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Article ; Online: Cell cycle regulation of the psoriasis associated gene CCHCR1 by transcription factor E2F1.

Ling, Yick Hin / Chen, Yingying / Leung, Kwok Nam / Chan, King Ming / Liu, W K

2023 Volume 18, Issue 12, Page(s) e0294661

Abstract: The coiled-coil alpha-helical rod protein 1 (CCHCR1) was first identified as a candidate gene in psoriasis and has lately been found to be associated with a wide range of clinical conditions including COVID-19. CCHCR1 is located within P-bodies and ... ...

Abstract	The coiled-coil alpha-helical rod protein 1 (CCHCR1) was first identified as a candidate gene in psoriasis and has lately been found to be associated with a wide range of clinical conditions including COVID-19. CCHCR1 is located within P-bodies and centrosomes, but its exact role in these two subcellular structures and its transcriptional control remain largely unknown. Here, we showed that CCHCR1 shares a bidirectional promoter with its neighboring gene, TCF19. This bidirectional promoter is activated by the G1/S-regulatory transcription factor E2F1, and both genes are co-induced during the G1/S transition of the cell cycle. A luciferase reporter assay suggests that the short intergenic sequence, only 287 bp in length, is sufficient for the G1/S induction of both genes, but the expression of CCHCR1 is further enhanced by the presence of exon 1 from both TCF19 and CCHCR1. This research uncovers the transcriptional regulation of the CCHCR1 gene, offering new perspectives on its function. These findings contribute to the broader understanding of diseases associated with CCHCR1 and may serve as a foundational benchmark for future research in these vital medical fields.
MeSH term(s)	Humans ; E2F1 Transcription Factor/genetics ; E2F1 Transcription Factor/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Psoriasis/genetics ; Psoriasis/metabolism ; Gene Expression Regulation ; Cell Cycle ; E2F Transcription Factors/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
Chemical Substances	E2F1 Transcription Factor ; Intracellular Signaling Peptides and Proteins ; E2F Transcription Factors ; TCF19 protein, human ; Transcription Factors ; CCHCR1 protein, human ; E2F1 protein, human
Language	English
Publishing date	2023-12-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0294661
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Article ; Online: Artificial intelligence data-driven 3D model for AIS.

Tajdari, M / Maqsood, A / Li, H / Saha, S / Sarwark, J F / Liu, W K

Studies in health technology and informatics

2021 Volume 280, Page(s) 141–145

Abstract: Scoliosis is a 3D deformation of the spinal column, characterized by a lateral deviation of the spine, accompanied by axial rotation of the vertebrae. Adolescent Idiopathic Scoliosis (AIS), is the most common type, affecting children between ages 8 to 18 ...

Abstract	Scoliosis is a 3D deformation of the spinal column, characterized by a lateral deviation of the spine, accompanied by axial rotation of the vertebrae. Adolescent Idiopathic Scoliosis (AIS), is the most common type, affecting children between ages 8 to 18 when bone growth is at its maximum rate. The selection of the most appropriate treatment options is based on the surgeon's experience. So, developing a clinically validated patient-specific model of the spine would aid surgeons in understanding AIS in early stages and propose an efficient method of treatment for the individual patient. This project steps include: Developing a clinically validated patient-specific Reduced Order Finite Element Model (ROFEM) of the spine, predicting AIS progression using data mining and proposing a method of treatment. First we implement FE synergistically with bio-mechanical information, image processing and data science techniques to improve predictive ability. Initial geometry of the spine will be extracted from the x-ray images from different planes and imported to FEM software to generate the spine model and perform analysis. A RO model is developed based on the detailed spinal FEM. Next, a neural network is used to predict the spinal curvature. The ability to predict the severity of AIS will have an immense impact on the treatment of AIS-affected children. Access to a predictive and patient-specific model will enable the physicians to have a better understanding of spinal curvature progression. Consequently, the physicians will be able to educate families, choose the most appropriate treatment option and asses for surgical intervention.
MeSH term(s)	Adolescent ; Artificial Intelligence ; Child ; Humans ; Imaging, Three-Dimensional ; Kyphosis ; Rotation ; Scoliosis/diagnostic imaging ; Spine/diagnostic imaging
Language	English
Publishing date	2021-06-30
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI210453
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Article: [Diagnosis and treatment of pancreatic neuroendocrine neoplasmas in Von Hippel-Lindau syndrome].

Liu, W K / Tian, X D / Yang, Y M

Zhonghua wai ke za zhi [Chinese journal of surgery

2018 Volume 56, Issue 11, Page(s) 869–872

Abstract: Von Hippel-Lindau(VHL) syndrome is a rare autosomal dominant hereditary disease, and pancreas is one of the frequently involved intra-abdominal organs, including simple pancreatic cysts, pancreatic serous cystadenomas and neuroendocrine neoplasmas. Most ... ...

Abstract	Von Hippel-Lindau(VHL) syndrome is a rare autosomal dominant hereditary disease, and pancreas is one of the frequently involved intra-abdominal organs, including simple pancreatic cysts, pancreatic serous cystadenomas and neuroendocrine neoplasmas. Most of the VHL-related pancreatic neuroendocrine neoplasmas (VHL-pNEN)were non-functional, but they still have a tendency to be malignant. Treatment options for VHL-pNEN include regular follow-up, surgical resection, and medication therapy. When compared with sporadic pNEN, the malignant degree of VHL-pNEN is lower, with a better prognosis, so the surgical treatment should be carefully considered. The indications of surgery for VHL-pNEN include big primary lesions (≥3 cm), fast tumor doubling time (<500 days), VHL gene mutation on exon 3, malignant manifestations on imaging findings, and functional pNEN lesions. The function-preserving approach should be performed to keep the functional pancreatic parenchyma as much as possible. Even for patients with a late stage malignancy that cannot be radically resected, active medication therapy may still lead to a long-term survival.
MeSH term(s)	Cystadenoma, Serous/complications ; Cystadenoma, Serous/diagnosis ; Humans ; Neuroendocrine Tumors/complications ; Neuroendocrine Tumors/diagnosis ; Pancreatic Cyst/complications ; Pancreatic Cyst/diagnosis ; Pancreatic Neoplasms/complications ; Pancreatic Neoplasms/diagnosis ; von Hippel-Lindau Disease/complications
Language	Chinese
Publishing date	2018-11-03
Publishing country	China
Document type	Journal Article
ZDB-ID	604573-x
ISSN	0529-5815
ISSN	0529-5815
DOI	10.3760/cma.j.issn.0529-5815.2018.11.017
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Zs.B 2469: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: MRI-based radiogenomics analysis for predicting genetic alterations in oncogenic signalling pathways in invasive breast carcinoma.

Lin, P / Liu, W K / Li, X / Wan, D / Qin, H / Li, Q / Chen, G / He, Y / Yang, H

Clinical radiology

2020 Volume 75, Issue 7, Page(s) 561.e1–561.e11

Abstract: Aim: To investigate the effect of radiomics in the assessment of alterations in canonical cancer pathways in breast cancer.: Materials and methods: Eighty-eight biopsy-proven breast cancer cases were included in the present study. Radiomics features ... ...

Abstract	Aim: To investigate the effect of radiomics in the assessment of alterations in canonical cancer pathways in breast cancer. Materials and methods: Eighty-eight biopsy-proven breast cancer cases were included in the present study. Radiomics features were extracted from T1-weighted sagittal dynamic contrast-enhanced magnetic resonance imaging (MRI) images. Radiomics signatures were developed to predict genetic alterations in the cell cycle, Myc, PI3K, RTK/RAS, and p53 signalling pathways by using hypothesis testing combined with least absolute shrinkage and selection operator (LASSO) regression analysis. The predictive powers of the models were examined by the area under the curve (AUC) of the receiver operating characteristic curve. Results: A total of 5,234 radiomics features were obtained from MRI images based on the tumour region of interest. Hypothesis tests screened 250, 229, 156, 785, and 319 radiomics features that were differentially displayed between cell cycle, Myc, PI3K, RTK/RAS, and p53 alterations and no alteration status. According to the LASSO algorithm, 11, 12, 12, 15, and 13 features were identified for the construction of the radiomics signatures to predict cell cycle, Myc, PI3K, RTK/RAS, and p53 alterations, with AUC values of 0.933, 0.926, 0.956, 0.940, and 0.886, respectively. The cell cycle radiomics score correlated closely with the RTK/RAS and p53 radiomics scores. These signatures were also dysregulated in patients with different oestrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 statuses. Conclusion: MRI-based radiogenomics analysis exhibits excellent performance in predicting genetic pathways alterations, thus providing a novel approach for non-invasively obtaining genetic-level molecular characteristics of tumours.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Breast/diagnostic imaging ; Breast/metabolism ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Female ; Humans ; Imaging Genomics/methods ; Magnetic Resonance Imaging ; Middle Aged ; Signal Transduction/genetics
Language	English
Publishing date	2020-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	391227-9
ISSN	1365-229X ; 0009-9260
ISSN (online)	1365-229X
ISSN	0009-9260
DOI	10.1016/j.crad.2020.02.011
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Ue I Zs.201: Show issues

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Article: Cytotoxicity of fly-ash in alveolar macrophages from hypothyroid rats.

Liu, W K / Wong, C C

Toxicology in vitro : an international journal published in association with BIBRA

2010 Volume 3, Issue 2, Page(s) 95–102

Abstract: Fly-ash particles of a diameter smaller than 2 mu were collected from the electrostatic precipitator of a coal-fired power plant, and their cytotoxicity was studied in culture using alveolar macrophages from healthy and hypothyroid rats. The mortality ... ...

Abstract	Fly-ash particles of a diameter smaller than 2 mu were collected from the electrostatic precipitator of a coal-fired power plant, and their cytotoxicity was studied in culture using alveolar macrophages from healthy and hypothyroid rats. The mortality rate and the secretion rates of cytoplasmic (lactate dehydrogenase) and lysosomal (acid phosphatase and beta-glucuronidase) enzymes into the culture medium were greater in the alveolar macrophages from hypothyroid rats than in the control macrophages. Electron microscopy showed a retraction of filapodia, loss of ruffled membrane and distortion of cell shape in the alveolar macrophages from hypothyroid rats. These results demonstrate that the cytotoxicity of fly-ash particles was enhanced in the macrophages from hypothyroid rats, and indicate that the normal functions of alveolar macrophages are impaired by changes in thyroid status.
Language	English
Publishing date	2010-07-28
Publishing country	England
Document type	Journal Article
ZDB-ID	639064-x
ISSN	1879-3177 ; 0887-2333
ISSN (online)	1879-3177
ISSN	0887-2333
DOI	10.1016/0887-2333(89)90051-9
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Zs.A 2223: Show issues

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Article: Effects of short-term treatment with various light intensities and hydroponic solutions on nitrate concentration of lettuce

Liu, W. K. / Yang, Q. C.

Acta agriculturae Scandinavica : Section B, Soil and plant science

2012 Volume 62, Issue 2, Page(s) 109

Language	English
Document type	Article
ZDB-ID	32458-9
ISSN	0906-4710
Database	Current Contents Nutrition, Environment, Agriculture

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Article: Effects of led light qualities on growth and photosynthetic pigments of Atractylodes macrocephala

Zhao, J. J / Yang, Q. C / Liu, W. K

Acta horticulturae. 2014 May 25, , no. 1037

2014

Abstract: In order to examine the effects of different light qualities (white, red, blue, and red light plus blue light) irradiated by LED lamps at 100 µmol.m-2.s-1 light intensity on the growth and photosynthetic pigment content of Atractylodes macrocephala ... ...

Abstract	In order to examine the effects of different light qualities (white, red, blue, and red light plus blue light) irradiated by LED lamps at 100 µmol.m-2.s-1 light intensity on the growth and photosynthetic pigment content of Atractylodes macrocephala seedlings, a kind of valuable Chinese medicinal plant, a pot cultivation experiment in growth chamber was conducted. Main wavelengths of red LED and blue LED were 619 nm and 458 nm, and light intensity ratio of red light plus blue light treatment was 1:1. The results showed that shoot height of Atractylodes macrocephala under red light was highest, while shortest under red plus blue light. However, root fresh weight and root length of Atractylodes macrocephala under red light treatment were lower compared with white light treatment, and there was no significant difference between the other three light treatments. The data indicated that root to shoot ratio under blue light was the biggest. Light qualities did not affect shoot fresh weight and photosynthetic pigment contents of Atractylodes macrocephala. The results suggested that LED light quality could regulate the growth of Atractylodes macrocephala seedlings, which was not due to the changes of photosynthetic pigment contents.
Keywords	Atractylodes ; blue light ; growth chambers ; lamps ; light intensity ; light quality ; medicinal plants ; pigments ; red light ; root shoot ratio ; seedlings ; shoots ; wavelengths ; white light
Language	English
Dates of publication	2014-0525
Size	p. 849-854.
Publishing place	International Society for Horticultural Science.
Document type	Article
Note	Paper presented at the International Symposium on New Technologies for Environment Control, Energy-Saving and Crop Production in Greenhouse and Plant Factory - Greensys 2013, held Oct 6-11, 2013, Jeju, Korea.
ISSN	0567-7572
Database	NAL-Catalogue (AGRICOLA)

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Article: Effects of nitrogen fertilizer on nutritional quality and root secretion accumulation of hydroponic lettuce

Qiu, Z. P / Yang, Q. C / Liu, W. K

Acta horticulturae. 2014 May 25, , no. 1037

2014

Abstract: A glasshouse experiment was carried out to investigate the effects of nitrogen levels (5 and 10 mmol/L) and forms (nitrate nitrogen and nitrate plus ammonia nitrogen) on growth, photosynthetic pigment content, nutritional quality and root secretion ... ...

Abstract	A glasshouse experiment was carried out to investigate the effects of nitrogen levels (5 and 10 mmol/L) and forms (nitrate nitrogen and nitrate plus ammonia nitrogen) on growth, photosynthetic pigment content, nutritional quality and root secretion accumulation of hydroponically cultivated lettuce. The results showed that nitrogen level of the same nitrate form did not or slightly affect shoot, root and total biomass of lettuce, while nitrate plus ammonia nitrogen (1:1, mol/mol) treatments decreased shoot, root and total biomass of lettuce compared with entire nitrate nitrogen treatments. Two nitrogen levels of nitrate nitrogen or nitrate plus ammonia nitrogen did not make difference in leafy chlorophyll a, b and carotenoid contents of lettuce, but nitrate nitrogen plus ammonia nitrogen significantly increased chlorophyll a, b and carotenoid contents in leaves compared with entire nitrate nitrogen treatments. Both nitrogen level and form affected vitamin C content in leaves. Vitamin C contents in leaves were improved with the increase of nitrate nitrogen supply level, while ammonia nitrogen plus nitrate nitrogen treatments had higher vitamin C contents in leaves than those of entire nitrate nitrogen treatment at the same nitrogen level. Nitrate nitrogen supply levels did not altered nitrate content in leaves of lettuce, but ammonia nitrogen plus nitrate nitrogen treatments decreased nitrate content compared with the treatments with the same level of entire nitrate nitrogen supply. Entire nitrate nitrogen supply gave similar total organic carbon (TOC) concentration and content regardless of nitrogen level, but they were significantly lower than those of nitrate plus ammonia nitrogen treatments. Additionally, lower nitrogen level treatment with ammonia nitrogen plus nitrate nitrogen presented greatest TOC concentration and content.
Keywords	ammonium nitrogen ; ascorbic acid ; biomass ; carbon ; carotenoids ; chlorophyll ; greenhouse experimentation ; hydroponics ; leaves ; lettuce ; nitrate nitrogen ; nitrates ; nitrogen ; nitrogen fertilizers ; nutritive value ; secretion ; shoots
Language	English
Dates of publication	2014-0525
Size	p. 679-686.
Publishing place	International Society for Horticultural Science.
Document type	Article
Note	Paper presented at the International Symposium on New Technologies for Environment Control, Energy-Saving and Crop Production in Greenhouse and Plant Factory - Greensys 2013, held Oct 6-11, 2013, Jeju, Korea.
ISSN	0567-7572
Database	NAL-Catalogue (AGRICOLA)

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Article: Expression of tumor necrosis factor and c-fos genes in peritoneal macrophages of hypothyroid mice.

Liu, W K

Inflammation

1993 Volume 17, Issue 2, Page(s) 217–225

Abstract: It is well documented that hypothyroid patients are more susceptible to microbial infections. In order to study whether this impaired response is due to a decrease in production of antitumor molecules or an impaired ability to transmit information in the ...

Abstract	It is well documented that hypothyroid patients are more susceptible to microbial infections. In order to study whether this impaired response is due to a decrease in production of antitumor molecules or an impaired ability to transmit information in the macrophage, a hypothyroid animal model was used to study the expression of both tumor necrosis factor gene and c-fos protooncogene in peritoneal macrophages. Inbred mice were rendered hypothyroid by an antithyroid drug, methimazole, and the expression of tumor necrosis factor gene and c-fos protooncogene in peritoneal macrophages were studied. Impairment of c-fos and TNF genes were at both transcriptional and translational levels using northern blot analysis, bioassays, and immunocytochemical staining methods. These results indicate that the reduction in signal transduction and in the production of antitumor molecules may cause the poor defense ability of hypothyroid animals.
MeSH term(s)	Animals ; Blotting, Northern ; Cells, Cultured ; Gene Expression ; Genes ; Genes, fos ; Hypothyroidism/genetics ; Hypothyroidism/metabolism ; Hypothyroidism/pathology ; Immunohistochemistry ; Macrophages/metabolism ; Macrophages/physiology ; Male ; Mice ; Mice, Inbred BALB C ; Peritoneal Cavity/cytology ; Proto-Oncogene Proteins c-fos/metabolism ; Transcription, Genetic ; Tumor Necrosis Factor-alpha/genetics
Chemical Substances	Proto-Oncogene Proteins c-fos ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	1993-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	434408-x
ISSN	0360-3997
ISSN	0360-3997
DOI	10.1007/bf00916107
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Spatiotemporal changes of nitrate and Vc contents in hydroponic lettuce treated with various nitrogen-free solutions

Liu, W. K. / Yang, Q. C. / Qiu, Z. P.

Acta Agriculturae Scandinavica : Section B, Soil and plant science

2012 Volume 62, Issue 3, Page(s) 286

Language	English
Document type	Article
ZDB-ID	32458-9
ISSN	0906-4710
Database	Current Contents Nutrition, Environment, Agriculture

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