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Article: 吕梁山森林生态系统土壤螨类物种多样性和功能多样性对海拔梯度的响应.

Liu, Qian-Yu / Wang, Rang-Hu / Wu, Xin-Jie / Dou, Yong-Jing

Ying yong sheng tai xue bao = The journal of applied ecology

2024 Volume 34, Issue 12, Page(s) 3301–3312

Abstract: The altitudinal gradient pattern of mountain biodiversity and its formation mechanism are hot topics in ecological research. The altitudinal variations of belowground invertebrates are less understood than aboveground plants and animals. With soil mites ... ...

Title translation	Responses of taxonomic and functional diversity of soil mites to altitudinal changes in forest ecosystems of Lyuliang Mountains, Shanxi, China.
Abstract	The altitudinal gradient pattern of mountain biodiversity and its formation mechanism are hot topics in ecological research. The altitudinal variations of belowground invertebrates are less understood than aboveground plants and animals. With soil mites as the model soil animals, we investigated their distribution patterns from 1318 m to 2500 m above sea level in three mountains of Lyuliang Mountains based on species diversity and functional diversity. We used soil pH, total N, total P, total K, and organic matter content to identify potential drivers of soil mite communities and diversity along the altitudinal gradient. A total of 715 soil mites were collected, belonging to 3 orders, 27 families, 28 genera, and 29 species.
MeSH term(s)	Humans ; Animals ; Ecosystem ; Mites ; Soil ; Forests ; Biodiversity ; China ; Altitude
Chemical Substances	Soil
Language	Chinese
Publishing date	2024-03-21
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2881809-X
ISSN	1001-9332
ISSN	1001-9332
DOI	10.13287/j.1001-9332.202312.032
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Article ; Online: Exogenous applications of brassinosteroids promote secondary xylem differentiation in

Zhou, Fangping / Hu, Bing / Li, Juan / Yan, Huifang / Liu, Qianyu / Zeng, Bingshan / Fan, Chunjie

PeerJ

2024 Volume 12, Page(s) e16250

Abstract: Brassinosteroids (BRs) play many pivotal roles in plant growth and development, especially in cell elongation and vascular development. Although its biosynthetic and signal transduction pathway have been well characterized in model plants, their ... ...

Abstract	Brassinosteroids (BRs) play many pivotal roles in plant growth and development, especially in cell elongation and vascular development. Although its biosynthetic and signal transduction pathway have been well characterized in model plants, their biological roles in
MeSH term(s)	Eucalyptus ; Brassinosteroids/pharmacology ; Cell Differentiation ; Xylem ; Wood
Chemical Substances	Brassinosteroids
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.16250
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Article: The efficacy of modified contrast-enhanced ultrasound Liver Imaging Reporting and Data System (CEUS LI-RADS) using Sonazoid in diagnosis of hepatocellular carcinoma: a systematic review and meta-analysis.

Liu, Qianyu / Liu, Ting / Liu, Xiang / Zhang, Feng / Yang, Jinyu / Cheng, Yanan / Yang, Qing

Quantitative imaging in medicine and surgery

2024 Volume 14, Issue 4, Page(s) 2927–2937

Abstract: Background: The contrast-enhanced ultrasound Liver Imaging Reporting and Data System (CEUS LI-RADS) is an algorithm for the diagnosis of hepatocellular carcinoma (HCC) in high-risk populations. Previous studies have shown the algorithm to have high ... ...

Abstract	Background: The contrast-enhanced ultrasound Liver Imaging Reporting and Data System (CEUS LI-RADS) is an algorithm for the diagnosis of hepatocellular carcinoma (HCC) in high-risk populations. Previous studies have shown the algorithm to have high specificity and moderate sensitivity. Nevertheless, it is designated for utilization solely with blood pool contrast agents. Sonazoid, a contrast agent that combines blood pools and Kupffer cells properties, has recently gained approval for marketing in an increased number of countries. Enhanced sensitivity in diagnosing HCC may be achieved through the distinctive Kupffer phase (KP) exhibited by Sonazoid. Certain academics have suggested the modified CEUS LI-RADS using Sonazoid. The main criteria of mild and late (≥60 seconds) washout in CEUS LI-RADS LR-5 were replaced by KP (>10 minutes) defects as the primary criteria. The purpose of this research was to evaluate the effectiveness of the modified CEUS LI-RADS using Sonazoid in diagnosing HCC. Methods: Original studies on Sonazoid and CEUS LI-RADS were searched in the PubMed, Embase, Cochrane Library, and Web of Science databases until 13 July 2023, with no restrictions on language. We enrolled studies that applied Sonazoid for CEUS in patients at high risk of HCC and modified CEUS LI-RADS for the diagnosis of intrahepatic nodules. Meta-analyses, evaluations, case studies, correspondences, remarks, and summaries of conferences were excluded. Additionally, studies that fell outside the scope of this study and contained data on the same patients were also excluded. We evaluated the quality of research by employing the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool. A bivariate mixed effects model was utilized to conduct a meta-analysis, summarizing the sensitivity and specificity in the diagnosis of HCC. The investigation of potential factors contributing to study heterogeneity was conducted using meta-regression analysis. Results: Out of the 103 studies screened, 6 studies (835 lesions) were included in the final results. Modified CEUS LR-5 exhibited a sensitivity of 0.77 [95% confidence interval (CI): 0.70-0.82; I Conclusions: The modified CEUS LI-RADS LR-5 categorization demonstrates a reasonable level of sensitivity 0.77, but an insufficient level of specificity 0.88 when diagnosing HCC. KP defects cannot be used as a primary feature in the diagnosis of HCC by CEUS LI-RADS, perhaps as an ancillary feature.
Language	English
Publishing date	2024-03-21
Publishing country	China
Document type	Journal Article
ZDB-ID	2653586-5
ISSN	2223-4306 ; 2223-4292
ISSN (online)	2223-4306
ISSN	2223-4292
DOI	10.21037/qims-23-1184
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Article: An optimal Fe-C coordination ensemble for hydrocarbon chain growth: a full Fischer-Tropsch synthesis mechanism from machine learning.

Liu, Qian-Yu / Chen, Dongxiao / Shang, Cheng / Liu, Zhi-Pan

Chemical science

2023 Volume 14, Issue 35, Page(s) 9461–9475

Abstract: Fischer-Tropsch synthesis (FTS, CO + ... ...

Abstract	Fischer-Tropsch synthesis (FTS, CO + H
Language	English
Publishing date	2023-08-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d3sc02054a
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Article ; Online: In Situ

Liu, Qian-Yu / Shang, Cheng / Liu, Zhi-Pan

The journal of physical chemistry letters

2022 Volume 13, Issue 15, Page(s) 3342–3352

Abstract: Fischer-Tropsch synthesis (FTS) that converts syngas into long-chain hydrocarbons is a key technology in the chemical industry. As one of the best catalysts for FTS, the Fe-based composite develops rich solid phases (metal, oxides, and carbides) in the ... ...

Abstract	Fischer-Tropsch synthesis (FTS) that converts syngas into long-chain hydrocarbons is a key technology in the chemical industry. As one of the best catalysts for FTS, the Fe-based composite develops rich solid phases (metal, oxides, and carbides) in the catalytic reaction, which triggered the quest for the true active site in catalysis in the past century. Recent years have seen great advances in probing the active-site structure using modern experimental and theoretical tools. This Perspective serves to highlight these latest achievements, focusing on the geometrical structure and thermodynamic stability of Fe carbide bulk phases, the exposed surfaces, and their relationship to FTS activity. The current reaction mechanisms on CO activation and carbon chain growth are also discussed, in the context of theoretical models and experimental evidence. We also present the outlook regarding the current challenges in Fe-based FTS.
MeSH term(s)	Carbon/chemistry ; Carbon Monoxide/chemistry ; Catalysis ; Catalytic Domain ; Hydrocarbons/chemistry
Chemical Substances	Hydrocarbons ; Carbon (7440-44-0) ; Carbon Monoxide (7U1EE4V452)
Language	English
Publishing date	2022-04-08
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1948-7185
ISSN (online)	1948-7185
DOI	10.1021/acs.jpclett.2c00549
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Article ; Online: In Situ

Liu, Qian-Yu / Shang, Cheng / Liu, Zhi-Pan

Journal of the American Chemical Society

2021

Abstract: ... In ... ...

Abstract	In situ
Language	English
Publishing date	2021-07-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.1c04624
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Article: Diminished hedonic capacity in social activities as a mediator of the link between dysfunctional behavioral activation system and depressive symptoms.

Kuan, Chi-Son / Liu, Qian-Yu / Xu, Gang-Min / Zhou, Han-Yu / Nie, Jia-Hui / Yan, Chao

Frontiers in psychiatry

2024 Volume 15, Page(s) 1337847

Abstract: Background: Adolescence is a crucial period for the development of depression, and previous studies have suggested that the Behavioral Activation System (BAS) plays a significant role. However, little is known about the underlying mechanisms. This study ...

Abstract	Background: Adolescence is a crucial period for the development of depression, and previous studies have suggested that the Behavioral Activation System (BAS) plays a significant role. However, little is known about the underlying mechanisms. This study aimed to explore the mediating role of anhedonia in the relationship between BAS and depressive symptoms among Chinese adolescents. Method: A total of 1,023 high-school students aged 15-18 years participated in the study, with 916 continuing their participation three months later. All participants completed the Behavioral Inhibition System/Activation System (BIS/BAS) scale, Dimensional Anhedonia Rating Scale (DARS), Children's Depression Inventory (CDI), and the State-Trait Anxiety Inventory (STAI-S/T). Pathway model analysis was performed to examine the concurrent and prospective mediating effects of anhedonia and the potential moderating effect of sex. Result: Anhedonia in the domains of social activities, hobbies and sensory experiences significantly mediated the cross-sectional relationship between BAS and depressive level three months later. Furthermore, the beta-value of the mediating effect of social activities was significantly higher than that of the other domains of hedonic capacity cross-sectionally and longitudinally. However, sex showed no significant moderating effect. Conclusion: Our findings underscore the importance of hedonic capacity, especially within the social domain, in the development of depressive symptoms. These findings contribute to the early diagnosis and prevention of depressive disorders.
Language	English
Publishing date	2024-02-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2024.1337847
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Article ; Online: PRODH safeguards human naive pluripotency by limiting mitochondrial oxidative phosphorylation and reactive oxygen species production.

Chen, Cheng / Liu, Qianyu / Chen, Wenjie / Gong, Zhiyuan / Kang, Bo / Sui, Meihua / Huang, Liming / Wang, Ying-Jie

EMBO reports

2024 Volume 25, Issue 4, Page(s) 2015–2044

Abstract: Naive human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood. Here we report that, proline ... ...

Abstract	Naive human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood. Here we report that, proline dehydrogenase (PRODH), a mitochondria-localized proline metabolism enzyme, is dramatically upregulated in naive hESCs compared to their primed counterparts. The upregulation of PRODH is induced by a reduction in c-Myc expression that is dependent on PD0325901, a MEK inhibitor routinely present in naive hESC culture media. PRODH knockdown in naive hESCs significantly promoted mitochondrial oxidative phosphorylation (mtOXPHOS) and reactive oxygen species (ROS) production that triggered autophagy, DNA damage, and apoptosis. Remarkably, MitoQ, a mitochondria-targeted antioxidant, effectively restored the pluripotency and proliferation of PRODH-knockdown naive hESCs, indicating that PRODH maintains naive pluripotency by preventing excessive ROS production. Concomitantly, PRODH knockdown significantly slowed down the proteolytic degradation of multiple key mitochondrial electron transport chain complex proteins. Thus, we revealed a crucial role of PRODH in limiting mtOXPHOS and ROS production, and thereby safeguarding naive pluripotency of hESCs.
MeSH term(s)	Humans ; Reactive Oxygen Species/metabolism ; Proline Oxidase/genetics ; Proline Oxidase/metabolism ; Oxidative Phosphorylation ; Mitochondria/metabolism ; Apoptosis
Chemical Substances	Reactive Oxygen Species ; Proline Oxidase (EC 1.5.3.-) ; PRODH protein, human (EC 1.5.5.2)
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2020896-0
ISSN	1469-3178 ; 1469-221X
ISSN (online)	1469-3178
ISSN	1469-221X
DOI	10.1038/s44319-024-00110-z
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Article ; Online: Childhood Adversity and Adolescent Smartphone Use Across Sexual Orientation and Gender Expression.

Zheng, Xinyu / Jiang, Weiqing / Peng, Shuyi / Liu, Qianyu / He, Yitong / Huang, Cuihong / Hua, Yilin / Lu, Ciyong / Guo, Lan

JAMA network open

2024 Volume 7, Issue 4, Page(s) e246448

Abstract: Importance: Nonheterosexual and gender-nonconforming (GNC) individuals tend to report adverse childhood experiences (ACEs) more frequently compared with heterosexual and gender-conforming individuals, and individuals who have experienced ACEs, identify ... ...

Abstract	Importance: Nonheterosexual and gender-nonconforming (GNC) individuals tend to report adverse childhood experiences (ACEs) more frequently compared with heterosexual and gender-conforming individuals, and individuals who have experienced ACEs, identify as nonheterosexual, or exhibit moderate to high levels of GNC are more prone to engaging in problematic smartphone use (PSU). However, there is limited school-based data among adolescents regarding this matter. Objectives: To explore the associations between ACEs and PSU among adolescents across different sexual orientation and gender expression groups. Design, setting, and participants: Using data from the 2021 School-Based Chinese Adolescents Health Survey, this cross-sectional study includes participants from 288 public high schools across 8 provinces in China. Statistical analysis was performed from October 2023 to February 2024. Exposures: Data on ACEs, sexual orientations, and gender expressions (high, moderate, and low GNC) were collected. Main outcomes and measures: PSU was assessed using the 10-item Smartphone Addiction Scale-Short Version (SAS-SV). Weighted linear, logistic, or Poisson regression models were used. Results: Among the 85 064 adolescents included (mean [SD] age, 14.92 [1.77] years), 42 632 (50.1%) were female, 70 157 (83.2%) identified as Han Chinese, and 14 208 (16.8) identified as other ethnicities (Miao, Hui, Yi, Dai, and other ethnic groups). The prevalence of PSU among participants was 35.4%. Weighted Poisson regression models indicated that the interaction between GNC and ACE was significant (adjusted prevalence ratio [APR], 0.98; 95% CI, 0.97-0.99). Further stratified analysis demonstrated homosexual adolescents who experienced 4 or more ACEs showed a significantly increased prevalence of PSU (APR, 1.79; 95% CI, 1.64-1.96). Similarly, a markedly higher prevalence of PSU was observed among bisexual individuals with 4 or more ACEs (APR, 1.60; 95% CI, 1.41-1.80). Regarding gender expression categories, a significantly higher prevalence of PSU was noted among high GNC adolescents with 4 or more ACEs (APR, 1.78; 95% CI, 1.60-1.98) compared with low GNC adolescents without ACEs. Furthermore, experiencing any 3 ACE categories (abuse, neglect, and household dysfunction) was associated with an increased prevalence of PSU across different sexual orientation and gender expression subgroups. Conclusions and relevance: In this cross-sectional study, the amalgamation of elevated ACE scores with nonheterosexual orientations or GNC identities was significantly associated with increased PSU prevalence. These findings underscore that preventing ACEs may be beneficial in mitigating PSU among adolescents, particularly for nonheterosexual adolescents and those with high levels of GNC.
MeSH term(s)	Female ; Adolescent ; Humans ; Child ; Male ; Adverse Childhood Experiences ; Cross-Sectional Studies ; Smartphone ; Heterosexuality ; Homosexuality
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2024.6448
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Article: In Situ Active Site for CO Activation in Fe-Catalyzed Fischer–Tropsch Synthesis from Machine Learning

Liu, Qian-Yu / Shang, Cheng / Liu, Zhi-Pan

Journal of the American Chemical Society. 2021 July 17, v. 143, no. 29

2021

Abstract: In situ-formed iron carbides (FeCₓ) are the key components responsible for Fischer–Tropsch synthesis (FTS, CO + H₂ → long-chain hydrocarbons) on Fe-based catalysts in industry. The true active site is, however, highly controversial despite more than a ... ...

Abstract	In situ-formed iron carbides (FeCₓ) are the key components responsible for Fischer–Tropsch synthesis (FTS, CO + H₂ → long-chain hydrocarbons) on Fe-based catalysts in industry. The true active site is, however, highly controversial despite more than a century of study, which is largely due to the combined complexity in both FeCₓ structures and mechanism of CO hydrogenation. Herein powered by machine learning simulation, millions of structure candidates for FeCₓ bulk and surfaces are explored under FTS conditions, which leads to resolving the active site for CO activation. This is achieved without a priori input from experiment by first constructing the thermodynamics convex hull of bulk phases, followed by identifying the low surface energy surfaces and evaluating the adsorption ability of CO and H, and finally determining the lowest energy reaction pathway of CO activation. Rich information on FeCₓ structures and CO hydrogenation pathways is gleaned: (i) Fe₅C₂, Fe₇C₃, and Fe₂C are the three stable bulk phases under FTS in producing olefins, where Fe₇C₃ and Fe₂C have multiple energetically nearly degenerate bulk crystal phases; (ii) only three low surface energy surfaces of these bulk phases, namely, χ-Fe₅C₂(510), χ-Fe₅C₂(111), and η-Fe₂C(111), expose the Fe sites that can adsorb H atoms exothermically, where the surface Fe:C ratio is 2, 1.75, and 2, respectively; (iii) CO activation via direct dissociation can occur at the surface C vacancies (e.g., with a barrier of 1.1 eV) that are created dynamically via hydrogenation. These atomic-level understandings facilitate the building of the structure–activity correlation and designing better FT catalysts.
Keywords	Fischer-Tropsch reaction ; active sites ; adsorption ; dissociation ; energy ; hydrogenation ; industry ; thermodynamics
Language	English
Dates of publication	2021-0717
Size	p. 11109-11120.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.1c04624
Database	NAL-Catalogue (AGRICOLA)

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