Article ; Online: Characterization and antioxidant activities of the polysaccharides from Radix Cyathulae officinalis Kuan.
International journal of biological macromolecules
2015 Volume 72, Page(s) 544–552
Abstract: A water-soluble polysaccharide (PSRC) was extracted and purified from the roots of Radix Cyathulae officinalis Kuan, and its chemical characteristics, monosaccharide composition and antioxidant activities were characterized. The average of molecular ... ...
Abstract | A water-soluble polysaccharide (PSRC) was extracted and purified from the roots of Radix Cyathulae officinalis Kuan, and its chemical characteristics, monosaccharide composition and antioxidant activities were characterized. The average of molecular weight (Mw) of PSRC was 182 kDa. The majority of monosaccharide components of PSRC was glucose (relative mass 48.8%) with lower levels of mannose, rhamnose, galactose, fructose and arabinose (relative mass of 15.7, 14.3, 10.6, 6.1 and 4.5%, respectively). In vitro assays revealed that RSRC possessed potent scavenging activities against DPPH, hydroxyl and superoxide anion radicals. Oral administration of PSRC significantly enhanced antioxidant enzyme activities (including total superoxide dismutase, copper-zinc superoxide dismutase (Cu,Zn-SOD), manganese superoxide dismutase (Mn-SOD), glutathione peroxidase and catalase (CAT)) and capacities of scavenging superoxide anion and hydroxyl radicals, markedly lowered lipid peroxidation formation of malondialdehyde and significantly up-regulated mRNA expressions of Cu,Zn-SOD, Mn-SOD, CAT, glutathione peroxidase 1, thioredoxin 1 and thioredoxin 2, in a d-galactose-induced aging mouse model. Taken together, these findings demonstrate that PSRC could be used as a novel promising source of natural antioxidants and antiaging drugs. |
|||||
---|---|---|---|---|---|---|
MeSH term(s) | Amaranthaceae/chemistry ; Animals ; Antioxidants/administration & dosage ; Antioxidants/chemistry ; Antioxidants/isolation & purification ; Catalase/biosynthesis ; Glutathione/biosynthesis ; Glutathione Peroxidase/biosynthesis ; Humans ; Lipid Peroxidation/drug effects ; Mice ; Oxidation-Reduction/drug effects ; Plant Roots/chemistry ; Polysaccharides/administration & dosage ; Polysaccharides/chemistry ; Polysaccharides/isolation & purification ; RNA, Messenger/biosynthesis ; Superoxide Dismutase/biosynthesis | |||||
Chemical Substances | Antioxidants ; Polysaccharides ; RNA, Messenger ; glutathione peroxidase GPX1 (EC 1.11.1.-) ; Catalase (EC 1.11.1.6) ; Glutathione Peroxidase (EC 1.11.1.9) ; Superoxide Dismutase (EC 1.15.1.1) ; superoxide dismutase 2 (EC 1.15.1.1) ; Glutathione (GAN16C9B8O) | |||||
Language | English | |||||
Publishing date | 2015-01 | |||||
Publishing country | Netherlands | |||||
Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
ZDB-ID | 282732-3 | |||||
ISSN | 1879-0003 ; 0141-8130 | |||||
ISSN (online) | 1879-0003 | |||||
ISSN | 0141-8130 | |||||
DOI | 10.1016/j.ijbiomac.2014.09.007 | |||||
Shelf mark |
|
|||||
Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
Zs.B 2374: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.