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Article: Targeting the nucleic acid oxidative damage repair enzyme MTH1: a promising therapeutic option.

Ding, Yifeng / Liu, Qingquan

Frontiers in cell and developmental biology

2024 Volume 12, Page(s) 1334417

Abstract: The accumulation of reactive oxygen species (ROS) plays a pivotal role in the development of various diseases, including cancer. Elevated ROS levels cause oxidative stress, resulting in detrimental effects on organisms and enabling tumors to develop ... ...

Abstract	The accumulation of reactive oxygen species (ROS) plays a pivotal role in the development of various diseases, including cancer. Elevated ROS levels cause oxidative stress, resulting in detrimental effects on organisms and enabling tumors to develop adaptive responses. Targeting these enhanced oxidative stress protection mechanisms could offer therapeutic benefits with high specificity, as normal cells exhibit lower dependency on these pathways. MTH1 (mutT homolog 1), a homolog of
Language	English
Publishing date	2024-01-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2024.1334417
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Article ; Online: A meta-analysis on diagnostic accuracy of spot urinary protein to creatinine ratio versus 12-h proteinuria in preeclampsia.

Tian, Ming / Chen, Ming / Huang, Luyan / Liu, Qingquan

iScience

2024 Volume 27, Issue 2, Page(s) 109026

Abstract: To systematically review the diagnostic accuracy of spot urinary protein to creatinine ratio (PCR) and 12-h proteinuria in preeclampsia and to estimate which is a preferred alternative method for 24-h proteinuria, we carried out this meta-analysis. 25 ... ...

Abstract	To systematically review the diagnostic accuracy of spot urinary protein to creatinine ratio (PCR) and 12-h proteinuria in preeclampsia and to estimate which is a preferred alternative method for 24-h proteinuria, we carried out this meta-analysis. 25 primary studies were included based on searching strategy. For spot urinary PCR, our results showed pooled sensitivity of 87% (95% confidence interval [CI] 83%-91%) and specificity of 86% (95% CI 79%-91%), with an area under curve (AUC) of 0.93 (0.90-0.95). For 12-h proteinuria, pooled sensitivity and specificity were 92% (95% CI 87%-96%) and 99% (95% CI 75%-100%), respectively, with an AUC of 0.97 (0.95-0.98). Fagan plot and likelihood ratio scattergram showed that 12-h proteinuria yielded a better discriminatory performance on diagnosis of proteinuria (≥0.3 g/24 h). These results indicated that 12-h proteinuria estimation shows better clinical value than spot urine PCR for diagnosis of preeclampsia. However, due to the severity of condition and the fact that preeclampsia patients cannot wait for 12 h, spot urine PCR can be used as one of the diagnostic indicators.
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2024.109026
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Article ; Online: LncTCONS_00058568 is involved in the pathophysiologic processes mediated by P2X7R in the lower thoracic spinal cord after acute kidney injury.

Wang, Yiru / Chen, Zhi / Liu, Qingquan / Lv, Yongman

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2024 Volume 38, Issue 6, Page(s) e23563

Abstract: Acute kidney injury (AKI), a prevalent clinical syndrome, involves the participation of the nervous system in neuroimmune regulation. However, the intricate molecular mechanism that governs renal function regulation by the central nervous system (CNS) is ...

Abstract	Acute kidney injury (AKI), a prevalent clinical syndrome, involves the participation of the nervous system in neuroimmune regulation. However, the intricate molecular mechanism that governs renal function regulation by the central nervous system (CNS) is complex and remains incompletely understood. In the present study, we found that the upregulated expression of lncTCONS_00058568 in lower thoracic spinal cord significantly ameliorated AKI-induced renal tissue injury, kidney morphology, inflammation and apoptosis, and suppressed renal sympathetic nerve activity. Mechanistically, the purinergic ionotropic P2X7 receptor (P2X7R) was overexpressed in AKI rats, whereas lncTCONS_00058568 was able to suppress the upregulation of P2X7R. In addition, RNA sequencing data revealed differentially expressed genes associated with nervous system inflammatory responses after lncTCONS_00058568 was overexpressed in AKI rats. Finally, the overexpression of lncTCONS_00058568 inhibited the activation of PI3K/Akt and NF-κB signaling pathways in spinal cord. Taken together, the results from the present study show that lncTCONS_00058568 overexpression prevented renal injury probably by inhibiting sympathetic nerve activity mediated by P2X7R in the lower spinal cord subsequent to I/R-AKI.
MeSH term(s)	Rats ; Animals ; Rats, Sprague-Dawley ; Receptors, Purinergic P2X7/genetics ; Receptors, Purinergic P2X7/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Acute Kidney Injury/metabolism ; Spinal Cord/metabolism
Chemical Substances	Receptors, Purinergic P2X7 ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.202301622RRR
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Zs.A 2266: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 296: Show issues

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Article ; Online: The influence of shift work: A bibliometric analysis of research progress and frontiers on health effects.

Chen, Shibo / Liu, Qingquan / Yan, Jianjun

Chronobiology international

2024 Volume 41, Issue 4, Page(s) 577–586

Abstract: Shift work has been found to disrupt the circadian system, leading to negative health effects. The objective of this study was to assess the progress and frontiers in research on the health-related influence of shift work. The study analyzed 3,696 data ... ...

Abstract	Shift work has been found to disrupt the circadian system, leading to negative health effects. The objective of this study was to assess the progress and frontiers in research on the health-related influence of shift work. The study analyzed 3,696 data points from Web of Science, using the bibliometric software CiteSpace to visualize and analyze the field. The results showed a steady increase in annual publications, particularly in the last 5 years, with a rapid increase in publications from China. The United States contributed the most to the number of publications and worldwide collaborations. The most prolific institution and author were the Brigham and Women's Hospital and Professor Bjorn Bjorvatn, respectively. The Journal of Chronobiology International ranked at the top and focused primarily on shift worker research. In the first decade of study, the primary focus was on the associations between shift work and cardiovascular disease and metabolic disorders. Over time, research on the health effects of shift work has expanded to include cancer and mental health, with subsequent studies investigating molecular mechanisms. This study provides a comprehensive and intuitive analysis of the negative health impacts of shift work. It highlights existing research hotspots and provides a roadmap for future studies. Further research is needed to explore the adverse health consequences and related mechanisms of shift work exposure, as well as interventions to mitigate its health effects.
MeSH term(s)	Humans ; Bibliometrics ; Shift Work Schedule ; Circadian Rhythm/physiology ; Work Schedule Tolerance/physiology ; Cardiovascular Diseases
Language	English
Publishing date	2024-04-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	998996-1
ISSN	1525-6073 ; 0742-0528
ISSN (online)	1525-6073
ISSN	0742-0528
DOI	10.1080/07420528.2024.2337885
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Zs.A 2068: Show issues

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Article ; Online: Generalized matrix factorization based on weighted hypergraph learning for microbe-drug association prediction.

Ma, Yingjun / Liu, Qingquan

Computers in biology and medicine

2022 Volume 145, Page(s) 105503

Abstract: The complex and diverse microbial communities are closely related to human health, and the research of microbial communities plays an increasingly critical role in drug development and precision medicine. Identifying potential microbe-drug associations ... ...

Abstract	The complex and diverse microbial communities are closely related to human health, and the research of microbial communities plays an increasingly critical role in drug development and precision medicine. Identifying potential microbe-drug associations not only benefits drug discovery and clinical therapy, but also contributes to a better understanding of the mechanisms of action of microbes. Compared with the complexity and high cost of biological experiments, computational methods can quickly and efficiently predict potential microbe-drug associations, which could be a useful complement to experimental methods. In this study, we propose a generalized matrix factorization based on weighted hypergraph learning, WHGMF, to predict potential microbial-drug associations. First, we integrate multi-omics data to compute multiple features of microbes and drugs, including functional and semantic similarity of microbes, structural similarity of drugs, and microbe-drug association information. Second, the hypergraph is constructed by using strong neighborhood information, and to improve the performance of the hypergraph, the simple volume is adopted to calculate the hyperedge weight. Finally, hypergraph regularization is introduced for the generalized matrix factorization model, and high-order structural information is used to improve the representation ability of low-dimensional features. Results from multiple experiments demonstrate that WHGMF not only accurately predicts potential microbe-drug associations, but also has considerable adaptability to class-imbalanced datasets. In addition, WHGMF is also suitable for the prediction of new drugs and new microbes. A case study further demonstrates the effectiveness of our method. The code and data in this study are freely available at https://github.com/Mayingjun20179/WHGMF.
MeSH term(s)	Algorithms ; Computational Biology/methods ; Drug Development ; Humans
Language	English
Publishing date	2022-04-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2022.105503
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Zs.A 653: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Study on Fine-Grained Visual Classification of Low-Resolution Urinary Erythrocyte.

Ji, Qingbo / Yin, Tingshuo / Zhang, Pengfei / Liu, Qingquan / Hou, Changbo

Journal of imaging informatics in medicine

2024

Abstract: The morphological analysis test item of urine red blood cells is referred to as "extracorporeal renal biopsy," which holds significant importance for medical department testing. However, the accuracy of existing urine red blood cell morphology analyzers ... ...

Abstract	The morphological analysis test item of urine red blood cells is referred to as "extracorporeal renal biopsy," which holds significant importance for medical department testing. However, the accuracy of existing urine red blood cell morphology analyzers is suboptimal, and they are not widely utilized in medical examinations. Challenges include low image spatial resolution, blurred distinguishing features between cells, difficulty in fine-grained feature extraction, and insufficient data volume. This article aims to improve the classification accuracy of low-resolution urine red blood cells. This paper proposes a super-resolution method based on category-aware loss and an RBC-MIX data enhancement approach. It optimizes the cross-entropy loss to maximize the classification boundary and improve intra-class tightness and inter-class difference, achieving fine-grained classification of low-resolution urine red blood cells. Experimental outcomes demonstrate that with this method, an accuracy rate of 97.8% can be achieved for low-resolution urine red blood cell images. This algorithm attains outstanding classification performance for low-resolution urine red blood cells with only category labels required. This method can serve as a practical reference for urine red blood cell morphology examination items.
Language	English
Publishing date	2024-04-15
Publishing country	Switzerland
Document type	Journal Article
ISSN	2948-2933
ISSN (online)	2948-2933
DOI	10.1007/s10278-024-01082-1
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Article ; Online: Use of nano-enabled approaches to advance acupuncture therapy for disease management.

Xu, Wenjie / Xiao, Yu / Wang, Peng / Meng, Huan / Liu, Qingquan

Nanoscale horizons

2024

Abstract: Acupuncture is an ancient form of therapy, which has long been part of traditional Chinese medicine (TCM); however, its use has spread globally, to the point where it is currently practiced worldwide. Although metal needles continue to be used most ... ...

Abstract	Acupuncture is an ancient form of therapy, which has long been part of traditional Chinese medicine (TCM); however, its use has spread globally, to the point where it is currently practiced worldwide. Although metal needles continue to be used most commonly, through multidisciplinary research, novel technologies, including nanotechnology, have allowed acupuncture to evolve to the point of achieving greater efficiency and more sophisticated functions in clinical practice. We summarized recent advancements in the literature using nano-enabled strategies to create novel needles that enhance and expand their therapeutic effects and found that nanotechnology may help provide new evidence to verify acupuncture theory, improve the features of acupuncture needles and their clinical effects by combining with drug delivery, and even enable new therapeutic methods when combined with acupuncture needles. The use of nano-technology with acupuncture delivery looks very promising for potential clinical applications. We also envisage that with nanotechnology, innovations in acupuncture needles could generate a multi-functional toolbox for use in both diagnostic and therapeutic medicine. Such new types of acupuncture needles could be used at acupoints and data collected to guide the planning of clinical trials may be more consistent with acupuncture theory and traditional clinical applications of this therapeutic modality.
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article ; Review
ISSN	2055-6764
ISSN (online)	2055-6764
DOI	10.1039/d3nh00469d
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Design of a hemispherical shell shaped natural ventilation temperature observation instrument.

Ma, Zilan / Yang, Jie / Jiang, Lixia / Liu, Qingquan / Ding, Renhui

The Review of scientific instruments

2024 Volume 95, Issue 4

Abstract: Atmospheric temperature is fundamental information for various industries, such as production, life, and scientific research. The temperature error induced by the solar rays can reach 1 °C or even higher. A hemispherical shell-shaped atmospheric ... ...

Abstract	Atmospheric temperature is fundamental information for various industries, such as production, life, and scientific research. The temperature error induced by the solar rays can reach 1 °C or even higher. A hemispherical shell-shaped atmospheric temperature measuring instrument that can reduce heat pollution and increase air velocity was designed. First, the instrument was optimized using computational fluid dynamics (CFD) software packages. Then, the CFD software packages were employed to quantify the temperature errors of the instrument with varying situations. A neural network model was employed to develop a temperature error correction model that can be targeted for multi-variable changes. This model provides accurate correction data when the influencing factors change continuously. Finally, field experiments were performed. The experimental data analysis indicates that the mean temperature error and the maximum error of the instrument before correction are 0.08 and 0.25 °C, respectively. The root mean square error, the mean absolute error, and the correlation coefficient between measured temperature errors from experiments and corrected temperature errors from the correction model are 0.099, 0.016, and 0.952 °C, respectively. By utilizing a temperature error correction model, the measuring error of the instrument can be minimized to a range between -0.05 and 0.04 °C. Consequently, the instrument is anticipated to enhance temperature measurement accuracy to ∼0.1 °C.
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0198389
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Article: [Preparation of Catalyst Cyclodextrin-Fe-TAML to Activate H

Liu, Qing-Quan / Cai, Ben-Zhe / Cai, Xi-Yun

Huan jing ke xue= Huanjing kexue

2023 Volume 44, Issue 7, Page(s) 3978–3989

Abstract: In order to improve the stability and catalytic activity of Fe-TAML, mono-6-oxy-cyclodextrin bonded Fe-TAML catalyst (CD-Fe-TAML) was prepared by bonding Fe-TAML with cyclodextrin (CD) through chlorosulfonylation reaction, metal chelation reaction, and ... ...

Abstract	In order to improve the stability and catalytic activity of Fe-TAML, mono-6-oxy-cyclodextrin bonded Fe-TAML catalyst (CD-Fe-TAML) was prepared by bonding Fe-TAML with cyclodextrin (CD) through chlorosulfonylation reaction, metal chelation reaction, and nucleophilic substitution reaction. The catalytic activity and stability of CD-Fe-TAML and the oxidation degradation efficiencies of 34 organic micropollutants such as antibiotics and pesticides by activation of H
Language	Chinese
Publishing date	2023-07-12
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202208235
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Article ; Online: Development of a surface atmosphere temperature observation instrument.

Yang, Jie / Tan, Mengqing / Liu, Qingquan / Ding, Renhui

The Review of scientific instruments

2023 Volume 94, Issue 1, Page(s) 15107

Abstract: To minimize the impact of various radiations on atmospheric temperature observation, a new natural ventilation temperature observation instrument is designed in this paper. First of all, the temperature measuring instrument model is constructed using the ...

Abstract	To minimize the impact of various radiations on atmospheric temperature observation, a new natural ventilation temperature observation instrument is designed in this paper. First of all, the temperature measuring instrument model is constructed using the means of computational fluid dynamics. Then, the radiation error of the device is quantified in different environmental conditions. Next, a back propagation neural network algorithm is adopted to fit a radiation error modified equation with multivariable changes. Finally, the measured values of a 076B forced ventilation temperature monitoring device are adopted as the temperature reference, and field tests are conducted. The average error of this new device is 0.12 °C. The root mean square error, mean square error, and correlation coefficient between the measured values of the new instrument and the reference temperature are 0.047 °C, 0.036 °C, and 0.999 °C, respectively.
Language	English
Publishing date	2023-01-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0125631
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