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Article ; Online: Combination chemotherapy with trastuzumab in early-stage breast cancer: a meta-analysis and Bayesian decision analysis of different treatment regimens.

Liu, Q

European review for medical and pharmacological sciences

2024 Volume 28, Issue 1, Page(s) 231–241

Abstract: Objective: HER2-positive breast cancer is a high-risk malignant tumor, and trastuzumab is an effective targeted therapy drug, but its optimal duration remains uncertain. To compare the efficacy and cost-effectiveness of different durations (6 months, 9 ... ...

Abstract	Objective: HER2-positive breast cancer is a high-risk malignant tumor, and trastuzumab is an effective targeted therapy drug, but its optimal duration remains uncertain. To compare the efficacy and cost-effectiveness of different durations (6 months, 9 months, 12 months, and 18 months) of trastuzumab combined with chemotherapy in patients with early breast cancer by meta-analysis and Bayesian decision analysis. Patients and methods: Randomized controlled trials comparing the effectiveness of different durations of trastuzumab combination chemotherapy in early-stage breast cancer patients were collected by searching multiple databases. Data synthesis was performed using the R software, and a decision tree model was constructed to simulate the expected outcomes and anticipated costs associated with different treatment durations. Results: This study included 9 randomized controlled trials involving 11,328 early-stage breast cancer patients. The meta-analysis results demonstrated that, compared to the control group, trastuzumab combination chemotherapy at different durations significantly improved disease-free survival and overall survival in early-stage breast cancer patients. Among the various treatment durations, it was observed that 12 months of trastuzumab combination chemotherapy, in comparison to other durations, significantly reduced the risk of recurrence and mortality in early-stage breast cancer patients while maintaining a favorable cost-effectiveness ratio. Bayesian decision analysis also confirmed that 12 months of trastuzumab combination chemotherapy is the optimal treatment duration. Conclusions: It is recommended to use 12 months of trastuzumab combination chemotherapy as the standard treatment for early-stage breast cancer patients.
MeSH term(s)	Humans ; Female ; Trastuzumab/therapeutic use ; Breast Neoplasms/pathology ; Bayes Theorem ; Receptor, ErbB-2 ; Chemotherapy, Adjuvant ; Disease-Free Survival ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Decision Support Techniques ; Randomized Controlled Trials as Topic
Chemical Substances	Trastuzumab (P188ANX8CK) ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2024-01-18
Publishing country	Italy
Document type	Meta-Analysis ; Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202401_34908
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Book ; Online: Metallurgical Process Simulation and Optimization

Liu, Qing / Zhang, Jiangshan

2023

Keywords	Technology: general issues ; History of engineering & technology ; Al-Ag alloys ; Ag clusters ; positron annihilation ; monovacancies ; shallow trapping ; continuous casting ; electromagnetic stirring ; flow behavior ; uniform index of solidified shell ; digital image correlation ; mechanical properties ; stainless steel ; temperature ; thermovision ; uniaxial tensile test ; cryogenic vessel steels ; cerium ; microstructure ; inclusions ; electric arc furnace ; energy efficiency modelling ; process optimization ; mass and energy balances ; blast furnace ; hydrogen injection ; gas utilisation efficiency ; energy consumption ; CO2 emission ; EDA-exploratory data analysis ; rare Earth metal oxides ; wear resistance ; heatmap ; correlation ; electro-gas welding ; high heat input ; heat source movement path ; finite element analysis ; thermal evolution ; fluid-particle flow ; submerged entry nozzle ; lattice Boltzmann method ; large eddy simulation ; vortex structures ; crystallization ratio ; flux film ; heat transfer ; longitudinal crack ; peritectic steels ; high carbon steel ; cracking con-rod ; C70S6 ; tundish ; flow field ; water modelling ; mathematical simulation ; temperature field ; bloom quality consistency ; PFR lime kiln ; lime calcination ; BFG ; numerical simulation ; PMM ; SCM ; high-temperature confocal microscope ; phase-field simulation ; duplex stainless steel ; cooling rate ; near-α titanium alloy ; TiH2-based powder metallurgy ; hot compression ; strain hardening exponents ; strain rate sensitivity ; processing map ; alumina inclusion ; interfacial tension ; steelmaking ; continuous casting mold ; surfactant ; sulfur ; simulation ; dry vibrating material ; collapsed ladle ; mathematical modeling ; stress field ; strain field ; molecular dynamics simulation ; CaF2 ; melts' structure ; transport properties ; viscosity ; inclusion ; ZrO2 ; nucleation mechanism ; first principles ; n/a
Language	English
Size	1 electronic resource (320 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030379091
ISBN	9783036564319 ; 3036564314
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: A case report of atrial septal puncture "mistakenly" penetrated the aorta during left bypass radiofrequency ablation.

Liu, Qian

Medicine

2024 Volume 103, Issue 14, Page(s) e37723

Abstract: Introduction: Transseptal punctures (TSPs) are widely used in left atrium and left ventricle surgery. Accidental puncture of the puncture needle into the aorta is a rare complication that is rarely reported but has serious consequences. The appropriate ... ...

Abstract	Introduction: Transseptal punctures (TSPs) are widely used in left atrium and left ventricle surgery. Accidental puncture of the puncture needle into the aorta is a rare complication that is rarely reported but has serious consequences. The appropriate management of this complication remains unclear. Patient concerns: This report describes a case of a male with the chief complaint: paroxysmal palpitation for 1 year, aggravated for 1 month. Diagnosis: The electrophysiological diagnosis was atrioventricular reentrant tachycardia caused by left-side bypass. Interventions: Radiofrequency ablation of the heart was a necessary treatment and a TSP operation was needed, in which a puncture was mistakenly believed to have entered the aorta, a series of measures were taken urgently. Although the surgical procedure in this case was a false alarm, we still initiated a series of emergency plans. Emergency measures to address the complications were effectively implemented, and the emergency measures were promptly terminated after it was clear that complications had been misjudged. Outcomes: At last, it was confirmed that the angiogram was a pulmonary artery image, not an aorta image. Then the atrial septal puncture operation was successfully completed, and under the guidance of the Carto system, the ablation was successfully completed. Postoperative fluoroscopy showed no complications, such as pericardial effusion. After 2 years of follow-up, there was no reoccurrence of tachycardia, and there were no complications. It is crucial that emergency procedures are terminated in a timely manner after a clear miscarriage of performance. Although accidental puncture into the aorta is urgent and serious, performing a blockage or even thoracotomy in an emergency if complications are not clearly confirmed can cause further damage to the patient and would be a definitively wrong strategy. Conclusion: Strict and standardized TSP operations can avoid complications. Correct judgment of the authenticity of complications is crucial, and remedial measures that may cause further damage should not be blindly adopted. The retention of the aortic guide wire can provide convenient access for further differential diagnosis and remedial treatment.
MeSH term(s)	Humans ; Male ; Aorta/surgery ; Atrial Fibrillation/surgery ; Catheter Ablation/adverse effects ; Catheter Ablation/methods ; Heart Septal Defects, Atrial/surgery ; Punctures/adverse effects ; Punctures/methods ; Radiofrequency Ablation ; Treatment Outcome
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037723
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Article ; Online: A Discrete Latent State-Trait Model.

Liu, Qimin

Multivariate behavioral research

2023 Volume 58, Issue 1, Page(s) 135–136

Language	English
Publishing date	2023-01-09
Publishing country	United States
Document type	Journal Article
ISSN	1532-7906
ISSN (online)	1532-7906
DOI	10.1080/00273171.2022.2160297
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Article ; Online: Analysis of governmental open letters mobilizing residents in China during the COVID-19 pandemic.

Liu, Qing

Discourse & society

2023 Volume 34, Issue 1, Page(s) 77–95

Abstract: In response to the threat of COVID-19, China initiated a nationwide campaign. Ideological work such as explaining the implemented policies and persuading the public always took a central role in mobilization, and it has been emphasized by Chinese ... ...

Abstract	In response to the threat of COVID-19, China initiated a nationwide campaign. Ideological work such as explaining the implemented policies and persuading the public always took a central role in mobilization, and it has been emphasized by Chinese government during Covid-19 as well. The legitimation discourse used in the campaign is the focus of the current study. The investigation takes into consideration the political logic of the relationship between the central and local governments as well as their working mechanism. More specifically, a total of 84 open letters written by the local governments to mobilize residents during the COVID-19 pandemic were analyzed. The study integrated the CDA perspective, legitimation theory, and campaign-style governance and examined what ideological discourses are constructed in the open letters, what type of authority is constructed for legitimation, and what is the main communication style used. In addition, the study paid attention to the patterns among the different local government ranks. The findings revealed that moral appeal and political authority were the key elements of legitimation discourse, but governments with lower ranks exhibited a trend of de-ideologization. Meanwhile, impersonal politeness and direct bold command contradictorily co-existed in open letters of basic level local governments. These finding reveal that despite the top government's centralized power, realization of ideological work in a national campaign is confined by the divergent and complicated realities of local governments.
Language	English
Publishing date	2023-10-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1484288-9
ISSN	1460-3624 ; 0957-9265
ISSN (online)	1460-3624
ISSN	0957-9265
DOI	10.1177/09579265221116980
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Article ; Online: Theoretical research on the dye molecules with different π-bridge structures.

Liu, Qun

Journal of molecular modeling

2023 Volume 29, Issue 8, Page(s) 248

Abstract: Context: Since 1991 when Grätzel et al. improved the conversion efficiency of dye-sensitized solar cells to 7.1% by applying nano technology as the first time, the researches on dye-sensitized solar cells have received widely attentions. The organic dye ...

Abstract	Context: Since 1991 when Grätzel et al. improved the conversion efficiency of dye-sensitized solar cells to 7.1% by applying nano technology as the first time, the researches on dye-sensitized solar cells have received widely attentions. The organic dye without precious metals has a lower cost, which is easily to get synthesized and its structure is easily decorated, owing a higher photoelectric conversion efficiency at the same time. Therefore, in recent years, the organic dye has attracted people's attentions more and more. In order to better understand the relationship between structure and properties of dye molecules, with ZL003 as a prototype, molecular modifications are then made and a scheme, with rigid fused π-bridge comprising electron-rich and deficient segments. The calculated results indicate that the π-bridge containing dithienopyrrolobenzothiadiazole and dipyrrolo-dithienobenzothiadiazole as π-bridge has been demonstrated to be successful to significantly redshift the absorption maximum wavelength, extend the lifetime of the first excited state, and decrease the energy gap between the highest occupied molecule orbital (HOMO) and the lowest unoccupied molecule orbital (LUMO). It is hoped that the calculation result of this paper would provide theoretical basis for the experimental synthesis of more efficient dye molecules. Method: All calculations were performed in Gaussian 09 program package. The ground state geometries (S0) and the first excited state (S1) were optimized using density function theory (DFT) with the hybrid function B3LYP functional, coupled with the 6-31G(d, p) basis set for optimization of molecule ground state conformations. TD-DFT calculations of excited state energies and absorption spectra were performed using MPWPW91 functional combined with the 6-31 + G (d) basis set.
MeSH term(s)	Humans ; Models, Molecular ; Solar Energy ; Molecular Conformation ; Metals ; Coloring Agents/chemistry
Chemical Substances	Metals ; Coloring Agents
Language	English
Publishing date	2023-07-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1284729-X
ISSN	0948-5023 ; 1610-2940
ISSN (online)	0948-5023
ISSN	1610-2940
DOI	10.1007/s00894-023-05655-9
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Article ; Online: A stochastic predator-prey model with two competitive preys and Ornstein-Uhlenbeck process.

Liu, Qun

Journal of biological dynamics

2023 Volume 17, Issue 1, Page(s) 2193211

Abstract: In this paper, a stochastic predator-prey model with two competitive preys and Ornstein-Uhlenbeck process is formulated and analysed, which is used to obtain a better understanding of the population dynamics. At first, we validate that the stochastic ... ...

Abstract	In this paper, a stochastic predator-prey model with two competitive preys and Ornstein-Uhlenbeck process is formulated and analysed, which is used to obtain a better understanding of the population dynamics. At first, we validate that the stochastic system has a unique global solution with any initial value. Then we analyse the stochastic dynamics of the model in detail, including
MeSH term(s)	Animals ; Models, Biological ; Population Dynamics ; Predatory Behavior ; Stochastic Processes
Language	English
Publishing date	2023-03-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2274786-2
ISSN	1751-3766 ; 1751-3758
ISSN (online)	1751-3766
ISSN	1751-3758
DOI	10.1080/17513758.2023.2193211
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Article ; Online: Reply to M. Shibusawa et al.

Liu, Qifa

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2023 Volume 41, Issue 7, Page(s) 1497

Language	English
Publishing date	2023-01-03
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.22.02505
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Article: The Emerging Landscape of Long Non-Coding RNAs in Wilms Tumor.

Liu, Qiang

Frontiers in oncology

2022 Volume 11, Page(s) 780925

Abstract: Long noncoding RNAs (LncRNAs) are transcripts of nucleic acid sequences with a length of more than 200 bp, which have only partial coding capabilities. Recent studies have shown that lncRNAs located in the nucleus or cytoplasm can be used as gene ... ...

Abstract	Long noncoding RNAs (LncRNAs) are transcripts of nucleic acid sequences with a length of more than 200 bp, which have only partial coding capabilities. Recent studies have shown that lncRNAs located in the nucleus or cytoplasm can be used as gene expression regulatory elements due to their important regulatory effects in a variety of biological processes. Wilms tumor (WT) is a common abdominal tumor in children whose pathogenesis remains unclear. In recent years, many specifically expressed lncRNAs have been found in WT, which affect the occurrence and development of WT. At the same time, lncRNAs may have the capacity to become novel biomarkers for the diagnosis and prognosis of WT. This article reviews related research progress on the relationship between lncRNAs and WT, to provide a new direction for clinical diagnosis and treatment of WT.
Language	English
Publishing date	2022-01-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2021.780925
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Article: Current Advances in N6-Methyladenosine Methylation Modification During Bladder Cancer.

Liu, Qiang

Frontiers in genetics

2022 Volume 12, Page(s) 825109

Abstract: N6-methyladenosine (m6A) is a dynamic, reversible post-transcriptional modification, and the most common internal modification of eukaryotic messenger RNA (mRNA). Considerable evidence now shows that m6A alters gene expression, thereby regulating cell ... ...

Abstract	N6-methyladenosine (m6A) is a dynamic, reversible post-transcriptional modification, and the most common internal modification of eukaryotic messenger RNA (mRNA). Considerable evidence now shows that m6A alters gene expression, thereby regulating cell self-renewal, differentiation, invasion, and apoptotic processes. M6A methylation disorders are directly related to abnormal RNA metabolism, which may lead to tumor formation. M6A methyltransferase is the dominant catalyst during m6A modification; it removes m6A demethylase, promotes recognition by m6A binding proteins, and regulates mRNA metabolic processes. Bladder cancer (BC) is a urinary system malignant tumor, with complex etiology and high incidence rates. A well-differentiated or moderately differentiated pathological type at initial diagnosis accounts for most patients with BC. For differentiated superficial bladder urothelial carcinoma, the prognosis is normally good after surgery. However, due to poor epithelial cell differentiation, BC urothelial cell proliferation and infiltration may lead to invasive or metastatic BC, which lowers the 5-years survival rate and significantly affects clinical treatments in elderly patients. Here, we review the latest progress in m6A RNA methylation research and investigate its regulation on BC occurrence and development.
Language	English
Publishing date	2022-01-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2021.825109
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