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  1. Article ; Online: Analysis on China's Real Estate Economy Based on Big Data

    Liu Weiwei

    E3S Web of Conferences, Vol 253, p

    2021  Volume 02058

    Abstract: Over the past 40 years of China's reform and opening -up, the Chinese society and national economy have been booming. The real estate economy as a pillar industry of the national economy has achieved rapid growth. However, the U.S. subprime mortgage ... ...

    Abstract Over the past 40 years of China's reform and opening -up, the Chinese society and national economy have been booming. The real estate economy as a pillar industry of the national economy has achieved rapid growth. However, the U.S. subprime mortgage crisis in 2007, COVID-19 and the intensifying China-US trade war in 2020 have repeatedly raged, like the "Three Sword of Damocles" hurting Chinese economy. Based on rencent 10 years data collection, the paper analyzes the trend of real estate prices and puts forward countermeasures from many aspects to achieve to stabilize the housing market, economic and social situation.
    Keywords Environmental sciences ; GE1-350
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Single-cell transcriptomics dissecting the development and evolution of nervous system in insects.

    Liu, Weiwei / Li, Qiye

    Current opinion in insect science

    2024  Volume 63, Page(s) 101201

    Abstract: Insects can display a vast repertoire of complex and adaptive behaviors crucial for survival and reproduction. Yet, how the neural circuits underlying insect behaviors are assembled throughout development and remodeled during evolution remains largely ... ...

    Abstract Insects can display a vast repertoire of complex and adaptive behaviors crucial for survival and reproduction. Yet, how the neural circuits underlying insect behaviors are assembled throughout development and remodeled during evolution remains largely obscure. The advent of single-cell transcriptomics has opened new paths to illuminate these historically intractable questions. Insect behavior is governed by its brain, whose functional complexity is realized through operations across multiple levels, from the molecular and cellular to the circuit and organ. Single-cell transcriptomics enables dissecting brain functions across all these levels and allows tracking regulatory dynamics throughout development and under perturbation. In this review, we mainly focus on the achievements of single-cell transcriptomics in dissecting the molecular and cellular architectures of nervous systems in representative insects, then discuss its applications in tracking the developmental trajectory and functional evolution of insect brains.
    Language English
    Publishing date 2024-04-10
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2772833-X
    ISSN 2214-5753 ; 2214-5745
    ISSN (online) 2214-5753
    ISSN 2214-5745
    DOI 10.1016/j.cois.2024.101201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Research progress in the correlation and treatment of menopause and non-alcoholic fatty liver disease in women

    LIU Weiwei / WANG Long

    Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 43, Iss 1, Pp 125-

    2023  Volume 131

    Abstract: Non-alcoholic fatty liver disease (NAFLD) is a chronic non-communicable disease. It is a metabolic syndrome (MS) in the liver. Menopause is a physiological phenomenon of women due to the decline of ovarian function, which is characterized by the ... ...

    Abstract Non-alcoholic fatty liver disease (NAFLD) is a chronic non-communicable disease. It is a metabolic syndrome (MS) in the liver. Menopause is a physiological phenomenon of women due to the decline of ovarian function, which is characterized by the deterioration of hypothalamic-pituitary function. Clinical and epidemiological studies have shown that the incidence trend of NAFLD has gender differences and is related to metabolic parameters such as glucose, lipids, and blood uric acid. The incidence of NAFLD in premenopausal women is lower than that in males, while the incidence of NAFLD in postmenopausal women gradually increases to the same as that in males. The mechanism may be mainly related to the changes of sex hormones in postmenopausal women (mainly the decrease of estrogen). The changes of sex hormones such as the decreased levels of estrogen and sex hormone binding globulin (SHBG) and the relatively increased level of androgen can increase the incidence of MS components such as abdominal obesity, abnormal blood lipid metabolism and insulin resistance (IR), making menopause an important independent risk factor for NAFLD in women. Estrogen, androgen receptor antagonists and phytoestrogens can improve hepatic steatosis and IR through many ways, reduce the severity of NAFLD and delay its progression to liver fibrosis, which have certain therapeutic significance for postmenopausal women with NAFLD, but also have some limitations. This paper reviews the research progress in the relationship between menopause and NAFLD in recent years, so as to provide ideas and reference for the prevention and treatment of NAFLD in postmenopausal women.
    Keywords nonalcoholic fatty liver disease (nafld) ; menopause ; insulin resistance (ir) ; metabolic syndrome (ms) ; phytoestrogen ; Medicine ; R
    Subject code 610
    Language Chinese
    Publishing date 2023-01-01T00:00:00Z
    Publisher Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Facilitators and barriers of initiation and maintenance of physical activity among people with coronary heart disease: a qualitative study.

    Zhang, Qianghuizi / Han, Hongya / Yang, Shupeng / Liu, Weiwei

    Disability and rehabilitation

    2024  , Page(s) 1–10

    Abstract: Purpose: We aimed to describe the facilitators and barriers of physical activity for patients with coronary heart disease.: Methods: A qualitative descriptive study using semi-structured interviews was conducted with 15 participants with coronary ... ...

    Abstract Purpose: We aimed to describe the facilitators and barriers of physical activity for patients with coronary heart disease.
    Methods: A qualitative descriptive study using semi-structured interviews was conducted with 15 participants with coronary heart disease. The interview guide was developed based on a multi-theory model. Interviews were audio-recorded, transcribed verbatim, and analyzed using a thematic analysis.
    Results: Two main themes were identified: facilitators of initiation and maintenance of physical activity (behavioral motivation, perceived benefits, behavioral confidence, supportive physical environment, positive emotional experience, self-regulation, supportive social environment, illness perception, and excellent self-control), barriers of initiation and maintenance of physical activity (perceived barriers, restricted physical environment, psychological distress, insufficient social support, and poor self-control).
    Conclusions: This study presents an in-depth theory-based exploration of facilitators and barriers to initiating and maintaining physical activity among people with coronary heart disease. Relevant factors should be taken into account to increase their effectiveness when designing the target interventions to encourage a physically active lifestyle in this population.
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1104775-6
    ISSN 1464-5165 ; 0963-8288
    ISSN (online) 1464-5165
    ISSN 0963-8288
    DOI 10.1080/09638288.2024.2309512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Dynamics of Lotka-Volterra Competition Patch Models in Streams with Two Branches.

    Liu, Weiwei / Liu, Jie / Chen, Shanshan

    Bulletin of mathematical biology

    2024  Volume 86, Issue 2, Page(s) 14

    Abstract: Streams may have many branches and form complex river networks. We investigate two competition patch models associated with two different river network modules, where one is a distributary stream with two branches at the downstream end, and the other is ... ...

    Abstract Streams may have many branches and form complex river networks. We investigate two competition patch models associated with two different river network modules, where one is a distributary stream with two branches at the downstream end, and the other is a tributary stream with two branches at the upstream end. Treating one species as resident species and the other one as mutant species, it is shown that, for each model, there exists a invasion curve such that the mutant species can invade when rare if and only if its dispersal strategy is below this curve, but the shapes of the invasion curves are different. Moreover, we show that the global dynamics of the two models can be similar or different depending on river networks. Especially, if the drift rates of the two species are equal, then the global dynamics are similar for small drift rate and different for large drift rate. Our results also confirm a conjecture in Jiang et al. (Bull Math Biol 82:131, 2020).
    MeSH term(s) Mathematical Concepts ; Models, Biological ; Rivers
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 184905-0
    ISSN 1522-9602 ; 0007-4985 ; 0092-8240
    ISSN (online) 1522-9602
    ISSN 0007-4985 ; 0092-8240
    DOI 10.1007/s11538-023-01243-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Perceptions and needs for a community nursing virtual simulation system for Chinese nursing students during the COVID-19 pandemic: A qualitative study.

    Liu, Zhe / Zhang, Qianghuizi / Liu, Weiwei

    Heliyon

    2024  Volume 10, Issue 7, Page(s) e28473

    Abstract: Background: Virtual simulation systems are being increasingly used in the field of nursing education. However, these systems are mostly designed based on the perspective of developers, and the needs of the end users are often neglected. The purpose of ... ...

    Abstract Background: Virtual simulation systems are being increasingly used in the field of nursing education. However, these systems are mostly designed based on the perspective of developers, and the needs of the end users are often neglected. The purpose of this study was to explore the perceptions and needs of Chinese undergraduate nursing students for the development of a community nursing virtual simulation system.
    Methods: This was a descriptive qualitative study enrolling 12 undergraduate nursing students at a University in China. Data were collected through semi-structured interviews. The content analysis method was used for data analysis.
    Result: Three themes and 15 sub-themes were extracted from this study: (1) Positive perceptions regarding virtual systems: a) Provides space for trials and errors, b) Not limited by time and space, c) Provides auxiliary tools; (2) Design and use requirements: a) Performance needs, b) Contents design needs, c) Appearance design needs, d) Support Needs; (3) Competency enhancement needs: a) Community nursing practice ability, b) Critical thinking ability, c) Independent thinking ability, d) Ability to deal with emergencies, e)Teamwork skills, f) Self-efficacy, g) Resilience, h)Interpersonal communication skills.
    Conclusion: Designers and engineers should consider students' needs, aim to improve students' abilities, improve the diversity, the scientific and rigor of content, and enhance user immersion and interest. The system should be programmed to provide real-time feedback, timely technical and professional support, in order to optimize use experience of nursing students.
    Language English
    Publishing date 2024-03-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e28473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: LINC00974 sponges miR-33a to facilitate cell proliferation, invasion, and EMT of ovarian cancer through HMGB2 upregulation.

    Liu, Weiwei / Cheng, Jing

    Genetics and molecular biology

    2022  Volume 45, Issue 1, Page(s) e20210224

    Abstract: The function and mechanism of long intergenic non-protein coding RNA 974 (LINC00974) are rarely reported in ovarian cancer (OC). The study aimed to investigate how LINC00974 affects the progression of OC. The expression levels of LINC00974, microRNA-33a ( ...

    Abstract The function and mechanism of long intergenic non-protein coding RNA 974 (LINC00974) are rarely reported in ovarian cancer (OC). The study aimed to investigate how LINC00974 affects the progression of OC. The expression levels of LINC00974, microRNA-33a (miR-33a), and high mobility group box 2 (HMGB2) mRNA were detected by qRT-PCR. The LINC00974/miR-33a/HMGB2 axis was confirmed by dual-luciferase reporter, RNA-binding protein immunoprecipitation (RIP), and biotinylated RNA pull-down assays. A series of in vitro experiments were employed to assess the effects of LINC00974/miR-33a/HMGB2 axis on the proliferation, invasion and epithelial mesenchymal transition (EMT) of OC cells. Results showed that LINC00974 and HMGB2 mRNA expression were upregulated in OC cells, while miR-33a expression was downregulated. HMGB2 was a direct target gene of miR-33a. LINC00974 act as a competing endogenous RNA (ceRNA) to directly bind with miR-33a, thereby upregulated HMGB2 expression. Notably, silencing of LINC00974 suppressed cell proliferation, invasion and EMT of OC cells, whereas miR-33a knockdown partially reversed the phenotypes of LINC00974 on OC cells. Overall, our study demonstrated that LINC00974 sponges miR-33a to promote cell proliferation, invasion, and EMT of OC through HMGB2 upregulation. LINC00974/miR-33a/HMGB2 axis may be an important signaling pathway in the progression of OC.
    Language English
    Publishing date 2022-01-31
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 1445712-x
    ISSN 1678-4685 ; 1415-4757
    ISSN (online) 1678-4685
    ISSN 1415-4757
    DOI 10.1590/1678-4685-GMB-2021-0224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Saturation- and Dose-Dependent Effects of a Teen Sexual Harassment Prevention Program: Findings from a Randomized Controlled Trial.

    Liu, Lin / Taylor, Bruce G / Liu, Weiwei / Stein, Nan D

    Prevention science : the official journal of the Society for Prevention Research

    2024  

    Abstract: Using a randomized controlled trial, we investigated changes in both sexual harassment (SH) perpetration and victimization of 2104 middle school students in New York City who received divergent saturation and dosage levels of Shifting Boundaries, an SH ... ...

    Abstract Using a randomized controlled trial, we investigated changes in both sexual harassment (SH) perpetration and victimization of 2104 middle school students in New York City who received divergent saturation and dosage levels of Shifting Boundaries, an SH prevention program, which was represented by the length of the program. We assessed the saturation effect of the program by comparing the outcomes across respondents from 26 schools in which there were varying percentages of students enrolled in the program. The data suggested that, overall, the program was effective in reducing sexual harassment victimization but achieved a null effect against respondents' SH perpetration and that neither the length nor the school-saturation level of the program exerted a significant effect on SH perpetration. Although the data indicated a significant difference in SH victimization between the treatment and control group, when comparing subgroups who received treatment with divergent saturation and dosage levels, no statistically significant difference was identified. Our results suggested that the program effect was not contingent on the portion of students in a school who enrolled in the program, nor was it contingent on the dosage.
    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2251270-6
    ISSN 1573-6695 ; 1389-4986
    ISSN (online) 1573-6695
    ISSN 1389-4986
    DOI 10.1007/s11121-024-01661-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: DuPont analysis was used to evaluate the operation of non-profit medical institutions in Chongqing

    Guo Tian / Liu Weiwei

    E3S Web of Conferences, Vol 275, p

    2021  Volume 03012

    Abstract: It has been nearly eleven years since the reform of China’s medical and health system entered the final sprint stage in early 2008. During this period, great changes have taken place in China’s medical system, which has had a huge impact on the operation ...

    Abstract It has been nearly eleven years since the reform of China’s medical and health system entered the final sprint stage in early 2008. During this period, great changes have taken place in China’s medical system, which has had a huge impact on the operation of public hospitals in China. This paper analyzes the key financial indicators of public hospitals in Chongqing from 2007 to 2017, including revenue and expenditure situation and structure, assets and liabilities situation and structure, finds out the problems in operation and puts forward suggestions. The key financial indicators of public hospitals in Chongqing were analyzed and evaluated by trend analysis, ratio analysis and DuPont analysis. The total revenue and expenditure of public hospitals in Chongqing increases with GDP year by year, the structure of revenue and expenditure has changed greatly, the debt level is reasonable, and the operating capacity is at a low level. The balance of drug revenue and expenditure in public hospitals is unbalanced, so it is necessary to strengthen the implementation of drug price adjustment plan; Public hospitals should strengthen the cost control, especially the cost control of drug expenditure, in order to meet the requirements of national policies and improve their own operating capacity.
    Keywords Environmental sciences ; GE1-350
    Subject code 950
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: The presence of benzene ring activating CoA ligases for aromatics degradation in the ANaerobic MEthanotrophic (ANME) archaea.

    Liu, Wei-Wei / Pan, Piaopiao / Zhou, Ning-Yi

    Microbiology spectrum

    2023  , Page(s) e0176623

    Abstract: Petroleum-source and black carbon-source aromatic compounds are present in the cold seep environments, where ANaerobic MEthanotrophic (ANME) archaea as the dominant microbial community mediates the anaerobic oxidation of methane to produce inorganic and ... ...

    Abstract Petroleum-source and black carbon-source aromatic compounds are present in the cold seep environments, where ANaerobic MEthanotrophic (ANME) archaea as the dominant microbial community mediates the anaerobic oxidation of methane to produce inorganic and organic carbon. Here, by predicting the aromatics catabolic pathways in ANME metagenome-assembled genomes, we provide genomic and biochemical evidences that ANME have the potential of metabolizing aromatics via the strategy of CoA activation of the benzene ring using phenylacetic acid and benzoate as the substrates. Two ring-activating enzymes phenylacetate-CoA ligase (PaaK
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01766-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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