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  1. Article: CircFAT1 is Overexpressed in Colorectal Cancer and Suppresses Cancer Cell Proliferation, Invasion and Migration by Increasing the Maturation of miR-10a.

    Liu, Meng

    Cancer management and research

    2021  Volume 13, Page(s) 4309–4315

    Abstract: Purpose: It has been reported that circFAT1 plays opposite roles in gastric cancer and osteosarcoma. This study aimed to explore the involvement of circFAT1 in colorectal cancer (CRC).: Patients and methods: Paired CRC and non-tumor tissues from 64 ... ...

    Abstract Purpose: It has been reported that circFAT1 plays opposite roles in gastric cancer and osteosarcoma. This study aimed to explore the involvement of circFAT1 in colorectal cancer (CRC).
    Patients and methods: Paired CRC and non-tumor tissues from 64 CRC patients were subjected to RNA preparations and RT-qPCRs to determine the expression of circFAT1, premature miR-10a, and mature miR-10a. In CRC cells, the effects of circFAT1 overexpression on miR-10a maturation were analyzed by determining the expression of both premature miR-10a and mature miR-10a using RT-qPCRs. The role of circFAT1 and miR-10a in regulating the proliferation, invasion, and migration of CRC cells was analyzed by BrdU and Transwell assays, respectively.
    Results: We found that circFAT1 was upregulated in CRC. Mature miR-10a, but not premature miR-10a, was overexpressed in CRC and positively correlated with circFAT1. CircFAT1 overexpression increased the expression of mature miR-10a, but not premature miR-10a. Overexpression of circFAT1 and miR-10a increased cell proliferation, invasion and migration, and miR-10a inhibitor suppressed cell behaviors and reversed the effects of circFAT1 overexpression.
    Conclusion: circFAT1 is overexpressed in CRC and may suppress CRC cell proliferation, invasion and migration by increasing miR-10a maturation.
    Language English
    Publishing date 2021-06-01
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2508013-1
    ISSN 1179-1322
    ISSN 1179-1322
    DOI 10.2147/CMAR.S287230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Dietary cysteine and methionine promote peroxisome elevation and fat loss by induction of CG33474 expression in Drosophila adipose tissue.

    Liu, Meng / He, Li

    Cellular and molecular life sciences : CMLS

    2024  Volume 81, Issue 1, Page(s) 190

    Abstract: The high-protein diet (HPD) has emerged as a potent dietary approach to curb obesity. Peroxisome, a highly malleable organelle, adapts to nutritional changes to maintain homeostasis by remodeling its structure, composition, and quantity. However, the ... ...

    Abstract The high-protein diet (HPD) has emerged as a potent dietary approach to curb obesity. Peroxisome, a highly malleable organelle, adapts to nutritional changes to maintain homeostasis by remodeling its structure, composition, and quantity. However, the impact of HPD on peroxisomes and the underlying mechanism remains elusive. Using Drosophila melanogaster as a model system, we discovered that HPD specifically increases peroxisome levels within the adipose tissues. This HPD-induced peroxisome elevation is attributed to cysteine and methionine by triggering the expression of CG33474, a fly homolog of mammalian PEX11G. Both the overexpression of Drosophila CG33474 and human PEX11G result in increased peroxisome size. In addition, cysteine and methionine diets both reduce lipid contents, a process that depends on the presence of CG33474. Furthermore, CG33474 stimulates the breakdown of neutral lipids in a cell-autonomous manner. Moreover, the expression of CG33474 triggered by cysteine and methionine requires TOR signaling. Finally, we found that CG33474 promotes inter-organelle contacts between peroxisomes and lipid droplets (LDs), which might be a potential mechanism for CG33474-induced fat loss. In summary, our findings demonstrate that CG33474/PEX11G may serve as an essential molecular bridge linking HPD to peroxisome dynamics and lipid metabolism.
    Language English
    Publishing date 2024-04-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-024-05226-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 195: Show issues Location:
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  3. Article: Neonatal hyperinsulinism with an

    Liu, Meng-Tong / Yang, Hui-Xia

    World journal of clinical cases

    2023  Volume 11, Issue 10, Page(s) 2254–2259

    Abstract: Background: Neonatal hyperinsulinism can result from perinatal stress, genetic disorders, or syndromes, which can lead to persistent or intractable hypoglycemia in newborns. Mutations in the : Case summary: We report a case of a high-birth-weight ... ...

    Abstract Background: Neonatal hyperinsulinism can result from perinatal stress, genetic disorders, or syndromes, which can lead to persistent or intractable hypoglycemia in newborns. Mutations in the
    Case summary: We report a case of a high-birth-weight infant with postnatal hypoglycemia and hyperinsulinemia, whose mother had pregestational diabetes mellitus with poor glycemic control and whose sister had a similar history at birth. Whole-exome sequencing revealed a new mutation in the
    Conclusion: We report a new mutation locus in the
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v11.i10.2254
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  4. Article ; Online: Role of subduction dynamics on the unevenly distributed volcanism at the Middle American subduction system.

    Liu, Meng / Gao, Haiying

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 14697

    Abstract: A typical subduction of an oceanic plate beneath a continent is expected to be accompanied by arc volcanoes along the convergent margin. However, subduction of the Cocos plate at the Middle American subduction system has resulted in an uneven ... ...

    Abstract A typical subduction of an oceanic plate beneath a continent is expected to be accompanied by arc volcanoes along the convergent margin. However, subduction of the Cocos plate at the Middle American subduction system has resulted in an uneven distribution of magmatism/volcanism along strike. Here we construct a new three-dimensional shear-wave velocity model of the entire Middle American subduction system, using full-wave ambient noise tomography. Our model reveals significant variations of the oceanic plates along strike and down dip, in correspondence with either weakened or broken slabs after subduction. The northern and southern segments of the Cocos plate, including the Mexican flat slab subduction, are well imaged as high-velocity features, where a low-velocity mantle wedge exists and demonstrate a strong correlation with the arc volcanoes. Subduction of the central Cocos plate encounters a thick high-velocity feature beneath North America, which hinders the formation of a typical low-velocity mantle wedge and arc volcanoes. We suggest that the presence of slab tearing at both edges of the Mexican flat slab has been modifying the mantle flows, resulting in the unusual arc volcanism.
    Language English
    Publishing date 2023-09-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-41740-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Global solvability of a chemotaxis-haptotaxis model in the whole 2-d space.

    Liu, Meng / Li, Yuxiang

    Mathematical biosciences and engineering : MBE

    2023  Volume 20, Issue 4, Page(s) 7565–7593

    Abstract: This paper investigates a two-dimensional chemotaxis-haptotaxis model $ \begin{eqnarray*} \left\{\begin{array}{lll} u_t = \Delta u-\chi\nabla\cdot(u\nabla v)-\xi\nabla\cdot(u\nabla w),&{} x\in\mathbb{R}^2,\ t>0,\\ v_t = \Delta v-v+u,&{}x\in\mathbb{R}^2,\ ...

    Abstract This paper investigates a two-dimensional chemotaxis-haptotaxis model $ \begin{eqnarray*} \left\{\begin{array}{lll} u_t = \Delta u-\chi\nabla\cdot(u\nabla v)-\xi\nabla\cdot(u\nabla w),&{} x\in\mathbb{R}^2,\ t>0,\\ v_t = \Delta v-v+u,&{}x\in\mathbb{R}^2,\ t>0,\\ w_t = -vw,&{}x\in\mathbb{R}^2,\ t>0, \end{array}\right. \end{eqnarray*} $ where $ \chi $ and $ \xi $ are positive parameters. It is proved that, for any suitable smooth initial data $ (u_0, v_0, w_0) $, this model admits a unique global strong solution if $ \left\|u_0\right\|_{L^1} < \frac{8 \pi}{\chi} $. Compared to the result by Calvez and Corrias (Calvez and Corrias, 2008
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2265126-3
    ISSN 1551-0018 ; 1551-0018
    ISSN (online) 1551-0018
    ISSN 1551-0018
    DOI 10.3934/mbe.2023327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Steady regime of radiation pressure acceleration with foil thickness adjustable within micrometers under a 10-100 PW laser.

    Liu, Meng / Wang, Wei-Min / Li, Yu-Tong

    Physical review. E

    2024  Volume 109, Issue 1-2, Page(s) 15208

    Abstract: Quasimonoenergetic GeV-scale protons are predicted to be efficiently generated via radiation pressure acceleration (RPA) when the foil thickness is matched with the laser intensity, e.g., L_{mat} of several nm to 100 nm for 10^{19}-10^{22}Wcm^{-2} ... ...

    Abstract Quasimonoenergetic GeV-scale protons are predicted to be efficiently generated via radiation pressure acceleration (RPA) when the foil thickness is matched with the laser intensity, e.g., L_{mat} of several nm to 100 nm for 10^{19}-10^{22}Wcm^{-2} available in laboratory. However, nonmonoenergetic protons with much lower energies than predicted were usually observed in RPA experiments because of too small foil thickness which cannot support insufficient laser contrast and foil surface roughness. Besides the technical problems, we here find that there is an upper-limit thickness L_{up} derived from the requirement that the laser energy should dominate over the ion source energy in the effective laser-proton interaction zone, and L_{up} is lower than L_{mat} with the intensity below 10^{22}Wcm^{-2}, which causes inefficient or unsteady RPA. As the intensity is enhanced to ≥10^{23}Wcm^{-2} provided by 10-100 PW laser facilities, L_{up} can significantly exceed L_{mat}, and therefore RPA becomes efficient. In this regime, L_{mat} acts as a lower-limit thickness for efficient RPA, so the matching thickness can be extended to a continuous range from L_{mat} to L_{up}; the range can reach micrometers, within which foil thickness is adjustable. This makes RPA steady and meanwhile the above technical problems can be overcome. Particle-in-cell simulation shows that multi-GeV quasimonoenergetic proton beams can be steadily generated and the fluctuation of the energy peaks and the energy conversation efficiency remains stable although the thickness is taken in a larger range with increasing intensity. This work predicts that near future RPA experiments with 10-100 PW facilities will enter a new regime with a large range of usable foil thicknesses that can be adjusted to the interaction conditions for steady acceleration.
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.109.015208
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  7. Article: Effect of Solution-Focused Approach on Insight and Phsychological Emotion of Patients with Nephrotic Syndrome: A Retrospective Study from the Hospital.

    Liu, Meng / Ge, Xiufen / Yan, Zhen

    Archivos espanoles de urologia

    2024  Volume 77, Issue 1, Page(s) 49–56

    Abstract: Objective: This study aims to explore the effect of the solution-focused approach on the insight and psychological emotion of patients with nephrotic syndrome (NS).: Methods: The clinical data of 185 Qingdao Municipal Hospital patients with NS from ... ...

    Abstract Objective: This study aims to explore the effect of the solution-focused approach on the insight and psychological emotion of patients with nephrotic syndrome (NS).
    Methods: The clinical data of 185 Qingdao Municipal Hospital patients with NS from December 2020 to December 2022 were selected for retrospective analysis. According to different nursing modes, the patients were divided into the control group (CG, conventional nursing, n = 90) and the study group (SG, conventional nursing + solution-focused approach, n = 95). The Hospital Anxiety and Depression Scale (HADS) was used to assess the anxiety and depression levels of the patients, and the insight and treatment attitudes questionnaire (ITAQ) was adopted to evaluate their insight. The short form-36 health survey (SF-36) was used to evaluate the patients' quality of life. The relationship of patients' anxiety and depression levels with their insight was analysed.
    Results: No statistical difference in the gender, age, body mass index, education level, disease types, hypertension, hyperlipidaemia, oedema, monthly family per capita income and residence indicators of the patients in the two groups (
    Conclusions: The application of the solution-focused approach to NS patients can improve their insight and anxiety and depression levels with certain clinical application value, providing more directions for the follow-up treatment of NS.
    MeSH term(s) Humans ; Retrospective Studies ; Quality of Life/psychology ; Nephrotic Syndrome ; Anxiety/etiology ; Hospitals ; Depression/etiology
    Language English
    Publishing date 2024-02-19
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 211673-x
    ISSN 0004-0614
    ISSN 0004-0614
    DOI 10.56434/j.arch.esp.urol.20247701.7
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1312: Show issues Location:
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  8. Article ; Online: The moderating effect of gender equality consciousness on environmental concern among males and females.

    Niu, Long / Liu, Meng / Fan, Lijuan / Yiting, E

    Work (Reading, Mass.)

    2024  

    Abstract: Background: In the discourse on the heterogeneity of gender and environmental concern, gender equality awareness can further illuminate the complexity of gender and environmental concern across different cultural backgrounds.: Objective: Differing ... ...

    Abstract Background: In the discourse on the heterogeneity of gender and environmental concern, gender equality awareness can further illuminate the complexity of gender and environmental concern across different cultural backgrounds.
    Objective: Differing from prior research, our study focuses on exploring the relationship between different genders, gender equality awareness, and environmental concern, as well as investigating whether gender equality awareness has distinct effects on environmental concern among different genders.
    Methods: Utilizing data from the 2021 China General Social Survey (CGSS), we conducted a theoretical investigation into gender differences in environmental concern. First, we used descriptive statistics to observe the differences between the samples. Secondly, in order to compare the influence of gender equality awareness on different genders, we conducted t-tests on gender subgroups. Subsequently, an Ordinary Least Squares (OLS) regression model was employed to examine the effects of gender and gender equality awareness on environmental issues. Finally, gender equality awareness was introduced as a moderating variable to explore its potential interaction with gender and investigate whether a moderation mechanism exists between gender and environmental concern.
    Results: Findings indicate that 1) male respondents in China exhibit greater concern for the environment compared to female respondents; 2) higher levels of gender equality awareness are positively correlated with higher levels of environmental concern; 3) the influence of gender on environmental concern is moderated by the degree of gender equality awareness. Specifically, when gender equality awareness is strengthened, female respondents exhibit a higher degree of environmental concern.
    Conclusion: Enhancing gender equality awareness contributes to improving both social gender equality and equitable concern for the environment. The findings could provide insights for similar developing countries like China.
    Language English
    Publishing date 2024-01-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1394194-x
    ISSN 1875-9270 ; 1051-9815
    ISSN (online) 1875-9270
    ISSN 1051-9815
    DOI 10.3233/WOR-230227
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4810: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article: A DNAzymes-in-droplets assay for

    Li, Xiaoqian / Chang, Yangyang / Wu, Yunping / Liu, Meng

    Chemical science

    2024  Volume 15, Issue 8, Page(s) 2996–3002

    Abstract: Foodborne pathogens pose a serious risk to human health, and the simple and rapid detection of such bacteria in complex food matrices remains challenging. Herein, we present the selection and characterization of a novel RNA-cleaving fluorogenic DNAzyme, ... ...

    Abstract Foodborne pathogens pose a serious risk to human health, and the simple and rapid detection of such bacteria in complex food matrices remains challenging. Herein, we present the selection and characterization of a novel RNA-cleaving fluorogenic DNAzyme, named RFD-BC1, with exceptional specificity for
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc05874c
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  10. Article: A High-Efficiency Wideband Grating Coupler Based on Si

    Liu, Meng / Zheng, Xu / Zheng, Xuan / Gong, Zisu

    Materials (Basel, Switzerland)

    2024  Volume 17, Issue 4

    Abstract: To fully utilize the advantages of ... ...

    Abstract To fully utilize the advantages of Si
    Language English
    Publishing date 2024-02-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17040947
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