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  1. Article ; Online: Turn-on fluorescent nanoprobe for ATP detection based on DNA-templated silver nanoclusters.

    Li, Yuxia / Meng, Zeting / Liu, Yating / Zhang, Baozhu

    RSC advances

    2024  Volume 14, Issue 8, Page(s) 5594–5599

    Abstract: A turn-on fluorescence nanoprobe was constructed for the determination of adenosine 5'-triphosphate (ATP) based on DNA-templated silver nanoclusters (DNA-AgNCs). The significant enhancement fluorescence intensity of DNA-AgNCs in the presence of ATP is ... ...

    Abstract A turn-on fluorescence nanoprobe was constructed for the determination of adenosine 5'-triphosphate (ATP) based on DNA-templated silver nanoclusters (DNA-AgNCs). The significant enhancement fluorescence intensity of DNA-AgNCs in the presence of ATP is due to the high special binding affinity between ATP and the aptamer, resulting in the environment of DNA-AgNCs with darkish fluorescence lying at one terminus of DNA slightly altering owing to the change of ATP aptamer conformation. A good linear range runs from 9 to 24 mM with a satisfactory detection limit of 3 μM. Furthermore, the proposed nanoprobe exhibited good performance for ATP detection in diluted fetal bovine serum.
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra07077h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ixekizumab successfully treated severe pityriasis rubra pilaris after COVID-19 vaccination.

    Liu, Ya-Ting / Wang, Shang-Shang

    Skin health and disease

    2022  , Page(s) e139

    Abstract: Pityriasis rubra pilaris is an inflammatory dermatologic disorder of unknown cause. We report a 67-year-old man with Pityriasis rubra pilaris might induced by COVID-19 vaccination. The patient developed the lesions after the first dose of vaccine and ... ...

    Abstract Pityriasis rubra pilaris is an inflammatory dermatologic disorder of unknown cause. We report a 67-year-old man with Pityriasis rubra pilaris might induced by COVID-19 vaccination. The patient developed the lesions after the first dose of vaccine and significantly aggravated after the second dose. He had poor effect and liver function impairment developed after acitretin used, but achieved satisfactory efficacy after replacement to ixekizumab, an interleukin-17A inhibitor.
    Language English
    Publishing date 2022-06-16
    Publishing country England
    Document type Case Reports
    ISSN 2690-442X
    ISSN (online) 2690-442X
    DOI 10.1002/ski2.139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Crude protein content in diets associated with intestinal microbiome and metabolome alteration in Huanjiang mini-pigs during different growth stages.

    Liu, Yating / Azad, Md Abul Kalam / Zhao, Xichen / Kong, Xiangfeng

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1398919

    Abstract: Introduction: Adequate crude protein (CP) content in diets plays a crucial role in the intestinal health of the animal. This study investigated the impacts of CP content in diets on the intestinal microbiome and metabolome profiles in growing Huanjiang ... ...

    Abstract Introduction: Adequate crude protein (CP) content in diets plays a crucial role in the intestinal health of the animal. This study investigated the impacts of CP content in diets on the intestinal microbiome and metabolome profiles in growing Huanjiang mini-pigs.
    Methods: A total of 360 pigs with similar body weight (BW) were allocated for three independent feeding trials based on three different BW stages, including (i) 5-10 kg BW, diets consisting of 14, 16, 18, 20, and 22% CP content; (ii) 10-20 kg BW, diets consisting of 12, 14, 16, 18, and 20% CP content; and (iii) 20-30 kg BW, diets consisting of 10, 12, 14, 16, and 18% CP content. These experiments lasted 28, 28, and 26 days, respectively.
    Results: The results showed that the Shannon and Simpson indices were decreased (
    Conclusion: These findings suggest that a diet containing lower CP content (16% CP) may be an appropriate dietary CP content for 5-10 kg Huanjiang mini-pigs, as 16% CP content in diet has shown beneficial impacts on the intestinal microbiome and metabolome profiles at the early growth stage of pigs.
    Language English
    Publishing date 2024-04-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1398919
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Evolution of Avian Eye Size Is Associated with Habitat Openness, Food Type and Brain Size

    Liu, Yating / Jiang, Ying / Xu, Jiliang / Liao, Wenbo

    Animals. 2023 May 18, v. 13, no. 10

    2023  

    Abstract: The eye is the primary sensory organ that obtains information from the ecological environments and specifically bridges the brain with the extra environment. However, the coevolutionary relationships between eye size and ecological factors, behaviours ... ...

    Abstract The eye is the primary sensory organ that obtains information from the ecological environments and specifically bridges the brain with the extra environment. However, the coevolutionary relationships between eye size and ecological factors, behaviours and brain size in birds remain poorly understood. Here, we investigate whether eye size evolution is associated with ecological factors (e.g., habitat openness, food type and foraging habitat), behaviours (e.g., migration and activity pattern) and brain size among 1274 avian species using phylogenetically controlled comparative analyses. Our results indicate that avian eye size is significantly associated with habitat openness, food type and brain size. Species living in dense habitats and consuming animals exhibit larger eye sizes compared to species living in open habitats and consuming plants, respectively. Large-brained birds tend to possess larger eyes. However, migration, foraging habitat and activity pattern were not found to be significantly associated with eye size in birds, except for nocturnal birds having longer axial lengths than diurnal ones. Collectively, our results suggest that avian eye size is primarily influenced by light availability, food need and cognitive ability.
    Keywords birds ; brain ; cognition ; eyes ; habitats ; phylogeny
    Language English
    Dates of publication 2023-0518
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13101675
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Progress in immune checkpoint inhibitor-based combined regimens in the treatment of metastatic urothelial carcinoma

    Liu Jianbing / Yue Zhongjin / Shang Panfeng / Liu Yating / Chang Hong

    Xin yixue, Vol 54, Iss 9, Pp 611-

    2023  Volume 617

    Abstract: Metastatic urothelial carcinoma （mUC） yields poor prognosis and is difficult to treat. Immunotherapy strategies have developed rapidly in recent years， and clinical prognosis of mUC patients has been significantly improved. However， immune checkpoint ... ...

    Abstract Metastatic urothelial carcinoma （mUC） yields poor prognosis and is difficult to treat. Immunotherapy strategies have developed rapidly in recent years， and clinical prognosis of mUC patients has been significantly improved. However， immune checkpoint inhibitors （ICIs） alone have limited efficacy， and some ICIs monotherapy indications for mUC have also been withdrawn in recent years. Therefore， combined therapy based on ICIs has become a research hotspot in the treatment of mUC. At present， multiple clinical studies of ICIs combined with chemotherapy， antibody-drug conjugates， and dual immunotherapy for multiple lines of treatment of mUC have proved that combined therapy possesses promising development prospect. In this article， latest progress in ICI-based combined treatment for mUC was reviewed， aiming to provide reference for clinicians.
    Keywords metastatic urothelial carcinoma|immune checkpoint inhibitor|combined therapy ; Medicine ; R
    Subject code 616 ; 610
    Language Chinese
    Publishing date 2023-09-01T00:00:00Z
    Publisher Editorial Office of Journal of New Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Evolution of Avian Eye Size Is Associated with Habitat Openness, Food Type and Brain Size.

    Liu, Yating / Jiang, Ying / Xu, Jiliang / Liao, Wenbo

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 10

    Abstract: The eye is the primary sensory organ that obtains information from the ecological environments and specifically bridges the brain with the extra environment. However, the coevolutionary relationships between eye size and ecological factors, behaviours ... ...

    Abstract The eye is the primary sensory organ that obtains information from the ecological environments and specifically bridges the brain with the extra environment. However, the coevolutionary relationships between eye size and ecological factors, behaviours and brain size in birds remain poorly understood. Here, we investigate whether eye size evolution is associated with ecological factors (e.g., habitat openness, food type and foraging habitat), behaviours (e.g., migration and activity pattern) and brain size among 1274 avian species using phylogenetically controlled comparative analyses. Our results indicate that avian eye size is significantly associated with habitat openness, food type and brain size. Species living in dense habitats and consuming animals exhibit larger eye sizes compared to species living in open habitats and consuming plants, respectively. Large-brained birds tend to possess larger eyes. However, migration, foraging habitat and activity pattern were not found to be significantly associated with eye size in birds, except for nocturnal birds having longer axial lengths than diurnal ones. Collectively, our results suggest that avian eye size is primarily influenced by light availability, food need and cognitive ability.
    Language English
    Publishing date 2023-05-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13101675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: utr.annotation: a tool for annotating genomic variants that could influence post-transcriptional regulation.

    Liu, Yating / Dougherty, Joseph D

    Bioinformatics (Oxford, England)

    2021  Volume 37, Issue 21, Page(s) 3926–3928

    Abstract: Summary: Whole genome sequencing of patient populations is identifying thousands of new variants in untranslated regions (UTRs). While the consequences of UTR mutations are not as easily predicted from primary sequence as coding mutations are, there are ...

    Abstract Summary: Whole genome sequencing of patient populations is identifying thousands of new variants in untranslated regions (UTRs). While the consequences of UTR mutations are not as easily predicted from primary sequence as coding mutations are, there are some known features of UTRs that modulate their function. utr.annotation is an R package that can be used to annotate potential deleterious variants in the UTR regions for both human and mouse species. Given a CSV or VCF format variant file, utr.annotation provides information of each variant on whether and how it alters known translational regulators including upstream open reading frames, upstream Kozak sequences, polyA signals, Kozak sequences at the annotated translation start site, start codons and stop codons, conservation scores in the variant position, and whether and how it changes ribosome loading based on a model derived from empirical data.
    Availability and implementation: utr.annotation is freely available on Bitbucket (https://bitbucket.org/jdlabteam/utr.annotation/src/master/) and CRAN (https://cran.r-project.org/web/packages/utr.annotation/index.html).
    Supplementary information: Supplementary data are available at Bioinformatics online.
    MeSH term(s) Mice ; Humans ; Animals ; Gene Expression Regulation ; Untranslated Regions ; Genomics
    Chemical Substances Untranslated Regions
    Language English
    Publishing date 2021-09-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1422668-6
    ISSN 1367-4811 ; 1367-4803
    ISSN (online) 1367-4811
    ISSN 1367-4803
    DOI 10.1093/bioinformatics/btab635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A cross-sectional study of factors influencing left ventricular myocardial work in peritoneal dialysis patients.

    Deng, Xiaozhi / Huang, Zhuo / Yu, Junyan / Liu, Yating / Zhu, Fang / Zhu, Wenhui

    Heliyon

    2024  Volume 10, Issue 3, Page(s) e25265

    Abstract: Objectives: To evaluate myocardial work in peritoneal dialysis patients by pressure-strain loop. To analyze the factors influencing myocardial work in peritoneal dialysis patients with preserved ejection fraction.: Methods: We collected clinical data ...

    Abstract Objectives: To evaluate myocardial work in peritoneal dialysis patients by pressure-strain loop. To analyze the factors influencing myocardial work in peritoneal dialysis patients with preserved ejection fraction.
    Methods: We collected clinical data on possible effects on myocardial work in 105 maintenance peritoneal dialysis patients with preserved ejection fraction and applied ultrasonic pressure-strain loops to obtain the left ventricular global constructive work (GCW), Global work index (GWI), global work waste (GWW), and global work efficiency (GWE) of the patients. Then, the clinical data and myocardial work indices were statistically described and correlated.
    Results: Left ventricular hypertrophy was observed in 78 % of peritoneal dialysis patients with left ventricular ejection fraction preservation. There is a correlation between the left ventricular mass index and myocardial work indices (P < 0.05). On multiple linear regression analysis, systolic blood pressure (SBP), IL-6, and hemoglobin correlated with GCW(P < 0.05); SBP and IL-6 correlated with GWI(P < 0.05); homocysteine, SBP, TNF-α, and hemoglobin correlated with GWW(P < 0.05); homocysteine, TNF-α and hemoglobin correlated with GWE (P < 0.05).
    Conclusions: Using noninvasive pressure-strain loops to assess left ventricular myocardial work can provide information on cardiac function more consistent with pathophysiological changes than conventional ejection fraction. Hypertension, anemia, hyperhomocysteinemia, and inflammation influence left ventricular myocardial work in peritoneal dialysis patients, and they selectively affect one or more myocardial work indices.
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e25265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Dual Interface Modification Using Potassium Aspartic Acid to Realize Low Dark Current, High-Speed Nonfullerene Photodetectors.

    Yang, Yujie / Liu, Yating / Zhou, Jing / Guo, Chuanhang / Liu, Dan / Wang, Tao / Li, Wei

    The journal of physical chemistry letters

    2024  Volume 15, Issue 10, Page(s) 2675–2681

    Abstract: Organic photodetectors (OPDs) have attracted tremendous interest due to their potential applications in wearable electronics. However, due to the nonideal contacts between the electrodes and organic semiconductors, OPDs still suffer from high dark ... ...

    Abstract Organic photodetectors (OPDs) have attracted tremendous interest due to their potential applications in wearable electronics. However, due to the nonideal contacts between the electrodes and organic semiconductors, OPDs still suffer from high dark current and slow frequency response. Herein, by inserting potassium aspartic acid (PAA) interlayers between ITO/metal oxides and the metal oxides/active layer, the shunts and hole injections are blocked and the energy levels of the electrodes are aligned. As a result, our dual-interface modified OPDs (ITO/PAA/ZnO/PAA/PTB7-Th:ITIC/MoO
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.4c00367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Construction and Activity Evaluation of Novel Bifunctional Inhibitors and a COF Carrier Based on a Fungal Infection Microenvironment.

    Yu, Shuai / He, Yan-Qin / Liu, Yating / Ji, Shilei / Wang, Yajing / Sun, Bin

    Journal of medicinal chemistry

    2024  

    Abstract: Faced with increasingly serious fungal infections and drug resistance issues, three different series of novel dual-target (programmed death ligand 1/14 α-demethylase) compounds were constructed through the fragment combination pathway in the study. Their ...

    Abstract Faced with increasingly serious fungal infections and drug resistance issues, three different series of novel dual-target (programmed death ligand 1/14 α-demethylase) compounds were constructed through the fragment combination pathway in the study. Their chemical structures were synthesized, characterized, and evaluated. Among them, preferred compounds
    Language English
    Publishing date 2024-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.4c00710
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 151: Show issues Location:
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