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  1. Book ; Online: Advances in Marine Engineering: Geological Environment and Hazards

    Liu, Xiaolei / Stoesser, Thorsten / Guo, Xingsen

    2023  

    Keywords Technology: general issues ; History of engineering & technology ; gas-hydrate-bearing sediments ; mechanical behavior ; dynamic loading ; discrete element simulation ; macro-meso ; South China Sea ; submarine soft soil ; triaxial test ; mechanical properties ; normalized behavior ; CO2 hydrate slurry ; rheology ; shear-thickening ; Herschel-Bulkley-type model ; sediment acoustic ; frequency dependence ; sound speed ; attenuation ; Biot-Stoll model ; seafloor sediments ; XGBoost ; the East China Sea ; groundwater ; hydrochemistry ; Guangdong coastal zone ; seawater intrusion ; nitrate pollution ; undrained shear strength ; clay samples ; mini-ball penetration test ; low temperature ; strength of bound water ; viscosity of free water ; seafloor bedform ; multibeam bathymetry ; sub-bottom profile ; bottom current ; laterally loaded piles ; initial stiffness ; undrained clay slope ; nonlinear formulations ; finite-element analysis ; cyclic shear test ; silt-steel interface ; stress-displacement mechanical properties ; submarine landslide ; in-situ investigation ; physical modelling ; numerical simulation ; calcareous sand ; cyclic load ; cumulative axial strain ; stiffness ; damping ratio ; deep-buried tunnel ; analytical solution ; anisotropic flow ; conformal mapping ; seepage field ; gas hydrate ; high-resolution seismic ; ultra-high-energy plasma source ; n/a
    Language English
    Size 1 electronic resource (254 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030374766
    ISBN 9783036570570 ; 3036570578
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Thesis: Caspase 3 as an alternative marker for increasing the throughput of the predictive radiation-induced lymphocyte apoptosis assay in malignancies

    Liu, Xiaolei / Veldwijk, Marlon Romano

    2022  

    Title variant Caspase three as an alternative marker for increasing the throughput of the predictive radiation-induced lymphocyte apoptosis assay in malignancies
    Institution Universität Heidelberg
    Author's details vorgelegt von Xiaolei Liu ; Referent: Prof. Dr. Marlon R. Veldwijk
    Language English
    Size 64 Seiten, Diagramme, Illustrationen
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2023
    HBZ-ID HT030626392
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2024 E 100 order for loan Magazin

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  3. Book ; Thesis: The role of cellular damage repair for the biological effect of intraoperative radiotherapy (IORT) with low-dose rate 50 kV X-rays

    Liu, Xiaolei

    2016  

    Author's details vorgelegt von Xiaolei Liu
    Language English
    Size 108 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität zu Heidelberg, 2016
    HBZ-ID HT019248769
    Database Catalogue ZB MED Medicine, Health

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  4. Book ; Online: New Advances in Marine Engineering Geology

    Yang, Qing / Jeng, Dong-Sheng / Liu, Xiaolei / Wang, Yin / Sturm, Hendrik

    2021  

    Keywords Technology: general issues ; marine soft soil ; double-layer foundation ; consolidation theory ; drainage boundary ; spudcan ; skirted footing ; footprint ; jack-up ; clay ; large deformation analysis ; coral sands ; porous media ; model test ; dispersion ; mechanical dispersion ; molecular diffusion ; soft clay ; cyclic loads ; residual pore pressure ; suction anchor ; wave ; seafloor instability ; pore pressure ; slide surface ; gas distribution ; meshfree method ; VARANS ; Biot's "u − p" approximation ; wave-current induced seabed response ; immersed tunnel ; sediment liquefaction ; heavy metal ; migration ; interior of sediment ; the subaqueous Yellow River Delta ; ocean waves ; double-frequency microseisms ; continental margin ; continental slope ; coral sand ; Fujian sand ; shaking table test ; dynamic response ; pile group ; marine engineering ; seismic liquefaction ; novel liquefaction-resistant structures ; mitigation strategies ; sand wave ; pressure sensing technique ; physical model test ; field application ; wingsail ; aerodynamics ; numerical simulation ; marine silty sand ; small-strain stiffness ; Hardin model ; binary packing model ; dredging and reclamation ; constitutive relationship ; centrifugal experiment ; void ratio-effective stress ; void ratio-permeability coefficient ; n/a
    Size 1 electronic resource (258 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021291793
    ISBN 9783036524221 ; 3036524223
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Streamlined Arsenolipid Identification via Direct Arsenic Detection Using RPLC-ESI-QTOF-MS with Collision-Induced Dissociation.

    Liu, Xiao-Lei

    Journal of the American Society for Mass Spectrometry

    2023  Volume 35, Issue 2, Page(s) 300–306

    Abstract: Arsenolipids are organoarsenicals with a long aliphatic chain that have been identified in a wide array of marine organisms. Precise analysis of arsenolipids is crucial for evaluating their toxicity, ensuring food safety, monitoring the environment, and ... ...

    Abstract Arsenolipids are organoarsenicals with a long aliphatic chain that have been identified in a wide array of marine organisms. Precise analysis of arsenolipids is crucial for evaluating their toxicity, ensuring food safety, monitoring the environment, and gaining insights into the evolution of arsenic biogeochemistry. However, the discovery of new arsenolipids is often impeded by existing analytical challenges, notably the need for multiple instruments, such as the combination of liquid chromatography electrospray ionization mass spectrometry (LC-ESI-MS) and inductively coupled plasma mass spectrometry (LC-ICP-MS). This study introduces a high-throughput untargeted analytical method on the basis of an unsophisticated instrumental configuration, LC-ESI-MS with collision-induced dissociation (CID) at 200 eV. This approach provides efficient dissociation of arsenic atoms from their precursor lipids and direct detection of the organic-bound arsenic as monatomic cations, As
    MeSH term(s) Arsenic ; Lipids/analysis ; Chromatography, High Pressure Liquid/methods ; Spectrometry, Mass, Electrospray Ionization/methods ; Arsenicals
    Chemical Substances Arsenic (N712M78A8G) ; Lipids ; Arsenicals
    Language English
    Publishing date 2023-12-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1073671-2
    ISSN 1879-1123 ; 1044-0305
    ISSN (online) 1879-1123
    ISSN 1044-0305
    DOI 10.1021/jasms.3c00367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4618: Show issues Location:
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    Zs.MO 241: Show issues

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  6. Article ; Online: The intermolecular interactions of ammonia with chlorine and bromine oxides: a theoretical study

    Liu, Xiaolei

    J Mol Model. 2023 Jan., v. 29, no. 1, p. 11

    2023  , Page(s) 11

    Abstract: The role of halogen oxides is substantial in the stratosphere, especially for ozone depletion. It is important to make clear the interaction of halogen oxides with other gaseous molecules. This work performed quantum chemical calculations to investigate ... ...

    Abstract The role of halogen oxides is substantial in the stratosphere, especially for ozone depletion. It is important to make clear the interaction of halogen oxides with other gaseous molecules. This work performed quantum chemical calculations to investigate the intermolecular interactions between XₘOₙ (X = Cl or Br, m, n = 1 or 2) and ammonia. The chlorine and bromine oxides selected in this paper include typical halogen oxides which can influence the atmospheric processes. For each complex, two different types of interactions, halogen and hydrogen bonds were identified. A π-hole interaction was also found in the XO₂···NH₃ complex. The interaction energy implies that the strength of the halogen bond is far more stronger than the hydrogen bond. A prominent difference exists between the halogen oxides of singlet or doublet state, which can be ascribed to the electron spin density distribution. The nature of the intermolecular interactions was identified by an independent gradient model based on Hirshfeld partition (IGMH) analysis. Symmetry-adapted perturbation theory (SAPT) calculation indicates that electrostatic interaction dominates the halogen-bonded complex, and hydrogen bond is driven by electrostatic interaction and dispersion.
    Keywords ammonia ; bromine ; chlorine ; electrostatic interactions ; energy ; hydrogen ; hydrogen bonding ; mathematical theory ; models ; ozone depletion ; quantum mechanics ; stratosphere
    Language English
    Dates of publication 2023-01
    Size p. 11
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 1284729-X
    ISSN 0948-5023 ; 1610-2940
    ISSN (online) 0948-5023
    ISSN 1610-2940
    DOI 10.1007/s00894-022-05415-1
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Collision-induced dissociation as "mass spectrometric filter" for rapid screening of tetrapyrrole derivatives and their chelated metal species in complex biological and environmental samples.

    Liu, Xiao-Lei

    Rapid communications in mass spectrometry : RCM

    2022  Volume 37, Issue 1, Page(s) e9413

    Abstract: Rationale: Cyclic tetrapyrroles, such as chlorophylls and their diagenetic derivatives, are structurally diverse and often chelated with certain metal species in the natural environment. A high throughput analytical method enabling quick tetrapyrrole ... ...

    Abstract Rationale: Cyclic tetrapyrroles, such as chlorophylls and their diagenetic derivatives, are structurally diverse and often chelated with certain metal species in the natural environment. A high throughput analytical method enabling quick tetrapyrrole screening in complex samples will promote the study of tetrapyrrole biogeochemistry and probably discoveries of new tetrapyrroles.
    Methods: Total lipid extracts of biological and environmental samples were injected onto a C18 column to separate compounds with a reverse-phase gradient. Collision-induced dissociation (CID) was performed at different energy levels, from 40 to 200 eV, on a quadrupole time-of-flight mass spectrometry (QTOF-MS) to identify cyclic tetrapyrroles in complex matrices.
    Results: Under 200 eV CID cyclic tetrapyrroles exhibit a unique fragmentation behavior, the production of fragments larger than 300 Da. Utilizing such feature as a filter to extract product ions in the range of 300-500 Da, various cyclic tetrapyrrole derivatives are readily recognized in all tested biological and environmental samples. The 200 eV CID setup also dissociates chelated to porphyrin metals, including Cu, Fe, Mn, Ni, and V, as single-charged ions for direct MS detection.
    Conclusions: The 200 eV CID setup provides an efficient approach for the identification of cyclic tetrapyrroles, such as chlorophylls and fossil metalloporphyrins, in complex environmental samples. The direct detection of chelated to porphyrin metal ions with QTOF-MS shows the potential for compound-specific metal isotope analysis.
    MeSH term(s) Tetrapyrroles/chemistry ; Spectrometry, Mass, Electrospray Ionization/methods ; Metals/chemistry ; Ions/chemistry ; Porphyrins
    Chemical Substances Tetrapyrroles ; Metals ; Ions ; Porphyrins
    Language English
    Publishing date 2022-10-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 58731-x
    ISSN 1097-0231 ; 0951-4198
    ISSN (online) 1097-0231
    ISSN 0951-4198
    DOI 10.1002/rcm.9413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3461: Show issues Location:
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  8. Article ; Online: A novel role of PSMB9 in endothelial cells and atherosclerosis: beyond its canonical function in immunoproteasome.

    Liu, Xiaolei / Delgado, Esteban

    Acta pharmacologica Sinica

    2024  

    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1360774-1
    ISSN 1745-7254 ; 0253-9756 ; 1671-4083
    ISSN (online) 1745-7254
    ISSN 0253-9756 ; 1671-4083
    DOI 10.1038/s41401-024-01267-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1904: Show issues Location:
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  9. Article ; Online: Tocopherols and associated derivatives track the phytoplanktonic response to evolving pelagic redox conditions spanning Oceanic Anoxic Event 2.

    Connock, Gregory T / Liu, Xiao-Lei

    Geobiology

    2023  Volume 21, Issue 6, Page(s) 743–757

    Abstract: Tocopherols serve a critical role as antioxidants inhibiting lipid peroxidation in photosynthetic organisms, yet are seldom used in geobiological investigations. The ubiquity of tocopherols in all photosynthetic lifeforms is often cited as an impediment ... ...

    Abstract Tocopherols serve a critical role as antioxidants inhibiting lipid peroxidation in photosynthetic organisms, yet are seldom used in geobiological investigations. The ubiquity of tocopherols in all photosynthetic lifeforms is often cited as an impediment to any diagnostic paleoenvironmental potential, while the inability to readily analyze these compounds via conventional methods, such as gas chromatography-mass spectrometry, further diminishes the capacity to serve as useful 'biomarkers'. Here, we analyzed an exceptionally preserved black shale sequence from the Demerara Rise that spans Oceanic Anoxic Event 2 (OAE-2) to reexamine the significance of tocopherols and associated derivatives (i.e. tocol derivatives) in ancient sediments. Tocol derivatives were analyzed via liquid chromatography-quadrupole time-of-flight-mass spectrometry and included tocopherols, a methyltrimethyltridecylchroman, and the first reported detection of tocopherol quinones and methylphytylbenzoquinones in the geologic record. Strong correlations between tocol derivatives were observed over the studied interval. Tocol derivative concentrations and ratios, which normalized tocopherols to potential derivatives, revealed absolute and relative increases in tocopherols as exclusive features of OAE-2 that can be explained by two possible mechanisms related to tocopherol production and preservation. The development of photic zone euxinia during OAE-2 likely forced an upward migration of oxygenic photoautotrophs, increasing oxidative stress that elicited heightened tocopherol biosynthesis. However, shoaling euxinic conditions may have simultaneously acted to enhance tocopherol preservation given the relatively high lability of tocopherols in the water column. Both scenarios could produce the observed stratigraphic distribution of tocol derivatives in this study, although the elevated tocopherol concentrations that define OAE-2 at the Demerara Rise are primarily attributed to enhanced tocopherol production by shoaling phytoplanktonic communities. Thus, the occurrence of tocopherols and associated derivatives in sediments and rocks of marine origin is likely indicative of shallow-water anoxia, tracking the phytoplanktonic response to the abiotic stresses associated with vertical fluctuations in pelagic redox.
    MeSH term(s) Humans ; Phytoplankton ; Tocopherols/chemistry ; Oxidation-Reduction ; Hypoxia ; Water
    Chemical Substances Tocopherols (R0ZB2556P8) ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-08-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2113509-5
    ISSN 1472-4669 ; 1472-4677
    ISSN (online) 1472-4669
    ISSN 1472-4677
    DOI 10.1111/gbi.12570
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  10. Article ; Online: The Lymphatic Vasculature in Cardiac Development and Ischemic Heart Disease.

    Liu, Xiaolei / Oliver, Guillermo

    Circulation research

    2023  Volume 132, Issue 9, Page(s) 1246–1253

    Abstract: In recent years, the lymphatic system has received increasing attention due to the fast-growing number of findings about its diverse novel functional roles in health and disease. It is well documented that the lymphatic vasculature plays major roles in ... ...

    Abstract In recent years, the lymphatic system has received increasing attention due to the fast-growing number of findings about its diverse novel functional roles in health and disease. It is well documented that the lymphatic vasculature plays major roles in the maintenance of tissue-fluid balance, the immune response, and in lipid absorption. However, recent studies have identified an additional growing number of novel and sometimes unexpected functional roles of the lymphatic vasculature in normal and pathological conditions in different organs. Among those, cardiac lymphatics have been shown to play important roles in heart development, ischemic cardiac disease, and cardiac disorders. In this review, we will discuss some of those novel functional roles of cardiac lymphatics, as well as the therapeutic potential of targeting lymphatics for the treatment of cardiovascular diseases.
    MeSH term(s) Humans ; Lymphangiogenesis ; Lymphatic Vessels ; Heart ; Heart Diseases ; Myocardial Ischemia/pathology
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.122.321672
    Database MEDical Literature Analysis and Retrieval System OnLINE

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