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Article ; Online: Influence of the Surface State on the Interfacial Bonding Strength of the Cold-Rolled Brass/Carbon Steel Composite.

Wang, Wen-Jing / Li, Jia-Hui / Liu, Xue-Feng / Bai, Yu-Liang

Langmuir : the ACS journal of surfaces and colloids

2023 Volume 39, Issue 33, Page(s) 11797–11806

Abstract: To improve the interfacial bonding of dissimilar composites, the interaction mechanism between the surface state and severe plastic deformation to strengthen the interfacial bonding strength was revealed. In this study, the different surface states of ... ...

Abstract	To improve the interfacial bonding of dissimilar composites, the interaction mechanism between the surface state and severe plastic deformation to strengthen the interfacial bonding strength was revealed. In this study, the different surface states of the steel strip were designed by louver blade grinding (LBG) and diamond bowl grinding (DBG), and the cold-rolled composite method was developed to prepare the brass/carbon steel composite strips. The results show that the steel surface after DBG has a large roughness of 9.79 μm, a hard hardening layer of 6.2 GPa, and high cleanliness of 1.34 atomic % oxygen content, while that after LBG has a roughness of 1.31 μm, a hardening layer of 4.2 GPa, and an oxygen content of 2.37 atomic %. The large roughness promotes the breaking of the hardening layer; the hardening layer is beneficial to obtain sufficient interfacial stress to expose the fresh metal; and the high cleanliness reduces the barrier to the fresh metal and contributes to the bonding of the fresh metal. The interface of the cold-rolled brass/carbon steel composite strip after LBG and DBG is mechanical bonding and metallurgical bonding, respectively. In the process of the cold-rolling composite, large shear deformation occurs at the interface of brass and steel, resulting in a high concentration of vacancy and dislocation defects, which provides a channel for interdiffusion of atoms at the interface. Under the diffusion driving force provided by the cold-rolling shear deformation heat, a nanodiffusion layer with a thickness of 60 nm and high interfacial bond strength was formed.
Language	English
Publishing date	2023-08-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.3c01524
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Article ; Online: High-quality compressed sensing imaging with limited detector bits using sparse measurements and multiple dithers.

Liu, Fan / Liu, Xue-Feng / Yao, Xu-Ri / Dou, Shen-Cheng / Li, Hu / Zhai, Guang-Jie

Optics express

2022 Volume 30, Issue 13, Page(s) 22608–22623

Abstract: High-flux measurement characteristics of compressed sensing (CS) imaging causes the imaging system prone to be disturbed by quantization. To realize high-quality CS imaging with limited detector bits, an improved imaging method combining sparse ... ...

Abstract	High-flux measurement characteristics of compressed sensing (CS) imaging causes the imaging system prone to be disturbed by quantization. To realize high-quality CS imaging with limited detector bits, an improved imaging method combining sparse measurements and multiple dithers is proposed to reduce the dynamic range of the measured signals and increase that of effective detection. Simulations and experiments show that compared with traditional CS imaging, the proposed system decreases reconstruction errors caused by quantization distortions and may reduce the required number of detector bits to 1. The effects of detector noise and system parameters are discussed to validate the feasibility and performance of this method.
Language	English
Publishing date	2022-09-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.455147
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Article ; Online: Prooxidative inhibition against NF-κB-mediated inflammation by pharmacological vitamin C.

Du, Yu-Ting / Long, Ying / Tang, Wei / Liu, Xue-Feng / Dai, Fang / Zhou, Bo

Free radical biology & medicine

2022 Volume 180, Page(s) 85–94

Abstract: Vitamin C (VC), widely found in vegetables and fruits, operates as an electron donor to perform various biological functions including anti-inflammatory activity. However, the mechanisms by which VC inhibits inflammation remain insufficiently understood. ...

Abstract	Vitamin C (VC), widely found in vegetables and fruits, operates as an electron donor to perform various biological functions including anti-inflammatory activity. However, the mechanisms by which VC inhibits inflammation remain insufficiently understood. Accordingly, we performed a detail mechanistic study on anti-inflammatory activity of VC at millimolar (pharmacological) concentrations in lipopolysaccharides-stimulated RAW264.7 cells. It was found that VC and its two-electron oxidative product, dehydroascorbate (DHA) constructs an efficient redox cycle with the aid of intracellular glutathione and copper ions, thereby facilitating the generation of reactive oxygen species (ROS) and the ROS-dependent inhibition against the NF-κB-mediated inflammation.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Ascorbic Acid/pharmacology ; Ascorbic Acid/therapeutic use ; Inflammation/drug therapy ; Lipopolysaccharides/pharmacology ; Mice ; NF-kappa B/genetics ; RAW 264.7 Cells ; Reactive Oxygen Species
Chemical Substances	Anti-Inflammatory Agents ; Lipopolysaccharides ; NF-kappa B ; Reactive Oxygen Species ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2022-01-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2022.01.007
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Article: [Protective effects of total saponins of

Liu, Xue Feng / Qiao, Jing / Gao, Jian de / Chen, Zheng Jun / Liu, Xiong

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology

2021 Volume 37, Issue 4, Page(s) 397–401

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Animals ; Codonopsis ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Colon ; Male ; NF-kappa B ; Rats ; Rats, Wistar ; Saponins/pharmacology ; Trinitrobenzenesulfonic Acid
Chemical Substances	NF-kappa B ; Saponins ; Trinitrobenzenesulfonic Acid (8T3HQG2ZC4)
Language	Chinese
Publishing date	2021-08-09
Publishing country	China
Document type	Journal Article
ISSN	1000-6834
ISSN	1000-6834
DOI	10.12047/j.cjap.6051.2021.032
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Article ; Online: Pseudolaric acid B promotes apoptosis of human laryngeal carcinoma cell line HEp-2

YANG Meng-sheng / LI Li / LIU Xue-feng / YANG Xiao-long

Jichu yixue yu linchuang, Vol 40, Iss 1, Pp 92-

2020 Volume 96

Abstract: Objective To investigate the effects of pseudolaric acid B (PAB) on the proliferation and apoptosis of HEp-2 cells. Methods Cell grouping and treatment: cells were treated with 0, 0.5, 1, 2, 4, 8 and 16 μmol/L PAB for 24, 48 and 72 h respectively; MTT ... ...

Abstract	Objective To investigate the effects of pseudolaric acid B (PAB) on the proliferation and apoptosis of HEp-2 cells. Methods Cell grouping and treatment: cells were treated with 0, 0.5, 1, 2, 4, 8 and 16 μmol/L PAB for 24, 48 and 72 h respectively; MTT assay was used to detect cell viability; flow cytometry was used to detect apoptosis; The expression of Bcl-2, Bax and caspase-3 protein and mRNA was detected by Western blot and qPCR. The expression of PARP and c-PARP was detected by immunohistochemistry. Results PAB inhibited HEp-2 proliferation in a time-concentration dependent manner. Compared with the control group, the apoptosis rate of HEp-2 cells in 4 μmol/L and 8 μmol/L PAB groups was significantly increased(P＜0.01). Compared with the control group, the expression of Bcl-2 and PARP in HEp-2 cells of 4 μmol/L and 8 μmol/L PAB groups were significantly decreased(P＜0.05), and the expression of Bax, caspase-3 and c-PARP was significantly increased(P＜0.05). Conclusions PAB can activate the mitochondrial apoptosis pathway thus induce apoptosis of HEp-2 cells and inhibit cell proliferation.
Keywords	pseudolaric acid b\|laryngeal cancer\|mitochondrial apoptosis\|mechanism ; Medicine ; R
Subject code	610 ; 570
Language	Chinese
Publishing date	2020-01-01T00:00:00Z
Publisher	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Document type	Article ; Online
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Article ; Online: Developing dietary curcumin mono-carbonyl piperidinone analogs as Nrf2-dependent cytoprotectors against oxidative damage: Structure-activity relationship and mechanisms.

Liu, Xue-Feng / Wang, Qi / Zheng, Jia-Fang / Chai, Zuo-Hu / Dai, Fang / Jin, Xiao-Jie / Zhou, Bo

Free radical biology & medicine

2022 Volume 186, Page(s) 66–75

Abstract: Developing nuclear factor erythroid-2 related factor 2 (Nrf2)-dependent cytoprotectors against oxidative damage is of concern because they can effectively reduce the risk of oxidative stress-related diseases, such as cancer and inflammation. This work ... ...

Abstract	Developing nuclear factor erythroid-2 related factor 2 (Nrf2)-dependent cytoprotectors against oxidative damage is of concern because they can effectively reduce the risk of oxidative stress-related diseases, such as cancer and inflammation. This work was aimed to develop more active Nrf2-dependent cytoprotectors than curcumin, a well-known dietary Nrf2 activator and cancer chemopreventive agent. Herein we designed a panel of curcumin-inspired mono-carbonyl piperidinone analogs differentiated by placing distinct electron-withdrawing and electron-donating groups on its two aromatic rings in the ortho, meta, or para position to the linker of α, β-unsaturated piperidinone. Among these, the ortho-fluorine-substituted CN-2F surfaced as a promising lead molecule, which was significantly superior to the parent curcumin in protecting HepG2 cells from oxidative damage induced by tert-butyl hydroperoxide. Mechanically, by virtue of its Michael receptor units and ortho-substituted mode, CN-2F activated Nrf2 signaling by covalently modifying Cys-151 and Cys-288 residues at Keap1, promoting phosphorylation of JNK, ERK and p38, as well as inhibiting Nrf2 degradation. This work reveals the structural determinants and the activity mechanisms of CN-2F as an Nrf2-dependent cytoprotector, and gives useful information on how to design curcumin-inspired Nrf2 activators and cytoprotectors.
MeSH term(s)	Antioxidants/pharmacology ; Curcumin/pharmacology ; GA-Binding Protein Transcription Factor ; Kelch-Like ECH-Associated Protein 1/metabolism ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Structure-Activity Relationship
Chemical Substances	Antioxidants ; GA-Binding Protein Transcription Factor ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; Reactive Oxygen Species ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2022-05-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2022.05.009
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Book ; Online: Mid-wave infrared super-resolution imaging based on compressive calibration and sampling

Jin, Xiao-Peng / Zhao, Qing / Liu, Xue-Feng / Xiong, An-Dong

2021

Abstract: Mid-wave infrared (MWIR) cameras for large number pixels are extremely expensive compared with their counterparts in visible light, thus, super-resolution imaging (SRI) for MWIR by increasing imaging pixels has always been a research hotspot in recent ... ...

Abstract	Mid-wave infrared (MWIR) cameras for large number pixels are extremely expensive compared with their counterparts in visible light, thus, super-resolution imaging (SRI) for MWIR by increasing imaging pixels has always been a research hotspot in recent years. Over the last decade, with the extensively investigation of the compressed sensing (CS) method, focal plane array (FPA) based compressive imaging in MWIR developed rapidly for SRI. This paper presents a long-distance super-resolution FPA compressive imaging in MWIR with improved calibration method and imaging effect. By the use of CS, we measure and calculate the calibration matrix of optical system efficiently and precisely, which improves the imaging contrast and signal-to-noise ratio(SNR) compared with previous work. We also achieved the 4x4 times super-resolution reconstruction of the long-distance objects which reaches the limit of the system design in our experiment.
Keywords	Electrical Engineering and Systems Science - Image and Video Processing ; Physics - Optics
Subject code	535
Publishing date	2021-09-08
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Epigenetic regulation of cellular and cytomegalovirus genes during myeloid cell development.

Liu, Xue-Feng / Hummel, Mary / Abecassis, Michael

Internal medicine review (Washington, D.C. : Online)

2017 Volume 3, Issue 3

Abstract: Myeloid cells are important cell types that carry human cytomegalovirus. Latent viral DNA is present in CD34+ progenitor cells and their derived monocytes. However, differentiation of latently infected monocytes to mature macrophages or dendritic cells ... ...

Abstract	Myeloid cells are important cell types that carry human cytomegalovirus. Latent viral DNA is present in CD34+ progenitor cells and their derived monocytes. However, differentiation of latently infected monocytes to mature macrophages or dendritic cells causes reactivation of latent viruses. During hematopoietic development, pluripotent genes are repressed, and lineage specific genes are activated in a step-wise manner. This process is governed by cell-type specific chromatin states. Enhancers in the hematopoietic system are highly dynamic and established by pioneer (first tier) transcription factors (TFs), which set the stage for second and third tier TF binding. In this review, we examine the epigenetic mechanisms that regulate myeloid cell development, cell identity, and activation with a special focus on factors that regulate viral gene expression and the status of viral infection in myeloid cells.
Language	English
Publishing date	2017-03
Publishing country	United States
Document type	Journal Article
ISSN	2470-3524
ISSN	2470-3524
DOI	10.18103/imr.v3i3.385
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Article: PCSK9 promotes tumor growth by inhibiting tumor cell apoptosis in hepatocellular carcinoma.

Zhang, Shi-Zhe / Zhu, Xiao-Dong / Feng, Long-Hai / Li, Xiao-Long / Liu, Xue-Feng / Sun, Hui-Chuan / Tang, Zhao-You

Experimental hematology & oncology

2021 Volume 10, Issue 1, Page(s) 25

Abstract: Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9), one of the key enzymes in the process of lipid transport, is involved in the disease progression of various types of tumors. This article is to study the role of PCSK9 in the progression ...

Abstract	Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9), one of the key enzymes in the process of lipid transport, is involved in the disease progression of various types of tumors. This article is to study the role of PCSK9 in the progression of hepatocellular carcinoma (HCC). Methods: Immunohistochemistry was used to assess the expression of PCSK9 in tumor specimens from 105 HCC patients who underwent curative resection. Western blotting and quantitative real-time PCR were used to test the protein and mRNA expression levels in HCC cell lines. Cell Counting Kit-8 (CCK-8) and clone formation assays were performed to evaluate the proliferation ability of different kinds of cells in vitro. Flow cytometry was used to analyze cell cycle distribution and apoptosis rate. A xenograft model was established to study the effect of PCSK9 on HCC growth in vivo. TUNEL and immunofluorescence assays were used to detect cell apoptosis. Results: High expression of PCSK9 in tumor tissues was related to microvascular invasion (p = 0.036) and large tumor size (p = 0.001) in HCC patients. Overall survival and disease-free survival after surgery were poor in patients with high expression of PCSK9 (p = 0.035 and p = 0.007, respectively). In vivo and in vitro experiments showed that PCSK9 promoted the growth of HCC by inhibiting cell apoptosis. A mechanistic study revealed that PCSK9 increases FASN expression, thereby inhibiting apoptosis of HCC cells via the Bax/Bcl-2/Caspase9/Caspase3 pathway. Conclusions: PCSK9 expression level in HCC is an indicator of poor prognosis for patients with HCC. FASN-mediated anti-apoptosis plays an important role in PCSK9-induced HCC progression.
Language	English
Publishing date	2021-03-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2669066-4
ISSN	2162-3619
ISSN	2162-3619
DOI	10.1186/s40164-021-00218-1
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Article: [Qualitative analysis of Gynostemma longipes for medicinal usage].

Zhang, Meng-Meng / Zheng, Wei / Zhang, Jie / Gao, Lin / Liu, Xue-Feng / Luo, Ding-Qiang / Guo, Bao-Lin / Ma, Bai-Ping

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2021 Volume 46, Issue 4, Page(s) 951–965

Abstract: The Qinling-Daba Mountains area is the main producing areas of Gynostemma longipes for medicinal usage, and samples of wild whole plants in Pingli, Shaanxi Province and Qingchuan, Sichuan Province were collected. The ultra-high performance liquid ... ...

Abstract	The Qinling-Daba Mountains area is the main producing areas of Gynostemma longipes for medicinal usage, and samples of wild whole plants in Pingli, Shaanxi Province and Qingchuan, Sichuan Province were collected. The ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS~E) was used to profile the chemical compositions and analyze the similarities and differences of G. longipes samples in these areas. Based on the accurate molecular weight and fragment information obtained from Q-TOF-MS~E, the structures of the main components were identified by combining with the mass spectra, chromatographic behaviors of reference standards and related literatures. The results showed that the components of wild G. longipes from different places among Qinling-Daba Mountains area were similar. Forty-five chemical components were identified in the whole plant of G. longipes from Pingli, Shaanxi Province, including 43 triterpenoid saponins and 2 flavonoids which contain all main peaks in its fingerprint. The main components are dammarane-type triterpenoid saponins, such asgypenoside ⅩLⅨ, gypenoside A and its malonylated product of glycosyl.
MeSH term(s)	Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal ; Gynostemma ; Mass Spectrometry ; Saponins
Chemical Substances	Drugs, Chinese Herbal ; Saponins
Language	Chinese
Publishing date	2021-03-01
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20200623.204
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