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Article ; Online: An atypical case of phosphoglycerate kinase deficiency with a novel PGK1 variant.

Zhou, Xizhong / Liu, Qiuli / Huang, Mingwei

2024 Volume 117, Page(s) 161–163

MeSH term(s)	Humans ; Phosphoglycerate Kinase/genetics ; Phosphoglycerate Kinase/deficiency ; Male ; Joint Instability/genetics ; Female ; Spinal Diseases/genetics ; Metabolism, Inborn Errors ; Genetic Diseases, X-Linked
Chemical Substances	Phosphoglycerate Kinase (EC 2.7.2.3) ; PGK1 protein, human (EC 2.7.2.3)
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Case Reports ; Letter ; Journal Article
ZDB-ID	1137610-7
ISSN	1532-2688 ; 1059-1311
ISSN (online)	1532-2688
ISSN	1059-1311
DOI	10.1016/j.seizure.2024.02.010
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Article ; Online: Progress of residual neuromuscular blockade after general anesthesia in elderly patients

LIU Qiuli / JIANG Lai / WENG Xiaojian

Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 43, Iss 1, Pp 108-

2023 Volume 113

Abstract: Muscle relaxation induced by muscle relaxants is one of the important conditions for endotracheal intubation and fixation, but sometimes muscle functions recover incompletely after operations, which is called postoperative residual neuromuscular block ( ... ...

Abstract	Muscle relaxation induced by muscle relaxants is one of the important conditions for endotracheal intubation and fixation, but sometimes muscle functions recover incompletely after operations, which is called postoperative residual neuromuscular block (PRNB). It can cause a series of serious postoperative complications and even death. Hence, it is essential to prevent and treat PRNB in the early stage during anesthesia implementation. With the rapid development of surgical technology and the gradual extension of the life span of the population, the number of operations for elderly patients is gradually increasing. Meanwhile, due to the physiological and pathological changes of the elderly and the combined underlying diseases, the elderly are more likely to suffer from PRNB in different degrees after surgery, which seriously damages the prognosis of elderly patients and increases the loss of medical resources. In these years, the successful application of short-acting muscle relaxants, new antagonists (such as sugammadex), and multi-mode neuromuscular monitoring devices in clinical practice have greatly reduced the incidence of PRNB in elderly patients. Furthermore, the basic researches which mainly based on the neuromuscular junction structure and the pharmacokinetic and pharmacodynamic studies of the elderly provide a new theoretical basis for reducing the harm of PRNB to elderly patients. This paper reviews the research progress of the mechanism, adverse events and clinical interventions of PRNB in elderly patients after general anesthesia surgeries to provide reference for muscle relaxation management and postoperative antagonism in these people.
Keywords	the elderly ; postoperative residual neuromuscular block (prnb) ; neuromuscular blocking agent ; muscle relaxant antagonism ; Medicine ; R
Subject code	796
Language	Chinese
Publishing date	2023-01-01T00:00:00Z
Publisher	Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Self-Adaptive Rapid Thermal Conductive Fabrics Based on Hygroscopic Shrinkage Response for Personal Cooling and Drying.

Liu, Hongkun / Xiao, Yanan / Shen, Yang / Liu, Qiuli / Hou, Jiazi

ACS applied materials & interfaces

2024 Volume 16, Issue 6, Page(s) 7917–7926

Abstract: Advanced fabrics with thermal wet management capability as low energy consumption media contribute to personal cooling and drying. Nevertheless, it remains a great challenge to obtain intelligent fabrics with adjustable thermal conductivity (TC) capable ... ...

Abstract	Advanced fabrics with thermal wet management capability as low energy consumption media contribute to personal cooling and drying. Nevertheless, it remains a great challenge to obtain intelligent fabrics with adjustable thermal conductivity (TC) capable of bridging the supply and demand between human body temperature and self-adaptive thermal conduction. Herein, we report hygroscopic-shrinkage nanofiber-based fabrics with excellent moisture sensitivity and significant volume shrinkage, which benefits the construction of high-density thermal conductive pathways by absorbing sweat, with a maximum sweat absorption rate reaching up to 1781%. The TC of the shrunken fabric is significantly increased from the initial 0.102 to 0.731 W·m
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c18476
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Emerging role of the RNA-editing enzyme ADAR1 in stem cell fate and function.

Lu, Di / Lu, Jianxi / Liu, Qiuli / Zhang, Qi

Biomarker research

2023 Volume 11, Issue 1, Page(s) 61

Abstract: Stem cells are critical for organism development and the maintenance of tissue homeostasis. Recent studies focusing on RNA editing have indicated how this mark controls stem cell fate and function in both normal and malignant states. RNA editing is ... ...

Abstract	Stem cells are critical for organism development and the maintenance of tissue homeostasis. Recent studies focusing on RNA editing have indicated how this mark controls stem cell fate and function in both normal and malignant states. RNA editing is mainly mediated by adenosine deaminase acting on RNA 1 (ADAR1). The RNA editing enzyme ADAR1 converts adenosine in a double-stranded RNA (dsRNA) substrate into inosine. ADAR1 is a multifunctional protein that regulate physiological processes including embryonic development, cell differentiation, and immune regulation, and even apply to the development of gene editing technologies. In this review, we summarize the structure and function of ADAR1 with a focus on how it can mediate distinct functions in stem cell self-renewal and differentiation. Targeting ADAR1 has emerged as a potential novel therapeutic strategy in both normal and dysregulated stem cell contexts.
Language	English
Publishing date	2023-06-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2699926-2
ISSN	2050-7771
ISSN	2050-7771
DOI	10.1186/s40364-023-00503-7
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Article ; Online: Diagnostic value of liquid-based cytology, DNA ploidy and fluorescence in situ hybridization in upper tract urothelial carcinoma

WANG Fushen / LIU Qiuli / YANG Xin

陆军军医大学学报, Vol 44, Iss 17, Pp 1736-

2022 Volume 1743

Abstract: Objective To investigate the application value of liquid-based cytology, DNA ploidy and fluorescence in situ hybridization (FISH) in the diagnosis of upper tract urothelial carcinoma (UTUC). Methods From January 2013 to June 2021, 246 cases with ... ...

Abstract	Objective To investigate the application value of liquid-based cytology, DNA ploidy and fluorescence in situ hybridization (FISH) in the diagnosis of upper tract urothelial carcinoma (UTUC). Methods From January 2013 to June 2021, 246 cases with suspected UTUC on CT or MRI images in the Army Medical Center of PLA were recruited and retrospectively analyzed. Among them, 190 cases were pathologically diagnosed as UTUC, 43 cases non-tumor lesions, and 13 cases other types of tumors. All the 246 cases were examined with liquid-based cytology of voided urine, 178 cases were also with DNA ploidy analysis and 167 cases with FISH. The diagnostic accuracy of liquid-based cytology, DNA ploidy and FISH alone or in combination was calculated and compared. Results The sensitivities of liquid-based cytology, DNA ploidy and FISH in the diagnosis of UTUC were 44.7%, 82.2%, and 57.9%, respectively; the specificities were 97.7%, 82.4%, and 92.3%, respectively. The diagnostic sensitivities of the above 3 methods for high-grade UTUC were 48.1%, 87.7%, and 60.7%, respectively, and for low-grade UTUC 25.0%, 52.4%, and 37.5%, respectively. When any one of the 3 methods is positive, the diagnostic sensitivity was increased to 93.8% (compared with the 3 methods being used alone, all P < 0.05). When any 2 of them were positive at the same time as the criteria for diagnosing UTUC (both negative or only 1 positive was regarded as negative), the positive predictive value and specificity of this combined diagnostic method were both 100%. Conclusion Urinary liquid-based cytology, DNA ploidy and FISH all are clinically valuable in the diagnosis of UTUC. The combination of the 3 methods can effectively improve the sensitivity or specificity of diagnosis, thereby helping to reduce the risk of missed diagnosis or misdiagnosis.
Keywords	upper tract urothelial carcinoma ; cytology ; fluorescence in situ hybridization ; dna ploidy ; Medicine (General) ; R5-920
Subject code	610
Language	Chinese
Publishing date	2022-09-01T00:00:00Z
Publisher	Editorial Office of Journal of Army Medical University
Document type	Article ; Online
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Article: Intestinal perforation caused by Epstein-Barr virus-positive primary diffuse large B-cell lymphoma in a patient with HIV.

Liu, Qiuli / Bao, Qun / Zhao, Bin / Chen, Kaidong / Weng, Xiaojian

Revista espanola de enfermedades digestivas

2023

Abstract: We report the case of a 48-year-old male who presented with right lower abdominal pain and a mass for 2 weeks and got constipation for 5 days. An abdominal CT scan conducted before admission at other hospitals revealed an obstruction in the blind ... ...

Abstract	We report the case of a 48-year-old male who presented with right lower abdominal pain and a mass for 2 weeks and got constipation for 5 days. An abdominal CT scan conducted before admission at other hospitals revealed an obstruction in the blind ascending colon, which was suspected to be a malignant tumor. Proctoscopy revealed peritoneal implantation metastasis and multiple pelvic lymph nodes. Physical examination was unremarkable except for multiple lymph node enlargements in the inguinal area, without pain. A whole-body contrast-enhanced FDG-PET/CT revealed lymphoma involvement in the ascending colon, peritoneum, bone marrow, and lymph nodes in multiple regions of the body, with DLBCL as a suspected diagnosis. Pathological findings from the colonoscopy revealed atypical lymphocyte infiltration and Immunostaining indicated the presence of atypical lymphocytes with Ki-67 (90%) and tested positive for CD20, CD19, CD10, and BCL-6. Based on the above findings, stage IV DLBCL was diagnosed. Furthermore, EBV-DNA amplification was positive. The patient received R-CHOP treatment for 2 days before experiencing symptoms of fevers, chills, and abdominal pain. He underwent emergency surgery due to intestinal perforation, and preoperative blood tests revealed HIV-positive. The prognosis for the patient is poor due to sepsis.
Language	English
Publishing date	2023-12-14
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1070381-0
ISSN	1130-0108 ; 0212-7512
ISSN	1130-0108 ; 0212-7512
DOI	10.17235/reed.2023.10124/2023
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Article: Mesenchymal Stem Cell-Macrophage Crosstalk and Maintenance of Inflammatory Microenvironment Homeostasis.

Lu, Di / Xu, Yan / Liu, Qiuli / Zhang, Qi

Frontiers in cell and developmental biology

2021 Volume 9, Page(s) 681171

Abstract: Macrophages are involved in almost every aspect of biological systems and include development, homeostasis and repair. Mesenchymal stem cells (MSCs) have good clinical application prospects due to their ability to regulate adaptive and innate immune ... ...

Abstract	Macrophages are involved in almost every aspect of biological systems and include development, homeostasis and repair. Mesenchymal stem cells (MSCs) have good clinical application prospects due to their ability to regulate adaptive and innate immune cells, particularly macrophages, and they have been used successfully for many immune disorders, including inflammatory bowel disease (IBD), acute lung injury, and wound healing, which have been reported as macrophage-mediated disorders. In the present review, we focus on the interaction between MSCs and macrophages and summarize their methods of interaction and communication, such as cell-to-cell contact, soluble factor secretion, and organelle transfer. In addition, we discuss the roles of MSC-macrophage crosstalk in the development of disease and maintenance of homeostasis of inflammatory microenvironments. Finally, we provide optimal strategies for applications in immune-related disease treatments.
Language	English
Publishing date	2021-06-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2021.681171
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Comparison of remimazolam and propofol combined with low dose esketamine for pediatric same-day painless bidirectional endoscopy: a randomized, controlled clinical trial.

Chu, Tiantian / Zhou, Siqi / Wan, Yingfeng / Liu, Qiuli / Xin, Yueyang / Tian, Zhang / Yan, Tianqing / Xu, Aijun

Frontiers in pharmacology

2024 Volume 15, Page(s) 1298409

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-02-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1298409
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Parthenolide plays a protective role in the liver of mice with metabolic dysfunction‑associated fatty liver disease through the activation of the HIPPO pathway.

Wang, Weihong / He, Yukai / Liu, Qiuli

Molecular medicine reports

2021 Volume 24, Issue 1

Abstract: Metabolic dysfunction‑associated fatty liver disease (MAFLD) is a serious threat to human health. Parthenolide (PAR) displays several important pharmacological activities, including the promotion of liver function recovery during hepatitis. The aim of ... ...

Abstract	Metabolic dysfunction‑associated fatty liver disease (MAFLD) is a serious threat to human health. Parthenolide (PAR) displays several important pharmacological activities, including the promotion of liver function recovery during hepatitis. The aim of the present study was to assess the effect of PAR on MAFLD in a mouse model. Body weight, liver to body weight ratios, histological score, alanine transaminase, aspartate transaminase, total cholesterol and triglyceride levels were determined to evaluate liver injury. Liver hydroxyproline concentrations were also assessed. The expression levels of lipid metabolism‑related genes (sterol regulatory element binding protein‑1c, fatty acid synthase, acetyl CoA carboxylase 1, stearoyl CoA desaturase 1 and carbohydrate response element‑binding protein, peroxisome proliferator‑activated receptor α, carnitine palmitoyl transferase 1α and acyl‑CoA dehydrogenase short chain), liver fibrosis‑associated genes (α‑smooth muscle actin, tissue inhibitor of metalloproteinase 1 and TGF‑β1), pro‑inflammatory cytokines (TNF‑α, IL‑1β and IL‑6) and oxidative stress‑associated enzymes (malondialdehyde, superoxide dismutase and glutathione peroxidase) were measured in mice with MAFLD. The expression levels of genes associated with the HIPPO pathway were also measured.
MeSH term(s)	Animals ; Disease Models, Animal ; Fibrosis/drug therapy ; Fibrosis/genetics ; Fibrosis/metabolism ; Hippo Signaling Pathway ; Inflammation/drug therapy ; Inflammation/genetics ; Inflammation/metabolism ; Lipid Metabolism/drug effects ; Lipid Metabolism/genetics ; Male ; Metabolic Diseases/complications ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/pathology ; Oxidative Stress/drug effects ; Protective Agents/pharmacology ; Protective Agents/therapeutic use ; Protein Serine-Threonine Kinases/metabolism ; Sesquiterpenes/pharmacology ; Sesquiterpenes/therapeutic use ; Signal Transduction/drug effects ; Mice
Chemical Substances	Protective Agents ; Sesquiterpenes ; parthenolide (2RDB26I5ZB) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2021-05-06
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2469505-1
ISSN	1791-3004 ; 1791-2997
ISSN (online)	1791-3004
ISSN	1791-2997
DOI	10.3892/mmr.2021.12126
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Article ; Online: STING-deficiency in lung resident mesenchymal stromal cells contributes to the alleviation of LPS-induced lung injury.

Zhao, Erming / Chen, Jiawen / Qiu, Dongbo / Liang, Rukang / Lu, Di / Tan, Weikeng / Qin, Yunfei / Liu, Qiuli

Biochemical and biophysical research communications

2024 Volume 714, Page(s) 149973

Abstract: Acute respiratory distress syndrome (ARDS) is characterized by acute diffuse inflammatory lung injury with a high mortality rate. Mesenchymal stromal cells (MSC) are pluripotent adult cells that can be extracted from a variety of tissues, including the ... ...

Abstract	Acute respiratory distress syndrome (ARDS) is characterized by acute diffuse inflammatory lung injury with a high mortality rate. Mesenchymal stromal cells (MSC) are pluripotent adult cells that can be extracted from a variety of tissues, including the lung. Lung-resident MSC (LR-MSC) located around vascular vessels and act as important regulators of lung homeostasis, regulating the balance between lung injury and repair processes. LR-MSC support the integrity of lung tissue by modulating immune responses and releasing trophic factors. Studies have reported that the STING pathway is involved in the progression of lung injury inflammation, but the specific mechanism is unclear. In this study, we found that STING deficiency could ameliorate lipopolysaccharides (LPS)-induced acute lung injury, STING knockout (STING KO) LR-MSC had an enhanced treatment effect on acute lung injury. STING depletion protected LR-MSC from LPS-induced apoptosis. RNA-sequencing and Western blot results showed that STING KO LR-MSC expressed higher levels of MSC immunoregulatory molecules, such as Igfbp4, Icam1, Hgf and Cox2, than WT LR-MSC. This study highlights that LR-MSC have a therapeutic role in acute lung injury, and we demonstrate that STING deficiency can enhance the immunomodulatory function of LR-MSC in controlling lung inflammation. Thus, STING can be used as an intervention target to enhance the therapeutic effect of MSC.
MeSH term(s)	Animals ; Lipopolysaccharides/toxicity ; Mesenchymal Stem Cells/metabolism ; Membrane Proteins/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/deficiency ; Mice, Inbred C57BL ; Lung/pathology ; Lung/metabolism ; Acute Lung Injury/chemically induced ; Acute Lung Injury/pathology ; Acute Lung Injury/therapy ; Acute Lung Injury/metabolism ; Mice ; Mice, Knockout ; Apoptosis ; Male
Chemical Substances	Lipopolysaccharides ; Membrane Proteins ; Sting1 protein, mouse
Language	English
Publishing date	2024-04-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2024.149973
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