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Article ; Online: Non-coding RNAs: a promising target for early metastasis intervention.

Xiao, Yi / Hu, Yijun / Liu, Shanrong

2023 Volume 136, Issue 21, Page(s) 2538–2550

Abstract: Abstract: Metastases account for the overwhelming majority of cancer-associated deaths. The dissemination of cancer cells from the primary tumor to distant organs involves a complex process known as the invasion-metastasis cascade. The underlying ... ...

Abstract	Abstract: Metastases account for the overwhelming majority of cancer-associated deaths. The dissemination of cancer cells from the primary tumor to distant organs involves a complex process known as the invasion-metastasis cascade. The underlying biological mechanisms of metastasis, however, remain largely elusive. Recently, the discovery and characterization of non-coding RNAs (ncRNAs) have revealed the diversity of their regulatory roles, especially as key contributors throughout the metastatic cascade. Here, we review recent progress in how three major types of ncRNAs (microRNAs, long non-coding RNAs, and circular RNAs) are involved in the multistep procedure of metastasis. We further examine interactions among the three ncRNAs as well as current progress in their regulatory mechanisms. We also propose the prevention of metastasis in the early stages of cancer progression and discuss current translational studies using ncRNAs as targets for metastasis diagnosis and treatments. These studies provide insights into developing more effective strategies to target metastatic relapse.
MeSH term(s)	Gene Expression Regulation, Neoplastic/genetics ; RNA, Untranslated/genetics ; MicroRNAs ; RNA, Long Noncoding ; RNA, Circular/genetics
Chemical Substances	RNA, Untranslated ; MicroRNAs ; RNA, Long Noncoding ; RNA, Circular
Language	English
Publishing date	2023-11-05
Publishing country	China
Document type	Review ; Journal Article
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000002619
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Article ; Online: Small extracellular vesicles: Non-negligible vesicles in tumor progression, diagnosis, and therapy.

Zhou, Xinru / Jia, Yin / Mao, Chuanbin / Liu, Shanrong

Cancer letters

2023 Volume 580, Page(s) 216481

Abstract: Small extracellular vesicles (sEVs) such as exosomes are nanoscale membranous particles (<200 nm) that have emerged as crucial targets for liquid biopsy and as promising drug delivery vehicles. They play a significant role in tumor progression as ... ...

Abstract	Small extracellular vesicles (sEVs) such as exosomes are nanoscale membranous particles (<200 nm) that have emerged as crucial targets for liquid biopsy and as promising drug delivery vehicles. They play a significant role in tumor progression as intercellular messengers. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment. This article reviews recent studies on sEVs in oncology and explores their potential as biomarkers and drug delivery vehicles. Following tumorigenesis, sEVs in the tumor microenvironment (TME) and circulatory system undergo modifications to regulate various events in the TME, including angiogenesis, epithelial-mesenchymal transition (EMT), and tumor immunity, with either pro- or anti-tumor effects. sEVs have been investigated for use as diagnostic and prognostic biomarkers for a variety of tumors, including lung cancer, melanoma, breast cancer, prostate cancer, and hepatocellular carcinoma. sEVs can be used for cancer therapy by packaging drugs or proteins into them through pre- and post-isolation modification techniques. The clinical trials of sEVs as biomarkers and drug carriers are also summarized. Finally, the challenges in the use of sEVs are described and the possible approaches to tackling them are suggested. Overall, sEVs will advance the precision cancer medicine and has shown great potential in clinical applications.
MeSH term(s)	Male ; Humans ; Lung Neoplasms ; Extracellular Vesicles ; Drug Carriers ; Liver Neoplasms ; Biomarkers ; Tumor Microenvironment
Chemical Substances	Drug Carriers ; Biomarkers
Language	English
Publishing date	2023-11-15
Publishing country	Ireland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/j.canlet.2023.216481
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Article ; Online: Integrated analysis revealing the role of TET3-mediated MUC13 promoter hypomethylation in hepatocellular carcinogenesis.

Kong, Ruijiao / Zhang, Hui / Jia, Yin / Man, Qiuhong / Liu, Shanrong

Epigenomics

2023 Volume 14, Issue 24, Page(s) 1579–1591

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Cell Line, Tumor ; DNA Methylation ; Cell Transformation, Neoplastic/genetics ; Neoplastic Stem Cells/metabolism ; Mucins/genetics ; Mucins/metabolism ; Dioxygenases/genetics
Chemical Substances	MUC13 protein, human ; Mucins ; TET3 protein, human (EC 1.-) ; Dioxygenases (EC 1.13.11.-)
Language	English
Publishing date	2023-03-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2537199-X
ISSN	1750-192X ; 1750-1911
ISSN (online)	1750-192X
ISSN	1750-1911
DOI	10.2217/epi-2022-0395
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Article ; Online: Pt/NiFe-LDH hybrids for quantification and qualification of polyphenols.

Ding, Chunmeng / Zhu, Yuexing / Huo, Zhiyuan / Yang, Shouzhi / Zhou, Yan / Yiming, Ayizekeranmu / Chen, Wei / Liu, Shanrong / Qian, Kun / Huang, Lin

Materials today. Bio

2024 Volume 26, Page(s) 101047

Abstract: Polyphenols with antioxidant properties are of significant interest in medical and pharmaceutical applications. Given the diverse range of activities of polyphenols in vivo, accurate detection of these compounds plays a crucial role in nutritional ... ...

Abstract	Polyphenols with antioxidant properties are of significant interest in medical and pharmaceutical applications. Given the diverse range of activities of polyphenols in vivo, accurate detection of these compounds plays a crucial role in nutritional surveillance and pharmaceutical development. Yet, the efficient quantitation of polyphenol contents and qualification of monomer compositions present a notable challenge when studying polyphenol bioavailability. In this study, platinum-modified nickel-iron layered double hydroxide (Pt/NiFe-LDH hybrids) were designed to mimic peroxidases for colorimetric analysis and act as enhanced matrices for laser desorption/ionization mass spectrometry (LDI MS) to quantify and qualify polyphenols. The hybrids exhibited an enzymatic activity of 33.472 U/mg for colorimetric assays, facilitating the rapid and direct quantitation of total tea polyphenols within approximately 1 min. Additionally, the heterogeneous structure and exposed hydroxyl groups on the hybrid surface contributed to photoelectric enhancement and
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article
ISSN	2590-0064
ISSN (online)	2590-0064
DOI	10.1016/j.mtbio.2024.101047
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Article: Integrated analysis identifies S100A16 as a potential prognostic marker for pancreatic cancer.

Chen, Tian / Xia, De-Meng / Qian, Chao / Liu, Shan-Rong

American journal of translational research

2021 Volume 13, Issue 5, Page(s) 5720–5730

Abstract: Background: The new S100 protein family member S100A16 is functionally expressed in various cancers. This study explored the prognostic value and potential role of S100A16 in pancreatic cancer (PC).: Methods: RNA-seq and clinical data were obtained ... ...

Abstract	Background: The new S100 protein family member S100A16 is functionally expressed in various cancers. This study explored the prognostic value and potential role of S100A16 in pancreatic cancer (PC). Methods: RNA-seq and clinical data were obtained from The Cancer Genome Atlas-Pancreatic Adenocarcinoma (TCGA-PAAD) dataset to compare the expression level of S100A16 between groups. The genes co-expressed with S100A16 in TCGA-PAAD were analyzed using cBioPortal. Gene Ontology and Kyoto Encyclopedia of Genes and genomes enrichment analyses were also performed on these genes. Pathways related to S100A16 expression dysregulation were explored using gene set enrichment analysis. The Tumor Immune Estimation Resource was used to analyze the correlation between S100A16 and infiltrating immune cells. The Kaplan-Meier method and Cox analyses were used to assess the prognostic significance of S100A16 for PC. Results: The S100A16 expression level was high in PC and increased with the degree of malignancy. The S100A16 functions in PC were mainly enriched in the immune modules, but negatively correlated with the immune activity (T-cell, cytokine, immune, co-receptor, signaling adaptor, cell adhesion molecule, chemokine, and JAK/STAT signaling) and infiltration level (T cells and macrophages). The strongest negative correlation was observed between the expression of CD8 Conclusion: S100A16 is a potential independent prognostic marker and immunotherapy target for PC. Mechanistically, S100A16 potentially affects prognosis by extensive immunosuppression, including the inhibition of the anti-tumor immune response of CD8
Language	English
Publishing date	2021-05-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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Article: Single-cell RNA sequencing of peripheral blood reveals immune cell dysfunction in premature ovarian insufficiency.

Zhang, Caihong / Yu, Dong / Mei, Yue / Liu, Shanrong / Shao, Huijing / Sun, Qianqian / Lu, Qiong / Hu, Jingjing / Gu, Hang

Frontiers in endocrinology

2023 Volume 14, Page(s) 1129657

Abstract: Background: Premature ovarian insufficiency (POI) is one of the most common causes of female infertility and the etiology is highly heterogeneous. Most cases are idiopathic and the pathogenesis remains unclear. Previous studies proved that the immune ... ...

Abstract	Background: Premature ovarian insufficiency (POI) is one of the most common causes of female infertility and the etiology is highly heterogeneous. Most cases are idiopathic and the pathogenesis remains unclear. Previous studies proved that the immune system plays a crucial role in POI. However, the precise role of immune system remains unclear. This study aimed to analyze the characteristics of peripheral blood mononuclear cells (PBMC) from patients with POI by single-cell RNA sequencing (scRNA-seq) and to explore the potential involvement of immune response in idiopathic POI. Methods: PBMC was collected from three normal subjects and three patients with POI. PBMC was subjected to scRNA-seq to identify cell clusters and differently expressed genes (DEGs). Enrichment analysis and cell-cell communication analysis were performed to explore the most active biological function in the immune cells of patients with POI. Results: In total, 22 cell clusters and 10 cell types were identified in the two groups. Compared with normal subjects, the percentage of classical monocytes and NK cells was decreased, the abundance of plasma B cells was increased, and CD4/CD8 ratio was significantly higher in POI. Furthermore, upregulation of Conclusions: Dysfunction of cellular immunity is related to idiopathic POI. Monocytes, NK cells, and B cells, and their enriched differential genes may play a role in the development of idiopathic POI. These findings provide novel mechanistic insight for understanding the pathogenesis of POI.
MeSH term(s)	Humans ; Female ; Leukocytes, Mononuclear ; Menopause, Premature ; Primary Ovarian Insufficiency/genetics ; Immune System Diseases ; Sequence Analysis, RNA
Language	English
Publishing date	2023-05-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1129657
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Article ; Online: Hypoxia-induced circ-CDYL-EEF1A2 transcriptional complex drives lung metastasis of cancer stem cells from hepatocellular carcinoma.

Kong, Ruijiao / Wei, Wenxin / Man, Qiuhong / Chen, Liang / Jia, Yin / Zhang, Hui / Liu, Zixin / Cheng, Kai / Mao, Chuanbin / Liu, Shanrong

Cancer letters

2023 Volume 578, Page(s) 216442

Abstract: Hepatocellular carcinoma (HCC) is often associated with poor outcomes due to lung metastasis. ICAM- ... ...

Abstract	Hepatocellular carcinoma (HCC) is often associated with poor outcomes due to lung metastasis. ICAM-1
MeSH term(s)	Humans ; Animals ; Mice ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Intercellular Adhesion Molecule-1/genetics ; Intercellular Adhesion Molecule-1/metabolism ; Cell Line, Tumor ; Lung Neoplasms/metabolism ; Hypoxia/genetics ; Neoplastic Stem Cells/metabolism ; Gene Expression Regulation, Neoplastic ; MicroRNAs/genetics ; Cell Proliferation ; Tumor Microenvironment ; Hydro-Lyases/genetics ; Hydro-Lyases/metabolism ; Co-Repressor Proteins/genetics
Chemical Substances	Intercellular Adhesion Molecule-1 (126547-89-5) ; MicroRNAs ; CDYL protein, human (EC 4.2.1.-) ; Hydro-Lyases (EC 4.2.1.-) ; Co-Repressor Proteins ; EIF4A3 protein, human (EC 3.6.1.-) ; EEF1A2 protein, human
Language	English
Publishing date	2023-10-16
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/j.canlet.2023.216442
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Article: Dual-modal nanoplatform integrated with smartphone for hierarchical diabetic detection

Huang, Lin / Zhou, Yan / Zhu, Yuexing / Su, Haiyang / Yang, Shouzhi / Feng, Lei / Zhao, Liang / Liu, Shanrong / Qian, Kun

Biosensors & bioelectronics. 2022 Aug. 15, v. 210

2022

Abstract: On-site screening of diabetes and precise diagnosis of diabetic complications may provide a conduit for early intervention and disease burden reduction. However, stratified metabolic analysis needs designed materials for colorimetric detection of ... ...

Abstract	On-site screening of diabetes and precise diagnosis of diabetic complications may provide a conduit for early intervention and disease burden reduction. However, stratified metabolic analysis needs designed materials for colorimetric detection of targeted biomarkers and direct metabolic fingerprinting of the native blood. Here, an advanced dual-modal nanoplatform is constructed based on PdPtAu alloys, which serve both as the nanoenzymes in colorimetric sensing for targeted metabolite quantitation and as matrix in laser desorption/ionization mass spectrometry for untargeted metabolic fingerprinting. The platform achieved rapid glucose quantitation toward point-of-care testing of 27 participants and identified diabetic retinopathy from diabetic population with a sensitivity and specificity of 84.6%. We further assessed the generalizability of the nanoplatform for real-case applications, through the captured digital images and computing resources equipped in smartphones. The results advance the design of material-based platforms for stratified metabolic analysis and display promise to fit in the current hierarchical medical system in practice.
Keywords	biomarkers ; biosensors ; blood ; burden of disease ; colorimetry ; desorption ; diabetic retinopathy ; glucose ; mass spectrometry ; metabolites ; mobile telephones
Language	English
Dates of publication	2022-0815
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2022.114254
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Peptides encoded by noncoding genes: challenges and perspectives.

Wang, Shuo / Mao, Chuanbin / Liu, Shanrong

Signal transduction and targeted therapy

2019 Volume 4, Page(s) 57

Abstract: In recent years, noncoding gene (NCG) translation events have been frequently discovered. The resultant peptides, as novel findings in the life sciences, perform unexpected functions of increasingly recognized importance in many fundamental biological ... ...

Abstract	In recent years, noncoding gene (NCG) translation events have been frequently discovered. The resultant peptides, as novel findings in the life sciences, perform unexpected functions of increasingly recognized importance in many fundamental biological and pathological processes. The emergence of these novel peptides, in turn, has advanced the field of genomics while indispensably aiding living organisms. The peptides from NCGs serve as important links between extracellular stimuli and intracellular adjustment mechanisms. These peptides are also important entry points for further exploration of the mysteries of life that may trigger a new round of revolutionary biotechnological discoveries. Insights into NCG-derived peptides will assist in understanding the secrets of life and the causes of diseases, and will also open up new paths to the treatment of diseases such as cancer. Here, a critical review is presented on the action modes and biological functions of the peptides encoded by NCGs. The challenges and future trends in searching for and studying NCG peptides are also critically discussed.
Language	English
Publishing date	2019-12-13
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2886872-9
ISSN	2059-3635 ; 2095-9907
ISSN (online)	2059-3635
ISSN	2095-9907
DOI	10.1038/s41392-019-0092-3
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Article: Noncoding RNAs in Growth and Death of Cancer Cells.

Liu, Anfei / Liu, Shanrong

Advances in experimental medicine and biology

2016 Volume 927, Page(s) 137–172

Abstract: The mammalian genomes are mostly comprised of noncoding genes. And mammalian genomes are characterized by pervasive expression of different types of noncoding RNAs (ncRNAs). In sharp contrast to previous collections, these ncRNAs show strong purifying ... ...

Abstract	The mammalian genomes are mostly comprised of noncoding genes. And mammalian genomes are characterized by pervasive expression of different types of noncoding RNAs (ncRNAs). In sharp contrast to previous collections, these ncRNAs show strong purifying selection evolutionary conservation. Previous studies indicated that only a small fraction of the mammalian genome codes for messenger RNAs destined to be translated into peptides or proteins, and it is generally assumed that a large portion of transcribed sequences-including pseudogenes and several classes of ncRNAs-do not give rise to peptides or proteins. However, ribosome profiling suggests that ribosomes occupy many regions of the transcriptome thought to be noncoding. Moreover, these observations highlight a potentially large and complex set of biologically regulated translational events from transcripts formerly thought to lack coding potential. Furthermore, accumulating evidence from previous studies has suggested that the novel translation products exhibit temporal regulation similar to that of proteins known to be involved in many biological activity processes. In this review, we focus on the coding potential of noncoding genes and ncRNAs. We also sketched the possible mechanisms for their coding activities. Overall, our review provides new insights into the word of central dogma and is an expansive resource of functional annotations for biomedical research. At last, the outcome of the majority of the translation events and their potential biological purpose remain an intriguing topic for future investigation.
MeSH term(s)	Animals ; Apoptosis/genetics ; Autophagy/genetics ; Cell Cycle/genetics ; Cell Proliferation/genetics ; Genome ; Humans ; Mammals/genetics ; Necrosis/genetics ; Neoplasms/genetics ; RNA, Long Noncoding/biosynthesis ; RNA, Long Noncoding/genetics
Chemical Substances	RNA, Long Noncoding
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-981-10-1498-7_5
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