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Article ; Online: The benefit of contrast-enhanced ultrasound in biopsies for focal liver lesions: a retrospective study of 820 cases.

Huang, Jia-Xin / Shi, Cai-Gou / Xu, Yan-Fen / Fu, Juan / Zhong, Yuan / Liu, Long-Zhong / Pei, Xiao-Qing

2022 Volume 32, Issue 10, Page(s) 6830–6839

Abstract: Objective: This study compared the performance between ultrasound (US)- and contrast-enhanced US (CEUS)-guided liver biopsies and evaluated the benefit of CEUS in percutaneous biopsy for focal liver lesions (FLLs).: Methods: We performed a ... ...

Abstract	Objective: This study compared the performance between ultrasound (US)- and contrast-enhanced US (CEUS)-guided liver biopsies and evaluated the benefit of CEUS in percutaneous biopsy for focal liver lesions (FLLs). Methods: We performed a retrospective study of 820 patients with FLLs, who underwent percutaneous liver biopsy in our center between 2017 and 2019. The patients were divided into two groups based on whether US (n = 362) or CEUS (n = 458) used before a biopsy. The two groups were compared based on specimen adequacy for pathological diagnosis and diagnostic accuracy of liver biopsy. Stratification analysis was performed based on lesion and protocol characteristics to provide detailed information for selecting the imaging guidance for biopsy. Results: Compared with the US group, the CEUS group yielded more acceptable samples (97.6% vs. 99.4%, p < 0.05) and improved diagnostic accuracy (92.6% vs. 96.4%, p < 0.05), and achieved better sensitivity (92.5% vs. 96.2%, p < 0.05) for liver biopsies, especially in FLLs ≥ 5 cm, heterogeneous hypoechoic FLLs, or FLLs with an obscure boundary. The CEUS group showed significantly higher accuracy compared with the US group pertaining to single-puncture biopsies (100% vs. 92.7%, p < 0.05) or biopsies with punctures ≤ 2 (97.6% vs. 94.3%, p < 0.05). Conclusion: CEUS achieved an enhanced success rate for sampling and diagnostic accuracy of liver biopsies, especially in FLLs ≥ 5 cm, heterogeneous hypoechoic FLLs, or FLLs with an obscure boundary. CEUS can be used to decrease the number of punctures needed, which might increase the safety of liver biopsy. Key points: • CEUS can help confirm an adequate biopsy site, increasing the sampling success rate and diagnostic accuracy of the liver biopsy. • CEUS can be used to decrease the number of punctures needed to improve the safety of liver biopsy. • It is recommended to use CEUS guidance for liver biopsies, especially with FLLs ≥ 5 cm, heterogeneous hypoechoic FLLs, or FLLs with an obscure boundary.
MeSH term(s)	Biopsy ; Contrast Media/pharmacology ; Humans ; Liver/diagnostic imaging ; Liver/pathology ; Liver Neoplasms/pathology ; Retrospective Studies ; Sensitivity and Specificity ; Ultrasonography/methods
Chemical Substances	Contrast Media
Language	English
Publishing date	2022-07-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-022-08988-w
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Zs.A 3300: Show issues

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Article ; Online: Deep Learning Model Based on Dual-Modal Ultrasound and Molecular Data for Predicting Response to Neoadjuvant Chemotherapy in Breast Cancer.

Huang, Jia-Xin / Shi, Jun / Ding, Sai-Sai / Zhang, Hui-Li / Wang, Xue-Yan / Lin, Shi-Yang / Xu, Yan-Fen / Wei, Ming-Jie / Liu, Long-Zhong / Pei, Xiao-Qing

Academic radiology

2023 Volume 30 Suppl 2, Page(s) S50–S61

Abstract: Rationale and objectives: To carry out radiomics analysis/deep convolutional neural network (CNN) based on B-mode ultrasound (BUS) and shear wave elastography (SWE) to predict response to neoadjuvant chemotherapy (NAC) in breast cancer patients.: ... ...

Abstract	Rationale and objectives: To carry out radiomics analysis/deep convolutional neural network (CNN) based on B-mode ultrasound (BUS) and shear wave elastography (SWE) to predict response to neoadjuvant chemotherapy (NAC) in breast cancer patients. Materials and methods: In this prospective study, 255 breast cancer patients who received NAC between September 2016 and December 2021 were included. Radiomics models were designed using a support vector machine classifier based on US images obtained before treatment, including BUS and SWE. And CNN models also were developed using ResNet architecture. The final predictive model was developed by combining the dual-modal US and independently associated clinicopathologic characteristics. The predictive performances of the models were assessed with five-fold cross-validation. Results: Pretreatment SWE performed better than BUS in predicting the response to NAC for breast cancer for both the CNN and radiomics models (P < 0.001). The predictive results of the CNN models were significantly better than the radiomics models, with AUCs of 0.72 versus 0.69 for BUS and 0.80 versus 0.77 for SWE, respectively (P = 0.003). The CNN model based on the dual-modal US and molecular data exhibited outstanding performance in predicting NAC response, with an accuracy of 83.60% ± 2.63%, a sensitivity of 87.76% ± 6.44%, and a specificity of 77.45% ± 4.38%. Conclusion: The pretreatment CNN model based on the dual-modal US and molecular data achieved excellent performance for predicting the response to chemotherapy in breast cancer. Therefore, this model has the potential to serve as a non-invasive objective biomarker to predict NAC response and aid clinicians with individual treatments.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Deep Learning ; Neoadjuvant Therapy ; Prospective Studies ; Ultrasonography/methods ; Retrospective Studies
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1355509-1
ISSN	1878-4046 ; 1076-6332
ISSN (online)	1878-4046
ISSN	1076-6332
DOI	10.1016/j.acra.2023.03.036
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Zs.A 4594: Show issues

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Article ; Online: Shear wave elastography-based ultrasomics: differentiating malignant from benign focal liver lesions.

Wang, Wei / Zhang, Jian-Chao / Tian, Wen-Shuo / Chen, Li-Da / Zheng, Qiao / Hu, Hang-Tong / Wu, Shan-Shan / Guo, Yu / Xie, Xiao-Yan / Lu, Ming-De / Kuang, Ming / Liu, Long-Zhong / Ruan, Si-Min

Abdominal radiology (New York)

2020 Volume 46, Issue 1, Page(s) 237–248

Abstract: Purpose: Ultrasomics is a radiomics technique that extracts high-throughput quantitative data from ultrasound imaging. The aim of this study was to differentiate malignant from benign focal liver lesions (FLLs) using two-dimensional shear wave ... ...

Abstract	Purpose: Ultrasomics is a radiomics technique that extracts high-throughput quantitative data from ultrasound imaging. The aim of this study was to differentiate malignant from benign focal liver lesions (FLLs) using two-dimensional shear wave elastography (2D-SWE)-based ultrasomics. Methods: A total of 175 FLLs in 169 patients were prospectively analyzed. The study population was divided into a training cohort (n = 122) and a validation cohort (n = 53). The maxima, minima, mean, and standard deviation of 2D-SWE measurements were expressed in kilopascals (E Results: A total of 1044 features were extracted and 15 features were selected. The AUC for the combined score, ultrasomics score, E Conclusion: The results of this study demonstrated that the combined score had good diagnostic accuracy in differentiating malignant from benign FLLs.
MeSH term(s)	Digestive System Diseases ; Elasticity Imaging Techniques ; Humans ; Liver Neoplasms/diagnostic imaging ; Sensitivity and Specificity ; Ultrasonography
Language	English
Publishing date	2020-06-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2839786-1
ISSN	2366-0058 ; 2366-004X
ISSN (online)	2366-0058
ISSN	2366-004X
DOI	10.1007/s00261-020-02614-3
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Zs.A 1262: Show issues

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Article ; Online: Transvaginal Ultrasound-Guided Core Needle Biopsy of Pelvic Masses.

Lin, Shi-Yang / Xiong, Yong-Hong / Yun, Miao / Liu, Long-Zhong / Zheng, Wei / Lin, Xi / Pei, Xiao-Qing / Li, An-Hua

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

2017 Volume 37, Issue 2, Page(s) 453–461

Abstract: Objectives: This study assessed the efficacy and safety of transvaginal ultrasound (US)-guided core needle biopsy (CNB) for obtaining adequate pelvic mass samples for histologic analysis and evaluated factors that may affect biopsy success.: Methods: ...

Abstract	Objectives: This study assessed the efficacy and safety of transvaginal ultrasound (US)-guided core needle biopsy (CNB) for obtaining adequate pelvic mass samples for histologic analysis and evaluated factors that may affect biopsy success. Methods: Two hundred cases underwent transvaginal US-guided CNBs for primary inoperable tumors, suspicion of metastases to the ovaries or peritoneum, recurrence, or other solid lesions in the pelvis. Biopsy samples were obtained from the pelvic cavity (67.0%), vaginal cuff or vaginal wall (17.5%), or peritoneal cake (15.5%). The potential influences of the biopsy site (pelvic cavity, vaginal cuff or vaginal wall, or peritoneal cake), vascularization, ascites, tumor size, and tumor type (inoperable, metastases, recurrence, or solid pelvic tumor) on the success of transvaginal US-guided CNB were evaluated by a univariate analysis. Results: Adequate samples were obtained in 192 of 200 biopsies (96.0%), of which 190 yielded successful diagnoses (95.0%). The biopsy site had a significant effect on biopsy adequacy, as there was a significantly lower probability of obtaining satisfactory specimens for histologic verification from the peritoneal cake compared to pelvic tumors and the vaginal cuff or vaginal wall (P < .01). Adequacy was also affected by tumor size (P < .05) but not by vascularization, ascites, or tumor type. No complications occurred during the biopsy procedures. Conclusions: Transvaginal US-guided CNB is a safe and effective alternative to more invasive methods for evaluating pelvic lesions, such as laparoscopy and laparotomy.
MeSH term(s)	Adult ; Biopsy, Large-Core Needle/methods ; Female ; Humans ; Image-Guided Biopsy/methods ; Middle Aged ; Pelvic Neoplasms/diagnostic imaging ; Pelvic Neoplasms/pathology ; Pelvis/diagnostic imaging ; Pelvis/pathology ; Reproducibility of Results ; Retrospective Studies ; Ultrasonography, Interventional/methods ; Vagina/diagnostic imaging
Language	English
Publishing date	2017-09-08
Publishing country	England
Document type	Journal Article
ZDB-ID	604829-8
ISSN	1550-9613 ; 0278-4297
ISSN (online)	1550-9613
ISSN	0278-4297
DOI	10.1002/jum.14356
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Zs.A 1793: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Can quantitative contrast-enhanced ultrasonography predict cervical tumor response to neoadjuvant chemotherapy?

Peng, Chuan / Liu, Long-Zhong / Zheng, Wei / Xie, Yan-Jun / Xiong, Yong-Hong / Li, An-Hua / Pei, Xiao-Qing

European journal of radiology

2016 Volume 85, Issue 11, Page(s) 2111–2118

Abstract: Objective: To evaluate the feasibility of quantitative contrast-enhanced ultrasonography (CEUS) for predicting and assessing cervical tumor response to neoadjuvant chemotherapy (NACT).: Methods: Thirty-eight cases with stage IB2 or IIA cervical ... ...

Abstract	Objective: To evaluate the feasibility of quantitative contrast-enhanced ultrasonography (CEUS) for predicting and assessing cervical tumor response to neoadjuvant chemotherapy (NACT). Methods: Thirty-eight cases with stage IB2 or IIA cervical cancer were studied using CEUS before and after one cycle of NACT. The quantitative CEUS parameters maximum intensity (IMAX), rise time (RT), time to peak (TTP), and mean transit time (MTT) were compared between cervical tumors and myometrium (reference zone) using Sonoliver software. Absolute and relative changes in quantitative CEUS parameters were also compared among complete response, partial response, and non-responsive groups. Correlations between pre-treatment IMAX and changes in quantitative parameters were assessed after one cycle of NACT. Results: There were significant changes in cervical tumor IMAX (P<0.001), RT (P<0.05), and TTP (P<0.05) after one cycle of NACT. According to the Response Evaluation Criteria In Solid Tumors guidelines, the enrollments were divided into complete response, partial response, stable disease and progressive disease groups. There were no significant differences in quantitative CEUS parameters among complete response, partial response, and non-responsive groups (P>0.05). In the stable disease group (n=17), cervical tumor IMAX, RT, and TTP decreased significantly after NACT (P<0.001). The absolute and percentage changes in IMAX were positively correlated with pre-treatment IMAX in all 38 patients (r=0.576, P<0.001 and r=0.429, P<0.001). Conclusion: Quantitative CEUS analysis can reveal changes in tumor perfusion following NACT. Tumor perfusion values changes likely precede size changes during the NACT course, and pre-treatment IMAX may be a valuable predictor of cervical tumor perfusion response to NACT with a great decrease in IMAX correlated with better perfusion response.
MeSH term(s)	Adult ; Antineoplastic Combined Chemotherapy Protocols ; Contrast Media/therapeutic use ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Neoadjuvant Therapy ; Neoplasm Staging ; Predictive Value of Tests ; Prospective Studies ; Treatment Outcome ; Uterine Cervical Neoplasms/diagnostic imaging ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/pathology
Chemical Substances	Contrast Media
Language	English
Publishing date	2016-11
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2016.09.025
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Zs.A 1630: Show issues

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Article ; Online: Combined percutaneous radiofrequency ablation and ethanol injection versus hepatic resection for 2.1-5.0 cm solitary hepatocellular carcinoma: a retrospective comparative multicentre study.

Chen, Shuling / Peng, Zhenwei / Lin, Manxia / Chen, Zebin / Hu, Wenjie / Xie, Xiaoyan / Liu, LongZhong / Qian, Guojun / Peng, Baogang / Li, Bin / Kuang, Ming

European radiology

2018 Volume 28, Issue 9, Page(s) 3651–3660

Abstract: Objectives: To compare combined percutaneous radiofrequency ablation and ethanol injection (RFA-PEI) with hepatic resection (HR) in the treatment of resectable solitary hepatocellular carcinoma (HCC) with 2.1-5.0 cm diameter.: Methods: From June 2009 ...

Abstract	Objectives: To compare combined percutaneous radiofrequency ablation and ethanol injection (RFA-PEI) with hepatic resection (HR) in the treatment of resectable solitary hepatocellular carcinoma (HCC) with 2.1-5.0 cm diameter. Methods: From June 2009 to December 2015, 271 patients whom underwent RFA-PEI (n = 141) or HR (n = 130) in three centres were enrolled. The overall survival (OS) and recurrence-free survival (RFS) between groups were compared with Kaplan-Meier method and log-rank tests. Complications, hospital stay and cost were assessed. Results: The OS rates at 1, 3 and 5 years were 93.5%, 72.7%, 58.6% in RFA-PEI group and 82.3%, 57.5%, 51.8% in HR group (p = 0.021). The corresponding 1-, 3- and 5-year RFS rates were 65.8%, 41.3%, 34.3% in RFA-PEI group and 50.5%, 33.8%, 28.4% in HR group (p = 0.038). For patients with 2.1-3.0 cm tumours, the 1-, 3- and 5-year OS after RFA-PEI and HR were 98.0%, 82.3%, 74.2% and 89.4%, 65.1%, 61.9%, respectively (p = 0.024). The corresponding RFS were 79.6%, 54.7%, 45.1% in RFA-PEI group, and 57.6%, 43.9%, 31.7% in HR group, respectively (p = 0.020). RFA-PEI was superior to HR in major complication rates, length of hospital stay and cost (all p < 0.001). Conclusion: RFA-PEI had a survival benefit over HR in the treatment of solitary HCCs, especially for those with 2.1-3.0 cm in diameter. Key points: • RFA-PEI provided superior survival to HR in solitary HCC with 2.1-5.0 cm in diameter. • RFA-PEI is superior to HR in complications, length of hospital stay and cost. • RFA-PEI might be an alternative treatment for solitary HCC within 5.0 cm in diameter.
MeSH term(s)	Adult ; Aged ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/secondary ; Carcinoma, Hepatocellular/therapy ; Catheter Ablation/methods ; Combined Modality Therapy ; Ethanol/administration & dosage ; Female ; Hepatectomy/methods ; Humans ; Injections, Intralesional ; Length of Stay/statistics & numerical data ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Retrospective Studies ; Survival Analysis ; Treatment Outcome ; Young Adult
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2018-03-29
Publishing country	Germany
Document type	Comparative Study ; Journal Article ; Multicenter Study
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-018-5371-9
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Article: A robust graph-based segmentation method for breast tumors in ultrasound images

Huang, Qing-Hua / Lee, Su-Ying / Liu, Long-Zhong / Lu, Min-Hua / Jin, Lian-Wen / Li, An-Hua

Ultrasonics. 2012 Feb., v. 52, no. 2

2012

Abstract: OBJECTIVES: This paper introduces a new graph-based method for segmenting breast tumors in US images. BACKGROUND AND MOTIVATION: Segmentation for breast tumors in ultrasound (US) images is crucial for computer-aided diagnosis system, but it has always ... ...

Abstract	OBJECTIVES: This paper introduces a new graph-based method for segmenting breast tumors in US images. BACKGROUND AND MOTIVATION: Segmentation for breast tumors in ultrasound (US) images is crucial for computer-aided diagnosis system, but it has always been a difficult task due to the defects inherent in the US images, such as speckles and low contrast. METHODS: The proposed segmentation algorithm constructed a graph using improved neighborhood models. In addition, taking advantages of local statistics, a new pair-wise region comparison predicate that was insensitive to noises was proposed to determine the mergence of any two of adjacent subregions. RESULTS AND CONCLUSION: Experimental results have shown that the proposed method could improve the segmentation accuracy by 1.5–5.6% in comparison with three often used segmentation methods, and should be capable of segmenting breast tumors in US images.
Keywords	algorithms ; breast neoplasms ; models ; statistics ; ultrasonics
Language	English
Dates of publication	2012-02
Size	p. 266-275.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	200839-7
ISSN	1874-9968 ; 0041-624X
ISSN (online)	1874-9968
ISSN	0041-624X
DOI	10.1016/j.ultras.2011.08.011
Database	NAL-Catalogue (AGRICOLA)

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Zs.B 1133: Show issues

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Article ; Online: Contrast-enhanced ultrasonography of hepatocellular carcinoma: correlation between quantitative parameters and arteries in neoangiogenesis or sinusoidal capillarization.

Pei, Xiao Qing / Liu, Long Zhong / Zheng, Wei / Cai, Mu Yan / Han, Feng / He, Jie Hua / Li, An Hua / Chen, Min Shan

European journal of radiology

2012 Volume 81, Issue 3, Page(s) e182–8

Abstract: Objective: The quantitative parameters in contrast-enhanced ultrasonography-time-intensity curve of hepatocellular carcinoma (HCC) were studied to explore their potential importance in monitoring the effects of anti-angiogenic therapy for HCC.: ... ...

Abstract	Objective: The quantitative parameters in contrast-enhanced ultrasonography-time-intensity curve of hepatocellular carcinoma (HCC) were studied to explore their potential importance in monitoring the effects of anti-angiogenic therapy for HCC. Methods: 115 HCC patients were studied with contrast-enhanced ultrasonography-time-intensity curve (CEUS-TIC) and with immunohistochemical analysis of tissue sections. The CEUS images were analyzed off-line to obtained quantitative parameters including maximum of intensity (IMAX), rise time (RT), time to peak (TTP), mean transit time (mTT), rise slope (RS), and washout time (WT). Monoclonal antibodies specific for smooth muscle actin and anti-CD34 were used to observe unpaired arteries (UAs) and microvessel area (MVA) of sinusoidal capillarization, respectively. The UAs and MVA of 82 HCC cases were successfully stained. Results: The number of UAs had moderate correlation with RT (r=-0.446), TTP (r=-0.432), and RS (r=0.431) (P<0.05), and it had mild correlation with IMAX (r=0.303) and WT (r=0.285) (P<0.05). MVA of sinusoidal capillarization had no correlation with perfusion parameters. Conclusion: Quantitative CEUS-TIC parameters reflecting hemodynamics of tumors are correlated with UAs, but not with MVA, and they might be used to monitor the effects of anti-angiogenic therapy on HCC.
MeSH term(s)	Adolescent ; Adult ; Arteries/diagnostic imaging ; Capillaries/diagnostic imaging ; Carcinoma, Hepatocellular/diagnostic imaging ; Contrast Media ; Female ; History, 18th Century ; Humans ; Image Enhancement/methods ; Immunohistochemistry ; Liver Neoplasms/diagnostic imaging ; Male ; Microcirculation ; Middle Aged ; Neovascularization, Pathologic/diagnostic imaging ; Phospholipids ; Prospective Studies ; Software ; Sulfur Hexafluoride ; Time Factors ; Ultrasonography
Chemical Substances	Contrast Media ; Phospholipids ; contrast agent BR1 ; Sulfur Hexafluoride (WS7LR3I1D6)
Language	English
Publishing date	2012-03
Publishing country	Ireland
Document type	Historical Article ; Journal Article
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2011.01.083
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Article ; Online: A robust graph-based segmentation method for breast tumors in ultrasound images.

Huang, Qing-Hua / Lee, Su-Ying / Liu, Long-Zhong / Lu, Min-Hua / Jin, Lian-Wen / Li, An-Hua

Ultrasonics

2012 Volume 52, Issue 2, Page(s) 266–275

Abstract: Objectives: This paper introduces a new graph-based method for segmenting breast tumors in US images.: Background and motivation: Segmentation for breast tumors in ultrasound (US) images is crucial for computer-aided diagnosis system, but it has ... ...

Abstract	Objectives: This paper introduces a new graph-based method for segmenting breast tumors in US images. Background and motivation: Segmentation for breast tumors in ultrasound (US) images is crucial for computer-aided diagnosis system, but it has always been a difficult task due to the defects inherent in the US images, such as speckles and low contrast. Methods: The proposed segmentation algorithm constructed a graph using improved neighborhood models. In addition, taking advantages of local statistics, a new pair-wise region comparison predicate that was insensitive to noises was proposed to determine the mergence of any two of adjacent subregions. Results and conclusion: Experimental results have shown that the proposed method could improve the segmentation accuracy by 1.5-5.6% in comparison with three often used segmentation methods, and should be capable of segmenting breast tumors in US images.
MeSH term(s)	Algorithms ; Breast Neoplasms/diagnostic imaging ; Female ; Humans ; Ultrasonography, Mammary/methods
Language	English
Publishing date	2012-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	200839-7
ISSN	1874-9968 ; 0041-624X
ISSN (online)	1874-9968
ISSN	0041-624X
DOI	10.1016/j.ultras.2011.08.011
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Article ; Online: miR-200c inhibits breast cancer proliferation by targeting KRAS.

Song, Cailu / Liu, Long-Zhong / Pei, Xiao-Qing / Liu, Xiaoping / Yang, Lu / Ye, Feng / Xie, Xinhua / Chen, Jianping / Tang, Hailin / Xie, Xiaoming

Oncotarget

2015 Volume 6, Issue 33, Page(s) 34968–34978

Abstract: The microRNA, miR-200c, is involved in the tumorigenesis and progression of a variety of cancers. The purpose of this study was to investigate the expression, mechanism and prognostic roles of miR-200c in breast cancer. We found that miR-200c was ... ...

Abstract	The microRNA, miR-200c, is involved in the tumorigenesis and progression of a variety of cancers. The purpose of this study was to investigate the expression, mechanism and prognostic roles of miR-200c in breast cancer. We found that miR-200c was downregulated in both breast cancer tissue and cell lines using quantitative real-time PCR (qRT-PCR). In situ hybridization (ISH) and microarrays showed that low miR-200c expression was associated with poor patient overall survival (OS) and disease free survival (DFS). We used luciferase reporter plasmids to find that miR-200c inhibited the AKT and ERK pathways by directly targeting KRAS. Repression of KRAS by miR-200c suppressed the proliferation and survival of breast cancer cells in vitro and in vivo. miR-200c also had an anti-tumor effect by negatively regulating KRAS in a xenograft mouse model. Our findings provide clues regarding the role of miR-200c as a tumor suppressor in breast cancer through the inhibition of KRAS translation both in vitro and in vivo. miR-200c could be a potential therapeutic target in breast cancer.
MeSH term(s)	Aged ; Animals ; Blotting, Western ; Breast Neoplasms/genetics ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Cell Proliferation/genetics ; Disease-Free Survival ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Genes, Tumor Suppressor/physiology ; Humans ; In Situ Hybridization ; Kaplan-Meier Estimate ; Mice ; Mice, Inbred BALB C ; MicroRNAs/biosynthesis ; MicroRNAs/genetics ; Middle Aged ; Oligonucleotide Array Sequence Analysis ; Proto-Oncogene Proteins p21(ras)/biosynthesis ; Proto-Oncogene Proteins p21(ras)/genetics ; Real-Time Polymerase Chain Reaction ; Transfection ; Xenograft Model Antitumor Assays
Chemical Substances	KRAS protein, human ; MIRN200 microRNA, human ; MicroRNAs ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
Language	English
Publishing date	2015-10-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.5198
Database	MEDical Literature Analysis and Retrieval System OnLINE

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