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Article ; Online: Prevotella histicola Prevented Particle-Induced Osteolysis via Gut Microbiota-Dependent Modulation of Inflammation in Ti-Treated Mice.

Huang, Furong / Pan, Hao / Tan, Zenglin / Chen, Lei / Li, Ting / Liu, Yangbo

2023 Volume 16, Issue 2, Page(s) 383–393

Abstract: Wear particles generated from total joint replacements induce chronic osteolysis mediated by inflammatory upregulation, which leads to implant failure. Recent studies have suggested an important role of the gut microbiota in modulating the host's ... ...

Abstract	Wear particles generated from total joint replacements induce chronic osteolysis mediated by inflammatory upregulation, which leads to implant failure. Recent studies have suggested an important role of the gut microbiota in modulating the host's metabolism and immune system, leading to alterations in bone mass. Following gavage with P. histicola, micro-CT and HE staining revealed that osteolysis was significantly reduced in titanium (Ti)-treated mice. Immunofluorescence analysis revealed an increased macrophage (M)1/M2 ratio in the guts of Ti-treated mice, which decreased when P. histicola was added. P. histicola was also found to upregulate the tight junction proteins ZO-1, occludin, claudin-1, and MUC2 in the gut, reduce the levels of inflammatory factors IL-1β, IL-6, IL-8, and TNF-α, primarily in the ileum and colon, and decrease the expression of IL-1β and TNF-α and increase the level of IL-10 in the serum and cranium. Furthermore, P. histicola treatment resulted in a significant downregulation of CTX-1, RANKL, and RANKL/OPG. These findings demonstrate that P. histicola significantly mitigates osteolysis in Ti-treated mice by improving intestinal microbiota that repairs intestinal leakage and reduces systemic and local inflammation which in turn inhibits RANKL expression for bone resorption. P. histicola treatment may thus be therapeutically beneficial for particle-induced osteolysis.
MeSH term(s)	Mice ; Animals ; Osteolysis/chemically induced ; Osteolysis/metabolism ; Osteolysis/prevention & control ; Tumor Necrosis Factor-alpha ; Osteoclasts/metabolism ; Titanium/adverse effects ; Titanium/metabolism ; Gastrointestinal Microbiome ; Inflammation/drug therapy ; Inflammation/metabolism ; Prevotella
Chemical Substances	Tumor Necrosis Factor-alpha ; Titanium (D1JT611TNE)
Language	English
Publishing date	2023-03-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2487792-X
ISSN	1867-1314 ; 1867-1306
ISSN (online)	1867-1314
ISSN	1867-1306
DOI	10.1007/s12602-023-10057-7
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Article ; Online: Comparison Between Periarticular Analgesia Versus Intraarticular Injection for Effectiveness and Safety After Total Knee Arthroplasty.

Su, Chenxian / Liu, Yangbo / Wu, Peng / Lang, Junzhe / Chen, Lei

Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses

2022 Volume 37, Issue 6, Page(s) 952–955

Abstract: Purpose: In most studies, local infiltration analgesia (LIA) can provide better analgesic effect in the early postoperative period, but the optimal technique is unknown. Our study was designed to evaluated the early clinical efficacy and safety of ... ...

Abstract	Purpose: In most studies, local infiltration analgesia (LIA) can provide better analgesic effect in the early postoperative period, but the optimal technique is unknown. Our study was designed to evaluated the early clinical efficacy and safety of periarticular analgesia versus intraarticular injection in Total knee arthroplasty (TKA). Design: A prospective study was conducted on 100 patients admitted for TKA. Subjects were divided into two groups: 50 in group A, 50 in Group B. Methods: Patients in group A received periarticular analgesia with ropivacaine 300 mg and morphine 5 mg (the drugs were diluted with saline to 50 ml) in the periosteal borders, posterior capsule and extensor apparatus and subcutaneous tissues during surgery. After stitching of joint capsule, tranexamic acid (TXA) 2 g (20 ml) was injected into the articular cavity. Group B patients had all of the 70 mL mixture (ropivacaine 300 mg, morphine 5 mg and TXA 2 g) injected intraarticularly after stitching of the joint capsule. We assessed postoperative length of stay (LOS), knee functional outcome, pain, and complications after surgery. Findings: There was no statistical difference in visual analog scale (VAS) scores for knee pain between the two groups on postoperative day (POD)1, 3, or 30 (P > .05). Mean postoperative LOS was 7.40 ± 1.98 days in Group A, compared to 8.02 ± 2.09 days in Group B (P > .05). No significant differences between groups were seen in the mean swelling ratio (P > .05), and no significant differences were found in the Hospital for Special Surgery (HSS) knee score and range of motion (ROM) at 30 days follow-up (P > .05). There was also no statistical difference in the incidence of complications (such as superficial wound infection, deep vein thrombosis (DVT) and nausea and vomiting) between the Group A and the Group B. Conclusions: In conclusion, it seems that intraarticular injection had a similar analgesic effect compared with periarticular injection when adopting a multi-modal analgesia regimen. Our results suggest that there is no obvious advantage with the use of periarticular injections compared to intraarticular injection. The authors believe that intraarticular injection may be a better technique compared with periarticular injections in the absence of a drainage tube because intraarticular injection can reduce the number of surgical steps and have similar postoperative outcomes.
MeSH term(s)	Humans ; Arthroplasty, Replacement, Knee/adverse effects ; Ropivacaine/therapeutic use ; Pain, Postoperative/drug therapy ; Pain, Postoperative/etiology ; Prospective Studies ; Anesthetics, Local/therapeutic use ; Pain Measurement ; Analgesia/methods ; Injections, Intra-Articular/adverse effects ; Morphine/therapeutic use ; Analgesics/therapeutic use ; Treatment Outcome
Chemical Substances	Ropivacaine (7IO5LYA57N) ; Anesthetics, Local ; Morphine (76I7G6D29C) ; Analgesics
Language	English
Publishing date	2022-09-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	1329844-6
ISSN	1532-8473 ; 0883-9433 ; 1089-9472
ISSN (online)	1532-8473
ISSN	0883-9433 ; 1089-9472
DOI	10.1016/j.jopan.2022.04.010
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Article ; Online: Analysis of flavonoid metabolism of compounds in succulent fruits and leaves of three different colors of Rosaceae.

Yang, Chen / Sun, Nan / Qin, Xin / Liu, Yangbo / Sui, Mengyi / Zhang, Yawen / Hu, Yanli / Mao, Yunfei / Shen, Xiang

Scientific reports

2024 Volume 14, Issue 1, Page(s) 4933

Abstract: Red flesh apple (Malus pumila var. medzwetzkyana Dieck), purple leaf plum (Prunus cerasifera Ehrhar f), and purple leaf peach (Prunus persica 'Atropurpurea') are significant ornamental plants within the Rosaceae family. The coloration of their fruits and ...

Abstract	Red flesh apple (Malus pumila var. medzwetzkyana Dieck), purple leaf plum (Prunus cerasifera Ehrhar f), and purple leaf peach (Prunus persica 'Atropurpurea') are significant ornamental plants within the Rosaceae family. The coloration of their fruits and leaves is crucial in their appearance and nutritional quality. However, qualitative and quantitative studies on flavonoids in the succulent fruits and leaves of multicolored Rosaceae plants are lacking. To unveil the diversity and variety-specificity of flavonoids in these three varieties, we conducted a comparative analysis of flavonoid metabolic components using ultra-high-performance liquid phase mass spectrometry (UPLC-MS/MS). The results revealed the detection of 311 metabolites, including 47 flavonoids, 105 flavonols, 16 chalcones, 37 dihydroflavonoids, 8 dihydroflavonols, 30 anthocyanins, 14 flavonoid carbon glycosides, 23 flavanols, 8 isoflavones, 11 tannins, and 12 proanthocyanidins. Notably, although the purple plum and peach leaves exhibited distinct anthocyanin compounds, paeoniflorin and corythrin glycosides were common but displayed varying glycosylation levels. While the green purple leaf peach fruit (PEF) and red flesh apple leaf (AL) possessed the lowest anthocyanin content, they exhibited the highest total flavonoid content. Conversely, the red flesh apple fruit (AF) displayed the highest anthocyanin content and a diverse range of anthocyanin glycosylation modifications, indicating that anthocyanins predominantly influenced the fruit's color. Purple PLF, PLL, and PEL showcased varying concentrations of anthocyanins, suggesting that their colors result from the co-color interaction between specific types of anthocyanins and secondary metabolites, such as flavonols, flavonoids, and dihydroflavonoids. This study provides novel insights into the variations in tissue metabolites among Rosaceae plants with distinct fruit and leaf colors.
MeSH term(s)	Anthocyanins/metabolism ; Fruit/metabolism ; Rosaceae/metabolism ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Plant Leaves/metabolism ; Flavonoids/metabolism ; Malus/metabolism ; Flavonols/metabolism ; Prunus persica/metabolism ; Gene Expression Regulation, Plant
Chemical Substances	Anthocyanins ; Flavonoids ; Flavonols
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-55541-4
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Article ; Online: Ferroptosis is Involved in the Pharmacological Effect of Ginsenoside.

Feng, Juling / Chen, Haodong / Liu, Yangbo / Ai, Qidi / Yang, Yantao / He, Wenbin / Zhao, Lei / Chu, Shifeng / Chen, Naihong

Mini reviews in medicinal chemistry

2024

Abstract: Ginsenoside is the principal active ingredient in ginseng. Several investigations have found that ginsenosides have anti-inflammatory, antioxidant, anti-apoptotic, anti-cancer, and antiallergic activities. Ferroptosis is an iron-dependent, non-apoptotic ... ...

Abstract	Ginsenoside is the principal active ingredient in ginseng. Several investigations have found that ginsenosides have anti-inflammatory, antioxidant, anti-apoptotic, anti-cancer, and antiallergic activities. Ferroptosis is an iron-dependent, non-apoptotic form of cell-regulated death caused by lipid peroxidation. Iron, lipid, and amino acid metabolism orchestrate the complex ferroptosis response through direct or indirect regulation of iron accumulation or lipid peroxidation. More and more research has demonstrated that ginsenoside impacts illnesses via ferroptosis, implying that ferroptosis might be employed as a novel target of ginsenoside for disease therapy. This article examines the molecular mechanism of ferroptosis as well as the current advancement of ginsenoside in influencing disorders via ferroptosis.
Language	English
Publishing date	2024-01-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2104081-3
ISSN	1875-5607 ; 1389-5575
ISSN (online)	1875-5607
ISSN	1389-5575
DOI	10.2174/0113895575277359231210145922
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Zs.A 5891: Show issues

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Article ; Online: Safety, pharmacokinetics and efficacy of selumetinib in Chinese adult and paediatric patients with neurofibromatosis type 1 and inoperable plexiform neurofibromas: The primary analysis of a phase 1 open-label study.

Wang, Zhichao / Zhang, Xin / Li, Chunyan / Liu, Yangbo / Ge, Xiaoyun / Zhao, Jiajia / Yuan, Xiaojun / Li, Qingfeng

Clinical and translational medicine

2024 Volume 14, Issue 3, Page(s) e1589

MeSH term(s)	Adult ; Humans ; Child ; Neurofibroma, Plexiform/drug therapy ; Neurofibromatosis 1/drug therapy ; Benzimidazoles ; China
Chemical Substances	AZD 6244 ; Benzimidazoles
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Clinical Trial, Phase I ; Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2697013-2
ISSN	2001-1326 ; 2001-1326
ISSN (online)	2001-1326
ISSN	2001-1326
DOI	10.1002/ctm2.1589
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Article ; Online: Analysis of Flavonoid Metabolism during the Process of Petal Discoloration in Three

Cui, Xueli / Qin, Xin / Liu, Yangbo / Zhang, Yawen / Bao, Huaixin / Hu, Yanli / Shen, Xiang

ACS omega

2022 Volume 7, Issue 42, Page(s) 37304–37314

Abstract: ... ...

Abstract	Malus
Language	English
Publishing date	2022-10-14
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c03820
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Article: Osteoporosis is associated with elevated baseline cerebrospinal fluid biomarkers and accelerated brain structural atrophy among older people.

Pan, Hao / Cao, Jiali / Wu, Congcong / Huang, Furong / Wu, Peng / Lang, Junzhe / Liu, Yangbo

Frontiers in aging neuroscience

2022 Volume 14, Page(s) 958050

Abstract: Objective: The aim of this study was to examine whether osteoporosis (OP) is associated with Alzheimer's disease-related cerebrospinal fluid (CSF) biomarkers and brain structures among older people.: Methods: From the Alzheimer's disease Neuroimaging ...

Abstract	Objective: The aim of this study was to examine whether osteoporosis (OP) is associated with Alzheimer's disease-related cerebrospinal fluid (CSF) biomarkers and brain structures among older people. Methods: From the Alzheimer's disease Neuroimaging Initiative database, we grouped participants according to the OP status (OP+/OP-) and compared the Alzheimer's disease (AD)-related CSF biomarker levels and the regional brain structural volumes between the two groups using multivariable models. These models were adjusted for covariates including age, education, gender, diagnosis of Alzheimer's disease, and apolipoprotein E4 carrier status. Results: In the cross-sectional analyses at baseline, OP was related to higher CSF t-tau (total tau) and p-tau Conclusion: OP was associated with elevated levels of CSF t-tau and p-tau
Language	English
Publishing date	2022-09-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2022.958050
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Article ; Online: CZK, a novel alkaloid derivative from Clausena lansium, alleviates ischemic stroke injury through Nrf2-mediated antioxidant effects.

Chen, Haodong / Liu, Yangbo / Feng, Juling / Wang, Hongyun / Yang, Yantao / Ai, Qidi / Zhang, Zhao / Chu, Shifeng / Chen, Naihong

Scientific reports

2023 Volume 13, Issue 1, Page(s) 6053

Abstract: Anti-oxidant stress is a potential strategy for the treatment of ischemic stroke. Here, we found a novel free radical scavenger termed as CZK, which is derived from alkaloids contained in Clausena lansium. In this study, we first compared cytotoxicity ... ...

Abstract	Anti-oxidant stress is a potential strategy for the treatment of ischemic stroke. Here, we found a novel free radical scavenger termed as CZK, which is derived from alkaloids contained in Clausena lansium. In this study, we first compared cytotoxicity and biological activity between CZK and its parent's compound Claulansine F. It was found that CZK had lower cytotoxicity and improved anti-oxygen-glucose deprivation/reoxygenation (OGD/R) injury than its parent's compound. Free radical scavenging test showed that CZK had a strong inhibitory effect on hydroxyl free radicals with the IC
MeSH term(s)	Antioxidants/pharmacology ; Antioxidants/therapeutic use ; NF-E2-Related Factor 2/metabolism ; Clausena ; Ischemic Stroke/drug therapy ; Molecular Docking Simulation ; Oxidative Stress ; Heme Oxygenase-1/metabolism ; Alkaloids/pharmacology ; Reperfusion Injury/drug therapy ; Glucose/pharmacology ; Apoptosis
Chemical Substances	Antioxidants ; NF-E2-Related Factor 2 ; Heme Oxygenase-1 (EC 1.14.14.18) ; Alkaloids ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-04-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-32999-2
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Article: Effects of Fusarium proliferatum on Aboveground Physiological Indicators of Superior Apple Rootstock Line 12-2 (Malus spectabilis) with Improved Apple-Replant-Disease Resistance

Cui, Xueli / Qin, Xin / Liu, Yangbo / Hu, Yanli / Mao, Zhiquan / Chen, Xuesen / Mao, Yunfei / Shen, Xiang

Horticulturae. 2022 Aug. 11, v. 8, no. 8

2022

Abstract: 1) Background: Cultivating resistant rootstocks is an effective way to mitigate apple replant disease (ARD), and we developed superior apple rootstock line 12-2 (self-named), which shows improved ARD resistance. (2) Methods: We used ARD-associated ... ...

Abstract	(1) Background: Cultivating resistant rootstocks is an effective way to mitigate apple replant disease (ARD), and we developed superior apple rootstock line 12-2 (self-named), which shows improved ARD resistance. (2) Methods: We used ARD-associated pathogen Fusarium proliferatum MR5 (MR5) to test the fungal infection in the 12-2 line. Seedlings of the 12-2, T337, and M26 rootstock lines were planted in a substrate with potato dextrose broth and MR5 spore solution, and aboveground physiological indicators were measured. (3) Results: MR5 had the greatest effect on the leaf growth of T337 and M26. The incidence rates of infectious symptoms in the T337 and M26 lines were 68 and 100%, respectively. MR5 significantly affected the leaf chlorophyll content, ETR, and NPQ of T337 and M26, as well as Pₙ and Tᵣ of M26. MR5 tended to reduce the leaf photosynthetic parameters of T337, but the decreases were not significant. The leaf reactive-oxygen-species levels of T337 and M26, the leaf antioxidant-enzyme activities of M26, and the superoxide-dismutase activity of T337 were significantly affected by MR5. MR5 also had a significant effect on the leaf malondialdehyde, proline, and soluble-sugar contents of T337 and M26. None of these aboveground physiological indicators were affected by MR5 in the 12-2 rootstock. (4) Conclusions: The 12-2 rootstock was more resistant to ARD-associated MR5 and could serve as an important test material for resistant-apple-rootstock breeding in China.
Keywords	Fusarium proliferatum ; Malus spectabilis ; apples ; fungi ; leaf chlorophyll content ; leaves ; malondialdehyde ; pathogens ; photosynthesis ; proline ; reactive oxygen species ; replant disease ; rootstocks ; spores ; superoxide dismutase ; China
Language	English
Dates of publication	2022-0811
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2813983-5
ISSN	2311-7524
ISSN	2311-7524
DOI	10.3390/horticulturae8080723
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Study of the grafting compatibility of the apple rootstock 12–2, resistant to apple replant diseases (ARD)

Mao, Yunfei / Cui, Xueli / Wang, Haiyan / Qin, Xin / Liu, Yangbo / Hu, Yanli / Chen, Xuesen / Mao, Zhiquan / Shen, Xiang

BMC Plant Biol. 2022 Dec., v. 22, no. 1 p.468-468

2022

Abstract: BACKGROUND: Cultivation of resistant rootstocks can effectively prevent apple replant disease (ARD), and grafting tests are an important means of evaluating the compatibility of rootstocks with scions. METHODS: The apple rootstocks 12–2 (self-named) and ... ...

Abstract	BACKGROUND: Cultivation of resistant rootstocks can effectively prevent apple replant disease (ARD), and grafting tests are an important means of evaluating the compatibility of rootstocks with scions. METHODS: The apple rootstocks 12–2 (self-named) and Malus hupehensis Rehd. (PYTC) were planted in a replanted 20-year-old apple orchard. The two rootstocks were grafted with scions of 13 apple varieties. Multiple aboveground physiological parameters of the grafted combinations were measured and evaluated to verify the grafting affinity of 12–2 with the scions as compared to Malus hupehensis Rehd. (PYTC). RESULTS: The graft survival rate and graft interface healing of 12–2 did not differ significantly from those of PYTC. Mechanical strength tests of the grafted interfaces showed that some mechanical strength indices of Redchief, Jonagold, Starking, Goldspur and Yinv apple varieties were significantly higher when they were grafted onto 12–2 compared to the PYTC control. The height and diameter of shoots and the relative chlorophyll content, photosynthetic and fluorescence parameters, antioxidant enzyme activities and malondialdehyde content of leaves showed that Fuji 2001, Tengmu No.1, RedChief, Gala, USA8, and Shoufu1 grew similarly on the two rootstocks, but Tianhong 2, Lvguang, Jonagold, Starking, Goldspur, Yinv and Luli grew better when grafted onto 12–2 than onto the PYTC control. The rootstock 12-2, therefore, showed good grafting affinity. CONCLUSION: These results provide experimental materials and theoretical guidance for the cultivation of a new grafting compatible rootstock to the 13 studied apple cultivars.
Keywords	Malus hupehensis ; antioxidant enzymes ; apples ; chlorophyll ; cultivars ; fluorescence ; malondialdehyde ; orchards ; photosynthesis ; replant disease ; rootstocks ; strength (mechanics) ; survival rate
Language	English
Dates of publication	2022-12
Size	p. 468.
Publishing place	BioMed Central
Document type	Article ; Online
ZDB-ID	2059868-3
ISSN	1471-2229
ISSN	1471-2229
DOI	10.1186/s12870-022-03847-8
Database	NAL-Catalogue (AGRICOLA)

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