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Article ; Online: Identification and bioinformatics analysis of lncRNAs in serum of patients with ankylosing spondylitis.

Kou, Jianqiang / Bie, Yongchen / Liu, Mingquan / Wang, Liqin / Liu, Xiangyun / Sun, Yuanliang / Zheng, Xiujun

2024 Volume 25, Issue 1, Page(s) 291

Abstract: Objectives: The aim of this study was to explore the long non-coding RNA (lncRNA) expression profiles in serum of patients with ankylosing spondylitis (AS). The role of these lncRNAs in this complex autoimmune situation needs to be evaluated.: Methods! ...

Abstract	Objectives: The aim of this study was to explore the long non-coding RNA (lncRNA) expression profiles in serum of patients with ankylosing spondylitis (AS). The role of these lncRNAs in this complex autoimmune situation needs to be evaluated. Methods: We used high-throughput whole-transcriptome sequencing to generate sequencing data from three patients with AS and three normal controls (NC). Then, we performed bioinformatics analyses to identify the functional and biological processes associated with differentially expressed lncRNAs (DElncRNAs). We confirmed the validity of our RNA-seq data by assessing the expression of eight lncRNAs via quantitative reverse transcription polymerase chain reaction (qRT-PCR) in 20 AS and 20 NC samples. We measured the correlation between the expression levels of lncRNAs and patient clinical index values using the Spearman correlation test. Results: We identified 72 significantly upregulated and 73 significantly downregulated lncRNAs in AS patients compared to NC. qRT-PCR was performed to validate the expression of selected DElncRNAs; the results demonstrated that the expression levels of MALAT1:24, NBR2:9, lnc-DLK1-35:13, lnc-LARP1-1:1, lnc-AIPL1-1:7, and lnc-SLC12A7-1:16 were consistent with the sequencing analysis results. Enrichment analysis showed that DElncRNAs mainly participated in the immune and inflammatory responses pathways, such as regulation of protein ubiquitination, major histocompatibility complex class I-mediated antigen processing and presentation, MAPkinase activation, and interleukin-17 signaling pathways. In addition, a competing endogenous RNA network was constructed to determine the interaction among the lncRNAs, microRNAs, and mRNAs based on the confirmed lncRNAs (MALAT1:24 and NBR2:9). We further found the expression of MALAT1:24 and NBR2:9 to be positively correlated with disease severity. Conclusion: Taken together, our study presents a comprehensive overview of lncRNAs in the serum of AS patients, thereby contributing novel perspectives on the underlying pathogenic mechanisms of this condition. In addition, our study predicted MALAT1 has the potential to be deeply involved in the pathogenesis of AS.
MeSH term(s)	Humans ; RNA, Long Noncoding/genetics ; Gene Expression Profiling/methods ; Spondylitis, Ankylosing/genetics ; MicroRNAs/metabolism ; Computational Biology/methods ; Gene Regulatory Networks ; Adaptor Proteins, Signal Transducing/genetics ; K Cl- Cotransporters
Chemical Substances	RNA, Long Noncoding ; MicroRNAs ; AIPL1 protein, human ; Adaptor Proteins, Signal Transducing ; SLC12A7 protein, human ; K Cl- Cotransporters
Language	English
Publishing date	2024-04-15
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-024-07396-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Highly Selective Electrocatalytic CuEDTA Reduction by MoS

Qin, Hehe / Liu, Xinru / Liu, Xiangyun / Zhao, Hongying / Mao, Shun

Nano-micro letters

2023 Volume 15, Issue 1, Page(s) 193

Abstract: Electrocatalytic reduction of ethylenediamine tetraacetic acid copper (CuEDTA), a typical refractory heavy metal complexation pollutant, is an environmental benign method that operates at mild condition. Unfortunately, the selective reduction of CuEDTA ... ...

Abstract	Electrocatalytic reduction of ethylenediamine tetraacetic acid copper (CuEDTA), a typical refractory heavy metal complexation pollutant, is an environmental benign method that operates at mild condition. Unfortunately, the selective reduction of CuEDTA is still a big challenge in cathodic process. In this work, we report a MoS
Language	English
Publishing date	2023-08-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2642093-4
ISSN	2150-5551 ; 2150-5551
ISSN (online)	2150-5551
ISSN	2150-5551
DOI	10.1007/s40820-023-01166-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exercise training-attenuated insulin resistance and liver injury in elderly pre-diabetic patients correlates with NLRP3 inflammasome.

Zhang, Tan / Tian, Jingjing / Fan, Jingcheng / Liu, Xiangyun / Wang, Ru

Frontiers in immunology

2023 Volume 14, Page(s) 1082050

Abstract: Background: Diabetes is one of the most common metabolic diseases and continues to be a leading cause of death worldwide. The NLRP3 inflammasome has been shown to exert detrimental effects on diabetic models. However, evidence linking NLRP3 inflammasome ...

Abstract	Background: Diabetes is one of the most common metabolic diseases and continues to be a leading cause of death worldwide. The NLRP3 inflammasome has been shown to exert detrimental effects on diabetic models. However, evidence linking NLRP3 inflammasome and pre-diabetes has been scarcely explored. Herein, we aimed to determine whether the NLRP3 inflammasome correlates with insulin resistance and liver pathology in a cohort of pre-diabetic subjects. Methods: 50 pre-diabetic subjects were randomly assigned to a Pre-diabetes Control (DC, n=25) and a Pre-diabetes exercise (DEx, n=25) group. 25 Normal subjects (NC) were selected as controls. The DEx group performed a 6-month combined Yijingjing and resistance training intervention, while DC and NC group remained daily routines. Clinical metabolic parameters were determined with an automatic biochemistry analyzer; inflammatory cytokines were quantified by the ELISA assay; the protein expressions of NLRP3 inflammasome components in PBMCs were evaluated by Western Blot. Results: The insulin resistance, liver injury and NLRP3 inflammasome activity were higher in pre-diabetic individuals than in normal control group. However, 6-month exercise intervention counteracted this trend, significantly improved insulin sensitivity, reduced liver injury and inhibited the overactivation of NLRP3 inflammasome in pre-diabetic subjects. Moreover, positive correlations between insulin resistance, liver pathology and NLRP3 inflammasome were also found. Conclusions: Our study suggests that exercise training is an effective strategy to alleviate insulin resistance and liver injury in elderly pre-diabetic subjects which is probably associated with the inhibition of NLRP3 inflammasome activity.
MeSH term(s)	Humans ; Aged ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Insulin Resistance ; Prediabetic State ; Liver/metabolism
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein
Language	English
Publishing date	2023-02-01
Publishing country	Switzerland
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1082050
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Contour integration deficits at high spatial frequencies in children treated for anisometropic amblyopia.

Jiang, Shu-Qi / Chen, Yan-Ru / Liu, Xiang-Yun / Zhang, Jun-Yun

Frontiers in neuroscience

2023 Volume 17, Page(s) 1160853

Abstract: Purpose: This study was conducted to reexamine the question of whether children treated for anisometropic amblyopia have contour integration deficits. To do so, we used psychophysical methods that require global contour processing while minimizing the ... ...

Abstract	Purpose: This study was conducted to reexamine the question of whether children treated for anisometropic amblyopia have contour integration deficits. To do so, we used psychophysical methods that require global contour processing while minimizing the influence of low-level deficits: visibility, shape perception, and positional uncertainty. Methods: Thirteen children with anisometropic amblyopia (age: 10.1 ± 1.8 years) and thirteen visually normal children (age: 10.8 ± 2.0 years) participated in this study. The stimuli were closed figures made up of Gabor patches either in noise or on a blank field. The contrast thresholds to detect a circular contour on a blank field, as well as the thresholds of aspect ratio and contour element number to discriminate a circular or elliptical contour in noise, were measured at Gabor spatial frequencies of 1.5, 3, and 6 cpd for amblyopic eyes (AEs), fellow eyes (FEs), and normal control eyes. Visual acuities and contrast sensitivity functions for AEs and FEs and the Randot stereoacuity were measured before testing. Results: The AEs showed contrast deficits and degraded shape perception compared to the FEs at higher spatial frequencies (6 cpd). When the influence of abnormal contrast sensitivity and shape perception were minimized, the AEs showed contour integration deficits at spatial frequencies 3 and 6 cpd. These deficits were not related to basic losses in contrast sensitivity and acuity, stereoacuity, and visual crowding. Besides, no significant difference was found between the fellow eyes of the amblyopic children and the normal control eyes in the performance of contour integration. Conclusion: After eliminating or compensating for the low-level deficits, children treated for anisometropic amblyopia still show contour integration deficits, primarily at higher spatial frequencies, which might reflect the deficits in global processing caused by amblyopia. Contour integration deficits are likely independent of spatial vision deficits. Refractive correction and/or occlusion therapies may not be sufficient to fully restore contour integration deficits, which indicates the need for the development of clinical treatments to recover these deficits.
Language	English
Publishing date	2023-07-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2023.1160853
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Article ; Online: Tetramine-Based Hyperbranched Polyimide Membranes with Rigid Crosslinker for Improved Gas Permeability and Stability.

Liu, Xiangyun / Ling, Honglei / Luo, Jiangzhou / Zong, Xueping / Xue, Song

Polymers

2023 Volume 15, Issue 14

Abstract: Triamine-based HBPI membranes are known for high gas separation selectivity and physical stability, but their permeabilities are still very low. In this study, we utilized a tetramine monomer called TPDA (N,N,N',N'-tetrakis(4-aminophenyl)-1,4- ... ...

Abstract	Triamine-based HBPI membranes are known for high gas separation selectivity and physical stability, but their permeabilities are still very low. In this study, we utilized a tetramine monomer called TPDA (N,N,N',N'-tetrakis(4-aminophenyl)-1,4-benzenediamine) as a crosslinking center and incorporated an additional diamine comonomer called DAM (2,4,6-trimethyl-1,3-diaminobenzene) to enhance gas separation performance, especially gas permeability. The findings demonstrated that the resultant 6FDA-DAM/TPDA membranes based on tetramine TPDA exhibited a greater amount of free volume compared to the triamine-based HBPI membranes, resulting in significantly higher gas permeabilities. Furthermore, the higher concentration of DAM component led to the generation of more fractional free volumes (FFV). Consequently, the gas permeabilities of the 6FDA-DAM/TPDA membranes increased with an increase in DAM content, with a minimal compromise on selectivity. The enhanced gas permeabilities of the 6FDA-DAM/TPDA membranes enabled them to minimize the footprint required for membrane installations in real-world applications. Moreover, the 6FDA-DAM/TPDA membranes exhibited remarkable durability against physical aging and plasticization, thanks to the incorporation of a hyperbranched network structure.
Language	English
Publishing date	2023-07-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym15143017
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Article: Research Hotspots and Frontiers in Post Stroke Pain: A Bibliometric Analysis Study.

Li, Chong / Shu, Xiaoyi / Liu, Xiangyun

Frontiers in molecular neuroscience

2022 Volume 15, Page(s) 905679

Abstract: Background: Pain is a common complication after stroke with a high incidence and mortality rate. Many studies in the field of pain after stroke have been published in various journals. However, bibliometric analysis in the domain of pain after stroke is ...

Abstract	Background: Pain is a common complication after stroke with a high incidence and mortality rate. Many studies in the field of pain after stroke have been published in various journals. However, bibliometric analysis in the domain of pain after stroke is still lacking. This study aimed to deliver a visual analysis to analyze the global trends in research on the comorbidity of pain after stroke in the last 12 years. Methods: The publications from the Web of Science (WoS) in the last 12 years (from 2010 to 2021) were collected and retrieved. CiteSpace software was used to analyze the relationship of publication year with countries, institutions, journals, authors, references, and keywords. Results: A total of 322 publications were included in the analysis. A continuous but unstable growth in the number of articles published on pain after stroke was observed over the last 12 years. The Peoples' R China (65), Chang Gung University (10), and Conclusion: This study provides a visual analysis method for the trend and frontiers of pain research after stroke. In the future, large sample, randomized controlled trials are needed to identify the potential treatments and pathophysiology for pain after stroke.
Language	English
Publishing date	2022-05-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452967-9
ISSN	1662-5099
ISSN	1662-5099
DOI	10.3389/fnmol.2022.905679
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Article ; Online: Correction: Comparative effectiveness of aerobic exercise versus Yi Jin Jing on ovarian function in young overweight/obese women with polycystic ovary syndrome: study protocol for a randomized controlled trial.

Zhao, Jing / Ketlhoafetse, Antonnette / Liu, Xiangyun / Cao, Yang

Trials

2022 Volume 23, Issue 1, Page(s) 564

Language	English
Publishing date	2022-07-15
Publishing country	England
Document type	Published Erratum
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-022-06547-8
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Article ; Online: Comparative effectiveness of aerobic exercise versus Yi Jin Jing on ovarian function in young overweight/obese women with polycystic ovary syndrome: study protocol for a randomized controlled trial.

Zhao, Jing / Ketlhoafetse, Antonnette / Liu, Xiangyun / Cao, Yang

Trials

2022 Volume 23, Issue 1, Page(s) 459

Abstract: Background: Polycystic ovary syndrome (PCOS) is the most common heterogeneous endocrine disease among women of childbearing age, characterized by androgen excess and ovarian dysfunction. Aerobic exercise is an important solution used to manage PCOS, due ...

Abstract	Background: Polycystic ovary syndrome (PCOS) is the most common heterogeneous endocrine disease among women of childbearing age, characterized by androgen excess and ovarian dysfunction. Aerobic exercise is an important solution used to manage PCOS, due to its multiple benefits. Yi Jin Jing is an important component of traditional Chinese exercise (TCE), based on the root of traditional Chinese medicine theory (TCM), which focuses on keeping the body as a whole in a harmonious state. However, to date there is no literature on the benign effects of Yi Jin Jing on PCOS. The primary purpose of this protocol is to assess the effectiveness of aerobic exercise versus Yi Jin Jing, on the management of ovarian function in young overweight/obese women with PCOS. Methods: The study will conduct a controlled randomized, superiority trial with three-arm parallel groups, recruiting 90 women diagnosed with PCOS, ages between 18 and 35 years, with a body mass index (BMI) ≥ 23 kg/m Discussion: This proposed study will be the first randomized clinical trial to evaluate the comparative effectiveness of aerobic exercise versus Yi Jin Jing on the management of ovarian function in young overweight/obese women with PCOS. The results may provide a new evidence-based management strategy for young women with PCOS. Trial registration: Chinese Clinical Trial Registry ChiCTR1900022385 . Registered on 9 April 2019.
MeSH term(s)	Adolescent ; Adult ; Anti-Mullerian Hormone ; Exercise ; Female ; Humans ; Obesity/complications ; Obesity/diagnosis ; Obesity/therapy ; Overweight/complications ; Overweight/diagnosis ; Overweight/therapy ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/diagnosis ; Polycystic Ovary Syndrome/therapy ; Randomized Controlled Trials as Topic ; Young Adult
Chemical Substances	Anti-Mullerian Hormone (80497-65-0)
Language	English
Publishing date	2022-06-03
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-022-06377-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dichoptic De-Masking Learning in Adults With Amblyopia and Its Mechanisms.

Liu, Xiang-Yun / Zhang, Jun-Yun

Investigative ophthalmology & visual science

2019 Volume 60, Issue 8, Page(s) 2968–2977

Abstract: Purpose: Recently, we reported that dichoptic de-masking training can further boost stereoacuity, but not visual acuity, in adults with amblyopia after extensive monocular perceptual training. Here, we investigated whether this dichoptic training ... ...

Abstract	Purpose: Recently, we reported that dichoptic de-masking training can further boost stereoacuity, but not visual acuity, in adults with amblyopia after extensive monocular perceptual training. Here, we investigated whether this dichoptic training targets on interocular suppression directly, or improves vision through high-level brain mechanisms. Methods: Eleven adults with amblyopia first used amblyopic eyes (AEs) to perform contrast (n = 6) or orientation (n = 5) discrimination training, while resisting dichoptic noise masking from fellow eyes (FEs). Learning was indicated by increased maximal tolerable noise contrast (TNC) for AE contrast/orientation discrimination. After dichoptic training, six observers continued to use AEs to perform monocular training for nine sessions. Results: (1) Training of dichoptic de-masking doubled maximal TNC, but learning did not transfer much to the same task at an orthogonal orientation or a different task, showing orientation/task specificities. (2) Following a training-plus-exposure (TPE) protocol, AEs then received exposure of the orthogonal orientation by performing the other orientation/contrast discrimination task at the orthogonal orientation. After this TPE training, dichoptic learning with the original discrimination task transferred to the orthogonal orientation. (3) Dichoptic training improved AE's acuity (1.2 lines), stereoacuity (60.2%), and contrast sensitivity (mainly at higher spatial frequencies). (4) Additional monocular training did not produce further acuity and stereoacuity gains. Conclusions: The initial orientation/task specificities exclude the possibility that dichoptic training reduces physiological interocular suppression. The later transfer of learning to an orthogonal orientation with TPE training suggests improvement in high-level brain processing. Dichoptic training may strengthen top-down attention to AEs to counter the impacts of attentional bias to FEs and/or physiological interocular suppression and improve stereoacuity.
MeSH term(s)	Adult ; Amblyopia/physiopathology ; Contrast Sensitivity/physiology ; Female ; Humans ; Learning/physiology ; Male ; Orientation ; Perceptual Masking/physiology ; Sensory Thresholds ; Visual Acuity/physiology ; Young Adult
Language	English
Publishing date	2019-07-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391794-0
ISSN	1552-5783 ; 0146-0404
ISSN (online)	1552-5783
ISSN	0146-0404
DOI	10.1167/iovs.18-26483
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Article ; Online: Promotion of Phenol Electro-oxidation by Oxygen Evolution Reaction on an Active Electrode for Efficient Pollution Control and Hydrogen Evolution.

Qin, Hehe / Wei, Xiaojie / Ye, Ziwei / Liu, Xiangyun / Mao, Shun

Environmental science & technology

2022 Volume 56, Issue 9, Page(s) 5753–5762

Abstract: We report an electrolysis system using NiFe layered double hydroxide/ ... ...

Abstract	We report an electrolysis system using NiFe layered double hydroxide/CoMoO
MeSH term(s)	Electrodes ; Hydrogen ; Oxygen ; Phenol ; Phenols ; Titanium ; Waste Water ; Water Pollutants, Chemical
Chemical Substances	Phenols ; Waste Water ; Water Pollutants, Chemical ; Phenol (339NCG44TV) ; Hydrogen (7YNJ3PO35Z) ; Titanium (D1JT611TNE) ; Oxygen (S88TT14065)
Language	English
Publishing date	2022-04-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.1c08338
Database	MEDical Literature Analysis and Retrieval System OnLINE

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