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Article ; Online: The Relationship between Muscle Ultrasound Parameters and Diabetic Peripheral Neuropathy among Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study.

Zhong, Yanling / Liu, Xiaojia / Lin, Teng

2023 Volume 2023, Page(s) 8897065

Abstract: Background: Muscle dysfunction is an early complication of diabetic peripheral neuropathy (DPN). As a convenient and low-cost tool, muscle ultrasound has been used to assess muscle quality and muscle mass. However, the relationship between different ... ...

Abstract	Background: Muscle dysfunction is an early complication of diabetic peripheral neuropathy (DPN). As a convenient and low-cost tool, muscle ultrasound has been used to assess muscle quality and muscle mass. However, the relationship between different muscle ultrasound parameters and DPN is unclear. Objectives: This study was designed to investigate the relationship between ultrasound parameters of different muscles and DPN among patients with type 2 diabetes mellitus, including the rectus femoris (RF), tibialis anterior (TA), and medial head of gastrocnemius (MG). Materials and methods: The research enrolled 90 patients with type 2 diabetes mellitus (T2DM). All images were attained from both sides. Muscle measurements contained muscle thickness (MT), cross-sectional area (CSA), echo intensity (EI), and corrected EI. The binary logistic regression and multiple linear regression were used to investigate the association between muscle ultrasound parameters and DPN or vibration perception threshold (VPT). Results: EI, corrected EI, MT of MG, and EI of TA were associated with DPN separately after adjusting other clinical variates. Among these muscle parameters, the EI of MG had a better predictive value (OR: 1.114, 95% CI: 1.039, 1.196) of DPN. Combined with CSA of RF, peripheral artery disease (PAD), and sex, the corrected EI of MG was associated with the vibration perception threshold (VPT) (standard Conclusions: MG (MT, EI, and corrected EI) and TA (EI) were associated with DPN, respectively. CSA of RF and corrected EI or EI of MG combined with PAD and sex were associated with VPT significantly, which supported that muscle ultrasound might be a substantial quantitative tool for detecting the exercise benefits for DPN.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diagnostic imaging ; Diabetic Neuropathies/diagnosis ; Cross-Sectional Studies ; Perception/physiology ; Muscle, Skeletal/diagnostic imaging ; Peripheral Arterial Disease/complications
Language	English
Publishing date	2023-12-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2711897-6
ISSN	2314-6753 ; 2314-6753
ISSN (online)	2314-6753
ISSN	2314-6753
DOI	10.1155/2023/8897065
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Article ; Online: Grading criteria for venous invasion in thoracic esophageal squamous cell carcinoma.

Wang, An / Liu, Xiaojia / Lu, Lu / Wang, Shaohua / Chen, Xiaofeng

Journal of cardiothoracic surgery

2023 Volume 18, Issue 1, Page(s) 111

Abstract: Background: Venous invasion (VI) is an adverse prognostic indicator in esophageal squamous cell carcinoma. However, grading criteria for venous invasion in thoracic esophageal squamous cell carcinoma (ESCC) have not been established.: Methods: We ... ...

Abstract	Background: Venous invasion (VI) is an adverse prognostic indicator in esophageal squamous cell carcinoma. However, grading criteria for venous invasion in thoracic esophageal squamous cell carcinoma (ESCC) have not been established. Methods: We enrolled 598 thoracic ESCC patients from 2005 to 2017. We detected the presence of venous invasion using the hematoxylin and eosin (H&E)-staining method and evaluated the VI grade on the basis of the number and maximal size of the involved veins. The degree of VI was classified as either 0, V1, V2, or V3, according to the combination of V-number and V-size. Results: The 1-year, 3-year and 5-year disease-free survival rates were 79.7%, 64.7% and 61.2%, respectively. Multivariate analysis demonstrated that lymphatic invasion (HR: 1.457, 95% CI: 1.058-2.006, p = 0.021), T category (HR: 1.457, 95% CI: 1.058-2.006, p = 0.022), N category (HR: 1.535, 95% CI: 1.276-2.846, p < 0.001), stage (HR: 1.563, 95% CI: 1.235-1.976, p < 0.001) and the degree of venous invasion (HR: 1.526, 95% CI: 1.279-2.822, p < 0.001) were significant indicators of recurrence. The disease-free survival curves were distinguished especially well by the degree of venous invasion in stage III and IV patients. Conclusions: The present study explored an objective grading criterion for VI and proved the prognostic value of the degree of venous invasion in ESCC. The classification of venous invasion into 4 groups is useful for the differentiation of prognosis in ESCC patients. The prognostic significance of the degree of VI in advanced ESCC patients for recurrence may have to be considered.
MeSH term(s)	Humans ; Esophageal Squamous Cell Carcinoma/pathology ; Esophageal Neoplasms/pathology ; Prognosis ; Disease-Free Survival ; Neoplasm Staging
Language	English
Publishing date	2023-04-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-023-02272-8
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Article ; Online: Efficacy of pulsed dye laser combined with fractional CO

Liu, Xiao-Jia / Lei, Ying / Gold, Michael H / Tan, Jun

Lasers in surgery and medicine

2023 Volume 55, Issue 5, Page(s) 464–470

Abstract: Objective: The present study aimed to investigate the efficacy and safety of pulsed dye laser (PDL) combined with fractional CO: Methods: The present retrospective study enrolled 60 pediatric patients with burn scars from July 2017 to June 2021. In ... ...

Abstract	Objective: The present study aimed to investigate the efficacy and safety of pulsed dye laser (PDL) combined with fractional CO Methods: The present retrospective study enrolled 60 pediatric patients with burn scars from July 2017 to June 2021. In the 4-month treatment period, all patients received PDL treatment every 1 month and received fractional CO Results: Among all patients, 38 (63.33%) cases were scald-induced scars and 22 (36.67%) cases were burn-induced scars. The mean diameter of the scar area was 107.53 ± 2.92 cm Conclusion: The combination of PDL and fractional CO
MeSH term(s)	Humans ; Child ; Cicatrix/etiology ; Cicatrix/therapy ; Cicatrix/pathology ; Carbon Dioxide ; Lasers, Dye/therapeutic use ; Cicatrix, Hypertrophic/pathology ; Retrospective Studies ; Treatment Outcome ; Lasers, Gas/therapeutic use ; Burns/complications ; Burns/therapy
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Case Reports
ZDB-ID	604493-1
ISSN	1096-9101 ; 0196-8092
ISSN (online)	1096-9101
ISSN	0196-8092
DOI	10.1002/lsm.23648
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Article ; Online: Familial amyotrophic lateral sclerosis induced by gene mutation of SOD1G142A: a case report.

Cui, Xiangqin / Gao, Min / Huang, Yuanhua / Liu, Xiaojia / Xu, Yunqi

Annals of palliative medicine

2022 Volume 10, Issue 12, Page(s) 12900–12905

Abstract: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease involving both upper and lower motor neurons. The total prevalence of ALS is [2-9]/100,000, with an annual incidence rate of 3/100,000. The disease progresses rapidly and clinically is ... ...

Abstract	Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease involving both upper and lower motor neurons. The total prevalence of ALS is [2-9]/100,000, with an annual incidence rate of 3/100,000. The disease progresses rapidly and clinically is considered to be progressive degeneration of the upper and lower motor neurons. Although this is a kind of rare disease, the mortality is high once it occurs, which has a great impact on patients and their families. Currently there is no treatment for either the sporadic or familial form. Therefore, it is of great significance to explore the diagnosis and treatment of familial amyotrophic lateral sclerosis (FALS). We report the diagnosis and treatment of a patient with familial ALS caused by mutation of the Cu/Zn superoxide dismutase (SOD1) gene c.425g > C (p.g142a), which is considered rare. We got to know that genetic testing of the patient and his immediate family members assisted in diagnosis and palliative care. Edaravone and Riluzole were used in this case according to the guideline in this case. The progress of the disease was alleviated and the survival experience of patients improved because of this medication administration. The aim of this case report is to provide a reference for the diagnosis and treatment strategy in FALS. What's more, further exploration of treatment using integrated traditional Chinese and Western medicine to delay the disease process has great significance for improved patient outcomes.
MeSH term(s)	Amyotrophic Lateral Sclerosis/genetics ; Humans ; Mutation ; Neurodegenerative Diseases ; Superoxide Dismutase/genetics ; Superoxide Dismutase-1/genetics
Chemical Substances	Superoxide Dismutase (EC 1.15.1.1) ; Superoxide Dismutase-1 (EC 1.15.1.1)
Language	English
Publishing date	2022-01-07
Publishing country	China
Document type	Case Reports
ZDB-ID	2828544-X
ISSN	2224-5839 ; 2224-5839
ISSN (online)	2224-5839
ISSN	2224-5839
DOI	10.21037/apm-21-3254
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Article ; Online: Detecting Trivariate Associations in High-Dimensional Datasets.

Liu, Chuanlu / Wang, Shuliang / Yuan, Hanning / Dang, Yingxu / Liu, Xiaojia

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 7

Abstract: Detecting correlations in high-dimensional datasets plays an important role in data mining and knowledge discovery. While recent works achieve promising results, detecting multivariable correlations especially trivariate associations still remains a ... ...

Abstract	Detecting correlations in high-dimensional datasets plays an important role in data mining and knowledge discovery. While recent works achieve promising results, detecting multivariable correlations especially trivariate associations still remains a challenge. For example, maximal information coefficient (MIC) introduces generality and equitability to detect bivariate correlations but fails to detect multivariable correlation. To solve the problem mentioned above, we proposed quadratic optimized trivariate information coefficient (QOTIC). Specifically, QOTIC equitably measures dependence among three variables. Our contributions are three-fold: (1) we present a novel quadratic optimization procedure to approach the correlation with high accuracy; (2) QOTIC exceeds existing methods in generality and equitability as QOTIC has general test functions and is applicable in detecting multivariable correlation in datasets of various sample sizes and noise levels; (3) QOTIC achieved both higher accuracy and higher time-efficiency than previous methods. Extensive experiments demonstrate the excellent performance of QOTIC.
MeSH term(s)	Data Mining/methods
Language	English
Publishing date	2022-04-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22072806
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Article ; Online: Antibacterial activities of plant-derived xanthones.

Liu, Xiaojia / Shen, Jianzhong / Zhu, Kui

RSC medicinal chemistry

2021 Volume 13, Issue 2, Page(s) 107–116

Abstract: The increasing threat to global health posed by antibiotic resistance remains a serious concern. This troublesome scenario has steered a need for the discovery and evaluation of novel antibacterial agents. Natural products are the main sources of ... ...

Abstract	The increasing threat to global health posed by antibiotic resistance remains a serious concern. This troublesome scenario has steered a need for the discovery and evaluation of novel antibacterial agents. Natural products are the main sources of antimicrobials used in clinical practice, serving as a rich reservoir for the discovery of new antibiotics. Pharmaceutical phenolics especially xanthones widely exist in the plant kingdom, and are important plant metabolites. They possess versatile biological activities, including antiviral, antibacterial, neurotrophic, and anticancer. In the present study, we focus on the antibacterial activities of phytoxanthones and summarize their structures and sources, categories and drug-likeness evaluations, and antibacterial activities. A total of 226 different plant xanthones are identified through the NETs screening, and most of them are distributed in
Language	English
Publishing date	2021-12-21
Publishing country	England
Document type	Journal Article ; Review
ISSN	2632-8682
ISSN (online)	2632-8682
DOI	10.1039/d1md00351h
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Article ; Online: Detecting Unbiased Associations in Large Data Sets.

Liu, Chuanlu / Wang, Shuliang / Yuan, Hanning / Liu, Xiaojia

Big data

2021 Volume 10, Issue 4, Page(s) 337–355

Abstract: Maximal information coefficient (MIC) explores the associations between pairwise variables in complex relationships. It approaches the correlation by optimized partition on the axis. However, when the relationships meet special noise, MIC may ... ...

Abstract	Maximal information coefficient (MIC) explores the associations between pairwise variables in complex relationships. It approaches the correlation by optimized partition on the axis. However, when the relationships meet special noise, MIC may overestimate the correlated value, which leads to the misidentification of the relationship without noiseless. In this article, a novel method of weighted information coefficient mean (WICM) is proposed to detect unbiased associations in large data sets. First, we mathematically analyze the cause of giving an abnormal correlation value to a noisy relationship. Then, the WICM is presented in two core steps. One is to detect the potential overestimation from the relationships with high value, and the other is to rectify the overestimation by calculating information coefficient mean instead of just selecting the maximum element in the characteristic matrix. Finally, experiments in functional relationships and real-world data relationships show that the overestimation can be solved by WICM with both feasibility and effectiveness.
MeSH term(s)	Algorithms
Language	English
Publishing date	2021-12-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2167-647X
ISSN (online)	2167-647X
DOI	10.1089/big.2021.0193
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Article ; Online: Landscape Aesthetic Value of Waterfront Green Space Based on Space-Psychology-Behavior Dimension: A Case Study along Qiantang River (Hangzhou Section).

Liu, Xiaojia / Chen, Xi / Huang, Yan / Wang, Weihong / Zhang, Mingkan / Jin, Yang

International journal of environmental research and public health

2023 Volume 20, Issue 4

Abstract: As an important part of urban green infrastructure, the landscape effect of the urban waterfront green space varies, and sometimes, the green space with an excellent landscape aesthetic value fails to serve the needs of most citizens. This seriously ... ...

Abstract	As an important part of urban green infrastructure, the landscape effect of the urban waterfront green space varies, and sometimes, the green space with an excellent landscape aesthetic value fails to serve the needs of most citizens. This seriously affects the construction of a green ecological civilization and the implementation of the concept of "common prosperity" in China. Based on multi-source data, this study took the Qiantang River Basin as an example, selected 12 representative waterfront green spaces along the river as the research objects, and used qualitative and quantitative analysis methods to determine the landscape aesthetic value of the research area from the different dimensions of space, psychology, and physiology. We examined the relationship between each dimension so as to objectively and comprehensively reflect the landscape value characteristics of the waterfront green space in the study area and provide a reasonable theoretical framework and practical development path for future urban waterfront green space landscape design. We obtained the following results: (1) The results of the spatial dimension research indicated that the spatial value index of the waterfront green space in the study area was three-dimensional space > vertical space > horizontal space, and the overall spatial value was low; Qianjiang Ecological Park obtained the highest value (0.5473), and Urban Balcony Park obtained the lowest value (0.4619). (2) The results of the psychological dimension indicated that people's perceptions of the waterfront green space in the study area were relatively weak, mainly focusing on visual perception, but the waterfront green space with a relative emotional value greater than one accounted for 75%, and the overall recognition of the landscape was high. (3) The results of the behavioral dimension showed that the overall heat of the waterfront green space in the study area was insufficient (1.3719-7.1583), which was mainly concentrated in low-heat levels, and the population density was unevenly distributed (0.0014-0.0663), which was mainly concentrated in the medium-density level. The main purpose of users was to visit, and they stayed an average of 1.5 h. (4) The results of the coupling coordination analysis of the spatial-psychological-behavioral dimensions showed that the landscape value of the waterfront green space in the study area presented a form of 'high coupling degree and low coordination degree'.
MeSH term(s)	Humans ; Parks, Recreational ; Rivers ; China ; Spatial Behavior ; Cities
Language	English
Publishing date	2023-02-10
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20043115
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Article ; Online: Effective Attenuation of Arteriosclerosis Following Lymphatic-Targeted Delivery of Hyaluronic Acid-Decorated Rapamycin Liposomes.

Liu, Xiaojia / Lin, Caiyan / Zhong, Wenfei / Yuan, Zhongwen / Yan, Pengke / Guan, Shixia

International journal of nanomedicine

2023 Volume 18, Page(s) 4403–4419

Abstract: Background: The activation of lymphatic vessel function is the crux to resolving atherosclerosis (AS), a chronic inflammatory disease. Rapamycin (RAPA) recently has attracted considerable attention as a potent drug to induce atherosclerotic plaque ... ...

Abstract	Background: The activation of lymphatic vessel function is the crux to resolving atherosclerosis (AS), a chronic inflammatory disease. Rapamycin (RAPA) recently has attracted considerable attention as a potent drug to induce atherosclerotic plaque attenuation. The objective of this work was to develop a ligand-decorated, RAPA-loaded liposome for lymphatic-targeted delivery of drugs to improve abnormal lymphatic structure and function, resulting in highly effective regression of atherosclerotic plaques. Methods: Hyaluronic acid-decorated, RAPA-loaded liposomes (HA-RL) were fabricated by emulsion-solvent evaporation. The average size, zeta potential, entrapment efficiency were characterized, and the stability and drug release in vitro were investigated. Furthermore, the in vitro and in vivo lymphatic targeting ability were evaluated on lymphatic endothelial cells and LDLR Results: HA-RL had a size of 100 nm, over 90% drug encapsulation efficiency, the storage stability was distinguished, demonstrating a slow release from the lipid nano-carriers. The mean retention time (MRT) and elimination half-life (t Conclusion: HA-RL exhibited the most appreciable lymphatic targeting ability and best atherosclerotic plaques attenuation efficiency, opening a new paradigm and promising perspective for the treatment of arteriosclerosis.
MeSH term(s)	Mice ; Animals ; Liposomes/chemistry ; Hyaluronic Acid/chemistry ; Sirolimus/pharmacology ; Plaque, Atherosclerotic/drug therapy ; Endothelial Cells ; Drug Delivery Systems/methods ; Atherosclerosis/drug therapy
Chemical Substances	Liposomes ; Hyaluronic Acid (9004-61-9) ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2023-08-02
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S410653
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Zs.A 6606: Show issues

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Article ; Online: Reconstruction of Concha-Type Microtia Using a Delayed Postauricular Skin Flap.

Li, Gaofeng / Zhang, Bo / Ding, Wei / Ouyang, Huawei / Long, Xiren / Fu, Anqi / Liu, Xiaojia

Plastic and reconstructive surgery

2023 Volume 153, Issue 2, Page(s) 407e–410e

Abstract: Summary: Understanding how to remove and retain the relatively large residual auricle is important in concha-type microtia reconstruction. The authors present a method for concha-type microtia reconstruction using a delayed postauricular skin flap. A ... ...

Abstract	Summary: Understanding how to remove and retain the relatively large residual auricle is important in concha-type microtia reconstruction. The authors present a method for concha-type microtia reconstruction using a delayed postauricular skin flap. A total of 40 patients with concha-type microtia who underwent ear reconstruction using a delayed postauricular skin flap were retrospectively examined. Reconstruction was performed in three stages. The first stage consisted of preparing a delayed postauricular skin flap and dealing with the residual auricle including removal of the upper residual auricular cartilage. In the second stage, an autogenous rib cartilage framework was placed and covered with a delayed postauricular skin flap, postauricular fascia flap, and autologous medium-thickness skin graft. The ear framework was carefully articulated and secured with the retained residual auricular cartilage to achieve a smooth junction between the two. The third stage involved modification of the reconstructed ear. Patients were followed up for 12 months after ear reconstruction. All reconstructed auricles had a good appearance, and there was a smooth connection between the reconstructed auricle and the residual ear, with similar color as well as a flat and thin scar. All patients were satisfied with the results. Clinical question/level of evidence: Therapeutic, IV.
MeSH term(s)	Humans ; Congenital Microtia/surgery ; Retrospective Studies ; Skin Transplantation/methods ; Surgical Flaps/transplantation ; Plastic Surgery Procedures ; Ear Auricle/surgery
Language	English
Publishing date	2023-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0000000000010547
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