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Article: [Measurement of external deviation angle of patellar tendon and its application on diagnosis of recurrent patellar dislocation].

Li, Jian / Dai, Zhu / Liao, Ying / Wu, Biao / Liu, Quan-Hui

Zhongguo gu shang = China journal of orthopaedics and traumatology

2022 Volume 35, Issue 6, Page(s) 532–537

Abstract: Objective: To compare computed tomography (CT) measurement results of external deviation angle of patellar tendon and tibia tubercle-trochlea groove (TT-TG), as well as the diagnostic ability and pathology in recurrent patellar dislocation threshold.: ...

Abstract	Objective: To compare computed tomography (CT) measurement results of external deviation angle of patellar tendon and tibia tubercle-trochlea groove (TT-TG), as well as the diagnostic ability and pathology in recurrent patellar dislocation threshold. Methods: From January 2015 to March 2020, 46 patients with recurrent patella dislocation and 112 patients with non-patella dislocation were retrospectively analyzed. Forty-six patients with recurrent patella dislocation were divived into 2 groups according to TT-TG value, 11 patients with patellar dislocation with TT-TG≥20 mm(group A), including 7 males and 4 females, aged from 16 to 27 years old with an average of(21.00±3.98) years old; 35 patients with patellar dislocation with TT-TG<20 mm(group B), including 14 males and 21 females, aged from 16 to 37 years old with an average of(22.83±6.09) years old. While 112 patients with non-patella dislocation(group C) included 63 males and 49 females, aged 16 to 36 years old with an average of(22.87±5.69) years old. The measurement data of external deviation angle of patellar tendon and TT-TG value among three groups were compared. Spearman analysis was used to analyze correlation among them. Intraclass correlation coefficient (ICC) was used to determine repeatability within group. Receiver operating characteristic (ROC) area under the curve was used to evaluate diagnostic ability of parameters, and calculate osteotomy parameters of external deviation angle of patellar tendon, as well as external deviation angle of patellar tendon and TT-TG value in the diagnosis of recurrent patella diagnostic parameters of dislocation. Results: External deviation angle of patellar tendon in group A, B and C was (22.04±3.09)°, (17.20±4.43)°and (10.22±3.45)° respectively;while TT-TG value was(21.15±0.71) mm, (15.97±2.69) mm and (11.12±3.77) mm, there were significance among three groups ( Conclusion: CT imaging could reliably measure external deviation angle of patellar tendon.There is a strong positive correlation between external deviation angle of patellar tendon and value of TT-TG, which could be used to determine pathological state of recurrent patellar dislocation, and external deviation angle of patellar tendon is superior to the TT-TG value in the diagnosis of recurrent patellar dislocation. The external deviation angle of patellar tendon could also be used to guide the formulation of the tibial osteotomy plan for recurrent patellar dislocation.
MeSH term(s)	Adolescent ; Adult ; Female ; Humans ; Joint Instability ; Male ; Patella/surgery ; Patellar Dislocation/diagnostic imaging ; Patellar Ligament/diagnostic imaging ; Patellofemoral Joint ; Retrospective Studies ; Tibia/surgery ; Young Adult
Language	Chinese
Publishing date	2022-06-07
Publishing country	China
Document type	Journal Article
ISSN	1003-0034
ISSN	1003-0034
DOI	10.12200/j.issn.1003-0034.2022.06.006
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Article ; Online: What is the role of aerosol transmission in SARS-Cov-2 Omicron spread in Shanghai?

Sun, Gui-Quan / Ma, Xia / Zhang, Zhenzhen / Liu, Quan-Hui / Li, Bai-Lian

BMC infectious diseases

2022 Volume 22, Issue 1, Page(s) 880

Abstract: The Omicron transmission has infected nearly 600,000 people in Shanghai from March 26 to May 31, 2022. Combined with different control measures taken by the government in different periods, a dynamic model was constructed to investigate the impact of ... ...

Abstract	The Omicron transmission has infected nearly 600,000 people in Shanghai from March 26 to May 31, 2022. Combined with different control measures taken by the government in different periods, a dynamic model was constructed to investigate the impact of medical resources, shelter hospitals and aerosol transmission generated by clustered nucleic acid testing on the spread of Omicron. The parameters of the model were estimated by least square method and MCMC method, and the accuracy of the model was verified by the cumulative number of asymptomatic infected persons and confirmed cases in Shanghai from March 26 to May 31, 2022. The result of numerical simulation demonstrated that the aerosol transmission figured prominently in the transmission of Omicron in Shanghai from March 28 to April 30. Without aerosol transmission, the number of asymptomatic subjects and symptomatic cases would be reduced to 130,000 and 11,730 by May 31, respectively. Without the expansion of shelter hospitals in the second phase, the final size of asymptomatic subjects and symptomatic cases might reach 23.2 million and 4.88 million by May 31, respectively. Our results also revealed that expanded vaccination played a vital role in controlling the spread of Omicron. However, even if the vaccination rate were 100%, the transmission of Omicron should not be completely blocked. Therefore, other control measures should be taken to curb the spread of Omicron, such as widespread antiviral therapies, enhanced testing and strict tracking quarantine measures. This perspective could be utilized as a reference for the transmission and prevention of Omicron in other large cities with a population of 10 million like Shanghai.
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19/prevention & control ; China/epidemiology ; Quarantine ; Respiratory Aerosols and Droplets
Language	English
Publishing date	2022-11-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-022-07876-4
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Article ; Online: Evaluating the impact of test-trace-isolate for COVID-19 management and alternative strategies.

Zhang, Kun / Xia, Zhichu / Huang, Shudong / Sun, Gui-Quan / Lv, Jiancheng / Ajelli, Marco / Ejima, Keisuke / Liu, Quan-Hui

PLoS computational biology

2023 Volume 19, Issue 9, Page(s) e1011423

Abstract: There are many contrasting results concerning the effectiveness of Test-Trace-Isolate (TTI) strategies in mitigating SARS-CoV-2 spread. To shed light on this debate, we developed a novel static-temporal multiplex network characterizing both the regular ( ... ...

Abstract	There are many contrasting results concerning the effectiveness of Test-Trace-Isolate (TTI) strategies in mitigating SARS-CoV-2 spread. To shed light on this debate, we developed a novel static-temporal multiplex network characterizing both the regular (static) and random (temporal) contact patterns of individuals and a SARS-CoV-2 transmission model calibrated with historical COVID-19 epidemiological data. We estimated that the TTI strategy alone could not control the disease spread: assuming R0 = 2.5, the infection attack rate would be reduced by 24.5%. Increased test capacity and improved contact trace efficiency only slightly improved the effectiveness of the TTI. We thus investigated the effectiveness of the TTI strategy when coupled with reactive social distancing policies. Limiting contacts on the temporal contact layer would be insufficient to control an epidemic and contacts on both layers would need to be limited simultaneously. For example, the infection attack rate would be reduced by 68.1% when the reactive distancing policy disconnects 30% and 50% of contacts on static and temporal layers, respectively. Our findings highlight that, to reduce the overall transmission, it is important to limit contacts regardless of their types in addition to identifying infected individuals through contact tracing, given the substantial proportion of asymptomatic and pre-symptomatic SARS-CoV-2 transmission.
MeSH term(s)	Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; SARS-CoV-2 ; Contact Tracing ; Epidemics ; Physical Distancing
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2193340-6
ISSN	1553-7358 ; 1553-734X
ISSN (online)	1553-7358
ISSN	1553-734X
DOI	10.1371/journal.pcbi.1011423
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Article ; Online: Reactive school closure weakens the network of social interactions and reduces the spread of influenza.

Litvinova, Maria / Liu, Quan-Hui / Kulikov, Evgeny S / Ajelli, Marco

Proceedings of the National Academy of Sciences of the United States of America

2019 Volume 116, Issue 27, Page(s) 13174–13181

Abstract: School-closure policies are considered one of the most promising nonpharmaceutical interventions for mitigating seasonal and pandemic influenza. However, their effectiveness is still debated, primarily due to the lack of empirical evidence about the ... ...

Abstract	School-closure policies are considered one of the most promising nonpharmaceutical interventions for mitigating seasonal and pandemic influenza. However, their effectiveness is still debated, primarily due to the lack of empirical evidence about the behavior of the population during the implementation of the policy. Over the course of the 2015 to 2016 influenza season in Russia, we performed a diary-based contact survey to estimate the patterns of social interactions before and during the implementation of reactive school-closure strategies. We develop an innovative hybrid survey-modeling framework to estimate the time-varying network of human social interactions. By integrating this network with an infection transmission model, we reduce the uncertainty surrounding the impact of school-closure policies in mitigating the spread of influenza. When the school-closure policy is in place, we measure a significant reduction in the number of contacts made by students (14.2 vs. 6.5 contacts per day) and workers (11.2 vs. 8.7 contacts per day). This reduction is not offset by the measured increase in the number of contacts between students and nonhousehold relatives. Model simulations suggest that gradual reactive school-closure policies based on monitoring student absenteeism rates are capable of mitigating influenza spread. We estimate that without the implemented reactive strategies the attack rate of the 2015 to 2016 influenza season would have been 33% larger. Our study sheds light on the social mixing patterns of the population during the implementation of reactive school closures and provides key instruments for future cost-effectiveness analyses of school-closure policies.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Aged ; Child ; Child, Preschool ; Health Policy ; Humans ; Infant ; Infant, Newborn ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Influenza, Human/transmission ; Interpersonal Relations ; Middle Aged ; Models, Statistical ; Pandemics/prevention & control ; Russia/epidemiology ; Schools/organization & administration ; Schools/statistics & numerical data ; Students/statistics & numerical data ; Young Adult
Language	English
Publishing date	2019-06-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1821298116
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Article: Incremental value of enhanced plaque length for identifying intracranial atherosclerotic culprit plaques: a high-resolution magnetic resonance imaging study.

Cheng, XiaoQing / Liu, Jia / Li, HongXia / Yang, JiaLuo / Zhou, ChangSheng / Zhi, BeiBei / Liu, QuanHui / Li, YingLe / Xiao, LuLu / Zhu, WuSheng / Lu, GuangMing

Insights into imaging

2023 Volume 14, Issue 1, Page(s) 99

Abstract: Objectives: Besides plaque enhancement grade, the incremental value of enhancement-related high-resolution MRI features in defining culprit plaques needs further evaluation. This study was focused on assessing whether plaque enhancement features ... ...

Abstract	Objectives: Besides plaque enhancement grade, the incremental value of enhancement-related high-resolution MRI features in defining culprit plaques needs further evaluation. This study was focused on assessing whether plaque enhancement features contribute to culprit plaque identification and further risk stratification. Methods: We retrospectively studied patients who experienced an acute ischaemic stroke and transient ischaemic attack due to intracranial atherosclerosis from 2016 to 2022. The enhancement features included enhancement grade, enhanced length, and enhancement quadrant. Associations between plaque enhancement features and culprit plaques, as well as diagnostic value, were investigated using logistic regression and receiver operating characteristic analyses. Results: Overall, 287 plaques were identified, of which 231 (80.5%) and 56 (19.5%) were classified as culprit and non-culprit plaques, respectively. Comparison of the pre- and post-enhancement images revealed enhanced length longer than the plaque length in 46.32% of the culprit plaques. Multivariate logistic regression showed that enhanced length longer than plaque length (OR 6.77; 95% CI 2.47-18.51) and grade II enhancement (OR 7.00; 95% CI 1.69-28.93) were independently associated with culprit plaques. The area under the curve value for the combination of stenosis and plaque enhancement grade for the diagnosis of culprit plaques was 0.787, which increased significantly to 0.825 on the addition of enhanced length longer than the plaque length (p = 0.026 for DeLong's test). Conclusions: Enhanced length longer than the plaque length and grade II enhancement were independently associated with culprit plaques. The combination of the enhanced plaque features resulted in better culprit plaque identification.
Language	English
Publishing date	2023-05-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2543323-4
ISSN	1869-4101
ISSN	1869-4101
DOI	10.1186/s13244-023-01449-y
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Article ; Online: Distinguishing Intracranial Diabetes-Related Atherosclerotic Plaques: A High-Resolution Magnetic Resonance Imaging-Based Radiomics Study.

Cheng, XiaoQing / Li, HongXia / Liu, Jia / Zhou, ChangSheng / Liu, QuanHui / Chen, XingZhi / Huang, ChenCui / Li, YingLe / Zhu, WuSheng / Lu, GuangMing

Cerebrovascular diseases (Basel, Switzerland)

2023 Volume 53, Issue 1, Page(s) 105–114

Abstract: Introduction: Diabetes markedly affects the formation and development of intracranial atherosclerosis. The study was aimed at evaluating whether radiomics features can help distinguish plaques primarily associated with diabetes.: Materials and methods! ...

Abstract	Introduction: Diabetes markedly affects the formation and development of intracranial atherosclerosis. The study was aimed at evaluating whether radiomics features can help distinguish plaques primarily associated with diabetes. Materials and methods: We retrospectively analyzed patients who were admitted to our center because of acute ischemic stroke due to intracranial atherosclerosis between 2016 and 2022. Clinical data, blood biomarkers, conventional plaque features, and plaque radiomics features were collected for all patients. Odds ratios (ORs) with 95% confidence intervals (CIs) were determined from logistic regression models. The receiver operating characteristic (ROC) curve and area under the ROC curve (AUC) were used to describe diagnostic performance. The DeLong test was used to compare differences between models. Results: Overall, 157 patients (115 men; mean age, 58.7 ± 10.7 years) were enrolled. Multivariate logistic regression analysis showed that plaque length (OR: 1.17; 95% CI: 1.07-1.28) and area (OR: 1.13; 95% CI: 1.02-1.24) were independently associated with diabetes. On combining plaque length and area as a conventional model, the AUCs of the training and validation cohorts for identifying diabetes patients were 0.789 and 0.720, respectively. On combining radiomics features on T1WI and contrast-enhanced T1WI sequences, a better diagnostic value was obtained in the training and validation cohorts (AUC: 0.889 and 0.861). The DeLong test showed the model combining radiomics and conventional plaque features performed better than the conventional model in both cohorts (p < 0.05). Conclusions: The use of radiomics features of intracranial plaques on high-resolution magnetic resonance imaging can effectively distinguish culprit plaques with diabetes as the primary pathological cause, which will provide new avenues of research into plaque formation and precise treatment.
MeSH term(s)	Humans ; Male ; Middle Aged ; Aged ; Radiomics ; Ischemic Stroke/complications ; Plaque, Atherosclerotic/complications ; Retrospective Studies ; Magnetic Resonance Imaging/methods ; Diabetes Mellitus/diagnosis ; Intracranial Arteriosclerosis/complications ; Intracranial Arteriosclerosis/diagnostic imaging
Language	English
Publishing date	2023-04-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1069462-6
ISSN	1421-9786 ; 1015-9770
ISSN (online)	1421-9786
ISSN	1015-9770
DOI	10.1159/000530412
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Article ; Online: Social contagions on interconnected networks of heterogeneous populations.

Shu, Panpan / Liu, Quan-Hui / Wang, Shangping / Wang, Wei

Chaos (Woodbury, N.Y.)

2018 Volume 28, Issue 11, Page(s) 113114

Abstract: Recently, the dynamics of social contagions ranging from the adoption of a new product to the diffusion of a rumor have attracted more and more attention from researchers. However, the combined effects of individual's heterogenous adoption behavior and ... ...

Abstract	Recently, the dynamics of social contagions ranging from the adoption of a new product to the diffusion of a rumor have attracted more and more attention from researchers. However, the combined effects of individual's heterogenous adoption behavior and the interconnected structure on the social contagions processes have yet to be understood deeply. In this paper, we study theoretically and numerically the social contagions with heterogeneous adoption threshold in interconnected networks. We first develop a generalized edge-based compartmental approach to predict the evolution of social contagion dynamics on interconnected networks. Both the theoretical predictions and numerical results show that the growth of the final recovered fraction with the intralayer propagation rate displays double transitions. When increasing the initial adopted proportion or the adopted threshold, the first transition remains continuous within different dynamic parameters, but the second transition gradually vanishes. When decreasing the interlayer propagation rate, the change in the double transitions mentioned above is also observed. The heterogeneity of degree distribution does not affect the type of first transition, but increasing the heterogeneity of degree distribution results in the type change of the second transition from discontinuous to continuous. The consistency between the theoretical predictions and numerical results confirms the validity of our proposed analytical approach.
Language	English
Publishing date	2018-11-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1472677-4
ISSN	1089-7682 ; 1054-1500
ISSN (online)	1089-7682
ISSN	1054-1500
DOI	10.1063/1.5042677
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Article: Coevolution spreading in complex networks.

Wang, Wei / Liu, Quan-Hui / Liang, Junhao / Hu, Yanqing / Zhou, Tao

Physics reports

2019 Volume 820, Page(s) 1–51

Abstract: The propagations of diseases, behaviors and information in real systems are rarely independent of each other, but they are coevolving with strong interactions. To uncover the dynamical mechanisms, the evolving spatiotemporal patterns and critical ... ...

Abstract	The propagations of diseases, behaviors and information in real systems are rarely independent of each other, but they are coevolving with strong interactions. To uncover the dynamical mechanisms, the evolving spatiotemporal patterns and critical phenomena of networked coevolution spreading are extremely important, which provide theoretical foundations for us to control epidemic spreading, predict collective behaviors in social systems, and so on. The coevolution spreading dynamics in complex networks has thus attracted much attention in many disciplines. In this review, we introduce recent progress in the study of coevolution spreading dynamics, emphasizing the contributions from the perspectives of statistical mechanics and network science. The theoretical methods, critical phenomena, phase transitions, interacting mechanisms, and effects of network topology for four representative types of coevolution spreading mechanisms, including the coevolution of biological contagions, social contagions, epidemic-awareness, and epidemic-resources, are presented in detail, and the challenges in this field as well as open issues for future studies are also discussed.
Keywords	covid19
Language	English
Publishing date	2019-07-29
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	120601-1
ISSN	0370-1573
ISSN	0370-1573
DOI	10.1016/j.physrep.2019.07.001
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Article ; Online: Radiomics versus Conventional Assessment to Identify Symptomatic Participants at Carotid Computed Tomography Angiography.

Dong, Zheng / Zhou, ChangSheng / Li, HongXia / Shi, JiaQian / Liu, Jia / Liu, QuanHui / Su, XiaoQin / Zhang, FanDong / Cheng, XiaoQing / Lu, GuangMing

Cerebrovascular diseases (Basel, Switzerland)

2022 Volume 51, Issue 5, Page(s) 647–654

Abstract: Introduction: Carotid computed tomography angiography (CTA) is routinely used for evaluating the atherosclerotic process. Radiomics allows the extraction of imaging markers of lesion heterogeneity and spatial complexity. These quantitative features can ... ...

Abstract	Introduction: Carotid computed tomography angiography (CTA) is routinely used for evaluating the atherosclerotic process. Radiomics allows the extraction of imaging markers of lesion heterogeneity and spatial complexity. These quantitative features can be used as the input for machine learning (ML). Therefore, in this study, we aimed to evaluate the diagnostic performance of radiomics-based ML assessment of carotid CTA data to identify symptomatic patients with carotid artery atherosclerosis. Methods: In this retrospective study, participants with carotid artery atherosclerosis who underwent carotid CTA and brain magnetic resonance imaging from May 2010 to December 2017 were studied. The participants were grouped into symptomatic and asymptomatic groups according to their recent symptoms (determination of ipsilateral ischemic stroke). Eight conventional plaque features and 2,107 radiomics parameters were extracted from carotid CTA images. A radiomics-based ML model was fitted on the training set, and the radiomics-based ML model and conventional assessment were compared using the area under the curve (AUC) to identify symptomatic participants. Results: After excluding participants with other stroke sources, 120 patients with 148 carotid arteries were analyzed. Of these 148 carotid arteries, 34 (22.97%) were classified into the symptomatic group. Plaque ulceration (odds ratio [OR] = 0.257; 95% confidence interval [CI], 0.094-0.698) and plaque enhancement (OR = 0.305; 95% CI, 0.094-0.988) were associated with the symptomatic status. Twenty radiomics parameters were chosen to be inputs in the radiomics-based ML model. In the identification of symptomatic participants, the discriminatory value of the radiomics-based ML model was significantly higher than that of the conventional assessment (AUC = 0.858 vs. AUC = 0.706, p = 0.021). Conclusion: Radiomics-based ML analysis improves the discriminatory power of carotid CTA in the identification of recent ischemic symptoms in patients with carotid artery atherosclerosis.
MeSH term(s)	Atherosclerosis/complications ; Carotid Arteries/pathology ; Carotid Artery Diseases/complications ; Carotid Artery Diseases/diagnostic imaging ; Carotid Stenosis/complications ; Computed Tomography Angiography/methods ; Humans ; Plaque, Atherosclerotic/complications ; Plaque, Atherosclerotic/diagnosis ; Plaque, Atherosclerotic/pathology ; Retrospective Studies
Language	English
Publishing date	2022-03-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1069462-6
ISSN	1421-9786 ; 1015-9770
ISSN (online)	1421-9786
ISSN	1015-9770
DOI	10.1159/000522058
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Zs.A 3181: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: ASPECTS-Based Attenuation Changes on CT Angiography as an Imaging Biomarker to Predict Hemorrhagic Transformation in Acute Ischemic Stroke.

Cheng, XiaoQing / Shi, JiaQian / Wu, Hang / Dong, Zheng / Liu, Jia / Zhou, ChangSheng / Liu, QuanHui / Su, XiaoQin / Shi, Zhao / Li, YingLe / Xiao, LuLu / Zhu, WuSheng / Lu, GuangMing

Cerebrovascular diseases (Basel, Switzerland)

2022 Volume 51, Issue 4, Page(s) 532–541

Abstract: Introduction: Imaging-based early warning indicators and feasible stratification of acute ischemic stroke (AIS) patients with hemorrhagic transformation (HT), especially high-risk patients with parenchymal hematoma (PH), are crucial in determining ... ...

Abstract	Introduction: Imaging-based early warning indicators and feasible stratification of acute ischemic stroke (AIS) patients with hemorrhagic transformation (HT), especially high-risk patients with parenchymal hematoma (PH), are crucial in determining subsequent treatment strategies. This study combined automated ASPECTS software with noncontrast CT (NCCT) and CTA source image (CTASI) attenuation changes using Hounsfield unit (HU) values to predict HT and PH in patients with AIS. Materials and methods: We retrospectively enrolled 172 consecutive patients with anterior circulation large-vessel occlusion between 2016 and 2020. Univariate and multivariate logistic regression and receiver operating characteristic (ROC) analyses were used to investigate the relationship between NCCT and CTASI-ASPECTS-HU, as well as other clinical and radiological parameters of HT and PH. Univariate and multivariate logistic regression analyses were performed to explore risk factors for HT or PH, and an ROC curve was used to evaluate their diagnostic values. Results: A multivariate analysis showed that CTASI-ASPECTS-HU and NIHSS score were independent predictors of HT (CTASI-ASPECTS-HU: odds ratio (OR), 2.22; 95% CI, 1.01-4.92; NIHSS: OR, 1.07; 95% CI, 1.02-1.13) and PH (CTASI-ASPECTS-HU: OR, 6.51; 95% CI, 2.29-18.50; NIHSS: OR, 1.07; 95% CI, 1.01-1.13). According to ROC analysis, CTASI-ASPECTS-HU >0.09 identified HT (area under the curve, 0.70; sensitivity, 70.15%; specificity, 61.90%), and CTASI-ASPECTS-HU >0.10 identified PH (area under the curve, 0.79; sensitivity, 76.19%; specificity, 73.33%). The area under the curve for predicting HT or PH increased when CTASI-ASPECTS-HU was combined with NIHSS score (HT: area under the curve, 0.74; sensitivity, 73.13%; specificity, 70.48%; PH: area under the curve, 0.81; sensitivity, 85.71%; specificity, 72.38%). Conclusion: CTASI-ASPECTS-HU is a reliable radiological predictor of HT and PH in patients with AIS. Its predictive efficacy is moderately improved when combined with NIHSS score.
MeSH term(s)	Biomarkers ; Brain Ischemia/diagnostic imaging ; Brain Ischemia/therapy ; Cerebral Angiography/methods ; Computed Tomography Angiography/methods ; Hemorrhage ; Humans ; Ischemic Stroke/diagnostic imaging ; Ischemic Stroke/etiology ; Ischemic Stroke/therapy ; Retrospective Studies ; Stroke/diagnostic imaging ; Stroke/etiology ; Stroke/therapy
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-01-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1069462-6
ISSN	1421-9786 ; 1015-9770
ISSN (online)	1421-9786
ISSN	1015-9770
DOI	10.1159/000521026
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