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  1. Article ; Online: Correction: Quake et al. Early Introduction of Multi-Allergen Mixture for Prevention of Food Allergy: Pilot Study. Nutrients 2022, 14, 737

    Quake, Antonia Zoe / Liu, Taryn Audrey / D'Souza, Rachel / Jackson, Katherine G / Woch, Margaret / Tetteh, Afua / Sampath, Vanitha / Nadeau, Kari C / Sindher, Sayantani / Chinthrajah, R Sharon / Cao, Shu

    Nutrients

    2022  Volume 15, Issue 1

    Abstract: In the original publication [ ... ]. ...

    Abstract In the original publication [...].
    Language English
    Publishing date 2022-12-28
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15010135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Early Introduction of Multi-Allergen Mixture for Prevention of Food Allergy: Pilot Study.

    Quake, Antonia Zoe / Liu, Taryn Audrey / D'Souza, Rachel / Jackson, Katherine G / Woch, Margaret / Tetteh, Afua / Sampath, Vanitha / Nadeau, Kari C / Sindher, Sayantani / Chinthrajah, R Sharon / Cao, Shu

    Nutrients

    2022  Volume 14, Issue 4

    Abstract: The incidence and prevalence of food allergy (FA) is increasing. While several studies have established the safety and efficacy of early introduction of single allergens in infants for the prevention of FA, the exact dose, frequency, and number of ... ...

    Abstract The incidence and prevalence of food allergy (FA) is increasing. While several studies have established the safety and efficacy of early introduction of single allergens in infants for the prevention of FA, the exact dose, frequency, and number of allergens that can be safely introduced to infants, particularly in those at high or low risk of atopy, are still unclear. This 1-year pilot study evaluated the safety of the early introduction of single foods (milk, egg, or peanut) vs. two foods (milk/egg, egg/peanut, milk/peanut) vs. multiple foods (milk/egg/peanut/cashew/almond/shrimp/walnut/wheat/salmon/hazelnut at low, medium, or high doses) vs. no early introduction in 180 infants between 4-6 months of age. At the end of the study, they were evaluated for plasma biomarkers associated with food reactivity via standardized blood tests. Two to four years after the start of the study, participants were evaluated by standardized food challenges. The serving sizes for the single, double, and low dose mixtures were 300 mg total protein per day. The serving sizes for the medium and high dose mixtures were 900 mg and 3000 mg total protein, respectively. Equal parts of each protein were used for double or mixture foods. All infants were breastfed until at least six months of age. The results demonstrate that infants at either high or low risk for atopy were able to tolerate the early introduction of multiple allergenic foods with no increases in any safety issues, including eczema, FA, or food protein induced enterocolitis. The mixtures of foods at either low, medium, or high doses demonstrated trends for improvement in food challenge reactivity and plasma biomarkers compared to single and double food introductions. The results of this study suggest that the early introduction of foods, particularly simultaneous mixtures of many allergenic foods, may be safe and efficacious for preventing FA and can occur safely. These results need to be confirmed by larger randomized controlled studies.
    MeSH term(s) Allergens ; Arachis ; Food Hypersensitivity/epidemiology ; Food Hypersensitivity/prevention & control ; Humans ; Hypersensitivity, Immediate ; Infant ; Pilot Projects
    Chemical Substances Allergens
    Language English
    Publishing date 2022-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14040737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Early Introduction of Multi-Allergen Mixture for Prevention of Food Allergy: Pilot Study

    Quake, Antonia Zoe / Liu, Taryn Audrey / D’Souza, Rachel / Jackson, Katherine G. / Woch, Margaret / Tetteh, Afua / Sampath, Vanitha / Nadeau, Kari C. / Sindher, Sayantani / Chinthrajah, R. Sharon / Cao, Shu

    Nutrients. 2022 Feb. 09, v. 14, no. 4

    2022  

    Abstract: The incidence and prevalence of food allergy (FA) is increasing. While several studies have established the safety and efficacy of early introduction of single allergens in infants for the prevention of FA, the exact dose, frequency, and number of ... ...

    Abstract The incidence and prevalence of food allergy (FA) is increasing. While several studies have established the safety and efficacy of early introduction of single allergens in infants for the prevention of FA, the exact dose, frequency, and number of allergens that can be safely introduced to infants, particularly in those at high or low risk of atopy, are still unclear. This 1-year pilot study evaluated the safety of the early introduction of single foods (milk, egg, or peanut) vs. two foods (milk/egg, egg/peanut, milk/peanut) vs. multiple foods (milk/egg/peanut/cashew/almond/shrimp/walnut/wheat/salmon/hazelnut at low, medium, or high doses) vs. no early introduction in 180 infants between 4–6 months of age. At the end of the study, they were evaluated for plasma biomarkers associated with food reactivity via standardized blood tests. Two to four years after the start of the study, participants were evaluated by standardized food challenges. The serving sizes for the single, double, and low dose mixtures were 300 mg total protein per day. The serving sizes for the medium and high dose mixtures were 900 mg and 3000 mg total protein, respectively. Equal parts of each protein were used for double or mixture foods. All infants were breastfed until at least six months of age. The results demonstrate that infants at either high or low risk for atopy were able to tolerate the early introduction of multiple allergenic foods with no increases in any safety issues, including eczema, FA, or food protein induced enterocolitis. The mixtures of foods at either low, medium, or high doses demonstrated trends for improvement in food challenge reactivity and plasma biomarkers compared to single and double food introductions. The results of this study suggest that the early introduction of foods, particularly simultaneous mixtures of many allergenic foods, may be safe and efficacious for preventing FA and can occur safely. These results need to be confirmed by larger randomized controlled studies.
    Keywords allergenicity ; almonds ; atopy ; biomarkers ; breast feeding ; dietary protein ; eczema ; eggs ; enterocolitis ; food allergies ; hazelnuts ; milk ; peanuts ; protein content ; risk ; salmon ; shrimp ; walnuts ; wheat
    Language English
    Dates of publication 2022-0209
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14040737
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Gastrointestinal γδ T cells reveal differentially expressed transcripts and enriched pathways during peanut oral immunotherapy.

    Zhang, Wenming / Dhondalay, Gopal Krishna / Liu, Taryn Audrey / Kaushik, Abhinav / Hoh, Ramona / Kwok, Shirley / Kambham, Neeraja / Fernandez-Becker, Nielsen Q / Andorf, Sandra / Desai, Manisha / Galli, Stephen J / Boyd, Scott D / Nadeau, Kari C / Manohar, Monali / DeKruyff, Rosemarie H / Chinthrajah, R Sharon

    Allergy

    2022  Volume 77, Issue 5, Page(s) 1606–1610

    MeSH term(s) Arachis ; Humans ; Immunologic Factors ; Immunotherapy ; Peanut Hypersensitivity/therapy ; Receptors, Antigen, T-Cell, gamma-delta ; T-Lymphocytes
    Chemical Substances Immunologic Factors ; Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2022-02-18
    Publishing country Denmark
    Document type Letter ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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