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  1. Article ; Online: Rheumatoid arthritis: pathogenesis and therapeutic advances.

    Gao, Ying / Zhang, Yunkai / Liu, Xingguang

    MedComm

    2024  Volume 5, Issue 3, Page(s) e509

    Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the unresolved synovial inflammation for tissues-destructive consequence, which remains one of significant causes of disability and labor loss, affecting about 0.2-1% global ... ...

    Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the unresolved synovial inflammation for tissues-destructive consequence, which remains one of significant causes of disability and labor loss, affecting about 0.2-1% global population. Although treatments with disease-modifying antirheumatic drugs (DMARDs) are effective to control inflammation and decrease bone destruction, the overall remission rates of RA still stay at a low level. Therefore, uncovering the pathogenesis of RA and expediting clinical transformation are imminently in need. Here, we summarize the immunological basis, inflammatory pathways, genetic and epigenetic alterations, and metabolic disorders in RA, with highlights on the abnormality of immune cells atlas, epigenetics, and immunometabolism. Besides an overview of first-line medications including conventional DMARDs, biologics, and small molecule agents, we discuss in depth promising targeted therapies under clinical or preclinical trials, especially epigenetic and metabolic regulators. Additionally, prospects on precision medicine based on synovial biopsy or RNA-sequencing and cell therapies of mesenchymal stem cells or chimeric antigen receptor T-cell are also looked forward. The advancements of pathogenesis and innovations of therapies in RA accelerates the progress of RA treatments.
    Language English
    Publishing date 2024-03-10
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2688-2663
    ISSN (online) 2688-2663
    DOI 10.1002/mco2.509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Establishment and Analysis of Hypoxia-Related Model in Oral Squamous Cell Carcinoma.

    Lu, Xingwei / Liu, Xingguang

    publication RETRACTED

    Journal of healthcare engineering

    2022  Volume 2022, Page(s) 6602648

    Abstract: Oral squamous cell carcinoma (OSCC) is one of the most common cancers in the world. Hypoxia is closely related to immunity in tumor microenvironment and also affects the prognosis of patients. However, there is still a lack of articles related to tumor ... ...

    Abstract Oral squamous cell carcinoma (OSCC) is one of the most common cancers in the world. Hypoxia is closely related to immunity in tumor microenvironment and also affects the prognosis of patients. However, there is still a lack of articles related to tumor hypoxia in oral squamous cell carcinoma. Therefore, we aimed to develop a hypoxia model for future application in patient prognosis analysis and immunotherapy. The transcriptome and survival information of OSCC were downloaded from GEO database. The Cox regression model of the lasso method was used to identify prognostic genes and develop gene characteristics based on hypoxia immunity. According to the median risk value, the patients were divided into high-risk group and low-risk group. Then, the estimated algorithm was used to estimate the relationship between hypoxia and immune status. At the same time, we evaluated the correlation and expression differences of immune-related genes between different risk groups. By using the lasso model, we identified two genes, including PFKP and SERPINE1, to construct gene signatures for risk stratification. We observed that both genes were highly expressed in the high-risk group, which was not conducive to the prognosis of the tumor. In addition, in the analysis of the degree of immune infiltration, we observed that there were differences in the content of a variety of immune cells between the two groups. It can be seen that there were great differences in the immune cells constituting the tumor microenvironment in oral squamous cell carcinoma. There remain significant differences in the expression levels of multitudinous immune-related genes. These immune-related genes include CCL chemokines, Chemokine (C-X-C motif) ligand (CXCL), CD antigens, HSP family, interferon family, and interleukin family. The hypoxia-immune-based gene signature represents a promising tool for risk stratification tool in oral squamous cell carcinoma cancer. It might serve as a prognostic classifier for clinical decision-making regarding individualized prognostication and treatment and follow-up scheduling.
    MeSH term(s) Biomarkers, Tumor/genetics ; Carcinoma, Squamous Cell/genetics ; Gene Expression Regulation, Neoplastic ; Head and Neck Neoplasms ; Humans ; Hypoxia/genetics ; Mouth Neoplasms/genetics ; Squamous Cell Carcinoma of Head and Neck/genetics ; Tumor Microenvironment/genetics
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2022-04-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Retracted Publication
    ZDB-ID 2545054-2
    ISSN 2040-2309 ; 2040-2295
    ISSN (online) 2040-2309
    ISSN 2040-2295
    DOI 10.1155/2022/6602648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Maximum chirality of THz metasurfaces with quasi-bound states in the continuum.

    Wang, Baoku / Yan, Fei / Liu, Xingguang / Sun, Weimin / Li, Li

    Optics express

    2024  Volume 32, Issue 6, Page(s) 8974–8985

    Abstract: Metasurfaces hold great promise for terahertz (THz) chiral-optical devices. Here, we proposed a chiral THz metasurface with quasi-bound state in the continuum (BIC) for maximum chirality. By exploiting structural perturbations of the dipole displacement ... ...

    Abstract Metasurfaces hold great promise for terahertz (THz) chiral-optical devices. Here, we proposed a chiral THz metasurface with quasi-bound state in the continuum (BIC) for maximum chirality. By exploiting structural perturbations of the dipole displacement and the diverging angle for the THz metasurface, the symmetry-protected BIC transforms into quasi-BIC. The critical coupling condition is satisfied by the introduction of graphene, enabling the theoretical maximum absorption of the quasi-BIC. Subsequently, the perturbations are balanced to obtain maximum chirality. The numerical simulations show that the THz metasurface exhibits strong linear chirality with the circular dichroism (CD) of 0.99 at the quasi-BIC. Additionally, the chiral third harmonic generation (THG) is achieved, characterized by high efficiency up to 19% and strong THG-CD as high as 0.99. It is expected that the THz metasurfaces has great potential for applications in chiral sensing and imaging.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.519234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Retraction Note: MIR600HG sponges miR-125a-5p to regulate glycometabolism and cisplatin resistance of oral squamous cell carcinoma cells via mediating RNF44.

    Liu, Xingguang / Zhao, Tengda / Yuan, Zhe / Ge, Shaohua

    Cell death discovery

    2023  Volume 9, Issue 1, Page(s) 422

    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Retraction of Publication
    ISSN 2058-7716
    ISSN 2058-7716
    DOI 10.1038/s41420-023-01711-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Unidirectional asymmetry transmission based on quasi-accidental bound states in the continuum.

    Zhang, Yingjie / Liu, Xingguang / Zhao, Rui / Li, Junqing

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 46, Page(s) 31869–31873

    Abstract: The unidirectional asymmetry transmission is demonstrated based on quasi-accidental bound states in the continuum by a one-dimensional chiral photonic crystal slab (CPhCs) composed of tilted silicon nano-pillars. The chirality breaks symmetries on the ... ...

    Abstract The unidirectional asymmetry transmission is demonstrated based on quasi-accidental bound states in the continuum by a one-dimensional chiral photonic crystal slab (CPhCs) composed of tilted silicon nano-pillars. The chirality breaks symmetries on the far field polarization and radiation
    Language English
    Publishing date 2023-11-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp03265e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Murine neonatal cardiac B cells promote cardiomyocyte proliferation and heart regeneration.

    Tan, Yong / Duan, Xuewen / Wang, Bo / Liu, Xingguang / Zhan, Zhenzhen

    NPJ Regenerative medicine

    2023  Volume 8, Issue 1, Page(s) 7

    Abstract: The irreversible loss of cardiomyocytes in the adult heart following cardiac injury leads to adverse cardiac remodeling and ventricular dysfunction. However, the role of B cells in cardiomyocyte proliferation and heart regeneration has not been clarified. ...

    Abstract The irreversible loss of cardiomyocytes in the adult heart following cardiac injury leads to adverse cardiac remodeling and ventricular dysfunction. However, the role of B cells in cardiomyocyte proliferation and heart regeneration has not been clarified. Here, we found that the neonatal mice with B cell depletion showed markedly reduced cardiomyocyte proliferation, leading to cardiac dysfunction, fibrosis scar formation, and the complete failure of heart regeneration after apical resection. B cell depletion also significantly impaired heart regeneration and cardiac function in neonatal mice following myocardial infarction (MI). However, B cell depletion in adult mice suppressed tissue inflammation, inhibited myocardial fibrosis, and improved cardiac function after MI. Interestingly, B cell depletion partially restricted cardiomyocyte proliferation in adult mice post-MI. Single-cell RNA sequencing showed that cardiac B cells possessed a more powerful ability to inhibit inflammatory responses and enhance angiogenesis in the postnatal day 1 (P1) mice compared with P7 and adult mice. Besides, the proportion of cardioprotective B cell clusters with high expression levels of S100a6 (S100 calcium-binding protein A6) and S100a4 (S100 calcium-binding protein A4) was greatly decreased in adult heart tissues compared with neonatal mice after cardiac damage. Thus, our study discovers that cardiac B cells in neonatal mice are required for cardiomyocyte proliferation and heart regeneration, while adult B cells promote inflammation and impair cardiac function after myocardial injury.
    Language English
    Publishing date 2023-02-11
    Publishing country United States
    Document type Journal Article
    ISSN 2057-3995
    ISSN (online) 2057-3995
    DOI 10.1038/s41536-023-00282-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Metabolic Regulation of Cardiac Regeneration.

    Duan, Xuewen / Liu, Xingguang / Zhan, Zhenzhen

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 933060

    Abstract: The mortality due to heart diseases remains highest in the world every year, with ischemic cardiomyopathy being the prime cause. The irreversible loss of cardiomyocytes following myocardial injury leads to compromised contractility of the remaining ... ...

    Abstract The mortality due to heart diseases remains highest in the world every year, with ischemic cardiomyopathy being the prime cause. The irreversible loss of cardiomyocytes following myocardial injury leads to compromised contractility of the remaining myocardium, adverse cardiac remodeling, and ultimately heart failure. The hearts of adult mammals can hardly regenerate after cardiac injury since adult cardiomyocytes exit the cell cycle. Nonetheless, the hearts of early neonatal mammals possess a stronger capacity for regeneration. To improve the prognosis of patients with heart failure and to find the effective therapeutic strategies for it, it is essential to promote endogenous regeneration of adult mammalian cardiomyocytes. Mitochondrial metabolism maintains normal physiological functions of the heart and compensates for heart failure. In recent decades, the focus is on the changes in myocardial energy metabolism, including glucose, fatty acid, and amino acid metabolism, in cardiac physiological and pathological states. In addition to being a source of energy, metabolites are becoming key regulators of gene expression and epigenetic patterns, which may affect heart regeneration. However, the myocardial energy metabolism during heart regeneration is majorly unknown. This review focuses on the role of energy metabolism in cardiac regeneration, intending to shed light on the strategies for manipulating heart regeneration and promoting heart repair after cardiac injury.
    Language English
    Publishing date 2022-07-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.933060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Plasmonic characteristics of the structure with double graphene layers immersed in chiral media and applications in detection of chirality.

    Zhao, Rui / Liu, Xingguang / Li, Junqing / Zhang, Yingjie

    Physical chemistry chemical physics : PCCP

    2022  Volume 24, Issue 46, Page(s) 28325–28332

    Abstract: The propagating behavior of surface plasmons in chiral media is different from that in achiral media. By comparing the propagation behavior of SPPs, the chirality of the environment can be evaluated. We theoretically reveal the features of SPPs in a ... ...

    Abstract The propagating behavior of surface plasmons in chiral media is different from that in achiral media. By comparing the propagation behavior of SPPs, the chirality of the environment can be evaluated. We theoretically reveal the features of SPPs in a structure with two individual graphene sheets surrounded by chiral environment. A more universal dispersion relation covering the achiral cases is obtained. The effects of the chirality of medium and the chemical potential of graphene on the SPPs are explored. Besides, a novel method of detecting the chirality of the environment based on the lateral optical force and torque is proposed. The characteristics of the structure may enrich the surface plasmonic wave theory on the waveguides with multiple graphene sheets and provide new opportunities for the design of more compact nanophotonic functional devices and novel biosensors.
    Language English
    Publishing date 2022-11-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d2cp03773d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: MIR600HG sponges miR-125a-5p to regulate glycometabolism and cisplatin resistance of oral squamous cell carcinoma cells via mediating RNF44.

    Liu, Xingguang / Zhao, Tengda / Yuan, Zhe / Ge, Shaohua

    publication RETRACTED

    Cell death discovery

    2022  Volume 8, Issue 1, Page(s) 216

    Abstract: There is increasing evidence that dysregulated long non-coding RNA (lncRNA) is implicated in tumorigenesis and progression. We aim to explore the role of lncRNA MIR600HG in glycometabolism and cisplatin (DDP) resistance of oral squamous cell carcinoma ( ... ...

    Abstract There is increasing evidence that dysregulated long non-coding RNA (lncRNA) is implicated in tumorigenesis and progression. We aim to explore the role of lncRNA MIR600HG in glycometabolism and cisplatin (DDP) resistance of oral squamous cell carcinoma (OSCC) cells via regulating microRNA-125a-5p (miR-125a-5p) and RING finger 44 (RNF44). Expression of MIR600HG, miR-125a-5p, and RNF44 in OSCC clinical samples, cell lines, and DDP-resistant OSCC cells (SCC-9/DDP) was determined. In SCC-9 cells, proliferation, IC
    Language English
    Publishing date 2022-04-20
    Publishing country United States
    Document type Journal Article ; Retracted Publication
    ISSN 2058-7716
    ISSN 2058-7716
    DOI 10.1038/s41420-022-01000-w
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  10. Article: Analysis of Cutting Stability of a Composite Variable-Section Boring Bar with a Large Length-to-Diameter Ratio Considering Internal Damping.

    Ma, Jingmin / Xu, Jianfeng / Li, Longfei / Liu, Xingguang / Gao, Ming

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 15

    Abstract: Chattering in composite deep-hole boring can directly affect surface processing quality and efficiency and has always been a research hotspot in machining mechanics. In this study, based on Euler-Bernoulli beam theory, the fine control equations for the ... ...

    Abstract Chattering in composite deep-hole boring can directly affect surface processing quality and efficiency and has always been a research hotspot in machining mechanics. In this study, based on Euler-Bernoulli beam theory, the fine control equations for the cutting stability of composite variable-section boring bars were established using the Hamilton principle, in which the sectional change and internal damping of the material were considered. Next, using the Galerkin method and semi-discrete method, the effects of the taper ratio, damping ratio, length-to-diameter ratio, and ply angle on the free vibration characteristics and cutting stability were analyzed in detail. The results show that at a low damping ratio, both the first-order inherent frequency and boring stability can be enhanced with the increase in the taper ratio; at a large damping ratio, increasing the taper ratio can reduce the first-order inherent frequency and boring stability. Finally, the effects of the sectional change on the inherent frequency, displacement response, and convergence were analyzed. A numerical simulation was performed for the model reliability validation. The present research results can provide a theoretical basis and technical guidance for analyzing the cutting stability and fine control of composite variable-section boring bars with large length-to-diameter ratios.
    Language English
    Publishing date 2022-08-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15155465
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