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Article ; Online: Study on the outdoor thermal comfort of college students under different activity intensities in a high-altitude climate zone.

Zhang, Yingzi / Zhang, Xiaobo / Han, Jiaqin / Liu, Xinxing

2024 Volume 12, Page(s) 1365470

Abstract: Introduction: Research on the outdoor thermal comfort (OTC) of a university campus is beneficial to the physical and mental health of college students.: Methods: In this study, the OTC of students attending Tibet University in Lhasa, which ... ...

Abstract	Introduction: Research on the outdoor thermal comfort (OTC) of a university campus is beneficial to the physical and mental health of college students. Methods: In this study, the OTC of students attending Tibet University in Lhasa, which experiences high-altitude cold climate conditions, under different activity intensities was studied using field measurements and a questionnaire survey. Results: With the increase in activity intensity, the comfort physiologically equivalent temperature (PET) value gradually increased in summer, while the comfortable PET value gradually decreased in winter. The most comfortable PET value is 17.6°C in summer and 11.5°C in winter. The neutral PET of Tibetan college students during outdoor activities in summer was 16.3°C, and the neutral PET of outdoor activities in winter was 12.1°C. Gender and ethnicity had different effects on thermal sensation under different activity intensities. Under vigorous-intensity activities, PET in winter and summer had the greatest influence on thermal sensation. The situation was different under moderate-intensity activity. PET had the greatest influence on thermal sensation in summer, and Tmrt had the greatest influence on thermal sensation in winter. Discussion: These findings provide a basis for an improved design of the outdoor environment under different outdoor activity intensities in high-altitude areas.
MeSH term(s)	Humans ; Altitude ; Climate ; Seasons ; Temperature ; Surveys and Questionnaires
Language	English
Publishing date	2024-03-18
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2024.1365470
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Article ; Online: Evaluation and Optimization Design for Microclimate Comfort of Traditional Village Squares Based on Extension Correlation Function.

Guo, Qiang / Liu, Xinxing

Journal of environmental and public health

2022 Volume 2022, Page(s) 6106463

Abstract: The evaluation approaches for microclimate comfort in traditional villages often ignore the year-round impact and the impact from dynamic and static behaviors, as well as the composite impact of wind and heat environments. To solve the problem, this ... ...

Abstract	The evaluation approaches for microclimate comfort in traditional villages often ignore the year-round impact and the impact from dynamic and static behaviors, as well as the composite impact of wind and heat environments. To solve the problem, this study presents an evaluation and optimization design strategy for microclimate comfort of traditional village squares based on extension correlation function, using field survey, computer simulation, and example analysis. Firstly, the wind and heat environments in the space of the square were measured on the site with an ultrasonic integrated weather station. Secondly, simulation parameters were configured on PHOENICS (computational fluid dynamics software), namely, boundary conditions, wind environment, heat environment, and green plants, and used to simulate the wind and heat environments in the space of the square, followed by a correlation analysis between the simulation results and the measured results. Finally, the extension correlation function was adopted to comprehensively evaluate the microclimate comfort of the preliminary design scheme, and the design scheme of the square was finalized through repeated adjustments. The proposed strategy was verified on an example: Xieduqi square, Zoumatang village, eastern China's Zhejiang Province. The example analysis shows that the proposed strategy is highly operable. The research effectively improves the optimization design of traditional village squares, extends the digital technology system of traditional villages, and greatly drives rural construction in the future.
MeSH term(s)	Computer Simulation ; Hot Temperature ; Microclimate ; Temperature ; Weather ; Wind
Language	English
Publishing date	2022-07-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2526611-1
ISSN	1687-9813 ; 1687-9813
ISSN (online)	1687-9813
ISSN	1687-9813
DOI	10.1155/2022/6106463
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Article ; Online: Bioactive compound schaftoside from Clinacanthus nutans attenuates acute liver injury by inhibiting ferroptosis through activation the Nrf2/GPX4 pathway.

Yu, Yi / Liang, Jingwei / Yuan, Zhexin / Wang, Aiping / Liu, Xinxing / Chen, Yu / Zhang, Min / Gao, Yanan / Zhang, Haiying / Liu, Yan

Journal of ethnopharmacology

2024 Volume 328, Page(s) 118135

Abstract: Ethnopharmacological relevance: Clinacanthus nutans (Burm. f.) Lindau, a traditional herb renowned for its anti-tumor, antioxidant, and anti-inflammatory properties, has garnered considerable attention. Although its hepatoprotective effects have been ... ...

Abstract	Ethnopharmacological relevance: Clinacanthus nutans (Burm. f.) Lindau, a traditional herb renowned for its anti-tumor, antioxidant, and anti-inflammatory properties, has garnered considerable attention. Although its hepatoprotective effects have been described, there is still limited knowledge of its treatment of acute liver injury (ALI), and its mechanisms remain unclear. Aim of the study: To assess the efficacy of Clinacanthus nutans in ALI and to identify the most effective fractions and their underlying mechanism of action. Methods: Bioinformatics was employed to explore the underlying anti-hepatic injury mechanisms and active compounds of Clinacanthus nutans. The binding ability of schaftoside, a potential active ingredient in Clinacanthus nutans, to the core target nuclear factor E2-related factor 2 (Nrf2) was further determined by molecular docking. The role of schaftoside in improving histological abnormalities in the liver was observed by H&E and Masson's staining in an ALI model induced by CCl Results: Bioinformatics analysis and molecular docking showed that schaftoside is the principal compound from Clinacanthus nutans. Schaftoside was shown to diminish oxidative stress levels, attenuate liver fibrosis, and forestall ferroptosis. Deeper investigations revealed that schaftoside amplified Nrf2 expression and triggered the Nrf2/GPX4 pathway, thereby reversing mitochondrial aberrations triggered by lipid peroxidation, GPX4 depletion, and ferroptosis. Conclusion: The lead compound schaftoside counters ferroptosis through the Nrf2/GPX4 axis, providing insights into a novel molecular mechanism for treating ALI, thereby presenting an innovative therapeutic strategy for ferroptosis-induced ALI.
MeSH term(s)	NF-E2-Related Factor 2 ; Ferroptosis ; Molecular Docking Simulation ; Liver ; Acanthaceae ; Glycosides
Chemical Substances	schaftoside ; NF-E2-Related Factor 2 ; Glycosides
Language	English
Publishing date	2024-03-30
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.118135
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Article ; Online: Levels, distribution characteristics, and sources of heavy metals in indoor dust in Shijiazhuang, China.

Zhao, Peipei / Liu, Xinxing / Yin, Lu / Tian, Dezhi / Wang, Xingqi

Environmental monitoring and assessment

2022 Volume 194, Issue 12, Page(s) 857

Abstract: Heavy metals in indoor dust are associated with health risks in humans. However, in Shijiazhuang, a city in northern China with severe haze, no research has been published on this topic. To determine the content, distribution characteristics, and sources ...

Abstract	Heavy metals in indoor dust are associated with health risks in humans. However, in Shijiazhuang, a city in northern China with severe haze, no research has been published on this topic. To determine the content, distribution characteristics, and sources of heavy metals in indoor dust in the city of Shijiazhuang, indoor dust samples from 33 sampling points in the main urban area of Shijiazhuang were collected and tested. Concentrations of Cu, Ni, Cr, Zn, Cd, and Pb were 87.0, 35.1, 104.4, 568.0, 1.980, and 187.6 mg·kg
MeSH term(s)	Cadmium/analysis ; China ; Cities ; Dust/analysis ; Environmental Monitoring/methods ; Humans ; Lead/analysis ; Metals, Heavy/analysis ; Risk Assessment ; Soil
Chemical Substances	Dust ; Metals, Heavy ; Soil ; Cadmium (00BH33GNGH) ; Lead (2P299V784P)
Language	English
Publishing date	2022-10-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-022-10543-5
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Article ; Online: Levels, distribution characteristics, and sources of heavy metals in indoor dust in Shijiazhuang, China

Zhao, Peipei / Liu, Xinxing / Yin, Lu / Tian, Dezhi / Wang, Xingqi

Environ Monit Assess. 2022 Dec., v. 194, no. 12 p.857-857

2022

Abstract	Heavy metals in indoor dust are associated with health risks in humans. However, in Shijiazhuang, a city in northern China with severe haze, no research has been published on this topic. To determine the content, distribution characteristics, and sources of heavy metals in indoor dust in the city of Shijiazhuang, indoor dust samples from 33 sampling points in the main urban area of Shijiazhuang were collected and tested. Concentrations of Cu, Ni, Cr, Zn, Cd, and Pb were 87.0, 35.1, 104.4, 568.0, 1.980, and 187.6 mg·kg⁻¹, respectively; their levels have been discussed statistically in comparison with the reported values in other cities in China. The sources of heavy metals were analyzed using enrichment factor, correlation coefficient, and principal component analysis. The results showed that the levels of all six elements in indoor dust in Shijiazhuang exceeded the background values of soil in Hebei Province. Among these, Cd, Pb, and Zn were significantly enriched. The enrichment factors of Cu, Ni, and Cr were below 10, and their levels at different sampling points were similar, indicating their geogenic source. The corresponding pollution levels of Cd, Pb, and Zn were relatively high, and their levels at different points were significantly different and correlated, indicating that they were derived mainly from transportation. Additionally, the level of Zn was significantly affected by the indoor environment. Our findings provide a basis for conducting health risk assessments in the future.
Keywords	dust ; pollution ; principal component analysis ; risk ; soil ; transportation ; urban areas ; China
Language	English
Dates of publication	2022-12
Size	p. 857.
Publishing place	Springer International Publishing
Document type	Article ; Online
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-022-10543-5
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Article: Pyrite-Based Cr(VI) Reduction Driven by Chemoautotrophic Acidophilic Bacteria.

Liu, Xinxing / Wu, Haiyan / Gan, Min / Qiu, Guanzhou

Frontiers in microbiology

2020 Volume 10, Page(s) 3082

Abstract: Cr(VI) is considered as a priority pollutant, and its remediation has attracted increasing attention in the environmental area. In this study, the driving of pyrite-based Cr(VI) reduction ... ...

Abstract	Cr(VI) is considered as a priority pollutant, and its remediation has attracted increasing attention in the environmental area. In this study, the driving of pyrite-based Cr(VI) reduction by
Language	English
Publishing date	2020-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2019.03082
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Article ; Online: An integrated machine learning framework with uncertainty quantification for three-dimensional lithological modeling from multi-source geophysical data and drilling data

Zhang, Zhiqiang / Wang, Gongwen / Carranza, Emmanuel John M. / Liu, Chong / Li, Junjian / Fu, Chao / Liu, Xinxing / Chen, Chao / Fan, Junjie / Dong, Yulong

Engineering Geology. 2023 Aug. 07, p.107255-

2023 , Page(s) 107255–

Abstract: Nowadays, it is commonplace for geological surveys to integrate multi-source geophysical data and drilling data in order to construct three-dimensional (3D) lithological models. In this context, manual translation of complex geophysical data into ... ...

Abstract	Nowadays, it is commonplace for geological surveys to integrate multi-source geophysical data and drilling data in order to construct three-dimensional (3D) lithological models. In this context, manual translation of complex geophysical data into parameters used for 3D lithological modeling is challenging. Machine learning has recently shown great potential in 3D lithological modeling. However, the performance of machine learning algorithm is influenced by the imbalance in number of categories of lithological samples. In addition, the uncertainty associated with 3D lithological modeling by machine learning has rarely been quantified. This study presents a novel integrated machine learning framework to address the imbalance issue and to quantify uncertainty in 3D lithological modeling. As its novelty, our integrated machine learning framework can subdivide total uncertainty into aleatoric and epistemic uncertainties in the 3D lithological modeling procedure by stochastic gradient Langevin boosting. Another innovation of this study is the use of Bayesian hyperparameter optimization for automatic tuning of hyperparameters of the integrated machine learning framework. The 3D lithological and uncertainty modeling case study in the Jiaojia–Sanshandao gold district of China demonstrated the superiority of our proposed integrated machine learning framework. The proposed framework has great potential in integrating multi-source geophysical and drilling data for 3D lithological and uncertainty modeling in engineering geology.
Keywords	Bayesian theory ; algorithms ; case studies ; geophysics ; gold ; uncertainty ; China ; 3D lithological model ; Lithologic imbalance ; Aleatoric uncertainty, Epistemic uncertainty ; Bayesian hyperparameter optimization ; Machine learning
Language	English
Dates of publication	2023-0807
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ISSN	0013-7952
DOI	10.1016/j.enggeo.2023.107255
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Article ; Online: Response of rhizosphere bacterial community of Taxus chinensis var. mairei to temperature changes.

Yu, Xianghua / Liu, Xinxing / Liu, Xueduan

PloS one

2019 Volume 14, Issue 12, Page(s) e0226500

Abstract: Background: Temperature is a key factor influencing the growth and distribution of Taxus chinensis var. mairei, which is of high medicinal value. However, there is little information about the changes in rhizosphere bacterial community of Taxus ... ...

Abstract	Background: Temperature is a key factor influencing the growth and distribution of Taxus chinensis var. mairei, which is of high medicinal value. However, there is little information about the changes in rhizosphere bacterial community of Taxus chinensis var. maire under different temperatures. Methods: In this study, the rhizosphere bacterial communities of Taxus chinensis var. maire under a series of temperatures [5°C (T5), 15°C (T15), 25°C (T25), 35°C (T35)] were assessed through high-throughput sequencing. And some taxa annotated as Mitochondria were positively correlated with the activity of SOD. Results: Activity of peroxidase (POD) and superoxide dismutase (SOD) were increased and decreased respectively with increasing incubation temperature, showing that SOD may be the dominant reactive oxygen species (ROS) detoxifying enzyme in Taxus chinensis var. maire under low temperature. Taxus chinensis var. maire enriched specific bacterial taxa in rhizosphere under different temperature, and the rhizosphere bacterial diversity decreased with increasing temperature. Conclusion: The results indicated that rhizosphere bacteria may play important role for Taxus chinensis var. maire in coping with temperature changes, and the management of rhizosphere bacteria in a potential way to increase the cold resistance of Taxus chinensis var. mairei, thus improving its growth under low temperature and enlarging its habitats.
MeSH term(s)	Antioxidants/metabolism ; Bacteria/classification ; Bacteria/genetics ; Bacteria/isolation & purification ; Reactive Oxygen Species/metabolism ; Rhizosphere ; Soil Microbiology ; Taxus/growth & development ; Taxus/microbiology ; Temperature
Chemical Substances	Antioxidants ; Reactive Oxygen Species
Language	English
Publishing date	2019-12-12
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0226500
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Article ; Online: Proteomic characterization of hUC-MSC extracellular vesicles and evaluation of its therapeutic potential to treat Alzheimer's disease.

Li, Shuang / Zhang, Jiayi / Liu, Xinxing / Wang, Ningmei / Sun, Luyao / Liu, Jianling / Liu, Xingliang / Masoudi, Abolfazl / Wang, Hui / Li, Chunxia / Guo, Chunyan / Liu, Xifu

Scientific reports

2024 Volume 14, Issue 1, Page(s) 5959

Abstract: In recent years, human umbilical cord mesenchymal stem cell (hUC-MSC) extracellular vesicles (EVs) have been used as a cell replacement therapy and have been shown to effectively overcome some of the disadvantages of cell therapy. However, the specific ... ...

Abstract	In recent years, human umbilical cord mesenchymal stem cell (hUC-MSC) extracellular vesicles (EVs) have been used as a cell replacement therapy and have been shown to effectively overcome some of the disadvantages of cell therapy. However, the specific mechanism of action of EVs is still unclear, and there is no appropriate system for characterizing the differences in the molecular active substances of EVs produced by cells in different physiological states. We used a data-independent acquisition (DIA) quantitative proteomics method to identify and quantify the protein composition of two generations EVs from three different donors and analysed the function and possible mechanism of action of the proteins in EVs of hUC-MSCs via bioinformatics. By comparative proteomic analysis, we characterized the different passages EVs. Furthermore, we found that adaptor-related protein complex 2 subunit alpha 1 (AP2A1) and adaptor-related protein complex 2 subunit beta 1 (AP2B1) in hUC-MSC-derived EVs may play a significant role in the treatment of Alzheimer's disease (AD) by regulating the synaptic vesicle cycle signalling pathway. Our work provides a direction for batch-to-batch quality control of hUC-MSC-derived EVs and their application in AD treatment.
MeSH term(s)	Humans ; Alzheimer Disease/metabolism ; Proteomics ; Adaptor Protein Complex 2/metabolism ; Extracellular Vesicles/metabolism ; Mesenchymal Stem Cells
Chemical Substances	Adaptor Protein Complex 2
Language	English
Publishing date	2024-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-56549-6
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Article: Biochemical synthesis of palladium nanoparticles: The influence of chemical fixatives used in electron microscopy on nanoparticle formation and catalytic performance

Tan, Ling / Ray Jones, Thomas / Poitras, Jordan / Xie, Jianping / Liu, Xinxing / Southam, Gordon

Journal of hazardous materials. 2020 Nov. 05, v. 398

2020

Abstract: Palladium nanoparticles (PdNPs) can catalyse a range of reductive chemical reactions transforming both organic and inorganic environmental pollutants. PdNPs that ranged from <2 to 2–40 nm were synthesized using chemical methods, and bacterial biomass ... ...

Abstract	Palladium nanoparticles (PdNPs) can catalyse a range of reductive chemical reactions transforming both organic and inorganic environmental pollutants. PdNPs that ranged from <2 to 2–40 nm were synthesized using chemical methods, and bacterial biomass with/without chemical fixatives. PdNP formation was enhanced by adsorption of Pd(II) to bacterial biomass, followed by fixation with formate or glutaraldehyde. TEM-SAED analyses confirmed that the cell associated PdNPs were polycrystalline with a face-centered cubic structure. Chemically formed PdNPs possessed a higher Pd(0):Pd(II) ratio and produced structurally similar nanoparticles as the biotic systems. These PdNPs were employed to catalyze two, reductive chemical reactions, transforming 4-nitrophenol (4-NP) and hexavalent chromium [Cr(VI)], into 4-aminophenol and Cr(IV), respectively. In the reduction of 4-NP, the catalytic performance was directly proportional to PdNP surface area, i.e., the smallest PdNPs in formate-PdCH34 cells had the fastest rate of reaction. The mass of Pd(0) as PdNPs was the main contributor to Cr(VI) reduction; the chemically synthesized PdNPs showed the highest removal efficiency with 96% at 20 min. The use of glutaraldehyde enhanced the reduction of Pd(II) and promoted PdNPs formation, i.e., creating an artefact of fixation; however, this treatment also enhanced the catalytic performance of these PdNPs.
Keywords	adsorption ; aminophenols ; bacterial biomass ; catalytic activity ; chromium ; electron microscopy ; formates ; glutaraldehyde ; p-nitrophenol ; palladium ; surface area
Language	English
Dates of publication	2020-1105
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2020.122945
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