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Article ; Online: Effect of positive acceleration exposure on heart rate variability

ZHAI Jia / LIU Qiuhong / YAO Yongjie

陆军军医大学学报, Vol 46, Iss 1, Pp 33-

2024 Volume 38

Abstract: Objective To investigate the effect of exposure to positive acceleration on heart rate variability (HRV). Methods A single-arm trial was conducted on 12 participants who have a flight duration of >300 h were subjected from a same training batch between ... ...

Abstract	Objective To investigate the effect of exposure to positive acceleration on heart rate variability (HRV). Methods A single-arm trial was conducted on 12 participants who have a flight duration of >300 h were subjected from a same training batch between July 23 and 25, 2023. They were exposed to overloading with a peak value of +3.5 and +4.25 Gz for a duration of 10 s respectively on a manned centrifuge. Heart rate, respiratory rate, and time-domain and frequency-domain indicators of short-term HRV under exposure to overloaded positive acceleration were collected, recorded and analyzed. Results Under the overloaded +3.5 and +4.25 Gz positive acceleration for 10 s: ① The heart rate was 135.42±14.78 and 143.92±14.47 beats/min, the respiratory rate was 23.57±4.09 and 26.80±4.71 breaths/min, respectively, and both rates were significantly higher than those before exposure (97.08±14.61 beats/min and 14.86±2.06 breaths/min, P < 0.01); ② The time-domain indicator, root mean square of difference between successive normal RR intervals (RMSSD), was 7.69±4.32 and 6.84±3.41 ms respectively under +3.5 and +4.25 Gz positive acceleration, and both rates were obviously lower than before exposure (13.14±6.37 ms, P < 0.05); ③ The frequency-domain indicator, high frequency (HF) was 20.53±8.80 and 16.04±7.19 ms2, respectively, and both were obviously lower than those before exposure of (44.07±24.67 ms2, P < 0.05); another frequency-domain indicator, low frequency (LF) was 38.07±19.72 and 42.46±17.08 ms2 respectively, but the values had no statistical difference with the value before exposure (26.33±19.10 ms2, P>0.05); ④ The LF/HF ratio of the 2 exposure doses was 4.02±1.52 and 5.32±1.86 respectively after expose, and 0.67±0.32 before exposure, and a significant increase was observed (P < 0.05). Conclusion Positive acceleration exposure significantly affects heart rate, respiratory rate, and HRV time- and frequency-domain indicators RMSSD, LF/HF, and HF. Our results suggest that the exposure leads to increased tone ...
Keywords	positive acceleration ; heart rate variability ; manned centrifuge ; aviation medicine ; Medicine (General) ; R5-920
Subject code	600
Language	Chinese
Publishing date	2024-01-01T00:00:00Z
Publisher	Editorial Office of Journal of Army Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [The study on the characteristics of active force of neck muscles under rapid braking conditions].

Yuan, Xiaoxia / Li, Fan / Lei, Kang / Liu, Qiuhong

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi

2023 Volume 40, Issue 4, Page(s) 676–682

Abstract: This paper studies the active force characteristics of the neck muscles under the condition of rapid braking, which can provide theoretical support for reducing the neck injury of pilots when carrier-based aircraft blocks the landing. We carried out ... ...

Abstract	This paper studies the active force characteristics of the neck muscles under the condition of rapid braking, which can provide theoretical support for reducing the neck injury of pilots when carrier-based aircraft blocks the landing. We carried out static loading and real vehicle braking experiments under rapid braking conditions, collected the active contraction force and electromyography (EMG) signals of neck muscles, and analyzed the response characteristics of neck muscle active force response. The results showed that the head and neck forward tilt time was delayed and the amplitude decreased during neck muscle pre-tightening. The duration of the neck in the extreme position decreased, and the recovery towards the seat direction was faster. The EMG signals of trapezius muscle was higher than sternocleidomastoid muscle. This suggests that pilots can reduce neck injury by pre-tightening the neck muscles during actual braking flight. In addition, we can consider the design of relevant fittings for pre-tightening the neck muscles.
MeSH term(s)	Neck Muscles ; Neck ; Electromyography ; Head
Language	Chinese
Publishing date	2023-09-04
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2576847-5
ISSN	1001-5515
ISSN	1001-5515
DOI	10.7507/1001-5515.202301020
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Article ; Online: Lidocaine spray anesthesia with a disposable laryngeal anesthetic tube for gastroscopy.

Dai, Pinhong / Liu, Qiuhong / Zhu, Zhiyong / Wang, Yaping

Asian journal of surgery

2022 Volume 46, Issue 6, Page(s) 2550–2551

MeSH term(s)	Humans ; Lidocaine ; Gastroscopy ; Anesthetics ; Anesthesia ; Anesthetics, Local
Chemical Substances	Lidocaine (98PI200987) ; Anesthetics ; Anesthetics, Local
Language	English
Publishing date	2022-12-31
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2022.12.113
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Article: SGOL2 is a novel prognostic marker and fosters disease progression via a MAD2-mediated pathway in hepatocellular carcinoma.

Hu, Qingqing / Liu, Qiuhong / Zhao, Yalei / Zhang, Lingjian / Li, Lanjuan

Biomarker research

2022 Volume 10, Issue 1, Page(s) 82

Abstract: Background: Shugoshin-like protein 2 (SGOL2) is a centromeric protein that ensures the correct and orderly process of mitosis by protecting and maintaining centripetal adhesions during meiosis and mitosis. Here, we examined the potential role of SGOL2 ... ...

Abstract	Background: Shugoshin-like protein 2 (SGOL2) is a centromeric protein that ensures the correct and orderly process of mitosis by protecting and maintaining centripetal adhesions during meiosis and mitosis. Here, we examined the potential role of SGOL2 in cancers, especially in hepatocellular carcinoma (HCC). Methods: One hundred ninety-nine normal adjacent tissues and 202 HCC samples were collected in this study. Human HCC cells (SK-HEP-1 and HEP-3B) were employed in the present study. Immunohistochemistry, immunofluorescence, western blot, Co-Immunoprecipitation technique, and bioinformatic analysis were utilized to assess the role of SGOL2 in HCC development process. Results: Overexpression of SGOL2 predicted an unfavorable prognosis in HCC by The Cancer Genome Atlas database (TCGA), which were further validated in our two independent cohorts. Next, 47 differentially expressed genes positively related to both SGOL2 and MAD2 were identified to be associated with the cell cycle. Subsequently, we demonstrated that SGOL2 downregulation suppressed the malignant activities of HCC in vitro and in vivo. Further investigation showed that SGOL2 promoted tumor proliferation by regulating MAD2-induced cell-cycle dysregulation, which could be reversed by the MAD2 inhibitor M2I-1. Consistently, MAD2 upregulation reversed the knockdown effects of SGOL2-shRNA in HCC. Moreover, we demonstrated that SGOL2 regulated MAD2 expression level by forming a SGOL2-MAD2 complex, which led to cell cycle dysreuglation of HCC cells. Conclusion: SGOL2 acts as an oncogene in HCC cells by regulating MAD2 and then dysregulating the cell cycle, providing a potential therapeutic target in HCC.
Language	English
Publishing date	2022-11-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2699926-2
ISSN	2050-7771
ISSN	2050-7771
DOI	10.1186/s40364-022-00422-z
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Article ; Online: Analysis of Urban Built Environment Impacts on Outdoor Physical Activities-A Case Study in China.

Li, Bo / Liu, Qiuhong / Wang, Tong / He, He / Peng, You / Feng, Tao

Frontiers in public health

2022 Volume 10, Page(s) 861456

Abstract: Outdoor physical activities can promote public health and they are largely influenced by the built environment in different urban settings. Understanding the association between outdoor physical activities and the built environment is important for ... ...

Abstract	Outdoor physical activities can promote public health and they are largely influenced by the built environment in different urban settings. Understanding the association between outdoor physical activities and the built environment is important for promoting a high quality of life. Existing studies typically focus on one type of outdoor activity using interview-based small samples and are often lack of systematic understanding of the activities' intensity and frequency. In this study, we intend to gain deeper insight into how the built environment influences physical activities using the data extracted from individual's wearables and other open data sources for integrated analysis. Multi-linear regression with logarithm transformation is applied to perform the analysis using the data from Changsha, China. We found that built environment impacts on outdoor physical activities in Changsha are not always consistent with similar studies' results in other cities. The most effective measures to promote outdoor physical activities are the provision of good arterial and secondary road networks, community parks, among others in Changsha. The results shed light on future urban planning practices in terms of promoting public health.
MeSH term(s)	Built Environment ; China ; Exercise ; Parks, Recreational ; Quality of Life
Language	English
Publishing date	2022-04-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2022.861456
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Article: Characteristics and Prognostic Factors of Non-HIV Immunocompromised Patients With Pneumocystis Pneumonia Diagnosed by Metagenomics Next-Generation Sequencing.

Duan, Jiali / Gao, Jing / Liu, Qiuhong / Sun, Mengfei / Liu, Yang / Tan, Yingshuai / Xing, Lihua

Frontiers in medicine

2022 Volume 9, Page(s) 812698

Abstract: Objective: The aim of this study was to evaluate the potential of metagenomic next-generation sequencing (mNGS) for the diagnosis of pneumocystis pneumonia (PCP) in patients with non-human immunodeficiency virus-infection and to discuss the clinical ... ...

Abstract	Objective: The aim of this study was to evaluate the potential of metagenomic next-generation sequencing (mNGS) for the diagnosis of pneumocystis pneumonia (PCP) in patients with non-human immunodeficiency virus-infection and to discuss the clinical characteristics and identify prognostic factors associated with patients with non-HIV PCP. Methods: Forty-six patients with PCP who were admitted in respiratory intensive care unit (ICU) between May 2018 and May 2020 were retrospectively reviewed. The subjects were divided into survivor and non-survivor groups according to the patients' outcome. Conventional methods and mNGS for detecting Results: Metagenomic next-generation sequencing (mNGS) showed a satisfying diagnostic performance of 100% positive of detecting Conclusion: mNGS is a very sensitive diagnostic tool for identifying
Language	English
Publishing date	2022-03-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.812698
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Article ; Online: Correction to: PD-L1 Regulates Inflammation in LPS-Induced Lung Epithelial Cells and Vascular Endothelial Cells by Interacting with the HIF-1α Signaling Pathway.

Zhao, Shilong / Gao, Jing / Li, Jing / Wang, Shilei / Yuan, Congcong / Liu, Qiuhong

Inflammation

2022 Volume 45, Issue 2, Page(s) 931–932

Language	English
Publishing date	2022-01-27
Publishing country	United States
Document type	Published Erratum
ZDB-ID	434408-x
ISSN	1573-2576 ; 0360-3997
ISSN (online)	1573-2576
ISSN	0360-3997
DOI	10.1007/s10753-022-01634-z
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Article: Corrigendum: Role of aerobic exercise in ameliorating NASH: Insights into the hepatic thyroid hormone signaling and circulating thyroid hormones.

Liu, Qiuhong / Li, Han / He, Weiwei / Zhao, Qing / Huang, Caoxin / Wang, Qingxuan / Zheng, Zeyu / Zhang, Xiaofang / Shi, Xiulin / Li, Xuejun

Frontiers in endocrinology

2023 Volume 14, Page(s) 1146843

Abstract: This corrects the article DOI: 10.3389/fendo.2022.1075986.]. ...

Abstract	[This corrects the article DOI: 10.3389/fendo.2022.1075986.].
Language	English
Publishing date	2023-01-30
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1146843
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Article: Single-cell transcriptomics of hepatic stellate cells uncover crucial pathways and key regulators involved in non-alcoholic steatohepatitis.

He, Weiwei / Huang, Caoxin / Shi, Xiulin / Wu, Menghua / Li, Han / Liu, Qiuhong / Zhang, Xiaofang / Zhao, Yan / Li, Xuejun

Endocrine connections

2023 Volume 12, Issue 2

Abstract: Background: Fibrosis is an important pathological process in the development of non-alcoholic steatohepatitis (NASH), and the activation of hepatic stellate cell (HSC) is a central event in liver fibrosis. However, the transcriptomic change of activated ...

Abstract	Background: Fibrosis is an important pathological process in the development of non-alcoholic steatohepatitis (NASH), and the activation of hepatic stellate cell (HSC) is a central event in liver fibrosis. However, the transcriptomic change of activated HSCs (aHSCs) and resting HSCs (rHSCs) in NASH patients has not been assessed. This study aimed to identify transcriptomic signature of HSCs during the development of NASH and the underlying key functional pathways. Methods: NASH-associated transcriptomic change of HSCs was defined by single-cell RNA-sequencing (scRNA-seq) analysis, and those top upregulated genes were identified as NASH-associated transcriptomic signatures. Those functional pathways involved in the NASH-associated transcriptomic change of aHSCs were explored by weighted gene co-expression network analysis (WGCNA) and functional enrichment analyses. Key regulators were explored by upstream regulator analysis and transcription factor enrichment analysis. Results: scRNA-seq analysis identified numerous differentially expressed genes in both rHSCs and aHSCs between NASH patients and healthy controls. Both scRNA-seq analysis and in-vivo experiments showed the existence of rHSCs (mainly expressing a-SMA) in the normal liver and the increased aHSCs (mainly expressing collagen 1) in the fibrosis liver tissues. NASH-associated transcriptomic signature of rHSC (NASHrHSCsignature) and NASH-associated transcriptomic signature of aHSC (NASHaHSCsignature) were identified. WGCNA revealed the main pathways correlated with the transcriptomic change of aHSCs. Several key upstream regulators and transcription factors for determining the functional change of aHSCs in NASH were identified. Conclusion: This study developed a useful transcriptomic signature with the potential in assessing fibrosis severity in the development of NASH. This study also identified the main pathways in the activation of HSCs during the development of NASH.
Language	English
Publishing date	2023-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2668428-7
ISSN	2049-3614
ISSN	2049-3614
DOI	10.1530/EC-22-0502
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Article ; Online: Identifying a distinct fibrosis subset of NAFLD via molecular profiling and the involvement of profibrotic macrophages.

He, Weiwei / Huang, Yinxiang / Shi, Xiulin / Wang, Qingxuan / Wu, Menghua / Li, Han / Liu, Qiuhong / Zhang, Xiaofang / Huang, Caoxin / Li, Xuejun

Journal of translational medicine

2023 Volume 21, Issue 1, Page(s) 448

Abstract: Background: There are emerging studies suggesting that non-alcoholic fatty liver disease (NAFLD) is a heterogeneous disease with multiple etiologies and molecular phenotypes. Fibrosis is the key process in NAFLD progression. In this study, we aimed to ... ...

Abstract	Background: There are emerging studies suggesting that non-alcoholic fatty liver disease (NAFLD) is a heterogeneous disease with multiple etiologies and molecular phenotypes. Fibrosis is the key process in NAFLD progression. In this study, we aimed to explore molecular phenotypes of NAFLD with a particular focus on the fibrosis phenotype and also aimed to explore the changes of macrophage subsets in the fibrosis subset of NAFLD. Methods: To assess the transcriptomic alterations of key factors in NAFLD and fibrosis progression, we included 14 different transcriptomic datasets of liver tissues. In addition, two single-cell RNA sequencing (scRNA-seq) datasets were included to construct transcriptomic signatures that could represent specific cells. To explore the molecular subsets of fibrosis in NAFLD based on the transcriptomic features, we used a high-quality RNA-sequencing (RNA-seq) dataset of liver tissues from patients with NAFLD. Non-negative matrix factorization (NMF) was used to analyze the molecular subsets of NAFLD based on the gene set variation analysis (GSVA) enrichment scores of key molecule features in liver tissues. Results: The key transcriptomic signatures on NAFLD including non-alcoholic steatohepatitis (NASH) signature, fibrosis signature, non-alcoholic fatty liver (NAFL) signature, liver aging signature and TGF-β signature were constructed by liver transcriptome datasets. We analyzed two liver scRNA-seq datasets and constructed cell type-specific transcriptomic signatures based on the genes that were highly expressed in each cell subset. We analyzed the molecular subsets of NAFLD by NMF and categorized four main subsets of NAFLD. Cluster 4 subset is mainly characterized by liver fibrosis. Patients with Cluster 4 subset have more advanced liver fibrosis than patients with other subsets, or may have a high risk of liver fibrosis progression. Furthermore, we identified two key monocyte-macrophage subsets which were both significantly correlated with the progression of liver fibrosis in NAFLD patients. Conclusion: Our study revealed the molecular subtypes of NAFLD by integrating key information from transcriptomic expression profiling and liver microenvironment, and identified a novel and distinct fibrosis subset of NAFLD. The fibrosis subset is significantly correlated with the profibrotic macrophages and M2 macrophage subset. These two liver macrophage subsets may be important players in the progression of liver fibrosis of NAFLD patients.
MeSH term(s)	Humans ; Non-alcoholic Fatty Liver Disease/metabolism ; Liver/pathology ; Liver Cirrhosis/complications ; Macrophages/metabolism ; Gene Expression Profiling
Language	English
Publishing date	2023-07-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-023-04300-6
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