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  1. Article ; Online: The Spatio-Temporal Patterns of Regional Development in Shandong Province of China from 2012 to 2021 Based on Nighttime Light Remote Sensing.

    Zhang, Hongli / Yu, Quanzhou / Liu, Yujie / Jiang, Jie / Chen, Junjie / Liu, Ruyun

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 21

    Abstract: As a major coastal economic province in the east of China, it is of great significance to clarify the temporal and spatial patterns of regional development in Shandong Province in recent years to support regional high-quality development. Nightlight ... ...

    Abstract As a major coastal economic province in the east of China, it is of great significance to clarify the temporal and spatial patterns of regional development in Shandong Province in recent years to support regional high-quality development. Nightlight remote sensing data can reveal the spatio-temporal patterns of social and economic activities on a fine pixel scale. We based the nighttime light patterns at three spatial scales in three geographical regions on monthly nighttime light remote sensing data and social statistics. Different cities and different counties in Shandong Province in the last 10 years were studied by using the methods of trend analysis, stability analysis and correlation analysis. The results show that: (1) The nighttime light pattern was generally consistent with the spatial pattern of construction land. The nighttime light intensity of most urban, built-up areas showed an increasing trend, while the old urban areas of Qingdao and Yantai showed a weakening trend. (2) At the geographical unit scale, the total nighttime light in south-central Shandong was significantly higher than that in eastern and northwest Shandong, while the nighttime light growth rate in northwest Shandong was significantly highest. At the urban scale, Liaocheng had the highest nighttime light growth rate. At the county scale, the nighttime light growth rate of counties with a better economy was lower, while that of counties with a backward economy was higher. (3) The nighttime light growth was significantly correlated with Gross Domestic Product (GDP) and population growth, indicating that regional economic development and population growth were the main causes of nighttime light change.
    Language English
    Publishing date 2023-10-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23218728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Antidepressant effect of the novel histone deacetylase-5 inhibitor T2943 in a chronic restraint stress mouse model.

    Du, Juan / Liu, Ning / Ma, Lin / Liu, Ruyun / Zuo, Di / Lan, Xiaobing / Yang, Jiamei / Wei, Wei / Peng, Xiaodong / Yu, Jianqiang

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2024  Volume 171, Page(s) 116176

    Abstract: Depression is a prevalent and debilitating psychiatric illness. However, the antidepressant drugs currently prescribed are only effective in a limited group of patients. Histone modifications mediated by histone acetylation are considered to play an ... ...

    Abstract Depression is a prevalent and debilitating psychiatric illness. However, the antidepressant drugs currently prescribed are only effective in a limited group of patients. Histone modifications mediated by histone acetylation are considered to play an important role in the pathogenesis and treatment of depression. Recent studies have revealed that histone deacetylase inhibitors may be involved in the pathogenesis of depression and the underlying mechanism of the antidepressant therapeutic action. Here, we first conducted virtual screening of histone deacetylase-5 (HDAC5) inhibitors against HDAC5, a target closely related to depression, and identified compound T2943, further verifying its inhibitory effect on enzyme activities in vitro. After stereotaxic injection of T2943 into the hippocampus of mice, the antidepressant effect of T2943 was evaluated using behavioral experiments. We also used different proteomic and molecular biology analyses to determine and confirm that T2943 promoted histone 3 lysine 14 acetylation (H3K14ac) by inhibiting HDAC5 activity. Following the overexpression of adenoviral HDAC5 in the hippocampus of mice and subsequent behavioral analyses, we confirmed that T2943 exerts antidepressant effects by inhibiting HDAC5 activity. Our findings highlight the efficacy of targeting HDAC5 to treat depression and demonstrate the potential of using T2943 as an antidepressant.
    MeSH term(s) Humans ; Histones ; Proteomics ; Antidepressive Agents/pharmacology ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylases/metabolism
    Chemical Substances Histones ; Antidepressive Agents ; Histone Deacetylase Inhibitors ; Histone Deacetylases (EC 3.5.1.98)
    Language English
    Publishing date 2024-01-19
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2024.116176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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