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Article: [Research Progress of Cancer-associated Fibroblasts in Hematolo- gic Malignancies --Review].

Liu, Yi-Fan / Xi, Ya-Ming

2023 Volume 31, Issue 6, Page(s) 1885–1889

Abstract: Cancer-associated fibroblasts （CAF） are a key component of the tumor microenvironment, which can secrete a variety of cytokines, chemokines and growth factors, directly and indirectly support cancer cells, also alter the immune cellular environment by ... ...

Abstract	Cancer-associated fibroblasts （CAF） are a key component of the tumor microenvironment, which can secrete a variety of cytokines, chemokines and growth factors, directly and indirectly support cancer cells, also alter the immune cellular environment by inhibiting the activity of immune effector cells and recruiting immunosuppressive cells, thereby allowing cancer cells to evade immune surveillance. CAF has been proven to be associated with the development, progression, and poor prognosis of solid tumors. However, the role of CAF in hematological malignancies is still unclear. This article reviews the research progress of CAF in hematological malignancies.
MeSH term(s)	Humans ; Cancer-Associated Fibroblasts/metabolism ; Cancer-Associated Fibroblasts/pathology ; Neoplasms/metabolism ; Hematologic Neoplasms/metabolism ; Tumor Microenvironment ; Fibroblasts/pathology
Language	Chinese
Publishing date	2023-10-20
Publishing country	China
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2023.06.044
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Article: Real-time and lightweight detection of grape diseases based on Fusion Transformer YOLO.

Liu, Yifan / Yu, Qiudong / Geng, Shuze

Frontiers in plant science

2024 Volume 15, Page(s) 1269423

Abstract: Introduction: Grapes are prone to various diseases throughout their growth cycle, and the failure to promptly control these diseases can result in reduced production and even complete crop failure. Therefore, effective disease control is essential for ... ...

Abstract	Introduction: Grapes are prone to various diseases throughout their growth cycle, and the failure to promptly control these diseases can result in reduced production and even complete crop failure. Therefore, effective disease control is essential for maximizing grape yield. Accurate disease identification plays a crucial role in this process. In this paper, we proposed a real-time and lightweight detection model called Fusion Transformer YOLO for 4 grape diseases detection. The primary source of the dataset comprises RGB images acquired from plantations situated in North China. Methods: Firstly, we introduce a lightweight high-performance VoVNet, which utilizes ghost convolutions and learnable downsampling layer. This backbone is further improved by integrating effective squeeze and excitation blocks and residual connections to the OSA module. These enhancements contribute to improved detection accuracy while maintaining a lightweight network. Secondly, an improved dual-flow PAN+FPN structure with Real-time Transformer is adopted in the neck component, by incorporating 2D position embedding and a single-scale Transformer Encoder into the last feature map. This modification enables real-time performance and improved accuracy in detecting small targets. Finally, we adopt the Decoupled Head based on the improved Task Aligned Predictor in the head component, which balances accuracy and speed. Results: Experimental results demonstrate that FTR-YOLO achieves the high performance across various evaluation metrics, with a mean Average Precision (mAP) of 90.67%, a Frames Per Second (FPS) of 44, and a parameter size of 24.5M. Conclusion: The FTR-YOLO presented in this paper provides a real-time and lightweight solution for the detection of grape diseases. This model effectively assists farmers in detecting grape diseases.
Language	English
Publishing date	2024-02-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2024.1269423
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Article ; Online: Nonlinear large deformation of a spherical red blood cell induced by ultrasonic standing wave.

Liu, Yifan / Xin, Fengxian

Biomechanics and modeling in mechanobiology

2022 Volume 21, Issue 2, Page(s) 589–604

Abstract: A computational model is developed to investigate the nonlinear static deformation of a spherical (osmotically swollen) red blood cell (RBC) induced by ultrasonic standing wave. The ultrasonic standing wave can generate steady acoustic radiation stress ... ...

Abstract	A computational model is developed to investigate the nonlinear static deformation of a spherical (osmotically swollen) red blood cell (RBC) induced by ultrasonic standing wave. The ultrasonic standing wave can generate steady acoustic radiation stress to deform the cell, and in turn, the deformed cell reshapes the acoustic field. This is a real-time coupling problem between the acoustic field and the mechanical field. In the computational model, the acoustic radiation stress acting on the RBC membrane is modeled by adopting the nonviscous momentum flux theory. The RBC membrane is modeled as a hyperelastic shell considering the in-plane elasticity, bending elasticity, and surface tension of the membrane. The volume conservation constraint of the membrane sealing fluid is applied to ensure the osmotic balance of the membrane. To address this real-time coupling problem, the computational model is implemented by a finite element method algorithm. The numerical results are compared with the existing theoretical model and experimental data, and the strain hardening trend of the experimental data is successfully predicted, which verifies the accuracy and effectiveness of the computational model. The computational model can accurately extract the mechanical properties of cells from acoustic deformation experiments, which is helpful for the diagnosis of some human diseases.
MeSH term(s)	Elasticity ; Erythrocyte Membrane ; Erythrocytes ; Humans ; Models, Theoretical ; Ultrasonics
Language	English
Publishing date	2022-01-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2093052-5
ISSN	1617-7940 ; 1617-7959
ISSN (online)	1617-7940
ISSN	1617-7959
DOI	10.1007/s10237-021-01550-5
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Article: Sequential autologous CAR-T and allogeneic CAR-T therapy successfully treats central nervous system involvement relapsed/refractory ALL: a case report and literature review.

Liu, Yifan / Li, Yanfen / Yu, Zhangyu / Wang, Rongrong / Jing, Yu

Frontiers in oncology

2024 Volume 14, Page(s) 1341682

Abstract: Background: The central nervous system (CNS) is the most common site of extramedullary invasion in acute lymphoblastic leukemia (ALL), and involvement of the CNS is often associated with relapse, refractory disease, and poor prognosis. Chimeric antigen ... ...

Abstract	Background: The central nervous system (CNS) is the most common site of extramedullary invasion in acute lymphoblastic leukemia (ALL), and involvement of the CNS is often associated with relapse, refractory disease, and poor prognosis. Chimeric antigen receptor-T (CAR-T) cell therapy, a promising modality in cancer immunotherapy, has demonstrated significant advantages in the treatment of hematological malignancies. However, due to associated adverse reactions such as nervous system toxicity, the safety and efficacy of CAR-T cell therapy in treating CNSL remains controversial, with limited reports available. Case report: Here, we present the case of a patient with confirmed B-ALL who experienced relapse in both bone marrow (BM) and cerebrospinal fluid (CSF) despite multiple cycles of chemotherapy and intrathecal injections. The infusion of autologous CD19 CAR-T cells resulted in complete remission (CR) in both BM and CSF for 40 days. However, the patient later experienced a relapse in the bone marrow. Subsequently, allogeneic CD19 CAR-T cells derived from her brother were infused, leading to another achievement of CR in BM. Significantly, only grade 1 cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) events were detected during the treatment period and showed improvement with symptomatic management. During subsequent follow-up, the patient achieved a disease-free survival of 5 months and was successfully bridged to hematopoietic stem cell transplantation. Conclusion: Our study provides support for the argument that CNS involvement should not be deemed an absolute contraindication to CAR-T cell therapy. With the implementation of suitable management and treatment strategies, CAR-T therapy can proficiently target tumor cells within the CNS. This treatment option may be particularly beneficial for relapsed or refractory patients, as well as those with central nervous system involvement who have shown limited response to conventional therapies. Additionally, CAR-T cell therapy may serve as a valuable bridge to allogeneic hematopoietic stem cell transplantation (allo-HSCT) in these patients.
Language	English
Publishing date	2024-01-23
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1341682
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Article ; Online: Rapid electrodeposition of Cu nanoparticle film on Ni foam as an integrated 3D free-standing electrode for non-invasive and non-enzymatic creatinine sensing.

Hou, Hongming / Liu, Yifan / Li, Xianglong / Liu, Wenbo / Gong, Xiaoli

The Analyst

2024

Abstract: High cost, inherent destabilization, and intricate fixing of enzyme molecules are the main drawbacks of enzyme-based creatinine sensors. The design of a low-cost, stabilizable, and enzyme-free creatinine sensing probe is essential to address these ... ...

Abstract	High cost, inherent destabilization, and intricate fixing of enzyme molecules are the main drawbacks of enzyme-based creatinine sensors. The design of a low-cost, stabilizable, and enzyme-free creatinine sensing probe is essential to address these limitations. In this work, an integrated three-dimensional (3D) free-standing electrode was designed to serve as a non-enzymatic creatinine sensing platform and was fabricated by rapid electrodeposition of a dense copper nanoparticle film on nickel foam (Cu NP film/NF). This low-cost, stable, easy-to-fabricate, and binder-free Cu NP film/NF electrode has abundant active sites and excellent electrochemical performance. Cyclic voltammetry measurements show a wide linear range (0.25-24 mM), low detection limit (0.17 mM), and high sensitivity (306 μA mM
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d4an00162a
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Zs.A 2423: Show issues

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Article ; Online: Bubble Unidirectional Transportation on Multipath Aerophilic Surfaces by Adjusting the Surface Microstructure.

Dai, Xin / Si, Wen / Liu, Yifan / Zhang, Wenhao / Guo, Zhiguang

ACS applied materials & interfaces

2024 Volume 16, Issue 9, Page(s) 11984–11996

Abstract: Comprehending and controlling the behavior of bubbles on solid surfaces is of significant importance in various fields including catalysis and drag reduction, both industrially and scientifically. Herein, Inspired by the superaerophilic properties of the ...

Abstract	Comprehending and controlling the behavior of bubbles on solid surfaces is of significant importance in various fields including catalysis and drag reduction, both industrially and scientifically. Herein, Inspired by the superaerophilic properties of the lotus leaf surface, a series of asymmetrically patterned aerophilic surfaces were prepared by utilizing a facile mask-spraying method for directional transport of underwater bubbles. The ability of bubbles to undergo self-driven transportation in an asymmetric pattern is attributed to the natural tendency of bubbles to move toward regions with lower surface energy. In this work, the microstructure of the aerophilic surface is demonstrated as a critical element that influences the self-driven transport of bubbles toward regions of lower surface energy. The microstructure characteristic affects the energy barrier of forming a continuous gas film on the final regions. We classify three distinct bubble behaviors on the aerophilic surface, which align with three different underwater gas film evolution states: Model I, Model II, and Model III. Furthermore, utilizing the energy difference between the energy barrier that forms a continuous gas film and the gas-gas merging, gas-liquid microreaction in a specific destination on the multiple paths can be easily realized by preinjecting a bubble in the final region. This work provides a new view of the microevolutionary process for the diffusion, transport, and merging behavior of bubbles upon contact with an aerophilic pattern surface.
Language	English
Publishing date	2024-02-26
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c15880
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Article ; Online: Four new species of

Sun, Chang / Liu, Yi-Fan / Liang, Ying-Mei / Wang, Lei

Mycologia

2024 Volume 116, Issue 2, Page(s) 309–321

Abstract: ... Members ... ...

Abstract	Members of
MeSH term(s)	Puccinia ; Spores, Fungal/genetics ; Plants ; Basidiomycota/genetics ; China
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Journal Article
ZDB-ID	281335-x
ISSN	1557-2536 ; 0027-5514
ISSN (online)	1557-2536
ISSN	0027-5514
DOI	10.1080/00275514.2023.2289697
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Zs.A 1291: Show issues

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Article ; Online: Data aggregation algorithm for wireless sensor networks with different initial energy of nodes.

Liu, Zhenpeng / Zhang, Jialiang / Liu, Yi / Feng, Fan / Liu, Yifan

PeerJ. Computer science

2024 Volume 10, Page(s) e1932

Abstract: Data aggregation plays a critical role in sensor networks for efficient data collection. However, the assumption of uniform initial energy levels among sensors in existing algorithms is unrealistic in practical production applications. This discrepancy ... ...

Abstract	Data aggregation plays a critical role in sensor networks for efficient data collection. However, the assumption of uniform initial energy levels among sensors in existing algorithms is unrealistic in practical production applications. This discrepancy in initial energy levels significantly impacts data aggregation in sensor networks. To address this issue, we propose Data Aggregation with Different Initial Energy (DADIE), a novel algorithm that aims to enhance energy-saving, privacy-preserving efficiency, and reduce node death rates in sensor networks with varying initial energy nodes. DADIE considers the transmission distance between nodes and their initial energy levels when forming the network topology, while also limiting the number of child nodes. Furthermore, DADIE reconstructs the aggregation tree before each round of data transmission. This allows nodes closer to the receiving end with higher initial energy to undertake more data aggregation and transmission tasks while limiting energy consumption. As a result, DADIE effectively reduces the node death rate and improves the efficiency of data transmission throughout the network. To enhance network security, DADIE establishes secure transmission channels between transmission nodes prior to data transmission, and it employs slice-and-mix technology within the network. Our experimental simulations demonstrate that the proposed DADIE algorithm effectively resolves the data aggregation challenges in sensor networks with varying initial energy nodes. It achieves 5-20% lower communication overhead and energy consumption, 10-20% higher security, and 10-30% lower node mortality than existing algorithms.
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ISSN	2376-5992
ISSN (online)	2376-5992
DOI	10.7717/peerj-cs.1932
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Article ; Online: Ant Colony Optimization Algorithm Based on Dynamic Recombination and Co- operative Communication Strategy

LIU Yifan, YOU Xiaoming, LIU Sheng

Jisuanji kexue yu tansuo, Vol 15, Iss 8, Pp 1511-

2021 Volume 1525

Abstract: Aiming at the problems of traditional ant colony algorithm in solving traveling salesman problem (TSP), such as slow convergence speed and easy to fall into local optimum, an ant colony optimization algorithm (RCACO) based on dynamic recombination and ... ...

Abstract	Aiming at the problems of traditional ant colony algorithm in solving traveling salesman problem (TSP), such as slow convergence speed and easy to fall into local optimum, an ant colony optimization algorithm (RCACO) based on dynamic recombination and cooperative communication strategy is proposed. Firstly, the ant colony is divided into greedy ant colony and exploratory ant colony. The two ant colonies implement different path construction rules and pheromone update strategies to balance the convergence speed and diversity of the algorithm. Secondly, a new dynamic recombination operator based on the clew binary tree is adopted, and the solution set is dynamically recombined according to different strategies to improve the diversity of the algorithm. Furthermore, a collaborative communication strategy based on similarity and potential value is proposed. From a global perspective, the path with the most potential to become the optimal solution is found, and pheromone rewards are given to these paths to improve the convergence speed of the algorithm. Finally, the algorithm also adds a stagnation avoidance strategy to help the ant colony jump out of the local optimum and improve the accuracy of the algorithm. Through the Matlab simulation experiment of multiple groups of cases in TSPLIB, compared with the traditional ant colony algorithm and other optimization algorithms, the simulation results show that the improved ant colony algorithm significantly improves the convergence speed and solution accuracy.
Keywords	traveling salesman problem (tsp) ; ant colony optimization (aco) ; dynamic recombination ; collaborative communication ; stagnation avoidance ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	629
Language	Chinese
Publishing date	2021-08-01T00:00:00Z
Publisher	Journal of Computer Engineering and Applications Beijing Co., Ltd., Science Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Hybrid Boolean gates show that Cas12c controls transcription activation effectively in the yeast

Liu, Yifan / Ge, Huanhuan / Marchisio, Mario Andrea

Frontiers in bioengineering and biotechnology

2023 Volume 11, Page(s) 1267174

Abstract: Among CRISPR-Cas systems, type V CRISPR-Cas12c is of significant interest because Cas12c recognizes a very simple PAM (TN) and has the ability to silence gene expression without cleaving the DNA. We studied how new transcription factors for the ... ...

Abstract	Among CRISPR-Cas systems, type V CRISPR-Cas12c is of significant interest because Cas12c recognizes a very simple PAM (TN) and has the ability to silence gene expression without cleaving the DNA. We studied how new transcription factors for the yeast
Language	English
Publishing date	2023-09-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.1267174
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