LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 73

Search options

  1. Article ; Online: Design and control of a multi-mobile-robot cooperative transport system based on a novel six degree-of-freedom connector.

    Gong, Zhao / Nie, Zhenguo / Liu, Quan / Liu, Xin-Jun

    ISA transactions

    2023  Volume 139, Page(s) 606–620

    Abstract: Multi-robot cooperative object transport on uneven roads is challenging. The key barrier is dealing with nonholonomic and rigid-formation motion constraints. In this study, to alleviate the influence of these constraints on a multi-robot cooperative ... ...

    Abstract Multi-robot cooperative object transport on uneven roads is challenging. The key barrier is dealing with nonholonomic and rigid-formation motion constraints. In this study, to alleviate the influence of these constraints on a multi-robot cooperative transport system (MRCTS), a six degree-of-freedom connector capable of sensing three-axial displacements, three-axial forces, and three-axial angular displacements is designed and employed. Based on the local displacements derived from each connector, we develop a position calibration method to calculate the relative position of each robot and achieve a centralized control strategy. Based on the forces sensed by each connector, we design a decentralized control strategy to accomplish cooperative transport in which a leader robot guides the follower robots toward a destination by applying forces, instead of centralized information broadcasting. The experimental results show that the MRCTS works well on an uneven surface, and the tracking errors are within the design stroke of the connectors, demonstrating the effectiveness of the design and control methods of the MRCTS.
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2012746-7
    ISSN 1879-2022 ; 0019-0578
    ISSN (online) 1879-2022
    ISSN 0019-0578
    DOI 10.1016/j.isatra.2023.04.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Stretchable and conformable variable stiffness device through an electrorheological fluid.

    Pan, Yiyi / Liu, Xin-Jun / Zhao, Huichan

    Soft matter

    2022  

    Abstract: Stiffness variations extend creatures' functions and capabilities to deal with complex environments. In this study, we proposed an electrorheological fluid-based variable stiffness device, named VSERF, made up of soft materials. Our device is soft, thin, ...

    Abstract Stiffness variations extend creatures' functions and capabilities to deal with complex environments. In this study, we proposed an electrorheological fluid-based variable stiffness device, named VSERF, made up of soft materials. Our device is soft, thin, and stretchable so that it can conform to surfaces with complex morphologies. The stiffness of the VSERF device can be continuously, independently, and reversibly adjusted by applying an electric field. It achieves 14.8-times compressive stiffness variation and 3.5-times tangential stiffness variation when the electric field intensity increases from 0 V mm
    Language English
    Publishing date 2022-11-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2191476-X
    ISSN 1744-6848 ; 1744-683X
    ISSN (online) 1744-6848
    ISSN 1744-683X
    DOI 10.1039/d2sm01362b
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Current Harmonics Minimization of Permanent Magnet Synchronous Machine Based on Iterative Learning Control and Neural Networks

    Mai, Annette / Liu, Xinjun / Wagner, Bernhard / Hofmann, Maximilian

    2023  

    Abstract: Electrical machines generate unwanted flux and current harmonics. Harmonics can be suppressed using various methods. In this paper, the harmonics are significantly reduced using Iterative Learning Control (ILC) and Neural Networks (NNs). The ILC can ... ...

    Abstract Electrical machines generate unwanted flux and current harmonics. Harmonics can be suppressed using various methods. In this paper, the harmonics are significantly reduced using Iterative Learning Control (ILC) and Neural Networks (NNs). The ILC can compensate for the harmonics well for operation at constant speed and current reference values. The NNs are trained with the data from the ILC and help to suppress the harmonics well even in transient operation. The simulation model is based on flux and torque maps, depending on -currents and the electrical angle. The maps are generated from FEM simulation of an interior permanent magnet synchronous machine (IPM) and are published with the paper. They are intended to serve other researchers for direct comparison with their own methods. Simulation results in this paper verify that by using ILC and NNs together, current harmonics in transient operation can be eliminated better than without NNs.

    11

    8
    Keywords FOC ; harmonics ; iterative learning control ; neural networks ; PMSM ; PSM ; repetitive control
    Subject code 629
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Design Strategies and Precautions for Using Vaccinia Virus in Tumor Virotherapy.

    Liu, Xinjun / Zhao, Jian / Li, Xiaopeng / Lao, Fengxue / Fang, Min

    Vaccines

    2022  Volume 10, Issue 9

    Abstract: Oncolytic virotherapy has emerged as a novel form of cancer immunotherapy. Oncolytic viruses (OVs) can directly infect and lyse the tumor cells, and modulate the beneficial immune microenvironment. Vaccinia virus (VACV) is a promising oncolytic vector ... ...

    Abstract Oncolytic virotherapy has emerged as a novel form of cancer immunotherapy. Oncolytic viruses (OVs) can directly infect and lyse the tumor cells, and modulate the beneficial immune microenvironment. Vaccinia virus (VACV) is a promising oncolytic vector because of its high safety, easy gene editing, and tumor intrinsic selectivity. To further improve the safety, tumor-targeting ability, and OV-induced cancer-specific immune activation, various approaches have been used to modify OVs. The recombinant oncolytic VACVs with deleting viral virulence factors and/or arming various therapeutic genes have displayed better therapeutic effects in multiple tumor models. Moreover, the combination of OVs with other cancer immunotherapeutic approaches, such as immune checkpoint inhibitors and CAR-T cells, has the potential to improve the outcome in cancer patients. This will open up new possibilities for the application of OVs in cancer treatment, especially for personalized cancer therapies.
    Language English
    Publishing date 2022-09-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10091552
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Robotic mobile and mirror milling of large-scale complex structures.

    Xie, Zenghui / Xie, Fugui / Zhu, Limin / Liu, Xin-Jun

    National science review

    2022  Volume 10, Issue 5, Page(s) nwac188

    Abstract: Robotization, miniaturization and portability have become the new development trend of milling equipment for large-scale complex structures, and the robotic mobile and mirror milling technology has reached remarkable progress in practical production. ...

    Abstract Robotization, miniaturization and portability have become the new development trend of milling equipment for large-scale complex structures, and the robotic mobile and mirror milling technology has reached remarkable progress in practical production.
    Language English
    Publishing date 2022-09-07
    Publishing country China
    Document type Journal Article
    ZDB-ID 2745465-4
    ISSN 2053-714X ; 2053-714X
    ISSN (online) 2053-714X
    ISSN 2053-714X
    DOI 10.1093/nsr/nwac188
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: The protective effects of dezocine on interleukin-1β-induced inflammation, oxidative stress and apoptosis of human nucleus pulposus cells and the possible mechanisms.

    Zhu, Fang / Duan, Wei / Zhong, Chao / Ji, Bing / Liu, Xinjun

    Bioengineered

    2022  Volume 13, Issue 1, Page(s) 1399–1410

    Abstract: Intervertebral disc degeneration (IDD) is a natural problem linked to the inflammation. We aimed to investigate the role of dezocine (DEZ) in the development of IDD. Human nucleus pulposus cells (HNPCs) induced by interleukin (IL)-1β was used as a ... ...

    Abstract Intervertebral disc degeneration (IDD) is a natural problem linked to the inflammation. We aimed to investigate the role of dezocine (DEZ) in the development of IDD. Human nucleus pulposus cells (HNPCs) induced by interleukin (IL)-1β was used as a cellular model of IDD. After treatment with DEZ, HNPCs viability was evaluated with a CCK-8 assay. Then, the levels of inflammatory factors, including IL-6 and tumor necrosis factor-α (TNF-α), and oxidative stress-related markers, including reactive oxygen species (ROS), malondialdehyde (MDA) and reduced glutathione (GSH), were tested by RT-qPCR or kits. TUNEL staining was employed to detect cell apoptosis and Western blot was used to determine the expression of proteins related to inflammation, oxidative stress, apoptosis, endoplasmic reticulum stress (ERS) and MAPK signaling. Afterward, PMA, a MAPK signaling pathway agonist, was adopted for exploring the regulatory effects of DEZ on MAPK pathway. Results indicated that DEZ enhanced cell viability of HNPCs after IL-1β exposure. DEZ alleviated the inflammation and oxidative stress, evidenced by decreased levels of IL-6, TNF-α, ROS, MDA, p-NF-κB p65, NF-κB p65 in nucleus, cox-2 and increased levels of NF-κB p65 in cytoplasm, GSH, SOD1 and SOD2. Moreover, DEZ notably inhibited IL-1β-induced apoptosis of HNPCs. Furthermore, DEZ suppressed the levels of ERS-related proteins. The levels of related proteins in MAPK signaling including p-P38 and p-ERK1/2 were remarkably reduced after DEZ administration. By contrast, PMA crippled the impacts of DEZ on inflammation, oxidative stress and apoptosis of HNPCs induced by IL-1β. Collectively, DEZ ameliorates IL-1β-induced HNPCs injury via inhibiting MAPK signaling.
    MeSH term(s) Apoptosis/drug effects ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Cell Line ; Gene Expression Regulation/drug effects ; Humans ; Interleukin-1beta/adverse effects ; Interleukin-6/genetics ; Intervertebral Disc Degeneration/drug therapy ; Intervertebral Disc Degeneration/genetics ; Intervertebral Disc Degeneration/metabolism ; MAP Kinase Signaling System/drug effects ; Models, Biological ; Nucleus Pulposus/cytology ; Nucleus Pulposus/drug effects ; Nucleus Pulposus/metabolism ; Oxidative Stress/drug effects ; Tetrahydronaphthalenes/pharmacology ; Tumor Necrosis Factor-alpha/genetics
    Chemical Substances Bridged Bicyclo Compounds, Heterocyclic ; IL6 protein, human ; Interleukin-1beta ; Interleukin-6 ; TNF protein, human ; Tetrahydronaphthalenes ; Tumor Necrosis Factor-alpha ; dezocine (VHX8K5SV4X)
    Language English
    Publishing date 2022-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2737830-5
    ISSN 2165-5987 ; 2165-5979
    ISSN (online) 2165-5987
    ISSN 2165-5979
    DOI 10.1080/21655979.2021.2017700
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Phylogenetic relationship and characterization of the complete mitochondrial genome of

    Cheng, Gaoqi / Du, Yimin / Liu, Xinjun

    Mitochondrial DNA. Part B, Resources

    2021  Volume 6, Issue 8, Page(s) 2449–2451

    Abstract: Cheilomenes ... ...

    Abstract Cheilomenes sexmaculata
    Language English
    Publishing date 2021-07-21
    Publishing country England
    Document type Journal Article
    ISSN 2380-2359
    ISSN (online) 2380-2359
    DOI 10.1080/23802359.2021.1955767
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Gain of circBRAF Represses Glioma Progression by Regulating miR-1290/FBXW7 Axis.

    Zhang, Jinchao / Chen, Zhi / Liu, Xinjun / Yang, Chonglin / Xie, Donggen

    Neurochemical research

    2021  Volume 46, Issue 5, Page(s) 1203–1213

    Abstract: Dysregulated circular RNAs (circRNAs) have been confirmed to partake in the modulation of the glioma progression. Here, we intended to explore the role of circBRAF in glioma and the possible action mechanism. The expression levels of circBRAF, microRNA ( ... ...

    Abstract Dysregulated circular RNAs (circRNAs) have been confirmed to partake in the modulation of the glioma progression. Here, we intended to explore the role of circBRAF in glioma and the possible action mechanism. The expression levels of circBRAF, microRNA (miR)-1290 and F-box and WD repeat domain containing 7 (FBXW7) were analyzed by quantitative reverse transcription polymerase chain reaction (qRT-PCR) or western blot. Cell viability was assessed by 3-(4, 5)-dimethylthiazole-2-y1)-2, 5-biphenyl tetrazolium bromide (MTT) assay. Cell cycle distribution was determined by flow cytometry. Cell migration and invasion were evaluated through Trans-well assay. Related protein levels were detected by western blot. Targeted relation among circBRAF, miR-1290 and FBXW7 was validated by dual-luciferase reporter, RNA immunoprecipitation (RIP) and pull-down assays. Xenograft model was constructed to explore the function of circBRAF in vivo. Expression of circBRAF and FBXW7 was decreased in glioma tissues and cells. Upregulation of circBRAF inhibited glioma cell proliferation and metastasis in vitro. MiR-1290 was upregulated in glioma, which was sponged by circBRAF. Besides, circBRAF elevated FBXW7 expression by targeting miR-1290. Introduction of miR-1290 or FBXW7 knockdown could counteract the inhibitory effects of circBRAF upregulation on the malignant phenotypes of glioma cells. Overexpression of circBRAF repressed the tumor growth in vivo. Upregulation of circBRAF suppressed glioma evolvement in vitro and in vivo by regulating miR-1290/FBXW7 axis, broadening the cognition of glioma progression.
    MeSH term(s) Animals ; Cell Line, Tumor ; Cell Movement/physiology ; Cell Proliferation/physiology ; Disease Progression ; F-Box-WD Repeat-Containing Protein 7/metabolism ; Gene Expression Regulation, Neoplastic/physiology ; Glioma/metabolism ; Humans ; Male ; Mice, Inbred BALB C ; Mice, Nude ; MicroRNAs/metabolism ; Neoplasm Invasiveness/physiopathology ; Neoplasm Metastasis/physiopathology ; RNA, Circular/metabolism ; Mice
    Chemical Substances F-Box-WD Repeat-Containing Protein 7 ; Fbxw7 protein, mouse ; MIRN1290 microRNA, human ; MicroRNAs ; RNA, Circular
    Language English
    Publishing date 2021-03-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 199335-5
    ISSN 1573-6903 ; 0364-3190
    ISSN (online) 1573-6903
    ISSN 0364-3190
    DOI 10.1007/s11064-021-03259-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1368: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Effects of the Chinese Herb Medicine Formula "She-Xiang-Yu-Hong" Ointment on Wound Healing Promotion in Diabetic Mice.

    Li, Qingjie / Liu, Xinjun / Yang, Shihui / Li, Chunrun / Jin, Wei / Hou, Weiwei

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 1062261

    Abstract: Wound healing in diabetic patients is a difficult problem to be solved at present. In addition, patients with diabetes have an increased risk of postoperative wound complications. "She-Xiang-Yu-Hong" (SXYH) ointment is a type of traditional Chinese ... ...

    Abstract Wound healing in diabetic patients is a difficult problem to be solved at present. In addition, patients with diabetes have an increased risk of postoperative wound complications. "She-Xiang-Yu-Hong" (SXYH) ointment is a type of traditional Chinese medicine (TCM) compound used to treat wounds. Over the past few years, SXYH has been applied in the Affiliated Hospital of Chengdu University of TCM (Chengdu, China) for the treatment of diabetic foot infections and bedsores, whereas there has been rare research on the effect of SXYH ointment on wound healing. In this study, SXYH ointment was first applied to streptozotocin (STZ)-triggered diabetic ICR mice (4-6 weeks, 20 ± 2 g) to observe the accelerated wound healing and the shortened wound healing period. As indicated by the histology and biochemistry analyses of skin biopsies, the wounds treated using SXYH ointment showed an increase in the granulation tissue. Moreover, SXYH also modulated the inflammation response by regulating affinity proinflammatory cytokines release (e.g., IL-6 and TNF-
    Language English
    Publishing date 2022-01-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/1062261
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Predictive role of E2F6 in cancer prognosis and responses of immunotherapy.

    Gong, Chuandong / Tu, Zewei / Long, Xiaoyan / Liu, Xinjun / Liu, Feng / Liu, Jia / Zhu, Xingen / Li, Jingying / Huang, Kai

    International immunopharmacology

    2023  Volume 127, Page(s) 111302

    Abstract: Background: E2F6 is a member of the E2F transcription factor family. Numerous studies have demonstrated that E2F6 is critical to cancer development and progression, but its role in cancer immunotherapy remains unclear.: Methods: Genotype-Tissue ... ...

    Abstract Background: E2F6 is a member of the E2F transcription factor family. Numerous studies have demonstrated that E2F6 is critical to cancer development and progression, but its role in cancer immunotherapy remains unclear.
    Methods: Genotype-Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) databases were used to obtain RNA-seq data for cancer and normal tissues, and we utilized the cBioPortal to analyze E2F6 genomic alterations in pan-cancer. The protein localization of E2F6 was obtained using the Human Protein Atlas (HPA), and the upregulation of E2F6 expression in clinical glioblastoma multiforme (GBM) tissues was detected by Western blot analysis. The ComPPI website was used to analyze the protein interaction information of E2F6. To evaluate the role of E2F6 in pan-cancer prognosis, we used univariate Cox regression and Kaplan-Meier methods, and gene set enrichment analysis (GSEA) was utilized to identify markers associated with E2F6 expression in tumors. TIMER 2.0 was used to study E2F6-related immune cell infiltration in tumor tissues, and the correlation of E2F6 with immunotherapy biomarkers was investigated using Spearman correlation analysis. The role of E2F6 in the cell cycle was analyzed by flow cytometry, and the Cell Counting Kit-8 (CCK-8) and colony formation assays were utilized to determine the proliferative ability of cells.
    Results: In most tumor types, E2F6 was highly expressed and was a good predictor of prognosis. E2F6 was significantly related to markers of immune activation, tumor immune cell infiltration, and immune regulators. Furthermore, E2F6 knockdown significantly attenuated the proliferative ability of glioma cells. Finally, E2F6 effectively predicted anti-programmed cell death 1 (PD1) treatment response.
    Conclusion: E2F6 is an effective biomarker that predicts the prognosis of cancer patients treated with anti-immune checkpoint therapy.
    MeSH term(s) Humans ; Immunotherapy ; Biological Assay ; Blotting, Western ; Cell Count ; Neoplasms/therapy ; Prognosis ; Tumor Microenvironment ; E2F6 Transcription Factor
    Chemical Substances E2F6 protein, human ; E2F6 Transcription Factor
    Language English
    Publishing date 2023-12-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2023.111302
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5408: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top