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Article ; Online: Theranostic applications of selenium nanomedicines against lung cancer.

Liu, Shaowei / Wei, Weifeng / Wang, Jinlin / Chen, Tianfeng

2023 Volume 21, Issue 1, Page(s) 96

Abstract: The incidence and mortality rates of lung cancer are among the highest in the world. Traditional treatment methods include surgery, chemotherapy, and radiotherapy. Although rapid progress has been achieved in the past decade, treatment limitations remain. ...

Abstract	The incidence and mortality rates of lung cancer are among the highest in the world. Traditional treatment methods include surgery, chemotherapy, and radiotherapy. Although rapid progress has been achieved in the past decade, treatment limitations remain. It is therefore imperative to identify safer and more effective therapeutic methods, and research is currently being conducted to identify more efficient and less harmful drugs. In recent years, the discovery of antitumor drugs based on the essential trace element selenium (Se) has provided good prospects for lung cancer treatments. In particular, compared to inorganic Se (Inorg-Se) and organic Se (Org-Se), Se nanomedicine (Se nanoparticles; SeNPs) shows much higher bioavailability and antioxidant activity and lower toxicity. SeNPs can also be used as a drug delivery carrier to better regulate protein and DNA biosynthesis and protein kinase C activity, thus playing a role in inhibiting cancer cell proliferation. SeNPs can also effectively activate antigen-presenting cells to stimulate cell immunity, exert regulatory effects on innate and regulatory immunity, and enhance lung cancer immunotherapy. This review summarizes the application of Se-based species and materials in lung cancer diagnosis, including fluorescence, MR, CT, photoacoustic imaging and other diagnostic methods, as well as treatments, including direct killing, radiosensitization, chemotherapeutic sensitization, photothermodynamics, and enhanced immunotherapy. In addition, the application prospects and challenges of Se-based drugs in lung cancer are examined, as well as their forecasted future clinical applications and sustainable development.
MeSH term(s)	Humans ; Selenium/therapeutic use ; Selenium/metabolism ; Precision Medicine ; Nanomedicine ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology ; Antioxidants/metabolism ; Nanoparticles/therapeutic use ; Drug Carriers
Chemical Substances	Selenium (H6241UJ22B) ; Antioxidants ; Drug Carriers
Language	English
Publishing date	2023-03-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2100022-0
ISSN	1477-3155 ; 1477-3155
ISSN (online)	1477-3155
ISSN	1477-3155
DOI	10.1186/s12951-023-01825-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Reproductive-dependent effects of B vitamin deficiency on lifespan and physiology.

Yu, Guixiang / Liu, Shaowei / Yang, Kun / Wu, Qi

Frontiers in nutrition

2023 Volume 10, Page(s) 1277715

Abstract: B vitamins constitute essential micronutrients in animal organisms, executing crucial roles in numerous biological processes. B vitamin deficiency can result in severe health consequences, including the impairment of reproductive functions and increased ... ...

Abstract	B vitamins constitute essential micronutrients in animal organisms, executing crucial roles in numerous biological processes. B vitamin deficiency can result in severe health consequences, including the impairment of reproductive functions and increased susceptibility to age-related diseases. However, the understanding of how reproduction alters the requirements of each individual B vitamins for healthy aging and lifespan remains limited. Here, utilizing
Language	English
Publishing date	2023-10-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1277715
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Article ; Online: High-efficiency extraction of target particles in viscoelastic contraction-expansion microchannels.

Wu, Bin / Liu, Shaowei / Jiang, Di / Tang, Wenlai

Electrophoresis

2023

Abstract: The efficient and precise extraction of target particles is a crucial prerequisite for achieving accurate detection and analysis in microfluidic cell analysis. In this study, a symmetrical contraction-expansion microchannel with sheath flow was designed, ...

Abstract	The efficient and precise extraction of target particles is a crucial prerequisite for achieving accurate detection and analysis in microfluidic cell analysis. In this study, a symmetrical contraction-expansion microchannel with sheath flow was designed, aiming to extract target larger particles from particles of different sizes within the channel. This paper conducted numerical simulations to investigate the three-dimensional migration mechanisms of particles and performed experimental studies to examine the separation performance of particles with different sizes under varying flow rate ratios and different numbers of contraction-expansion structures. The experimental results indicate that at moderate sample flow rates and higher flow rate ratios, microchannels with fewer contraction-expansion structures are likely to achieve better performance in extracting target particles compared to microchannels with a greater number of these structures. Our work advances the application of viscoelastic contraction-expansion microchannels in particle separation. This device is easy to set up in parallel and significantly enhances throughput, providing an accurate and efficient solution for future particle separation applications.
Language	English
Publishing date	2023-12-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	619001-7
ISSN	1522-2683 ; 0173-0835
ISSN (online)	1522-2683
ISSN	0173-0835
DOI	10.1002/elps.202300251
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Article ; Online: Diagnostic procedure for localized constrictive pericarditis leading to bilateral pleural effusion: two case reports.

Liu, Shaowei / Li, Zhi / Li, Naijian / Wei, Weifeng / Liang, Xinyin / Wang, Jinlin

ESC heart failure

2024

Abstract: Constrictive pericarditis is a rare disease. Localized constrictive pericarditis leading to bilateral pleural effusion is more difficult to recognize, and the diagnostic procedure can be ambiguous. Here, we report two patients diagnosed with localized ... ...

Abstract	Constrictive pericarditis is a rare disease. Localized constrictive pericarditis leading to bilateral pleural effusion is more difficult to recognize, and the diagnostic procedure can be ambiguous. Here, we report two patients diagnosed with localized constrictive pericarditis who presented with bilateral pleural effusion. A thorough work-up showed that the pleural effusion was nonspecific, as was the pathology of the pleura. One patient had a history of pericardial effusion 2 years ago, and the other had undergone surgery for an anterior mediastinum teratoma. Pericardial scarring was found on their chest CT scans. The patients underwent pericardiectomy, and localized pericardial thickening was excised. The bilateral pleural effusion was effectively cured, and the patients showed satisfactory recovery on follow-up. Physicians should be aware of localized pericarditis leading to bilateral pleural effusion, and pericardiectomy is an effective diagnostic and therapeutic procedure.
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Case Reports
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.14708
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Article ; Online: Metal-Free Nitrogen-Doped Mesoporous Carbons for the Mild and Selective Synthesis of Pyrroles from Nitroarenes via Cascade Reaction.

Yu, Xiangzhu / Miao, Meng / Huo, Shuxiao / Tang, Xinyue / Ni, Ling / Liu, Shaowei / Wang, Lianyue

ACS applied materials & interfaces

2024 Volume 16, Issue 13, Page(s) 16363–16372

Abstract: The cascade synthesis of pyrroles from nitroarenes is an attractive alternative strategy. However, metal catalysts and relatively high temperatures cover the existing reported catalytic systems for this strategy. The development of nonmetallic ... ...

Abstract	The cascade synthesis of pyrroles from nitroarenes is an attractive alternative strategy. However, metal catalysts and relatively high temperatures cover the existing reported catalytic systems for this strategy. The development of nonmetallic heterogeneous catalytic systems for the one-pot synthesis of pyrrole from nitroarenes under mild conditions is both worthwhile and challenging. Herein, we describe an exceptionally efficient method for the synthesis of
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.4c01621
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Article: Strengthening Device for Improving Shear Performance of Anchor Cable in Rock Support.

Feng, Chao / Liu, Shaowei / Jia, Housheng / Fu, Mengxiong / He, Deyin

Materials (Basel, Switzerland)

2023 Volume 17, Issue 1

Abstract: Many designs of anchor cables are currently in use for rock support in civil and mining operations. Because of the exposed surface and weak shear performance of the cable bolt's free section (CBFS) in end-anchored structures, breaking failure frequently ... ...

Abstract	Many designs of anchor cables are currently in use for rock support in civil and mining operations. Because of the exposed surface and weak shear performance of the cable bolt's free section (CBFS) in end-anchored structures, breaking failure frequently occurs. Numerical simulations and laboratory experiments were performed in this study to develop measures to improve CBFS resistance to shear failure. Analysis of shear characteristics of the CBFS showed that higher axial tension weakens the cable bolt's shear resistance, and that shear damage on the cable surface and uneven distribution of shear stress aggravate CBFS tensile-shear failure. A high-strength steel pipe is proposed to protect the shear cable bolt, and the preliminary design of a CBFS-strengthening device (CFSD) is presented. Numerical simulation revealed that the CFSD effectively improved CBFS shear resistance and provided protection from harmful shear damage. The optimal performance of a Q-type (slotted steel pipe) CFSD was confirmed. The mechanism of improvement of the cable's shear resistance to surrounding rock by employing the CFSD was analyzed. Double-shear tests were carried out on a bare cable bolt and a cable bolt with a Q-CFSD. The results revealed that the CFSD increased the peak shear force on the joint plane, cable peak axial force, and ultimate shear displacement by 31%, 18%, and 11%, respectively. The proposed device is effective in improving the shear performance of end-anchored cable bolts and enhancing surrounding rock stability.
Language	English
Publishing date	2023-12-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17010197
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Biodegradable magnesium screw, titanium screw and direct embedding fixation in pedicled vascularized iliac bone graft transfer for osteonecrosis of the femoral head: a randomized controlled study.

Sun, Jiahao / Li, Zhipeng / Liu, Shaowei / Xia, Tianwei / Shen, Jirong

Journal of orthopaedic surgery and research

2023 Volume 18, Issue 1, Page(s) 523

Abstract: Background: The use of degradable magnesium screws to fix the bone flap implanted in the treatment of femoral head necrosis has achieved preliminary good therapeutic results. However, there is no conclusive evidence in the study to demonstrate whether ... ...

Abstract	Background: The use of degradable magnesium screws to fix the bone flap implanted in the treatment of femoral head necrosis has achieved preliminary good therapeutic results. However, there is no conclusive evidence in the study to demonstrate whether biodegradable magnesium screws promote angiogenesis and no comparison has been made between degradable magnesium screws and traditional screws. Objective: To investigate the clinical efficacy and safety of biodegradable magnesium screws in pedicled vascularized iliac bone graft transfer (PVIBGT) for osteonecrosis of the femoral head (ONFH). Materials and methods: A total of thirty-six patients (37 hips) with ONFH were recruited from March 2020 to July 2022. The study used a single-blind method, and patients who underwent PVIBGT were randomized into three groups: 12 patients (12 hips) were fixed with biodegradable magnesium screws (Group A), 12 patients (13 hips) were fixed with titanium screws (Group B), 12 patients (12 hips) were directly embedded (Group C). The operating time and the length of stay were recorded. Harris scores, radiological examinations (X-ray, CT, DCE-MRI), blood and serum tests were conducted before and after surgery. The gas yield and degradation rates of the magnesium screws were measured at the 3-months and 6-months post-operative follow-ups in Group A. Results: There was no statistically significant difference among these three groups in terms of types, gender, age, course of disease, surgical side, operation time, the length of stay (P > 0.05). All patients were followed up for 6 months. The mean Harris scores were higher in all groups 6 months after surgery (P < 0.05). The rates of excellent and good outcomes were 66.7%, 46.2%, and 33.3% in Groups A, B, and C, respectively. PVIBGT and magnesium screws can improve the blood supply of the femoral head via DCE-MRI evaluation. Two patients with poor incision healing received prompt treatment and subsequently recovered well. No adverse events, such as hip infection or deep vein thrombosis, were reported in the patients. The patients had good biocompatibility of magnesium screws, and no fracture of the magnesium screws was observed in Group A. Liver and kidney functions (including serum magnesium) were within normal ranges. The area of the intermuscular air space was 0 cm Conclusions: PVIBGT has a positive effect, especially with regard to improving blood supply of the femoral head. The fixation of biodegradable magnesium screws is reliable and safe in PVIBGT, and promote angiogenesis.
MeSH term(s)	Humans ; Magnesium ; Titanium ; Femur Head ; Single-Blind Method ; Osteonecrosis ; Bone Screws
Chemical Substances	Magnesium (I38ZP9992A) ; Titanium (D1JT611TNE)
Language	English
Publishing date	2023-07-22
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2252548-8
ISSN	1749-799X ; 1749-799X
ISSN (online)	1749-799X
ISSN	1749-799X
DOI	10.1186/s13018-023-04012-z
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Article ; Online: A Faster and Lighter Detection Method for Foreign Objects in Coal Mine Belt Conveyors.

Luo, Bingxin / Kou, Ziming / Han, Cong / Wu, Juan / Liu, Shaowei

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 14

Abstract: Coal flow in belt conveyors is often mixed with foreign objects, such as anchor rods, angle irons, wooden bars, gangue, and large coal chunks, leading to belt tearing, blockages at transfer points, or even belt breakage. Fast and effective detection of ... ...

Abstract	Coal flow in belt conveyors is often mixed with foreign objects, such as anchor rods, angle irons, wooden bars, gangue, and large coal chunks, leading to belt tearing, blockages at transfer points, or even belt breakage. Fast and effective detection of these foreign objects is vital to ensure belt conveyors' safe and smooth operation. This paper proposes an improved YOLOv5-based method for rapid and low-parameter detection and recognition of non-coal foreign objects. Firstly, a new dataset containing foreign objects on conveyor belts is established for training and testing. Considering the high-speed operation of belt conveyors and the increased demands for inspection robot data collection frequency and real-time algorithm processing, this study employs a dark channel dehazing method to preprocess the raw data collected by the inspection robot in harsh mining environments, thus enhancing image clarity. Subsequently, improvements are made to the backbone and neck of YOLOv5 to achieve a deep lightweight object detection network that ensures detection speed and accuracy. The experimental results demonstrate that the improved model achieves a detection accuracy of 94.9% on the proposed foreign object dataset. Compared to YOLOv5s, the model parameters, inference time, and computational load are reduced by 43.1%, 54.1%, and 43.6%, respectively, while the detection accuracy is improved by 2.5%. These findings are significant for enhancing the detection speed of foreign object recognition and facilitating its application in edge computing devices, thus ensuring belt conveyors' safe and efficient operation.
Language	English
Publishing date	2023-07-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23146276
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Fabrication and Manipulation of Non-Spherical Particles in Microfluidic Channels: A Review.

Jiang, Di / Liu, Shaowei / Tang, Wenlai

Micromachines

2022 Volume 13, Issue 10

Abstract: Non-spherical shape is a general appearance feature for bioparticles. Therefore, a mechanical mechanism study of non-spherical particle migration in a microfluidic chip is essential for more precise isolation of target particles. With the manipulation of ...

Abstract	Non-spherical shape is a general appearance feature for bioparticles. Therefore, a mechanical mechanism study of non-spherical particle migration in a microfluidic chip is essential for more precise isolation of target particles. With the manipulation of non-spherical particles, refined disease detection or medical intervention for human beings will be achievable in the future. In this review, fabrication and manipulation of non-spherical particles are discussed. Firstly, various fabrication methods for non-spherical microparticle are introduced. Then, the active and passive manipulation techniques for non-spherical particles are briefly reviewed, including straight inertial microchannels, secondary flow inertial microchannels and deterministic lateral displacement microchannels with extremely high resolution. Finally, applications of viscoelastic flow are presented which obviously increase the precision of non-spherical particle separation. Although various techniques have been employed to improve the performance of non-spherical particle manipulation, the universal mechanism behind this has not been fully discussed. The aim of this review is to provide a reference for non-spherical particle manipulation study researchers in every detail and inspire thoughts for non-spherical particle focused device design.
Language	English
Publishing date	2022-10-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi13101659
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Suppressing High-Order Phase for Efficient Pure Red Quasi-2D Perovskite Light-Emitting Diodes.

Liu, Shaowei / Zhan, Hongmei / Qin, Chuanli / Qin, Chuanjiang

The journal of physical chemistry letters

2022 , Page(s) 73–79

Abstract: Quasi-two-dimensional (quasi-2D) perovskites are promising for the realization of spectrally stable pure red perovskite light-emitting diodes (PeLEDs) with a single iodide component, because they avoid the halide separation that red three-dimensional ... ...

Abstract	Quasi-two-dimensional (quasi-2D) perovskites are promising for the realization of spectrally stable pure red perovskite light-emitting diodes (PeLEDs) with a single iodide component, because they avoid the halide separation that red three-dimensional perovskites of mixed halides have faced. However, the distribution of high-order phases in solution-processed quasi-2D perovskite films causes the spectral shift away from the pure red region. Here, we introduced a simple approach of adding excessive ligand combinations to redistribute the phase distribution of quasi-2D perovskite and to inhibit the high-order phase. Appropriate excess organic ligands will not affect charge injection but will keep the efficient energy funneling and passivate the defect. The narrowed phase distribution reduced the band tail state and restrained reverse charge transfer, resulting in enhanced radiation recombination. We obtained efficient and spectrally stable pure red PeLEDs at 638 nm (approaching the Rec. 2020 specification) with a peak EQE of 11.8% and maximum luminance of 1688 cd/cm
Language	English
Publishing date	2022-12-25
Publishing country	United States
Document type	Journal Article
ISSN	1948-7185
ISSN (online)	1948-7185
DOI	10.1021/acs.jpclett.2c03457
Database	MEDical Literature Analysis and Retrieval System OnLINE

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