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Article ; Online: A Single Bundle Anterior Cruciate Ligament Reconstruction (ACL-R) Using Hamstring Tendon Autograft and Tibialis Anterior Tendon Allograft: A Comparative Study.

Rai, Saroj / Jin, Sheng-Yang / Rai, Bimal / Tamang, Nira / Huang, Wei / Liu, Xian-Zhe / Meng, Chun-Qing / Wang, Hong

Current medical science

2018 Volume 38, Issue 5, Page(s) 818–826

Abstract: The main purpose of this study was to compare the clinical outcomes of patients undergoing a single bundle anterior cruciate ligament reconstruction (ACL-R) of using quadrupled hamstring (4HT) autografts and two-strand tibialis anterior (2TA) allografts, ...

Abstract	The main purpose of this study was to compare the clinical outcomes of patients undergoing a single bundle anterior cruciate ligament reconstruction (ACL-R) of using quadrupled hamstring (4HT) autografts and two-strand tibialis anterior (2TA) allografts, and to find out the rate of graft failure and possible causes. We hypothesized that there would be no difference in the clinical outcome, and graft failure would be associated with the use of small sized allograft in young active males with high demand of sports activities. We retrospectively evaluated 222 patients (male, n=167, female, n=55) undergoing ACL-R between January 2010 and July 2014. Of 222 patients, 115 were included in the 4HT autograft group and 107 patients in the 2TA allograft group. Inclusion criteria were primary unilateral ACL-R with a minor MCL (<grade II) injury with or without meniscus tear and had at least 2.5 years of follow-up. Subjective evaluation was performed using Tegner-Lysholm score, modified Cincinnati knee score, and IKDC knee form. Anteroposterior laxity was assessed using ADT and Lachman test whereas rotational laxity was assessed using pivot shift test. Similarly, functional assessment was performed using range of motion (ROM), Daniel's one-leg hop test, and overall IKDC score. Clinical outcomes were satisfactory and comparable in both groups with no statistically significant difference in all the respective parameters. No statistically significant difference was observed in graft re-rupture rate. However, most graft failures occurred in young active males with high demand of sports activities, graft size smaller than 8 mm, and use of allograft. An autograft with at least 8 mm diameter should be considered in a young active male with high demand of sports activities to avoid graft failure.<br />
MeSH term(s)	Adolescent ; Adult ; Allografts/transplantation ; Anterior Cruciate Ligament Injuries/physiopathology ; Anterior Cruciate Ligament Injuries/therapy ; Anterior Cruciate Ligament Reconstruction/methods ; Female ; Hamstring Tendons/physiopathology ; Hamstring Tendons/surgery ; Hamstring Tendons/transplantation ; Humans ; Knee/physiopathology ; Knee/surgery ; Male ; Middle Aged ; Quadruplets ; Rupture/physiopathology ; Rupture/surgery ; Tendons/physiopathology ; Tendons/surgery ; Tendons/transplantation ; Transplantation, Autologous ; Young Adult
Language	English
Publishing date	2018-10-20
Publishing country	China
Document type	Journal Article
ISSN	2523-899X
ISSN (online)	2523-899X
DOI	10.1007/s11596-018-1948-4
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Article: [The experience in the treatment of the critically ill and severely wounded in earthquake].

Su, Ming-li / Gao, Xue-cheng / Liu, Xian-zhe

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue

2009 Volume 21, Issue 1, Page(s) 57

MeSH term(s)	China ; Critical Illness ; Disasters ; Earthquakes ; Female ; Humans ; Male ; Wounds and Injuries/therapy
Language	English
Publishing date	2009-01
Publishing country	China
Document type	Journal Article
ISSN	1003-0603
ISSN	1003-0603
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Article ; Online: Analysis of Sagittal Parameters in Patients Undergoing One- or Two-Level Closing Wedge Osteotomy for Correcting Thoracolumbar Kyphosis Secondary to Ankylosing Spondylitis.

Hua, Wen-Bin / Zhang, Yu-Kun / Gao, Yong / Liu, Xian-Zhe / Yang, Shu-Hua / Wu, Xing-Huo / Wang, Jing / Yang, Cao

Spine

2016 Volume 42, Issue 14, Page(s) E848–E854

Abstract: Study design: Retrospective analysis of clinical records.: Objective: To assess and compare the improvement in sagittal balance after one- or two-level closing wedge osteotomy for correcting thoracolumbar kyphosis secondary to ankylosing spondylitis ( ...

Abstract	Study design: Retrospective analysis of clinical records. Objective: To assess and compare the improvement in sagittal balance after one- or two-level closing wedge osteotomy for correcting thoracolumbar kyphosis secondary to ankylosing spondylitis (AS). Summary of background data: Closing wedge osteotomy represents a common approach to correct kyphosis in AS. Although several reports have described the outcomes of one- or two-level closing wedge osteotomy in terms of sagittal parameters, data comparing the outcomes of these procedures are scarce. Methods: Between January 2010 and December 2014, 22 patients with AS underwent closing wedge osteotomy (one-level, 12 patients; two-level, 10 patients) for correcting thoracolumbar kyphosis (mean follow-up, 24.8 months; range, 12-60 months). Preoperative and postoperative chin-brow vertical angle, and the sagittal parameters of the vertebral osteotomy segment were documented and compared. Perioperative and postoperative complications were also recorded. Results: The chin-brow vertical angle improved significantly, from 55.0° ± 27.3° to 4.7° ± 4.9° and from 38.2° ± 14.9° to 3.2° ± 5.4° in the one-level and two-level groups, respectively. The total correction (thoracic kyphosis and lumbar lordosis) was 32.8° ± 18.2° and 53.7° ± 9.4° in the one-level and two-level groups, respectively. No death, complete paralysis, or vascular complications occurred during the procedure, but cerebrospinal fluid leak was noted in one and two patients from the one-level and two-level groups, respectively. A distal pedicle screw adjacent to the osteotomy segment became loose during surgery in one patient (one-level group). Postoperatively, no transient neurological deficit, infection, delay union, or loosening or breaking of the internal fixation devices was observed. Osteotomy site fusion was achieved in all patients, and the Oswestry Disability Index scores improved significantly. Conclusion: Closing wedge osteotomy is effective and safe for correcting thoracolumbar kyphosis in patients with AS. Significant correction and improvement in all sagittal parameters were noted in both groups, but two-level closing wedge osteotomy provided better correction. Level of evidence: 3.
MeSH term(s)	Adult ; Female ; Humans ; Kyphosis/diagnostic imaging ; Kyphosis/etiology ; Kyphosis/surgery ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery ; Male ; Middle Aged ; Osteotomy/methods ; Retrospective Studies ; Spondylitis, Ankylosing/complications ; Spondylitis, Ankylosing/diagnostic imaging ; Spondylitis, Ankylosing/surgery ; Thoracic Vertebrae/diagnostic imaging ; Thoracic Vertebrae/surgery ; Young Adult
Language	English
Publishing date	2016-11-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	752024-4
ISSN	1528-1159 ; 0362-2436
ISSN (online)	1528-1159
ISSN	0362-2436
DOI	10.1097/BRS.0000000000001984
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Article ; Online: Mid-term outcomes of primary constrained condylar knee arthroplasty for severe knee deformity.

Feng, Xiao-Bo / Yang, Cao / Fu, De-Hao / Ye, Shu-Nan / Liu, Xian-Zhe / Chen, Zhe / Rai, Saroj / Yang, Shu-Hua

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban

2016 Volume 36, Issue 2, Page(s) 231–236

Abstract: This study aimed to examine the clinical and radiographic outcomes of primary total knee arthroplasy (TKA) with use of NexGen® Legacy® Constrained Condylar Knee (CCK) prosthesis for severe knee deformity. Clinical data of 46 patients (48 knees in total, ... ...

Abstract	This study aimed to examine the clinical and radiographic outcomes of primary total knee arthroplasy (TKA) with use of NexGen® Legacy® Constrained Condylar Knee (CCK) prosthesis for severe knee deformity. Clinical data of 46 patients (48 knees in total, aged 61 years on average) with severe knee deformity who underwent TKA with NexGen® Legacy® CCK prosthesis between December 2007 and February 2012 were retrospectively analyzed. There were 34 knees with severe valgus with incompetent medial collateral ligament, 11 knees with severe flexion contracture with inability to achieve knee balancing in flexion and extension by posterior soft tissue release, 2 knees with Charcot arthritis with severe varus and bone loss, and 1 with traumatic osteoarthritis with severe varus and ligamentous instability. The mean duration of follow-up was 71 months (range 40-90 months). The New Knee Society scoring (NKSS) system and the Hospital for Special Surgery (HSS) score were used to evaluate the functional and clinical outcomes. Visual Analogue Scale (VAS) was used for pain measurement and Knee Society criteria for evaluation of radiological images. The results showed that, in the total 48 knees, 1 case of loosening due to short-stem tibial component at 3 months post-operatively underwent revision. The 6-year prosthesis survival rate in this cohort was 97.9%. There was no component infection occurring within 6 years. Significant post-operative improvements were found in NKSS and HSS scores. Patient satisfaction was significantly increased. Pain score was decreased significantly. Total functional score was improved from 31.46±11.43 to 86.42±8.87, range of motion (ROM) from 42.42°±23.57° to 95.31°±23.45° and the flexion contracture from 5.31°±7.87° to 0.92°±1.80°. Preoperative radiographic study showed excessive valgus (≥7°) in 37 knees, and varus deformity in 3 knees. Post-operative femorotibial alignment was valgus 3.88°±1.76° in 48 knees. Antero/posterior (A/P) view of X-ray films showed 4 radiolucent lines (RLL) in 48 tibial components. It was concluded that TKA with CCK is effective for the treatment of the severe unstable knee that cannot be balanced by soft tissue.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Knee/adverse effects ; Arthroplasty, Replacement, Knee/methods ; Female ; Gout/surgery ; Humans ; Leg Bones/surgery ; Male ; Middle Aged ; Osteoarthritis/surgery ; Pain/etiology ; Patient Satisfaction ; Postoperative Complications ; Prostheses and Implants/adverse effects ; Wound Infection/etiology
Language	English
Publishing date	2016-04
Publishing country	China
Document type	Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2090603-1
ISSN	1993-1352 ; 1672-0733 ; 0257-716X
ISSN (online)	1993-1352
ISSN	1672-0733 ; 0257-716X
DOI	10.1007/s11596-016-1572-0
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Article ; Online: Total hip arthroplasty with subtrochanteric femoral shortening osteotomy for high hip dislocation.

Hua, Wen-bin / Yang, Shu-hua / Xu, Wei-hua / Ye, Shu-nan / Liu, Xian-zhe / Wang, Jing / Feng, Yong

Orthopaedic surgery

2015 Volume 7, Issue 2, Page(s) 112–118

Abstract: Objective: To evaluate the outcomes of total hip arthroplasty (THA) with subtrochanteric femoral shortening osteotomy for high hip dislocation.: Methods: In this retrospective study, the results of 24 primary THAs with acetabular reconstruction and ... ...

Abstract	Objective: To evaluate the outcomes of total hip arthroplasty (THA) with subtrochanteric femoral shortening osteotomy for high hip dislocation. Methods: In this retrospective study, the results of 24 primary THAs with acetabular reconstruction and subtrochanteric femoral shortening osteotomy in 21 patients with high hip dislocation were evaluated. The acetabula were reconstructed with cemented or uncemented cups and bone grafting. Transverse subtrochanteric femoral shortening osteotomies were applied and the osteotomy sites treated by bone grafting and cable fixation. Assessment was by Hip Harris scores and radiographic evaluation. Results: The mean follow-up time was 42 months (18-108 months), three cases being lost to follow-up 18-27 months postoperatively. The HHS improved from 47.5 ± 8.7 to 88.5 ± 3.1. The mean length of femoral segments removed was 2.5 ± 0.8 cm (range, 1.0-4.5 cm) and mean acetabular inclination 43° ± 5° (range, 31°-54°). Caudalization of the femoral head center was 3.2 ± 3.0 mm (range, -3 to 12 mm) and lateralization 4.0 ± 4.0 mm (range, -9 to 11 mm). Mean greater trochanter height relative to theoretical hip center was 5.2 ± 1.0 cm (range, 3.5-7.1 cm) preoperatively and 0.2 ± 0.6 cm (range, -0.9 to 1.2 cm) postoperatively. Intraoperative trochanteric fractures occurred in three cases and sciatic nerve palsy in one. Conclusion: THA with subtrochanteric femoral shortening osteotomy is an effective technique for treating high hip dislocation. Its advantages include improvement in limb imbalance and decreased risk of sciatic nerve injury.
MeSH term(s)	Adult ; Aged ; Arthroplasty, Replacement, Hip/methods ; Bone Transplantation ; Female ; Femur/surgery ; Follow-Up Studies ; Hip Dislocation, Congenital/surgery ; Humans ; Male ; Middle Aged ; Osteotomy/methods ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2015-06-26
Publishing country	Australia
Document type	Evaluation Studies ; Journal Article ; Video-Audio Media
ZDB-ID	2503162-4
ISSN	1757-7861 ; 1757-7853 ; 1757-7861
ISSN (online)	1757-7861 ; 1757-7853
ISSN	1757-7861
DOI	10.1111/os.12176
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Article: Promotion of chondrogenesis of marrow stromal stem cells by TGF-β3 fusion protein in vivo. [corrected].

Wu, Wei / Dan, Yang / Yang, Shu-Hua / Yang, Cao / Shao, Zeng-Wu / Xu, Wei-Hua / Li, Jin / Liu, Xian-Zhe / Zheng, Dong

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban

2013 Volume 33, Issue 5, Page(s) 692–699

Abstract: The purpose of this study was to investigate the repair of the osteoarthritis(OA)-induced cartilage injury by transfecting the new TGF-β3 fusion protein (LAP-MMP-mTGF-β3) with targeted therapy function into the bone marrow-derived mesenchymal stem cells ( ...

Abstract	The purpose of this study was to investigate the repair of the osteoarthritis(OA)-induced cartilage injury by transfecting the new TGF-β3 fusion protein (LAP-MMP-mTGF-β3) with targeted therapy function into the bone marrow-derived mesenchymal stem cells (MSCs) in rats. The recombinant of pIRES-EGFP-MMP was constructed by combination of DNA encoding MMP enzyme cutting site and eukaryotic expression vector pIRES-EGFP. LAP and mTGF-β3 fragments were obtained from rat embryos by RT-PCR and inserted into the upstream and downstream of MMP from pIRES-EGFP-MMP respectively, so as to construct the recombinant plasmid of pIRES-EGFP-LAP-MMP-mTGF-β3. pIRES-EGFP-LAP-MMP-mTGF-β3 was transfected into rat MSCs. The genetically modified MSCs were cultured in medium with MMP-1 or not. The transfected MSCs were transplanted in the rat OA models. The OA animal models were surgically induced by anterior cruciate ligament transaction (ACLT). The pathological changes were observed under a microscope by HE staining, Alcian blue, Safranin-fast Green and graded by Mankin's scale. pIRES-EGFP-LAP-MMP-mTGF-β3 was successfully constructed by means of enzyme cutting and sequencing, and the mTGF-β3 fusion protein (39 kD) was certified by Western blotting. Those genetically modified MSCs could differentiate into chondrocytes induced by MMP and secrete the relevant-matrix. The transfected MSCs could promote chondrogenesis and matrix production in rat OA models in vivo. It was concluded that a new fusion protein LAP-MMP-mTGF-β3 was constructed successfully by gene engineering, and could be used to repair the OA-induced cartilage injury.
MeSH term(s)	Animals ; Base Sequence ; Blotting, Western ; Bone Marrow Cells/metabolism ; Cartilage, Articular/pathology ; Cartilage, Articular/surgery ; Cell Differentiation/genetics ; Cells, Cultured ; Chondrocytes/metabolism ; Chondrogenesis/genetics ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Matrix Metalloproteinases/genetics ; Matrix Metalloproteinases/metabolism ; Mesenchymal Stem Cell Transplantation/methods ; Mesenchymal Stem Cells/metabolism ; Microscopy, Fluorescence ; Molecular Sequence Data ; Osteoarthritis/surgery ; Rats ; Rats, Sprague-Dawley ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Transfection ; Transforming Growth Factor beta3/genetics ; Transforming Growth Factor beta3/metabolism ; Treatment Outcome
Chemical Substances	Recombinant Fusion Proteins ; Transforming Growth Factor beta3 ; Green Fluorescent Proteins (147336-22-9) ; Matrix Metalloproteinases (EC 3.4.24.-)
Language	English
Publishing date	2013-10-20
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2090603-1
ISSN	1993-1352 ; 1672-0733 ; 0257-716X
ISSN (online)	1993-1352
ISSN	1672-0733 ; 0257-716X
DOI	10.1007/s11596-013-1182-z
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Article: Total hip arthroplasty for treatment of elderly patients with comminuted intertrochanteric fracture accompanied by femoral head necrosis.

Liu, Xian-Zhe / Yang, Wen / Yang, Shu-Hua / Xu, Wei-Hua / Ye, Shu-Nan

Chinese journal of traumatology = Zhonghua chuang shang za zhi

2009 Volume 11, Issue 6, Page(s) 359–363

Abstract: Objective: To assess the curative effect and investigate the indications of total hip arthroplasty for treatment of comminuted intertrochanteric fractures.: Methods: Total hip arthroplasty was carried out in 9 cases of severe intertrochanteric ... ...

Abstract	Objective: To assess the curative effect and investigate the indications of total hip arthroplasty for treatment of comminuted intertrochanteric fractures. Methods: Total hip arthroplasty was carried out in 9 cases of severe intertrochanteric fracture. The patients included two men and seven women. The average age of the patients was 68 years (48-75 years). The period from fracture to operation was 5 days (2-10 days). The mean follow-up period lasted for 11 months (3 months-2 years). There was one patient with comminuted intertrochanteric fracture accompanied by femoral head necrosis and 2 patients with intertrochanteric fracture and stroke. Other 6 patients had severe osteoporosis. The Harris score before operation was 63 points (45-71 points). Results: At the last follow-up, the patients gained 86 points (70-100 points) according to the Harris score. The effects of the 8 cases were good. The Harris score of all patients improved after treatment. Only two hemiplegia patients needed sticks to walk. The others could walk without hip pain. No radiographic evidence of acetabular wear and prosthesis dislocation or other major complications happened during the follow-up. Conclusions: Prosthetic replacements can well treat unstable intertrochanteric fracture if operative indication is correctly selected. It is suitable for elderly patients and the operation should be performed by experienced surgeons.
MeSH term(s)	Aged ; Arthroplasty, Replacement, Hip/methods ; Female ; Femur Head Necrosis/epidemiology ; Fractures, Comminuted/surgery ; Hip Fractures/surgery ; Humans ; Male ; Middle Aged ; Postoperative Complications/epidemiology ; Treatment Outcome
Language	English
Publishing date	2009-02-22
Publishing country	China
Document type	Journal Article
ZDB-ID	2276839-7
ISSN	1008-1275
ISSN	1008-1275
DOI	10.1016/s1008-1275(08)60072-3
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Article: Herbal Fufang Xian Ling Gu Bao prevents corticosteroid-induced osteonecrosis of the femoral head-A first multicentre, randomised, double-blind, placebo-controlled clinical trial.

Li, Zi-Rong / Cheng, Li-Ming / Wang, Kun-Zheng / Yang, Nan-Ping / Yang, Shu-Hua / He, Wei / Wang, Yi-Sheng / Wang, Zhong-Ming / Yang, Pei / Liu, Xian-Zhe / Luo, Yue-Zhong / Sun, Wei / Wang, Hai-Tao / Zheng, Li-Zhen / Wang, Xin-Luan / Qin, Ling

Journal of orthopaedic translation

2017 Volume 12, Page(s) 36–44

Abstract: Background/objective: This is a multicentre, randomised, double-blind, placebo-controlled clinical trial to investigate the safety and efficacy of Chinese herbal Fufang Xian Ling Gu Bao (XLGB) with antiadipogenic compounds for the prevention of ... ...

Abstract	Background/objective: This is a multicentre, randomised, double-blind, placebo-controlled clinical trial to investigate the safety and efficacy of Chinese herbal Fufang Xian Ling Gu Bao (XLGB) with antiadipogenic compounds for the prevention of corticosteroid (CS)-induced osteonecrosis of femoral head (ONFH). Methods: Patients of both genders, aged between 18 and 65 years, with diseases such as systemic lupus erythematosus, nephrosis, dermatosis and rheumatoid arthritis indicated for CS treatment and who did not show magnetic resonance imaging of ONFH at baseline were recruited into the study and then randomised into either XLGB group (n = 129) with daily oral administration of XLGB or placebo group (n = 146). Results: Magnetic resonance imaging revealed a total of 30 ONFH cases at 6 months after CS treatment, with 6.98% (9 of 129 cases) and 14.4% (21 of 146 cases) in the XLGB group and placebo group, respectively, ( Conclusion: This is the first multicentre clinical study to demonstrate that the antiadipogenic compounds-rich herbal Fufang (formula) XLGB is effective in preventing CS-associated ONFH in patients with immune-inflammatory diseases under CS treatment. The translational potential of this article: The translation potential of this clinical trial is that the initially officially approved clinical indication for XLGB for treatment of osteoporosis has been now also proven to be effective for a new clinical application.
Language	English
Publishing date	2017-12-14
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2747531-1
ISSN	2214-031X
ISSN	2214-031X
DOI	10.1016/j.jot.2017.11.001
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Article ; Online: Clinical result of structural augmentation with cannulated bone screws for the treatment of osteonecrosis of the femoral head.

Yang, Shu-hua / Fu, De-hao / Yang, Cao / Li, Jin / Xu, Wei-hua / Ye, Shu-nan / Wu, Xing-huo / Liu, Xian-zhe

Orthopaedic surgery

2011 Volume 1, Issue 1, Page(s) 42–46

Abstract: Objective: To evaluate the results of treatment of osteonecrosis of the femoral head by structural augmentation through a routine core decompression procedure combined with insertion of cannulated bone screws incorporating autogenous bone graft and ... ...

Abstract	Objective: To evaluate the results of treatment of osteonecrosis of the femoral head by structural augmentation through a routine core decompression procedure combined with insertion of cannulated bone screws incorporating autogenous bone graft and biomaterial containing decalcified bone matrix. Methods: From February 2002 to February 2005, 31 patients (33 hips) with femoral head necrosis were treated in our hospital using insertion of cannulated bone screws incorporating autogenous bone graft. There were 18 men and 13 women with an average age of 37 years (range, 27-49). The Steinberg classification was stage I for 20 hips (61%) and stage II for 13 hips (39%). Clinical and radiographic evaluations were performed on all patients. The patient's satisfaction was also assessed. Results: All 31 patients (33 hips) were retrospectively studied after a mean follow-up of 38 months (range, 18-48). The average Harris hip score was 76 before surgery and 91 at the final follow-up. All patients stated that they were satisfied and had significantly reduced pain. According to the Harris hip score system, 21 cases were excellent, 8 good and 2 fair. No complications, such as wound infection, subtrochanteric fracture, neuropathy and deep vein thrombosis, were found. Conclusion: Structural augmentation using the insertion of cannulated bone screws incorporating autogenous bone graft is an effective option for Steinberg I-II stages of femoral head necrosis. Further study is needed to confirm mid- and long-term results.
MeSH term(s)	Adult ; Bone Screws ; Bone Transplantation/methods ; Female ; Femur Head Necrosis/diagnostic imaging ; Femur Head Necrosis/surgery ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prosthesis Design ; Tomography, X-Ray Computed
Language	English
Publishing date	2011-10-18
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	2503162-4
ISSN	1757-7861 ; 1757-7853 ; 1757-7861
ISSN (online)	1757-7861 ; 1757-7853
ISSN	1757-7861
DOI	10.1111/j.1757-7861.2008.00008.x
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Article ; Online: Matrix metalloproteinase-9 as new biomarkers of severity in multiple organ dysfunction syndrome caused by trauma and infection.

Teng, Lin / Yu, Min / Li, Jun-ming / Tang, Hua / Yu, Jing / Mo, Li-hua / Jin, Jing / Liu, Xian-zhe

Molecular and cellular biochemistry

2011 Volume 360, Issue 1-2, Page(s) 271–277

Abstract: Multiple organ dysfunction syndrome (MODS) is an important cause of morbidity and mortality in intensive care unit. A severe insult in the form of infection or trauma primes the host immune system so that a subsequent, relatively trivial insult produces ... ...

Abstract	Multiple organ dysfunction syndrome (MODS) is an important cause of morbidity and mortality in intensive care unit. A severe insult in the form of infection or trauma primes the host immune system so that a subsequent, relatively trivial insult produces systemic inflammation response syndrome, which can lead to MODS and death. Matrix metalloproteinase-9 (MMP-9) is stored in the tertiary granules of polymorphonuclear leukocytes. These cells are key effectors in acute inflammatory diseases, such as sepsis and MODS. Endotoxin leads to rapid release of MMP-9 from these granules in vitro and in vivo. However, the role of this enzyme in MODS, and whether it is associated with organ injury at the early stage of MODS remains unclear. This present work may study role of MMP-9 with the MODS rats that caused by trauma and infection and investigate the mechanism of organ injury at the early stage of MODS. Here, we developed a rat model for MODS caused by trauma and infection and analyzed the dynamic level of MMP-9 and determined the relationship between MMP-9 level and early phase of organ injury in MODS rat. The histological changes in pulmonary, renal, and hepatic tissue were observed by light microscope. The expressions of plasma MMP-9 proteins were detected by an enzyme linked immunosorbent assay and its levels in the pulmonary, renal, and hepatic tissue were detected by using immunohistochemistry, respectively. The results indicated that there were no significant improvements in histopathology of rats in control group. However, the pulmonary, renal, and hepatic damage were serious in MODS groups. The concentration of MMP-9 in plasma and tissues of MODS rats increased markedly at the early stage and were higher than that of the control group. Moreover, the MMP-9 level in plasma positively correlated with the levels of pulmonary, renal, and hepatic tissue. This study clearly shows that MMP-9 is good biomarker to predict the severity of injury organ at the early phase of MODS.
MeSH term(s)	Alanine Transaminase/blood ; Animals ; Aspartate Aminotransferases/blood ; Biomarkers/blood ; Blood Urea Nitrogen ; Creatine Kinase/blood ; Creatinine/blood ; Eye Injuries ; Kidney/enzymology ; Kidney/pathology ; L-Lactate Dehydrogenase/blood ; Lipopolysaccharides ; Liver/enzymology ; Liver/pathology ; Lung/enzymology ; Lung/pathology ; Male ; Matrix Metalloproteinase 9/blood ; Multiple Organ Failure/blood ; Multiple Organ Failure/enzymology ; Multiple Organ Failure/etiology ; Random Allocation ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Biomarkers ; Lipopolysaccharides ; lipopolysaccharide A ; Creatinine (AYI8EX34EU) ; L-Lactate Dehydrogenase (EC 1.1.1.27) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2) ; Creatine Kinase (EC 2.7.3.2) ; Matrix Metalloproteinase 9 (EC 3.4.24.35)
Language	English
Publishing date	2011-10-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	184833-1
ISSN	1573-4919 ; 0300-8177
ISSN (online)	1573-4919
ISSN	0300-8177
DOI	10.1007/s11010-011-1066-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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