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  1. Article ; Online: Prostate cancer T-stage intelligent diagnosis based on MRI images and deep learning

    XU Shanshan / HUYAN Ruoxi / WU Zhe / LIU Xiaobing

    陆军军医大学学报, Vol 45, Iss 11, Pp 1229-

    2023  Volume 1236

    Abstract: Objective To explore the advantages of Swin-Transformer (SwinT) network in the intelligent diagnosis of prostate cancer (PCA) based on MRI images by comparing Dense-Net, Res-Net, and Vision-Transformer (ViT) networks. Methods A total of 3 017 MRI images ... ...

    Abstract Objective To explore the advantages of Swin-Transformer (SwinT) network in the intelligent diagnosis of prostate cancer (PCA) based on MRI images by comparing Dense-Net, Res-Net, and Vision-Transformer (ViT) networks. Methods A total of 3 017 MRI images including T2WI and fT2WI from 152 patients with PCA confirmed by puncture biopsy were retrospectively collected from Shanxi Cancer Hospital and Second Affiliated Hospital of Army Medical University between April 2020 and March 2022. According to the results of clinical T stage, these images were divided into low- to middle-risk group (T≤T2c) and high-risk group (T≥T3a). And then, the patients were randomly divided into training set (n=107), verification set (n=15) and test set (n=30) at a ratio of 7:1:2 to train the intelligent T-stage diagnosis models. Finally, accuracy, precision, confusion matrix, receiver operating characteristic (ROC) curves and areas under the curve (AUC) were used to evaluate the performance of intelligent T-stage diagnosis of each network. Results In the low- to middle-risk and high-risk groups, the accuracy and AUC of above 4 networks were 0.587 and 0.630, 0.410 and 0.477, 0.600 and 0.648, and 0.680 and 0.708, respectively. The Grad-CAM of SwinT networks had the attention almost focused on the prostate, showing the best feature extraction. Conclusion Compared with the models based on Dense-Net, Res-Net and ViT networks, the SwinT model achieves the best predictive performance in the task of classification of PCA MRI images. The model can be used for the automatic diagnosis of PCA T-stage, and is helpful to improve diagnostic efficiency.
    Keywords deep learning ; prostate cancer ; t stage diagnosis ; classification ; mri ; Medicine (General) ; R5-920
    Subject code 610
    Language Chinese
    Publishing date 2023-06-01T00:00:00Z
    Publisher Editorial Office of Journal of Army Medical University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Enhancement and Broadening of the Internal Electric Field of Hole-Transport-Layer-Free Perovskite Solar Cells by Quantum Dot Interface Modification.

    Zhang, Wenhu / Zheng, Bowen / Sun, Hairui / Lv, Pin / Liu, Xiaobing

    ACS applied materials & interfaces

    2024  Volume 16, Issue 5, Page(s) 6665–6673

    Abstract: Hole-transport-layer-free perovskite solar cells have attracted strong interest due to their simple structure and low cost, but charge recombination is serious. Built-in electric field engineering is an intrinsic driver to facilitate charge separation ... ...

    Abstract Hole-transport-layer-free perovskite solar cells have attracted strong interest due to their simple structure and low cost, but charge recombination is serious. Built-in electric field engineering is an intrinsic driver to facilitate charge separation transport and improve the efficiency of photovoltaic devices. However, the enhancement of the built-in electric field strength is often accompanied by the narrowing of the space charge region, which becomes a key constraint to the performance improvement of the device. Here, we propose an effective regulation method, the component engineering of quantum dots, to enhance the strength of the built-in electric field and broaden the range of space charge. By using all inorganic CsPbBr
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c17432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Bismuth oxymetallate-modified biochar derived from Euryale ferox husk for efficient removal of Congo red from wastewater: adsorption behavior and mechanisms.

    Zhang, Luxin / Li, Qunshuai / Liu, Xiaobing / Shi, Weiwei / HanYu

    Environmental science and pollution research international

    2024  

    Abstract: Using Euryale ferox husk as raw material, pristine biochar (EBC), ... ...

    Abstract Using Euryale ferox husk as raw material, pristine biochar (EBC), Bi
    Language English
    Publishing date 2024-04-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-024-33106-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The balance between traffic control and economic development in tourist cities under the context of COVID-19: A case study of Xi'an, China.

    Xiang, Wang / Wang, Zezhi / Pan, Xin / Liu, Xiaobing / Yan, Xuedong / Chen, Li

    PloS one

    2024  Volume 19, Issue 1, Page(s) e0295950

    Abstract: Selecting an appropriate intensity of epidemic prevention and control measures is of vital significance to promoting the two-way dynamic coordination of epidemic prevention and control and economic development. In order to balance epidemic control and ... ...

    Abstract Selecting an appropriate intensity of epidemic prevention and control measures is of vital significance to promoting the two-way dynamic coordination of epidemic prevention and control and economic development. In order to balance epidemic control and economic development and suggest scientific and reasonable traffic control measures, this paper proposes a SEIQR model considering population migration and the propagation characteristics of the exposed and the asymptomatic, based on the data of COVID-19 cases, Baidu Migration, and the tourist economy. Further, the factor traffic control intensity is included in the model. After determining the functional relationship between the control intensity and the number of tourists and the cumulative number of confirmed cases, the NSGA-II algorithm is employed to perform multi-objective optimization with consideration of the requirements for epidemic prevention and control and for economic development to get an appropriate traffic control intensity and suggest scientific traffic control measures. With Xi'an City as an example. The results show that the Pearson correlation coefficient between the predicted data of this improved model and the actual data is 0.996, the R-square in the regression analysis is 0.993, with a significance level of below 0.001, suggesting that the predicted data of the model are more accurate. With the continuous rise of traffic control intensity in different simulation scenarios, the cumulative number of cases decreases by a significant amplitude. While balancing the requirements for epidemic prevention and control and for tourist economy development, the model works out the control intensity to be 0.68, under which some traffic control measures are suggested. The model presented in this paper can be used to analyze the impacts of different traffic control intensities on epidemic transmission. The research results in this paper reveal the traffic control measures balancing the requirements for epidemic prevention and control and for economic development.
    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; Cities/epidemiology ; Economic Development ; Epidemics ; China/epidemiology
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0295950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Diagnostic potential of NRG1 in benign nerve sheath tumors and its influence on the PI3K-Akt signaling and tumor immunity.

    Yan, Suwei / Zhao, Jingnan / Gao, Pengyang / Li, Zhaoxu / Li, Zhao / Liu, Xiaobing / Wang, Pengfei

    Diagnostic pathology

    2024  Volume 19, Issue 1, Page(s) 28

    Abstract: Objective: Benign nerve sheath tumors (BNSTs) present diagnostic challenges due to their heterogeneous nature. This study aimed to determine the significance of NRG1 as a novel diagnostic biomarker in BNST, emphasizing its involvement in the PI3K-Akt ... ...

    Abstract Objective: Benign nerve sheath tumors (BNSTs) present diagnostic challenges due to their heterogeneous nature. This study aimed to determine the significance of NRG1 as a novel diagnostic biomarker in BNST, emphasizing its involvement in the PI3K-Akt pathway and tumor immune regulation.
    Methods: Differential genes related to BNST were identified from the GEO database. Gene co-expression networks, protein-protein interaction networks, and LASSO regression were utilized to pinpoint key genes. The CIBERSORT algorithm assessed immune cell infiltration differences, and functional enrichment analyses explored BNST signaling pathways. Clinical samples helped establish PDX models, and in vitro cell lines to validate NRG1's role via the PI3K-Akt pathway.
    Results: Nine hundred eighty-two genes were upregulated, and 375 downregulated in BNST samples. WGCNA revealed the brown module with the most significant difference. Top hub genes included NRG1, which was also determined as a pivotal gene in disease characterization. Immune infiltration showed significant variances in neutrophils and M2 macrophages, with NRG1 playing a central role. Functional analyses confirmed NRG1's involvement in key pathways. Validation experiments using PDX models and cell lines further solidified NRG1's role in BNST.
    Conclusion: NRG1 emerges as a potential diagnostic biomarker for BNST, influencing the PI3K-Akt pathway, and shaping the tumor immune microenvironment.
    MeSH term(s) Humans ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt ; Nerve Sheath Neoplasms ; Algorithms ; Biomarkers ; Tumor Microenvironment ; Neuregulin-1/genetics
    Chemical Substances Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Biomarkers ; NRG1 protein, human ; Neuregulin-1
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2210518-9
    ISSN 1746-1596 ; 1746-1596
    ISSN (online) 1746-1596
    ISSN 1746-1596
    DOI 10.1186/s13000-024-01438-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The impact of traffic control measures on the spread of COVID-19 within urban agglomerations based on a modified epidemic model.

    Xiang, Wang / Chen, Li / Yan, Xuedong / Wang, Bin / Liu, Xiaobing

    Cities (London, England)

    2023  Volume 135, Page(s) 104238

    Abstract: With the spatial structure of urban agglomerations, well-developed transportation networks and close economic ties can increase the risk of intercity transmission of infectious diseases. To reveal the epidemic transmission mechanism in urban ... ...

    Abstract With the spatial structure of urban agglomerations, well-developed transportation networks and close economic ties can increase the risk of intercity transmission of infectious diseases. To reveal the epidemic transmission mechanism in urban agglomerations and to explore the effectiveness of traffic control measures, this study proposes an Urban-Agglomeration-based Epidemic and Mobility Model (UAEMM) based on the reality of urban transportation networks and population mobility factors. Since the model considers the urban population inflow, along with the active intracity population, it can be used to estimate the composition of urban cases. The model was applied to the Chang-Zhu-Tan urban agglomeration, and the results show that the model can better simulate the transmission process of the urban agglomeration for a certain scale of epidemic. The number of cases within the urban agglomeration is higher than the number of cases imported into the urban agglomeration from external cities. The composition of cases in the core cities of the urban agglomeration changes with the adjustment of prevention and control measures. In contrast, the number of cases imported into the secondary cities is consistently greater than the number of cases transmitted within the cities. A traffic control measures discount factor is introduced to simulate the development of the epidemic in the urban agglomeration under the traffic control measures of the first-level response to major public health emergency, traffic blockades in infected areas, and public transportation shutdowns. If none of those traffic control measures had been taken after the outbreak of COVID-19, the number of cases in the urban agglomeration would theoretically have increased to 3879, which is 11.61 times the actual number of cases that occurred. If only one traffic control measure had been used alone, each of the three measures would have reduced the number of cases in the urban agglomeration to 30.19 %-57.44 % of the theoretical values of infection cases, with the best blocking effect coming from the first-level response to major public health emergency. Traffic control measures have a significant effect in interrupting the spread of COVID-19 in urban agglomerations. The methodology and main findings presented in this paper are of general interest and can also be used in studies in other countries for similar purposes to help understand the spread of COVID-19 in urban agglomerations.
    Language English
    Publishing date 2023-02-13
    Publishing country England
    Document type Journal Article
    ISSN 0264-2751
    ISSN 0264-2751
    DOI 10.1016/j.cities.2023.104238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Immunological characterization and function analysis of L-type lectin from spotted knifejaw,

    Liu, Jinxiang / Liu, Xiaobing / Wang, Zhigang / Zhang, Quanqi

    Frontiers in immunology

    2022  Volume 13, Page(s) 993777

    Abstract: Lily-type lectin (LTL) plays significant roles in innate immune response against pathogen infection. LTL in animals and plants has received widespread attention. In the present study, an LTL (OppLTL) was identified from spotted ... ...

    Abstract Lily-type lectin (LTL) plays significant roles in innate immune response against pathogen infection. LTL in animals and plants has received widespread attention. In the present study, an LTL (OppLTL) was identified from spotted knifejaw
    MeSH term(s) Animals ; Fishes ; HEK293 Cells ; Humans ; Immunity, Innate ; Lectins/metabolism ; Mammals/metabolism ; NF-kappa B
    Chemical Substances Lectins ; NF-kappa B
    Language English
    Publishing date 2022-09-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.993777
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Establishment of a Nomogram Model for Predicting Cardiovascular and Cerebrovascular Events in Diabetic Nephropathy Patients Receiving Maintenance Hemodialysis.

    Liu, Xiaobing / Yan, Caili / Niu, Xiuxiu / Zeng, Jiechun

    publication RETRACTED

    Applied bionics and biomechanics

    2022  Volume 2022, Page(s) 2909726

    Abstract: Objective: The objective of this study is to explore the risk factors of cardiovascular and cerebrovascular events (CCE) in patients with diabetic nephropathy (DN) receiving maintenance hemodialysis, and to establish a nomogram model on this basis.: ... ...

    Abstract Objective: The objective of this study is to explore the risk factors of cardiovascular and cerebrovascular events (CCE) in patients with diabetic nephropathy (DN) receiving maintenance hemodialysis, and to establish a nomogram model on this basis.
    Method: 144 patients with DN receiving maintenance hemodialysis from February 2020 to February 2021 were selected and followed up for 12 months. They were divided into the occurrence and nonoccurrence groups according to whether CCE occurred. The multivariate logistic regression analysis was used to analyze the influencing factors of CCE, and a predictive nomogram model was established. The receiver operating characteristic (ROC) curve was drawn to evaluate the predictive effect of the nomogram model. The Hosmer-Lemeshow method was used to test the calibration degree.
    Results: Among the patients, 63 patients (43.75%) encountered CCE. Multivariate logistic regression analysis showed that age >60 years old, history of CCE, dialysis age >12 months, systolic blood pressure >140 mmHg, blood phosphorus level >1.5 mmol/L, triglyceride (TG) level >2.30 mmol/l, adiponectin (ADPN) level <5 mg/L, high-sensitivity-C-reactive protein (hs-CRP) level >10 mg/L, hemoglobin (Hb) level <120 g/L, serum creatinine (SCr) level >720 
    Conclusion: Age, history of CCE, dialysis age, systolic blood pressure and serum phosphorus, and TG, ADPN, hs-CRP, Hb, SCr, and ALB levels are all influencing factors for the occurrence of CCE in patients with DN receiving maintenance hemodialysis, and the nomogram model has a great predictive effect on CCE.
    Language English
    Publishing date 2022-07-07
    Publishing country Egypt
    Document type Journal Article ; Retracted Publication
    ZDB-ID 2179924-6
    ISSN 1754-2103 ; 1176-2322
    ISSN (online) 1754-2103
    ISSN 1176-2322
    DOI 10.1155/2022/2909726
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Determination of benzimidazoles in fruits by open-tubular capillary electrochromatography based on ionic liquids grafted covalent organic frameworks.

    Liu, Cuicui / Zhao, Buyi / Liu, Xiaobing / Zhang, Ailin

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

    2022  Volume 38, Issue 10, Page(s) 1277–1287

    Abstract: A novel capillary electrochromatography method has been developed for the simultaneous quantification of ten benzimidazole fungicides in fruits. Herein, covalent organic frameworks (COFs) and ionic liquids (ILs) were successfully introduced to prepare ... ...

    Abstract A novel capillary electrochromatography method has been developed for the simultaneous quantification of ten benzimidazole fungicides in fruits. Herein, covalent organic frameworks (COFs) and ionic liquids (ILs) were successfully introduced to prepare open-tubular capillary column to improve the loading capacity and separation performance. The parameters effecting the analytical performance including pH and concentration of running buffer, separation voltage and the addition of organic solvent were investigated systematically. Under the optimized conditions, the method allowed the baseline separation of ten benzimidazole fungicides, and showed a good linearity in the range of 3.5-200 μg kg
    MeSH term(s) Benzimidazoles ; Capillary Electrochromatography/methods ; Fruit ; Fungicides, Industrial ; Ionic Liquids ; Metal-Organic Frameworks/chemistry
    Chemical Substances Benzimidazoles ; Fungicides, Industrial ; Ionic Liquids ; Metal-Organic Frameworks
    Language English
    Publishing date 2022-07-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1483376-1
    ISSN 1348-2246 ; 1348-2246
    ISSN (online) 1348-2246
    ISSN 1348-2246
    DOI 10.1007/s44211-022-00157-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A large left ventricle and extremely low ejection fraction in a 5-month-old girl with ALCAPA.

    Yu, Juemin / Liu, Xiaobing / Zhuang, Jian

    Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

    2022  Volume 69, Page(s) 71–72

    MeSH term(s) Female ; Humans ; Infant ; Bland White Garland Syndrome ; Heart Ventricles/diagnostic imaging ; Stroke Volume ; Coronary Vessel Anomalies ; Pulmonary Artery
    Language English
    Publishing date 2022-09-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2215027-4
    ISSN 2241-5955 ; 1109-9666
    ISSN (online) 2241-5955
    ISSN 1109-9666
    DOI 10.1016/j.hjc.2022.09.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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