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Article ; Online: MiR-148b caused liver injury in rats with traumatic hemorrhagic shock by inhibiting SIRT6 expression.

Ma, Xiongfei / Liu, Mingchen

2023

Abstract: Background: The purpose of this study was to investigate the role of miR-148b in liver injury in rats with traumatic hemorrhagic shock (THS) and to elucidate its potential mechanism.: Methods: The levels of alanine aminotransferase (ALT) and ... ...

Abstract	Background: The purpose of this study was to investigate the role of miR-148b in liver injury in rats with traumatic hemorrhagic shock (THS) and to elucidate its potential mechanism. Methods: The levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the serum of rats were detected by enzyme-linked immune sorbent assay (ELISA), and the injury of rat liver was analyzed by hematoxylin-eosin (H&E) staining. Apoptosis of rat hepatocytes and normal rat liver cell line (BRL3A) was identified by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) assay and flow cytometry, respectively. MiR-148b and sirtuin 6 (SIRT6) expression was measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blot. Lactate dehydrogenase (LDH) content and cell viability were measured by commercial kits and cell counting kit-8 (CCK-8) assay, respectively. The binding sites of miR-148b and SIRT6 were predicted by the Starbase database and verified by dual luciferase reporter assay. Results: MiR-148b expression in THS rats or ischemia-reperfusion (I/R)-treated cells was higher than in the control group. Overexpression of miR-148b further promoted the effects of I/R, which enhanced the levels of ALT, AST and LDH, cell apoptosis of liver tissue or BRL3A cells and decreased the expression of SITR6. Besides, miR-148b negatively correlated with SIRT6, and upregulated the expression of SIRT6 could partly reverse the effect of miR-148b. Conclusion: Hepatocyte injury induced by I/R was achieved by regulating miR-148b /SIRT6 axis.
Language	English
Publishing date	2023-08-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2064873-X
ISSN	1875-5666 ; 1566-5240
ISSN (online)	1875-5666
ISSN	1566-5240
DOI	10.2174/1566524023666230816112629
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mid-infrared cross-comb spectroscopy.

Liu, Mingchen / Gray, Robert M / Costa, Luis / Markus, Charles R / Roy, Arkadev / Marandi, Alireza

Nature communications

2023 Volume 14, Issue 1, Page(s) 1044

Abstract: Dual-comb spectroscopy has been proven beneficial in molecular characterization but remains challenging in the mid-infrared region due to difficulties in sources and efficient photodetection. Here we introduce cross-comb spectroscopy, in which a mid- ... ...

Abstract	Dual-comb spectroscopy has been proven beneficial in molecular characterization but remains challenging in the mid-infrared region due to difficulties in sources and efficient photodetection. Here we introduce cross-comb spectroscopy, in which a mid-infrared comb is upconverted via sum-frequency generation with a near-infrared comb of a shifted repetition rate and then interfered with a spectral extension of the near-infrared comb. We measure CO
MeSH term(s)	Spectrophotometry, Infrared ; Signal-To-Noise Ratio
Language	English
Publishing date	2023-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-36811-7
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Article ; Online: Standardized neutralization antibody analytical procedure for clinical samples based on the AQbD concept.

Liu, Jianyang / Bai, Yu / Liu, Mingchen / Tan, Dejiang / Li, Jing / Wang, Zhongfang / Liang, Zhenglun / Xu, Miao / Wang, Junzhi / Mao, Qunying

Signal transduction and targeted therapy

2023 Volume 8, Issue 1, Page(s) 165

MeSH term(s)	Antibodies, Neutralizing ; Clinical Laboratory Techniques
Chemical Substances	Antibodies, Neutralizing
Language	English
Publishing date	2023-04-28
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2886872-9
ISSN	2059-3635 ; 2095-9907
ISSN (online)	2059-3635
ISSN	2095-9907
DOI	10.1038/s41392-023-01389-5
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Article ; Online: Visible-to-mid-IR tunable frequency comb in nanophotonics.

Roy, Arkadev / Ledezma, Luis / Costa, Luis / Gray, Robert / Sekine, Ryoto / Guo, Qiushi / Liu, Mingchen / Briggs, Ryan M / Marandi, Alireza

Nature communications

2023 Volume 14, Issue 1, Page(s) 6549

Abstract: Optical frequency comb is an enabling technology for a multitude of applications from metrology to ranging and communications. The tremendous progress in sources of optical frequency combs has mostly been centered around the near-infrared spectral region, ...

Abstract	Optical frequency comb is an enabling technology for a multitude of applications from metrology to ranging and communications. The tremendous progress in sources of optical frequency combs has mostly been centered around the near-infrared spectral region, while many applications demand sources in the visible and mid-infrared, which have so far been challenging to achieve, especially in nanophotonics. Here, we report widely tunable frequency comb generation using optical parametric oscillators in lithium niobate nanophotonics. We demonstrate sub-picosecond frequency combs tunable beyond an octave extending from 1.5 up to 3.3 μm with femtojoule-level thresholds on a single chip. We utilize the up-conversion of the infrared combs to generate visible frequency combs reaching 620 nm on the same chip. The ultra-broadband tunability and visible-to-mid-infrared spectral coverage of our source highlight a practical and universal path for the realization of efficient frequency comb sources in nanophotonics, overcoming their spectral sparsity.
Language	English
Publishing date	2023-10-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-42289-0
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Article ; Online: Effective protection of ZF2001 against the SARS-CoV-2 Delta variant in lethal K18-hACE2 mice

Bian, Lianlian / Bai, Yu / Gao, Fan / Liu, Mingchen / He, Qian / Wu, Xing / Mao, Qunying / Xu, Miao / Liang, Zhenglun

Virol J. 2022 Dec., v. 19, no. 1 p.86-86

2022

Abstract: To investigate the protective efficacy and mechanism of ZF2001 (a protein subunit vaccine with conditional approval in China) to SARS-CoV-2 Delta variant-induced severe pneumonia, the lethal challenge model of K18-hACE2 transgenic mice was used in this ... ...

Abstract	To investigate the protective efficacy and mechanism of ZF2001 (a protein subunit vaccine with conditional approval in China) to SARS-CoV-2 Delta variant-induced severe pneumonia, the lethal challenge model of K18-hACE2 transgenic mice was used in this study. An inactivated-virus vaccine at the research and development stage (abbreviated as RDINA) was compared to ZF2001. We found that ZF2001 and RDINA could provide the protective effect against Delta variant-induced severe cases, as measured by the improved survival rates, the reduced virus loads, the alleviated lung histopathology and the high neutralizing antibody geomean titers, compared to aluminum adjuvant group. To prevent and control Omicron or other variant epidemics, further improvements in vaccine design and compatibilities with the novel adjuvant are required to achieve better immunogenicity.
Keywords	Severe acute respiratory syndrome coronavirus 2 ; adjuvants ; aluminum ; antibodies ; genetically modified organisms ; histopathology ; immunogenicity ; lungs ; models ; pneumonia ; protective effect ; protein subunits ; research and development ; subunit vaccines ; vaccine development ; viruses ; China
Language	English
Dates of publication	2022-12
Size	p. 86.
Publishing place	BioMed Central
Document type	Article ; Online
ZDB-ID	2160640-7
ISSN	1743-422X
ISSN	1743-422X
DOI	10.1186/s12985-022-01818-x
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2-TGFβ2-Smad2/3 signaling pathway in cervical cancer.

Zheng, Han / Liu, Mingchen / Shi, Shu / Huang, Hongxin / Yang, Xingwen / Luo, Ziheng / Song, Yarong / Xu, Qiang / Li, Tingting / Xue, Lixiang / Lu, Fengmin / Wang, Jie

Molecular oncology

2024 Volume 18, Issue 5, Page(s) 1327–1346

Abstract: SRY-box transcription factor 6 (SOX6) is a member of the SOX gene family and inhibits the proliferation of cervical cancer cells by inducing cell cycle arrest. However, the final cell fate and significance of these cell-cycle-arrested cervical cancer ... ...

Abstract	SRY-box transcription factor 6 (SOX6) is a member of the SOX gene family and inhibits the proliferation of cervical cancer cells by inducing cell cycle arrest. However, the final cell fate and significance of these cell-cycle-arrested cervical cancer cells induced by SOX6 remains unclear. Here, we report that SOX6 inhibits the proliferation of cervical cancer cells by inducing cellular senescence, which is mainly mediated by promoting transforming growth factor beta 2 (TGFB2) gene expression and subsequently activating the TGFβ2-Smad2/3-p53-p21
MeSH term(s)	Animals ; Female ; Humans ; Mice ; Activating Transcription Factor 2/metabolism ; Activating Transcription Factor 2/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cellular Senescence ; Gene Expression Regulation, Neoplastic ; Mice, Inbred BALB C ; Mice, Nude ; Protein Serine-Threonine Kinases/metabolism ; Protein Serine-Threonine Kinases/genetics ; Signal Transduction ; Smad2 Protein/metabolism ; Smad3 Protein ; SOXD Transcription Factors/metabolism ; SOXD Transcription Factors/genetics ; Transforming Growth Factor beta2/metabolism ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/genetics
Chemical Substances	Activating Transcription Factor 2 ; ATF2 protein, human ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Smad2 Protein ; SMAD2 protein, human ; Smad3 Protein ; SMAD3 protein, human ; SOX6 protein, human ; SOXD Transcription Factors ; TGFB2 protein, human ; Transforming Growth Factor beta2 ; MAP4K4 protein, human (EC 2.7.1.11) ; WT1 protein, human
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2415106-3
ISSN	1878-0261 ; 1574-7891
ISSN (online)	1878-0261
ISSN	1574-7891
DOI	10.1002/1878-0261.13613
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Article ; Online: Effective protection of ZF2001 against the SARS-CoV-2 Delta variant in lethal K18-hACE2 mice.

Bian, Lianlian / Bai, Yu / Gao, Fan / Liu, Mingchen / He, Qian / Wu, Xing / Mao, Qunying / Xu, Miao / Liang, Zhenglun

Virology journal

2022 Volume 19, Issue 1, Page(s) 86

Abstract	To investigate the protective efficacy and mechanism of ZF2001 (a protein subunit vaccine with conditional approval in China) to SARS-CoV-2 Delta variant-induced severe pneumonia, the lethal challenge model of K18-hACE2 transgenic mice was used in this study. An inactivated-virus vaccine at the research and development stage (abbreviated as RDINA) was compared to ZF2001. We found that ZF2001 and RDINA could provide the protective effect against Delta variant-induced severe cases, as measured by the improved survival rates, the reduced virus loads, the alleviated lung histopathology and the high neutralizing antibody geomean titers, compared to aluminum adjuvant group. To prevent and control Omicron or other variant epidemics, further improvements in vaccine design and compatibilities with the novel adjuvant are required to achieve better immunogenicity.
MeSH term(s)	Animals ; COVID-19/prevention & control ; Melphalan ; Mice ; Mice, Transgenic ; SARS-CoV-2 ; Vaccines, Inactivated ; gamma-Globulins
Chemical Substances	K-18 conjugate ; Vaccines, Inactivated ; gamma-Globulins ; Melphalan (Q41OR9510P)
Language	English
Publishing date	2022-05-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2160640-7
ISSN	1743-422X ; 1743-422X
ISSN (online)	1743-422X
ISSN	1743-422X
DOI	10.1186/s12985-022-01818-x
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Article ; Online: How SARS-CoV-2 dodges immune surveillance and facilitates infection: an analytical review.

Wang, Qian / Wu, Xing / Mao, Qunying / Gao, Fan / Liu, Mingchen / Song, Ziyang / Bian, Lianlian / Liang, Zhenglun

Expert review of anti-infective therapy

2022 Volume 20, Issue 8, Page(s) 1119–1127

Abstract: Introduction: Effective treatments for the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic are limited. The virus has evolved strategies to evade the immune system or hijack immune responses to facilitate infection and ... ...

Abstract	Introduction: Effective treatments for the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic are limited. The virus has evolved strategies to evade the immune system or hijack immune responses to facilitate infection and escape immune surveillance. Mechanistically, SARS-CoV-2 takes advantage of TLR4 and cytokine-induced integrins to promote its entrance into the cell. Furthermore, the activation of pattern recognition receptors (PRR)-mediated signaling pathways is compromised by SARS-CoV-2 non-structural proteins (NSPs), accessory protein open reading frames (ORFs), and structural proteins upon infection, contributing to viral infection and replication. Host factors necessary for cellular protein synthesis, metabolism, and viral replication can also be inhibited by the SARS-CoV-2 proteins. Exploring specific mechanisms would optimize the therapy methods and benefit drug research and development. Areas covered: We describe pathways and mechanisms by which SARS-CoV-2 evades immune system; these include the mechanisms that operate during virus entry, signaling pathways involved, and processes at RNA and protein levels. Expert opinion: Increased understanding of how viruses interfere with immune responses would provide more evidence for drug development. Drugs targeting conserved viral proteins to inhibit their replication or host factors to enhance immune responses would minimize the impact of virus mutations and prepare for future coronavirus outbreaks.
MeSH term(s)	COVID-19/immunology ; COVID-19/virology ; Cytokines ; Humans ; Immunologic Surveillance ; Pandemics ; SARS-CoV-2 ; Virus Replication
Chemical Substances	Cytokines
Language	English
Publishing date	2022-05-26
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2181279-2
ISSN	1744-8336 ; 1478-7210
ISSN (online)	1744-8336
ISSN	1478-7210
DOI	10.1080/14787210.2022.2078307
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Article ; Online: A screening study on the detection strain of Coxsackievirus A6: the key to evaluating neutralizing antibodies in vaccines.

Gao, Fan / Liu, Pei / Huo, Yaqian / Bian, Lianlian / Wu, Xing / Liu, Mingchen / Wang, Qian / He, Qian / Dong, Fangyu / Wang, Zejun / Xie, Zhongping / Zhang, Zhongyang / Gu, Meirong / Xu, Yingzhi / Li, Yajing / Zhu, Rui / Cheng, Tong / Wang, Tao / Mao, Qunying /

Liang, Zhenglun

Emerging microbes & infections

2024 Volume 13, Issue 1, Page(s) 2322671

Abstract: The increasing incidence of diseases caused by Coxsackievirus A6 (CV-A6) and the presence of various mutants in the population present significant public health challenges. Given the concurrent development of multiple vaccines in China, it is challenging ...

Abstract	The increasing incidence of diseases caused by Coxsackievirus A6 (CV-A6) and the presence of various mutants in the population present significant public health challenges. Given the concurrent development of multiple vaccines in China, it is challenging to objectively and accurately evaluate the level of neutralizing antibody response to different vaccines. The choice of the detection strain is a crucial factor that influences the detection of neutralizing antibodies. In this study, the National Institutes for Food and Drug Control collected a prototype strain (Gdula), one subgenotype D1, as well as 13 CV-A6 candidate vaccine strains and candidate detection strains (subgenotype D3) from various institutions and manufacturers involved in research and development. We evaluated cross-neutralization activity using plasma from naturally infected adults (
MeSH term(s)	Adult ; Humans ; Animals ; Mice ; Rats ; Antibodies, Neutralizing ; Antibodies, Viral ; Vaccines ; Research ; China
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Vaccines
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2681359-2
ISSN	2222-1751 ; 2222-1751
ISSN (online)	2222-1751
ISSN	2222-1751
DOI	10.1080/22221751.2024.2322671
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Article ; Online: Ultrafast mode-locked laser in nanophotonic lithium niobate.

Guo, Qiushi / Gutierrez, Benjamin K / Sekine, Ryoto / Gray, Robert M / Williams, James A / Ledezma, Luis / Costa, Luis / Roy, Arkadev / Zhou, Selina / Liu, Mingchen / Marandi, Alireza

Science (New York, N.Y.)

2023 Volume 382, Issue 6671, Page(s) 708–713

Abstract: Mode-locked lasers (MLLs) generate ultrashort pulses with peak powers substantially exceeding their average powers. However, integrated MLLs that drive ultrafast nanophotonic circuits have remained elusive because of their typically low peak powers, lack ...

Abstract	Mode-locked lasers (MLLs) generate ultrashort pulses with peak powers substantially exceeding their average powers. However, integrated MLLs that drive ultrafast nanophotonic circuits have remained elusive because of their typically low peak powers, lack of controllability, and challenges when integrating with nanophotonic platforms. In this work, we demonstrate an electrically pumped actively MLL in nanophotonic lithium niobate based on its hybrid integration with a III-V semiconductor optical amplifier. Our MLL generates [Formula: see text]4.8-ps optical pulses around 1065 nm at a repetition rate of ∼10 GHz, with energies exceeding 2.6 pJ and peak powers beyond 0.5 W. The repetition rate and the carrier-envelope offset frequency of the output can be controlled in a wide range by using the driving frequency and the pump current, providing a route for fully stabilized on-chip frequency combs.
Language	English
Publishing date	2023-11-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.adj5438
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