyl cyclase, has been reported to be associated with functional recovery after ischemic ... ...

    Abstract Objectives: Ischemic stroke is a common and debilitating disease that can cause permanent neurological damage. Gucy1a3, which encodes the α1 subunit of soluble guanylyl cyclase, has been reported to be associated with functional recovery after ischemic stroke. However, the mechanism is still not well understood. In the present study, we investigated the effects of Gucy1a3 on (i) post-stroke recovery; (ii) vascular endothelial growth factor A (VEGFA) and hypoxia inducible factor 1 alpha (HIF-1α) expression; and (iii) angiogenesis after ischemic stroke.
    Materials and methods: Wild-type and Gucy1a3 knockout C57BL/6J male mice were respectively used to establish the models of permanent middle cerebral artery occlusion (pMCAO). Neurological deficit scores were evaluated at 24 h and 96 h after pMCAO. Cerebral infarct volume was measured by 2,3,5-triphenyltetrazolium chloride (TTC) staining. For determining microvessel density, immunohistochemical analysis was performed with CD31. The expression of VEGFA and HIF-1α was detected by western blotting.
    Results: Our results suggest that loss of Gucy1a3 increased the infarct volume and aggravated neurological deficits after pMCAO. In addition, the Gucy1a3 knockout brains exhibited significantly lower microvessel densities and VEGFA and HIF-1α expression levels than the wild-type brains at 96 h post-pMCAO.
    Conclusions: Our study indicates that GUCY1A3 might be involved in angiogenesis after ischemic stroke. Further investigation of GUCY1A3 will provide a new therapeutic target for stroke.
    MeSH term(s) Animals ; Male ; Mice ; Angiogenesis ; Brain Ischemia/drug therapy ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Infarction, Middle Cerebral Artery/metabolism ; Ischemic Stroke ; Mice, Inbred C57BL ; Signal Transduction ; Soluble Guanylyl Cyclase/metabolism ; Soluble Guanylyl Cyclase/pharmacology ; Soluble Guanylyl Cyclase/therapeutic use ; Stroke ; Vascular Endothelial Growth Factor A/metabolism
    Chemical Substances Hypoxia-Inducible Factor 1, alpha Subunit ; Soluble Guanylyl Cyclase (EC 4.6.1.2) ; Vascular Endothelial Growth Factor A ; Gucy1a3 protein, mouse
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2023.107484
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  9. Article: Association between polymorphisms in ABO gene and stroke patients with small artery occlusion in southern Chinese Han population

    Jiang, Yi-ying / Li, Jian-li / Liu, Liu-yu / Zhou, Guo-qiu / Mo, Dong-can / Jiang, Dong-dong / Luo, Man

    Gene. 2021 Feb. 15, v. 769

    2021  

    Abstract: The purpose of this study was to investigate associations between two single nucleotide polymorphisms (SNPs) rs505922 and rs532436 in ABO gene and the risk of small artery occlusion stroke (SAO) in southern Chinese Han population.Our case-control study ... ...

    Abstract The purpose of this study was to investigate associations between two single nucleotide polymorphisms (SNPs) rs505922 and rs532436 in ABO gene and the risk of small artery occlusion stroke (SAO) in southern Chinese Han population.Our case-control study comprising 121 patients with SAO and 136 controls. All participants were Han population of southern China. IS sub-type was defined on the basis of the TOAST criteria. SAO was strictly diagnosed after a systematic physical examination and neuroimaging via MRI. Genotype analysis was conducted by the snapshot technique.The distribution of rs532436 genotype between these two groups showed a statistically significant difference (P = 0.048) while that of rs505922 genotype showed no significant difference (P = 0.572). SNP rs532436 was significantly associated with SAO in overdominant model (GA vs. GG + AA) after adjusting for age, hypertension history, diabetes history and cigarette smoking (adjusted OR = 2.03, 95% CI: 1.14–3.62, P = 0.016). However, under all genetic models, the rs505922 polymorphism failed to show association with SAO.The resultsindicate that rs532436 polymorphism in ABO gene may have association with SAO in southern Chinese Han population.
    Keywords Chinese people ; age ; case-control studies ; clinical examination ; diabetes ; genes ; genetic models ; genotype ; history ; hypertension ; patients ; polymorphism ; population ; risk ; single nucleotide polymorphism ; smoking (habit) ; stroke ; China
    Language English
    Dates of publication 2021-0215
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-light
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2020.145211
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  10. Article: Cancer Related Subarachnoid Hemorrhage: A Multicenter Retrospective Study Using Propensity Score Matching Analysis.

    Chen, Shijian / Zhang, Jian / Lu, Xianfu / Cen, Gengyu / Song, Yiting / Deng, Xuhui / Xie, Yiju / Liu, Liuyu / Liu, Qianqian / Huang, Junling / Li, Jing / Yang, Hong / Shi, Shengliang / Pan, Liya / Liang, Zhijian

    Frontiers in cellular neuroscience

    2022  Volume 16, Page(s) 813084

    Abstract: Objective: To investigate the clinical features, risk factors and underlying pathogenesis of cancer related subarachnoid hemorrhage (SAH).: Methods: Clinical data of SAH in patients with active cancer from January 2010 to December 2020 at four ... ...

    Abstract Objective: To investigate the clinical features, risk factors and underlying pathogenesis of cancer related subarachnoid hemorrhage (SAH).
    Methods: Clinical data of SAH in patients with active cancer from January 2010 to December 2020 at four centers were retrospectively reviewed. Patients with active cancer without SAH were matched to SAH patients with active cancer group. Logistic regression was applied to investigate the independent risk factors of SAH in patients with active cancer, after a 1:1 propensity score matching (PSM). A receiver operator characteristic curve was configured to calculate the optimal cut-off value of the joint predictive factor for cancer related SAH.
    Results: A total of 82 SAH patients with active cancer and 309 patients with active cancer alone were included. Most SAH patients with cancer had poor outcomes, with 30-day mortality of 41.5%, and with 90-day mortality of 52.0%. The PSM yielded 75 pairs of study participants. Logistic regression revealed that a decrease in platelet and prolonged prothrombin time were the independent risk factors of cancer related SAH. In addition, receiver operator characteristic curve of the joint predictive factor showed the largest AUC of 0.8131, with cut-off value equaling to 11.719, with a sensitivity of 65.3% and specificity of 89.3%.
    Conclusion: Patients with cancer related SAH often have poor outcomes. The decrease in platelet and prolonged prothrombin time are the independent risk factors of cancer related SAH, and the joint predictive factor with cutoff value equal to 11.719 should hence serve as a novel biomarker of cancer related SAH.
    Language English
    Publishing date 2022-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2022.813084
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