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Article ; Online: Effect of epidural dexmedetomidine in single-dose combined with ropivacaine for cesarean section.

Liu, Minghao / Chen, Xuezi / Guo, Dan

2024 Volume 24, Issue 1, Page(s) 134

Abstract: Background: Dexmedetomidine has arousal sedation and analgesic effects. We hypothesize that epidural dexmedetomidine in single-dose combined with ropivacaine improves the experience of parturient undergoing cesarean section under epidural anesthesia. ... ...

Abstract	Background: Dexmedetomidine has arousal sedation and analgesic effects. We hypothesize that epidural dexmedetomidine in single-dose combined with ropivacaine improves the experience of parturient undergoing cesarean section under epidural anesthesia. This study is to investigate the effect of 0.5 µg/kg epidural dexmedetomidine combined with epidural anesthesia (EA) in parturients undergoing cesarean section. Methods: A total of 92 parturients were randomly divided into Group R (receiveing epidural ropivacaine alone) Group RD (receiveing epidural ropivacaine with 0.5 µg/kg dexmedetomidine). The primary outcome and second outcome will be intraoperative NRS pain scores and Ramsay Sedation Scale. Results: All 92 parturients were included in the analysis. The NRS were significantly lower in Group RD compared to Group R at all observation timepoint (P > 0.05). Higher Ramsay Sedation Scale was found in Group RD compared to Group R (P < 0.001). No parturient has experienced sedation score of 4 and above. No significant difference regarding the incidence of hypotension, bradycardia and nausea or vomiting, Apgar scores and the overall satisfaction with anesthesia was found between Group R and Group RD (P > 0.05). Conclusion: Epidural dexmedetomidine of 0.5 µg/kg added slightly extra analgesic effect to ropivacaine in EA for cesarean section. The sedation of 0.5 µg/kg epidural dexmedetomidine did not cause mother-baby bonding deficit. Satisfaction with anesthesia wasn't significantly improved by epidural dexmedetomidine of 0.5 µg/kg. No additional side effect allows larger dose of epidural dexmedetomidine attempt. Trial registration: This study was registered at www.chictr.org.cn (ChiCTR2000038853).
MeSH term(s)	Female ; Humans ; Pregnancy ; Analgesics/therapeutic use ; Anesthesia, Epidural/adverse effects ; Anesthetics, Local ; Cesarean Section/adverse effects ; Dexmedetomidine ; Pain/drug therapy ; Ropivacaine
Chemical Substances	Analgesics ; Anesthetics, Local ; Dexmedetomidine (67VB76HONO) ; Ropivacaine (7IO5LYA57N)
Language	English
Publishing date	2024-04-08
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2091252-3
ISSN	1471-2253 ; 1471-2253
ISSN (online)	1471-2253
ISSN	1471-2253
DOI	10.1186/s12871-024-02519-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Gender-affirming hormone therapy and cardiovascular health in transgender adults.

Ong, Caroline / Monita, Monique / Liu, Minghao

Climacteric : the journal of the International Menopause Society

2024 Volume 27, Issue 3, Page(s) 227–235

Abstract: A growing number of people identify as transgender and gender non-binary in the USA and worldwide. Concomitantly, an increasing number of patients are receiving gender-affirming hormone therapy (GAHT) to achieve gender congruence. GAHT has far-ranging ... ...

Abstract	A growing number of people identify as transgender and gender non-binary in the USA and worldwide. Concomitantly, an increasing number of patients are receiving gender-affirming hormone therapy (GAHT) to achieve gender congruence. GAHT has far-ranging effects on clinical and subclinical markers of cardiovascular risk. Transgender patients also appear to be at higher risk for cardiovascular diseases compared to their cisgender peers and the impact of gender-affirming therapy on cardiovascular health is unclear. Studies on the effect of GAHT on cardiovascular outcomes are confounded by differences in GAHT regimens and methodological challenges in a diverse and historically hard-to-reach population. Current cardiovascular guidelines do not incorporate gender identity and hormone status into risk stratification and clinical decision-making. In this review, we provide an overview on the cardiometabolic impact and clinical considerations of GAHT for cardiovascular risk in transgender patients.
MeSH term(s)	Humans ; Transgender Persons ; Cardiovascular Diseases/prevention & control ; Female ; Male ; Hormone Replacement Therapy/adverse effects ; Adult ; Sex Reassignment Procedures/adverse effects
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1469153-x
ISSN	1473-0804 ; 1369-7137
ISSN (online)	1473-0804
ISSN	1369-7137
DOI	10.1080/13697137.2024.2310518
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Article ; Online: Ionic Covalent Organic Frameworks in Adsorption and Catalysis.

Liu, Minghao / Xu, Qing / Zeng, Gaofeng

Angewandte Chemie (International ed. in English)

2024 Volume 63, Issue 22, Page(s) e202404886

Abstract: The ion extraction and electro/photo catalysis are promising methods to address environmental and energy issues. Covalent organic frameworks (COFs) are a class of promising template to construct absorbents and catalysts because of their stable frameworks, ...

Abstract	The ion extraction and electro/photo catalysis are promising methods to address environmental and energy issues. Covalent organic frameworks (COFs) are a class of promising template to construct absorbents and catalysts because of their stable frameworks, high surface areas, controllable pore environments, and well-defined catalytic sites. Among them, ionic COFs as unique class of crystalline porous materials, with charges in the frameworks or along the pore walls, have shown different properties and resulting performance in these applications with those from charge-neutral COFs. In this review, current research progress based on the ionic COFs for ion extraction and energy conversion, including cationic/anionic materials and electro/photo catalysis is reviewed in terms of the synthesis strategy, modification methods, mechanisms of adsorption and catalysis, as well as applications. Finally, we demonstrated the current challenges and future development of ionic COFs in design strategies and applications.
Language	English
Publishing date	2024-04-23
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202404886
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Article ; Online: Overview of Food Preservation and Traceability Technology in the Smart Cold Chain System

Bai, Lin / Liu, Minghao / Sun, Ying

Foods. 2023 July 29, v. 12, no. 15

2023

Abstract: According to estimates by the Food and Agriculture Organization of the United Nations (FAO), about a third of all food produced for human consumption in the world is lost or wasted—approximately 1.3 billion tons. Among this, the amount lost during the ... ...

Abstract	According to estimates by the Food and Agriculture Organization of the United Nations (FAO), about a third of all food produced for human consumption in the world is lost or wasted—approximately 1.3 billion tons. Among this, the amount lost during the storage stage is about 15–20% for vegetables and 10–15% for fruits. It is 5–10% for vegetables and fruits during the distribution stage, resulting in a large amount of resource waste and economic losses. At the same time, the global population affected by hunger has reached 828 million, exceeding one-tenth of the total global population. The improvement of the cold chain system will effectively reduce the amount of waste and loss of food during the storage and transportation stages. Firstly, this paper summarizes the concept and development status of traditional preservation technology; environmental parameter sensor components related to fruit and vegetable spoilage in the intelligent cold chain system; the data transmission and processing technology of the intelligent cold chain system, including wireless network communication technology (WI-FI) and cellular mobile communication; short-range communication technology, and the low-power, wide-area network (LPWAN). The smart cold chain system is regulated and optimized through the Internet of Things, blockchain, and digital twin technology to achieve the sustainable development of smart agriculture. The deep integration of artificial intelligence and traditional preservation technology provides new ideas and solutions for the problem of food waste in the world. However, the lack of general standards and the high cost of the intelligent cold chain system are obstacles to the development of the intelligent cold chain system. Governments and researchers at all levels should strive to highly integrate cold chain systems with artificial intelligence technology, establish relevant regulations and standards for cold chain technology, and actively promote development toward intelligence, standardization, and technology.
Keywords	Food and Agriculture Organization ; Internet ; artificial intelligence ; blockchain ; cold chain ; environmental factors ; food preservation ; food waste ; humans ; hunger ; spoilage ; sustainable development ; traceability ; transportation ; vegetables ; wireless technology
Language	English
Dates of publication	2023-0729
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12152881
Database	NAL-Catalogue (AGRICOLA)

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Article: Overview of Food Preservation and Traceability Technology in the Smart Cold Chain System.

Bai, Lin / Liu, Minghao / Sun, Ying

Foods (Basel, Switzerland)

2023 Volume 12, Issue 15

Abstract: According to estimates by the Food and Agriculture Organization of the United Nations (FAO), about a third of all food produced for human consumption in the world is lost or wasted-approximately 1.3 billion tons. Among this, the amount lost during the ... ...

Abstract	According to estimates by the Food and Agriculture Organization of the United Nations (FAO), about a third of all food produced for human consumption in the world is lost or wasted-approximately 1.3 billion tons. Among this, the amount lost during the storage stage is about 15-20% for vegetables and 10-15% for fruits. It is 5-10% for vegetables and fruits during the distribution stage, resulting in a large amount of resource waste and economic losses. At the same time, the global population affected by hunger has reached 828 million, exceeding one-tenth of the total global population. The improvement of the cold chain system will effectively reduce the amount of waste and loss of food during the storage and transportation stages. Firstly, this paper summarizes the concept and development status of traditional preservation technology; environmental parameter sensor components related to fruit and vegetable spoilage in the intelligent cold chain system; the data transmission and processing technology of the intelligent cold chain system, including wireless network communication technology (WI-FI) and cellular mobile communication; short-range communication technology, and the low-power, wide-area network (LPWAN). The smart cold chain system is regulated and optimized through the Internet of Things, blockchain, and digital twin technology to achieve the sustainable development of smart agriculture. The deep integration of artificial intelligence and traditional preservation technology provides new ideas and solutions for the problem of food waste in the world. However, the lack of general standards and the high cost of the intelligent cold chain system are obstacles to the development of the intelligent cold chain system. Governments and researchers at all levels should strive to highly integrate cold chain systems with artificial intelligence technology, establish relevant regulations and standards for cold chain technology, and actively promote development toward intelligence, standardization, and technology.
Language	English
Publishing date	2023-07-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12152881
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Article ; Online: Effect of different doses of epidural dexmedetomidine on reducing visceral traction reaction for cesarean section: a double-blind randomized controlled trial.

Liu, Minghao / Wang, Bin / Prudence, Bizimana / Chen, Xuezi

Journal of anesthesia

2023 Volume 37, Issue 3, Page(s) 371–378

Abstract: Purpose: This study aimed to evaluate the effect of different doses of epidural dexmedetomidine on reducing visceral traction reaction for cesarean section under epidural anesthesia.: Methods: Nulliparas were randomly allocated to receive epidural ... ...

Abstract	Purpose: This study aimed to evaluate the effect of different doses of epidural dexmedetomidine on reducing visceral traction reaction for cesarean section under epidural anesthesia. Methods: Nulliparas were randomly allocated to receive epidural ropivacaine alone (group R) or in combination with dexmedetomidine 0.5 μg/kg (group RD0.5), 0.75 μg/kg (group RD0.75), and 1 μg/kg (group RD1) with 46 nulliparas in each group. The primary outcome was intraoperative visceral traction reaction (graded from 0 to 3, with 0 and 3, respectively, regarded as 'no discomfort in stomach or perineum; no nausea, vomiting or intestinal tympanites' and 'serious visceral pain, nausea and vomiting, intestinal tympanites'). Results: Visceral traction reaction was significantly alleviated in group RD0.5, RD0.75, and RD1, respectively, compared to group R while it was comparable among RD groups. Increased Ramsay Sedation Scale and lower incidence of shivering were found in RD groups compared to group R (p < 0.001). None of the primipara has experienced Ramsay Sedation Scale above 4. Higher incidence of thirst was found in group RD0.75 and RD1 compared to group R and RD0.5 (p < 0.001). The Apgar scores at 1 and 5 min of the neonates, onset time to T6 sensory block, maximum sensory block level, the incidence of hypotension, bradycardia and nausea or vomiting were comparable among groups. Conclusion: It is suggested that 0.5 μg/kg epidural dexmedetomidine can be used as adjuvant to epidural ropivacaine during cesarean section, because of its alleviating visceral traction reaction, moderate sedating, and reducing shivering without thirst increase.
MeSH term(s)	Infant, Newborn ; Pregnancy ; Humans ; Female ; Ropivacaine ; Anesthetics, Local ; Dexmedetomidine ; Cesarean Section ; Traction ; Double-Blind Method ; Vomiting/chemically induced ; Vomiting/prevention & control
Chemical Substances	Ropivacaine (7IO5LYA57N) ; Anesthetics, Local ; Dexmedetomidine (67VB76HONO)
Language	English
Publishing date	2023-01-24
Publishing country	Japan
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1107821-2
ISSN	1438-8359 ; 0913-8668
ISSN (online)	1438-8359
ISSN	0913-8668
DOI	10.1007/s00540-023-03166-8
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Article ; Online: Molecular Mechanisms and Regulatory Pathways Underlying Drought Stress Response in Rice.

Geng, Anjing / Lian, Wenli / Wang, Yihan / Liu, Minghao / Zhang, Yue / Wang, Xu / Chen, Guang

International journal of molecular sciences

2024 Volume 25, Issue 2

Abstract: Rice is a staple food for 350 million people globally. Its yield thus affects global food security. Drought is a serious environmental factor affecting rice growth. Alleviating the inhibition of drought stress is thus an urgent challenge that should be ... ...

Abstract	Rice is a staple food for 350 million people globally. Its yield thus affects global food security. Drought is a serious environmental factor affecting rice growth. Alleviating the inhibition of drought stress is thus an urgent challenge that should be solved to enhance rice growth and yield. This review details the effects of drought on rice morphology, physiology, biochemistry, and the genes associated with drought stress response, their biological functions, and molecular regulatory pathways. The review further highlights the main future research directions to collectively provide theoretical support and reference for improving drought stress adaptation mechanisms and breeding new drought-resistant rice varieties.
MeSH term(s)	Humans ; Oryza/genetics ; Droughts ; Plant Breeding ; Food ; Sutures
Language	English
Publishing date	2024-01-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25021185
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Article ; Online: The Molecular Mechanism of the Response of Rice to Arsenic Stress and Effective Strategies to Reduce the Accumulation of Arsenic in Grain.

Geng, Anjing / Lian, Wenli / Wang, Yihan / Liu, Minghao / Zhang, Yue / Wang, Xu / Chen, Guang

International journal of molecular sciences

2024 Volume 25, Issue 5

Abstract: Rice ( ...

Abstract	Rice (
MeSH term(s)	Humans ; Arsenic/metabolism ; Oryza/genetics ; Soil Pollutants/metabolism ; Plant Breeding ; Plant Structures/metabolism ; Soil ; Edible Grain/metabolism
Chemical Substances	Arsenic (N712M78A8G) ; Soil Pollutants ; Soil
Language	English
Publishing date	2024-03-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25052861
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Article ; Online: Role of Biomarkers of Myocardial Injury to Predict Adverse Outcomes in Hypertrophic Cardiomyopathy.

Zhang, Yu / Liu, Minghao / Zhang, Channa / Zou, Yubao / Kang, Lianming / Song, Lei

Circulation. Cardiovascular quality and outcomes

2024 Volume 17, Issue 2, Page(s) e010243

Abstract: Background: Serum troponins and CK-MB (creatine kinase-MB) are readily detectable and reliable cardiac-specific biomarkers of subclinical myocardial injury. This study explores the roles of cTnI (cardiac troponin I) and CK-MB in hypertrophic ... ...

Abstract	Background: Serum troponins and CK-MB (creatine kinase-MB) are readily detectable and reliable cardiac-specific biomarkers of subclinical myocardial injury. This study explores the roles of cTnI (cardiac troponin I) and CK-MB in hypertrophic cardiomyopathy (HCM). Methods: This study included 1045 patients with HCM who had baseline cTnI and CK-MB measurements at Fuwai Hospital between 1999 and 2019. Patients were excluded if they had undergone percutaneous coronary intervention or coronary artery bypass grafting, or had renal failure. Five end points were studied: all-cause death, cardiovascular death, noncardiovascular death, sudden cardiac death, and other cardiovascular death. Cox regression was used to assess the associations of cTnI and CK-MB levels with outcomes. Results: Nine hundred seventy patients with available follow-up data were finally analyzed (mean age, 49.3 years; 36.4% female). During the median 4.3-year follow-up period, 87 patients reached the end points. Higher cTnI (per 0.05 ng/mL increase) and CK-MB (per 1 IU/L increase) levels were associated with increased risks of all-cause death (cTnI: adjusted hazard ratio [HR], 1.038, Conclusions: Comprehensive evaluations of biomarkers of myocardial injury, cTnI and CK-MB, have considerable value for predicting adverse outcomes among patients with HCM. Routine cTnI and CK-MB assessments may help to guide implantable cardioverter defibrillator implantation for primary prevention in HCM.
MeSH term(s)	Humans ; Female ; Middle Aged ; Male ; Biomarkers ; Creatine Kinase, MB Form ; Prognosis ; Cardiomyopathy, Hypertrophic/complications ; Cardiomyopathy, Hypertrophic/diagnosis ; Cardiomyopathy, Hypertrophic/therapy ; Death, Sudden, Cardiac/etiology ; Death, Sudden, Cardiac/prevention & control
Chemical Substances	Biomarkers ; Creatine Kinase, MB Form (EC 2.7.3.2)
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2483197-9
ISSN	1941-7705 ; 1941-7713
ISSN (online)	1941-7705
ISSN	1941-7713
DOI	10.1161/CIRCOUTCOMES.123.010243
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Article ; Online: pOsHAK1:OsSUT1

Chen, Guang / Lian, Wenli / Geng, Anjing / Wang, Yihan / Liu, Minghao / Zhang, Yue / Wang, Xu

International journal of molecular sciences

2024 Volume 25, Issue 4

Abstract: Plant cells accumulate osmotic substances (e.g., sugar) to protect cell components and maintain osmotic balance under drought stress conditions. Previous studies found ... ...

Abstract	Plant cells accumulate osmotic substances (e.g., sugar) to protect cell components and maintain osmotic balance under drought stress conditions. Previous studies found that
MeSH term(s)	Drought Resistance ; Oryza/genetics ; Oryza/metabolism ; Hydrogen Peroxide/metabolism ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Droughts ; Plants, Genetically Modified/genetics ; Plants, Genetically Modified/metabolism ; Sucrose/metabolism ; Sugars/metabolism ; Water/metabolism ; Gene Expression Regulation, Plant ; Stress, Physiological/genetics
Chemical Substances	Hydrogen Peroxide (BBX060AN9V) ; Plant Proteins ; Sucrose (57-50-1) ; Sugars ; Water (059QF0KO0R)
Language	English
Publishing date	2024-02-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25042158
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