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Article ; Online: Transcriptomic analysis identifies diagnostic genes in polycystic ovary syndrome and periodontitis.

Liu, Xiaodan / Zhang, Jingran / Wang, Xiao / Zhang, Zhihui

2024 Volume 29, Issue 1, Page(s) 3

Abstract: Purpose: To investigate underlying co-mechanisms of PCOS and periodontitis through transcriptomic approach.: Methods: PCOS and periodontitis gene expression data were downloaded from the GEO database to identify differentially expressed genes. GO and ...

Abstract	Purpose: To investigate underlying co-mechanisms of PCOS and periodontitis through transcriptomic approach. Methods: PCOS and periodontitis gene expression data were downloaded from the GEO database to identify differentially expressed genes. GO and KEGG pathway enrichment analysis and random forest algorithm were used to screen hub genes. GSEA analyzed the functions of hub genes. Correlations between hub genes and immune infiltration in two diseases were examined, constructing a TF-ceRNA regulatory network. Clinical samples were gathered from PCOS and periodontitis patients and RT-qPCR was performed to verify the connection. Results: There were 1661 DEGs in PCOS and 701 DEGs in periodontitis. 66 intersected genes were involved and were enriched in immune and inflammation-related biological pathways. 40 common genes were selected from the PPI network. RF algorithm demonstrated that ACSL5, NLRP12, CCRL2, and CEACAM3 were hub genes, and GSEA results revealed their close relationship with antigen processing and presentation, and chemokine signaling pathway. RT-qPCR results confirmed the upregulated gene expression in both PCOS and periodontitis. Conclusion: The 4 hub genes ACSL5, NLRP12, CCRL2, and CEACAM3 may be diagnostic genes for PCOS and periodontitis. The created ceRNA network could provide a molecular basis for future studies on the association between PCOS and periodontitis.
MeSH term(s)	Female ; Humans ; Polycystic Ovary Syndrome/genetics ; Periodontitis/genetics ; Gene Expression Profiling ; Inflammation ; Transcriptome/genetics ; RNA, Competitive Endogenous ; Computational Biology ; Carcinoembryonic Antigen
Chemical Substances	RNA, Competitive Endogenous ; CEACAM3 protein, human ; Carcinoembryonic Antigen
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1329381-3
ISSN	2047-783X ; 0949-2321
ISSN (online)	2047-783X
ISSN	0949-2321
DOI	10.1186/s40001-023-01499-4
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Article: Targeted next-generation sequencing of 491 lung cancers in clinical practice: Implications for future detection strategy and targeted therapy.

Liu, Xiao-Dan / Zhang, Yan / He, Hui-Ying

Heliyon

2024 Volume 10, Issue 6, Page(s) e27591

Abstract: Although lung cancer remains the most common cause of global cancer-related mortality, the identiﬁcation of oncogenic driver alterations and the development of targeted drugs has dramatically altered the therapeutic landscape. In this retrospective study, ...

Abstract	Although lung cancer remains the most common cause of global cancer-related mortality, the identiﬁcation of oncogenic driver alterations and the development of targeted drugs has dramatically altered the therapeutic landscape. In this retrospective study, we found that 97.7% samples carried at least one mutation in the 25 genes tested in our cohort. 53.6% samples were positive for EGFR mutations, followed by TP53 (41.1%), KRAS (11.8%), ERBB2 (4.3%). EGFR mutations were mainly found in female adenocarcinomas, while TP53 was mainly found in male non-adenocarcinomas. Significant differences can be found in the mutation rate of EGFR (60.9% vs 11.9%), KRAS (12.2% vs 25.0%), STK11 (1.5% vs 11.9%), FGFR3 (2.4% vs 0.0%) and ERBB4 (1.2% vs 6.1%) between adenocarcinoma in our cohort and TCGA-LUAD data (all p < 0.001). What's more, we found that the mutation of EGFR increased significantly from adenocarcinomas in situ (AIS, 21.4%) to microinvasive adenocarcinomas (MIA, 52.4%) and invasive adenocarcinomas (IA, 61.1%), while the mutation of ERBB2 dropped markedly from AIS (21.4%) to MIA (9.5%) and IA (4.1%). At last, comparations between targeted NGS and ARMS-based single gene test in the detection of EGFR showed a 94.6% consistence. In conclusion, targeted NGS can provide a comprehensive mutational profile of lung cancer. Considering the high mutation rate of EGFR in NSCLC of Asian populations, a specialized detection strategy should be conducted.
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e27591
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Article: Chromosome Rearrangement in

Jiang, Chengzhi / Liu, Xiaodan / Yang, Zujun / Li, Guangrong

Plants (Basel, Switzerland)

2023 Volume 12, Issue 18

Abstract: As a perennial herb in Triticeae, ...

Abstract	As a perennial herb in Triticeae,
Language	English
Publishing date	2023-09-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants12183268
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Article ; Online: Integrated pancancer analysis reveals the oncogene characteristics and prognostic value of DIP2B in breast cancer.

Song, Chengyang / Shang, Fangjian / Tu, Wei / Liu, Xiaodan

BMC cancer

2023 Volume 23, Issue 1, Page(s) 296

Abstract: Background: Disco-interaction protein 2 homologue B (DIP2B) plays an important role in DNA methylation. There have been many reports on DIP2B in various diseases, but neither the diagnostic value nor the prognostic value of DIP2B across cancer types has ...

Abstract	Background: Disco-interaction protein 2 homologue B (DIP2B) plays an important role in DNA methylation. There have been many reports on DIP2B in various diseases, but neither the diagnostic value nor the prognostic value of DIP2B across cancer types has been deeply explored. Methods: The expression levels of DIP2B in 33 cancer types were analysed based on data sets from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) database. The relationships of DIP2B expression with immune cell infiltration and immune-related gene expression were studied via the CIBERSORT, ESTIMATE and TISIDB tools. Gene set variation analysis (GSVA) was performed to identify pathways related to DIP2B. DIP2B knockdown by siRNA was performed in breast cancer cell lines to investigate the effect on proliferation, apoptosis and migration. The relationships of DIP2B expression with clinicopathological features and prognosis were analysed based on immunohistochemistry. Results: DIP2B was highly expressed in 26 of 33 cancer types and was significantly associated with poor overall survival (OS) in breast invasive carcinoma (BRCA), mesothelioma and chromophobe renal cell carcinoma (each P < 0.05). DIP2B showed a negative correlation with the immune score, the infiltration levels of key immune killer cells (CD8 + T cells, activated NK cells and plasma cells), and the expression of major histocompatibility complex-related genes and chemokine-related genes in BRCA. Subtype analysis showed that DIP2B expression was associated with poor OS in Her-2 + BRCA patients (P < 0.05). DIP2B showed a negative correlation with immune killer cell infiltration and immune regulatory genes in BRCA subtypes. In BRCA, the GSVA results revealed that genes correlating positively with DIP2B were enriched in cancer-related pathways (PI3K-AKT) and cell-cycle-related pathways (MITOTIC_SPINDLE, G2M_CHECKPOINT and E2F_TARGETS), while genes correlating negatively with DIP2B were enriched in DNA_REPAIR. Knockdown of the DIP2B gene induced a reduction in proliferation and migration and an increase in apoptosis in breast cancer cell lines. DIP2B expression was associated with lymph node metastasis and poor histological grade in BRCA according to immunohistochemistry (each P < 0.05). DIP2B expression predicted reduced disease-free survival and OS in BRCA patients (each P < 0.05), especially those with the Her-2 + subtype (P = 0.023 and P = 0.069). Conclusions: DIP2B may be a prognostic biomarker for BRCA, especially for the Her-2 + subtype. DIP2B is associated with a "cold" tumour immune microenvironment in BRCA and might serve as a future target for immunotherapy.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/genetics ; Prognosis ; Phosphatidylinositol 3-Kinases ; Oncogenes ; Kidney Neoplasms ; Tumor Microenvironment ; Nerve Tissue Proteins
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; DIP2B protein, human ; Nerve Tissue Proteins
Language	English
Publishing date	2023-03-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-023-10751-3
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Article ; Online: Snakehead vesiculovirus (SHVV) leader RNA interacts with host antiviral factors RPS8 and L13a and promotes virus replication.

Ji, Yan / Cheng, Rui / Zhou, Xuan / Zhang, Jiaqi / Liu, Xiaodan / Sheng, Suhong / Zhang, Chi

Fish & shellfish immunology

2024 Volume 148, Page(s) 109466

Abstract: To evade host antiviral response, viruses have evolved to take advantage of their noncoding RNAs (ncRNAs). Snakehead vesiculovirus (SHVV), a newly isolated fish rhabdovirus from diseased hybrid snakehead, has caused high mortality to the cultured ... ...

Abstract	To evade host antiviral response, viruses have evolved to take advantage of their noncoding RNAs (ncRNAs). Snakehead vesiculovirus (SHVV), a newly isolated fish rhabdovirus from diseased hybrid snakehead, has caused high mortality to the cultured snakehead fish during the past years in China. However, little is known about the mechanisms of its pathogenicity. Our study revealed that overexpression of the 30-nt leader RNA promoted SHVV replication. RNA-protein binding investigation revealed that SHVV leader RNA could interact with host 40S ribosomal protein S8 (RPS8) and 60S ribosomal protein L13a (L13a). Furthermore, we found that SHVV infection upregulated RPS8 and L13a, and in turn, overexpression of RPS8 or L13a inhibited, while knockdown of RPS8 or L13a promoted, SHVV replication, suggesting that RPS8 and L13a acted as host antiviral factors in response to SHVV infection. In addition, our study revealed that RPS8- or L13a-mediated inhibition of SHVV replication could be restored by co-transfection with leader RNA, suggesting that the interaction between leader RNA and RPS8 or L13a might affect the anti-SHVV effects of RPS8 and L13a. Taken together, these results suggest that SHVV leader RNA can interact with the host antiviral factors RPS8 and L13a, and promote SHVV replication. This study provides a better understanding of the molecular mechanism of the pathogenesis of SHVV and a potential antiviral strategy against SHVV infection.
MeSH term(s)	Animals ; Perciformes/physiology ; Vesiculovirus/genetics ; RNA, Viral/genetics ; Virus Replication ; Antiviral Agents/pharmacology
Chemical Substances	RNA, Viral ; Antiviral Agents
Language	English
Publishing date	2024-03-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1067738-0
ISSN	1095-9947 ; 1050-4648
ISSN (online)	1095-9947
ISSN	1050-4648
DOI	10.1016/j.fsi.2024.109466
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Article ; Online: Identification and verification of inflammatory biomarkers for primary Sjögren's syndrome.

Liu, Xiaodan / Wang, Haojie / Wang, Xiao / Jiang, Xiaodan / Jin, Yinji / Han, Ying / Zhang, Zhihui

Clinical rheumatology

2024 Volume 43, Issue 4, Page(s) 1335–1352

Abstract: Introduction: Primary Sjögren's syndrome (pSS) is an autoimmune disease characterized by inflammatory infiltration, and dysfunction of the salivary and lacrimal glands. This research aimed to explore the disease pathogenesis and improve the diagnosis ... ...

Abstract	Introduction: Primary Sjögren's syndrome (pSS) is an autoimmune disease characterized by inflammatory infiltration, and dysfunction of the salivary and lacrimal glands. This research aimed to explore the disease pathogenesis and improve the diagnosis and treatment of pSS by mining inflammation-associated biomarkers. Methods: Five pSS-related datasets were retrieved from the Gene Expression Omnibus (GEO) database. Inflammation-associated biomarkers were determined by the least absolute shrinkage and selection operator (LASSO) and support vector machines recursive feature elimination (SVM-RFE). Single sample gene set enrichment analysis (ssGSEA) was implemented to profile the infiltration levels of immune cells. Real-time quantitative PCR (RT-qPCR) verified the expression of biomarkers in clinical samples. Results: Four genes (LY6E, EIF2AK2, IL15, and CXCL10) were screened as inflammation-associated biomarkers in pSS, the predictive performance of which were determined among three pSS-related datasets (AUC > 0.7). Functional enrichment results suggested that the biomarkers were involved in immune and inflammation-related pathways. Immune infiltration analysis revealed that biomarkers were notably connected with type 2 T helper cells, regulatory T cells which were significantly expressed between pSS and control. TESTOSTERONE and CYCLOSPORINE were predicted to take effect by targeting CXCL10 and IL15 in pSS, respectively. Conclusion: Four inflammation-associated biomarkers (LY6E, EIF2AK2, IL15, and CXCL10) were explored, and the underlying regulatory mechanisms and targeted drugs associated with these biomarkers were preliminarily investigated according to a series of bioinformatics methods based on the online datasets of pSS, which provided a reference for understanding the pathogenesis of pSS. Key Points • Inflammation-associated biomarkers (LY6E, EIF2AK2, IL15, and CXCL10) were firstly identified in Sjögren's syndrome based on LASSO and SVM-RFE analyses. • CXCL10, EIF2AK2 and LY6E were prominently positively correlated with immature B cells, while IL15 were significantly negatively correlated with memory B cells in Sjögren's syndrome. • LY6E, EIF2AK2, IL15, and CXCL10 were significantly more highly expressed in clinical Sjögren's syndrome samples compared to healthy control samples, which was consistent with the analysis results of the GEO database. •LY6E, EIF2AK2, IL15, and CXCL10 might be used as the biomarkers for the treatment and diagnosis of Sjögren's syndrome.
MeSH term(s)	Humans ; Sjogren's Syndrome/pathology ; Interleukin-15 ; Biomarkers/metabolism ; Autoimmune Diseases ; Inflammation
Chemical Substances	Interleukin-15 ; Biomarkers
Language	English
Publishing date	2024-02-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	604755-5
ISSN	1434-9949 ; 0770-3198
ISSN (online)	1434-9949
ISSN	0770-3198
DOI	10.1007/s10067-024-06901-y
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Article ; Online: Application and development of a TaqMan-based real-time PCR assay for rapid detection of snakehead vesiculovirus.

Gong, Cuiping / Zhu, Panpan / Ye, Jiaxin / Lou, Jianfeng / Zhang, Liwen / Liu, Xiaodan / Kong, Weiguang

FEMS microbiology letters

2024 Volume 371

Abstract: Snakehead vesiculovirus (SHVV) is one of the primary pathogens responsible for viral diseases in the snakehead fish. A TaqMan-based real-time PCR assay was established for the rapid detection and quantification of SHVV in this study. Specific primers and ...

Abstract	Snakehead vesiculovirus (SHVV) is one of the primary pathogens responsible for viral diseases in the snakehead fish. A TaqMan-based real-time PCR assay was established for the rapid detection and quantification of SHVV in this study. Specific primers and fluorescent probes were designed for phosphoprotein (P) gene, and after optimizing the reaction conditions, the results indicated that the detection limit of this method could reach 37.1 copies, representing a 100-fold increase in detection sensitivity compared to RT-PCR. The specificity testing results revealed that this method exhibited no cross-reactivity with ISKNV, LMBV, RSIV, RGNNV, GCRV, and CyHV-2. Repetition experiments demonstrated that both intra-batch and inter-batch coefficients of variation were not higher than 1.66%. Through in vitro infection experiments monitoring the quantitative changes of SHVV in different tissues, the results indicated that the liver and spleen exhibited the highest viral load at 3 poi. The TaqMan-based real-time PCR method established in this study exhibits high sensitivity, excellent specificity, and strong reproducibility. It can be employed for rapid detection and viral load monitoring of SHVV, thus providing a robust tool for the clinical diagnosis and pathogen research of SHVV.
MeSH term(s)	Animals ; Perciformes/genetics ; Vesiculovirus/genetics ; Real-Time Polymerase Chain Reaction ; Fish Diseases/diagnosis ; Reproducibility of Results ; Rhabdoviridae Infections ; Iridoviridae/genetics ; Sensitivity and Specificity
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	752343-9
ISSN	1574-6968 ; 0378-1097
ISSN (online)	1574-6968
ISSN	0378-1097
DOI	10.1093/femsle/fnae018
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Article ; Online: Toxicity comparison of benzophenone-3 and its metabolite benzophenone-8 in different tissues of zebrafish.

Wang, Yonghua / Shang, Yujia / Liu, Xiaodan / Chen, Xi / Xu, Guanhua / Lu, Guanghua

Aquatic toxicology (Amsterdam, Netherlands)

2024 Volume 268, Page(s) 106852

Abstract: Benzophenone-3 (BP-3) is a commonly used ultraviolet absorber that has the potential to accumulate in organisms, leading to toxicity. Benzophenone-8 (BP-8) is one of the major metabolites of BP-3. In this study, zebrafish were exposed to different ... ...

Abstract	Benzophenone-3 (BP-3) is a commonly used ultraviolet absorber that has the potential to accumulate in organisms, leading to toxicity. Benzophenone-8 (BP-8) is one of the major metabolites of BP-3. In this study, zebrafish were exposed to different concentrations of BP-3 and BP-8 (1 μg/L, 30 μg/L, and 300 μg/L) to investigate their accumulation and toxic effects in various tissues, including zebrafish brain, gut, and liver. The analysis focused on neurotoxicity, oxidative damage, inflammation, and gene expressions. The results showed that both BP-3 and BP-8 accumulated in the tissues, with the highest concentration observed in the gut, followed by the liver and brain. BP-8 exhibited a stronger ability to accumulate. In the brain, exposure to 1 μg/L of BP-3 and BP-8 promoted cortisol production, while higher exposures (30 μg/L and 300 μg/L) inhibited acetylcholinesterase activity and suppressed cortisol production. In the gut, both BP-3 and BP-8 exposures disrupted oxidative stress, inflammatory immunity, and apoptosis functions. In the liver, BP-3 and BP-8 affected hepatic metabolism, oxidative stress, apoptosis, and inflammatory immunity. Comparing gene expression in the brain, gut, and liver, it was found that BP-3 and BP-8 had a lower effect on gene expression in the brain, while the effect on the gut and liver was significantly higher. BP-8 generally had a higher effect than BP-3, which aligns with the observed accumulation pattern. These findings provide valuable insights for the risk assessment of BP-3 and BP-8 in the aquatic environment.
MeSH term(s)	Animals ; Zebrafish/metabolism ; Acetylcholinesterase/metabolism ; Hydrocortisone ; Water Pollutants, Chemical/toxicity ; Benzophenones/toxicity
Chemical Substances	oxybenzone (95OOS7VE0Y) ; Acetylcholinesterase (EC 3.1.1.7) ; Hydrocortisone (WI4X0X7BPJ) ; Water Pollutants, Chemical ; benzophenone (701M4TTV9O) ; Benzophenones
Language	English
Publishing date	2024-01-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782699-0
ISSN	1879-1514 ; 0166-445X
ISSN (online)	1879-1514
ISSN	0166-445X
DOI	10.1016/j.aquatox.2024.106852
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Article ; Online: Aerobic exercise training engages the canonical wnt pathway to improve pulmonary function and inflammation in COPD.

Li, Peijun / Han, Xiaoyu / Li, Jian / Wang, Yingqi / Cao, Yuanyuan / Wu, Weibing / Liu, Xiaodan

BMC pulmonary medicine

2024 Volume 24, Issue 1, Page(s) 236

Abstract: Background: We studied whether the exercise improves cigarette smoke (CS) induced chronic obstructive pulmonary disease (COPD) in mice through inhibition of inflammation mediated by Wnt/β-catenin-peroxisome proliferator-activated receptor (PPAR) γ ... ...

Abstract	Background: We studied whether the exercise improves cigarette smoke (CS) induced chronic obstructive pulmonary disease (COPD) in mice through inhibition of inflammation mediated by Wnt/β-catenin-peroxisome proliferator-activated receptor (PPAR) γ signaling. Methods: Firstly, we observed the effect of exercise on pulmonary inflammation, lung function, and Wnt/β-catenin-PPARγ. A total of 30 male C57BL/6J mice were divided into the control group (CG), smoke group (SG), low-intensity exercise group (LEG), moderate-intensity exercise group (MEG), and high-intensity exercise group (HEG). All the groups, except for CG, underwent whole-body progressive exposure to CS for 25 weeks. Then, we assessed the maximal exercise capacity of mice from the LEG, MEG, and HEG, and performed an 8-week treadmill exercise intervention. Then, we used LiCl (Wnt/β-catenin agonist) and XAV939 (Wnt/β-catenin antagonist) to investigate whether Wnt/β-catenin-PPARγ pathway played a role in the improvement of COPD via exercise. Male C57BL/6J mice were randomly divided into six groups (n = 6 per group): CG, SG, LiCl group, LiCl and exercise group, XAV939 group, and XAV939 and exercise group. Mice except those in the CG were exposed to CS, and those in the exercise groups were subjected to moderate-intensity exercise training. All the mice were subjected to lung function test, lung histological assessment, and analysis of inflammatory markers in the bronchoalveolar lavage fluid, as well as detection of Wnt1, β-catenin and PPARγ proteins in the lung tissue. Results: Exercise of various intensities alleviated lung structural changes, pulmonary function and inflammation in COPD, with moderate-intensity exercise exhibiting significant and comprehensive effects on the alleviation of pulmonary inflammation and improvement of lung function. Low-, moderate-, and high-intensity exercise decreased β-catenin levels and increased those of PPARγ significantly, and only moderate-intensity exercise reduced the level of Wnt1 protein. Moderate-intensity exercise relieved the inflammation aggravated by Wnt agonist. Wnt antagonist combined with moderate-intensity exercise increased the levels of PPARγ, which may explain the highest improvement of pulmonary function observed in this group. Conclusions: Exercise effectively decreases COPD pulmonary inflammation and improves pulmonary function. The beneficial role of exercise may be exerted through Wnt/β-catenin-PPARγ pathway.
MeSH term(s)	Animals ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Pulmonary Disease, Chronic Obstructive/metabolism ; Male ; Wnt Signaling Pathway/physiology ; Mice, Inbred C57BL ; Mice ; Physical Conditioning, Animal/physiology ; PPAR gamma/metabolism ; Disease Models, Animal ; Lung/metabolism ; Lung/physiopathology ; Inflammation/metabolism
Language	English
Publishing date	2024-05-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-024-03048-z
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Article: Determinants of rural household clean energy adoption intention: Evidence from 72 typical villages in ecologically fragile regions of western China

Li, Lingyan / Fan, Fangmei / Liu, Xiaodan

Journal of cleaner production. 2022 May 01, v. 347

2022

Abstract: Encouraging efficient use of clean energy by farmers is central to promoting energy transformation in ecologically fragile regions of western China. However, existing research has not yet characterized the influencing factors and internal mechanism of ... ...

Abstract	Encouraging efficient use of clean energy by farmers is central to promoting energy transformation in ecologically fragile regions of western China. However, existing research has not yet characterized the influencing factors and internal mechanism of farmers’ clean energy adoption intention, which lead to the problem of misalignment in clean energy-promotion policies. In this study, 72 typical villages in three ecologically fragile loess, alpine, and karst areas in western China were targeted for research. Combining the theory of planned behavior with social cognition, a research model was constructed from the perspective of “external factors-internal psychology-adoption intention.” Then, 645 valid questionnaires were empirically analyzed by structural equation and hierarchical regression. The results show that psychological factors create multiple parallel mediating effects between energy attribute factors and adoption intention, and herd mentality is a crucial factor of farmers' clean energy adoption intention. Command-and-control policy instruments have a partial reverse moderating effect, while economic incentives and publicity and guidance policy instruments have positive moderating effects on the relationship between psychological factors and adoption intention. The results are helpful for policymakers seeking to implement effective measures to guide farmers in ecologically fragile regions of western China toward large scale use of clean energy.
Keywords	clean energy ; cognition ; energy conversion ; equations ; herds ; karsts ; loess ; models ; China
Language	English
Dates of publication	2022-0501
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0959-6526
DOI	10.1016/j.jclepro.2022.131296
Database	NAL-Catalogue (AGRICOLA)

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