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  1. Article ; Online: Bibliometric and Visualization Analysis of Stem Cell Therapy for Erectile Dysfunction.

    Sun, Taotao / Liu, Yipiao / Yuan, Penghui / Jia, Zhankui / Yang, Jinjian

    Drug design, development and therapy

    2024  Volume 18, Page(s) 731–746

    Abstract: Purpose: As a common male disease, erectile dysfunction (ED) seriously affects the physical and mental health of patients. In recent years, studies have continued to point out the great potential of stem cell therapy (SCT) in the treatment of ED. The ... ...

    Abstract Purpose: As a common male disease, erectile dysfunction (ED) seriously affects the physical and mental health of patients. In recent years, studies have continued to point out the great potential of stem cell therapy (SCT) in the treatment of ED. The purpose of this study is to comprehensively analyze the research of SCT for ED and understand the development trends and research frontiers in this field.
    Methods: Publications regarding SCT and ED were retrieved and collected from the Web of Science Core Collection. CiteSpace and VOSviewer software were then utilized for bibliometric and visualization analysis.
    Results: A total of 524 publications were eventually included in this study. The annual number of publications in this field was increasing year by year. China and the USA were the two most productive countries. Lin GT, Lue TF and Lin CS, and the University of California San Francisco where they worked were the most productive research group and institution, respectively. The journal with the largest number of publications was The Journal of Sexual Medicine, and the following were mostly professional journals of urology and andrology. Diabetes mellitus-induced ED and cavernous nerve injury-related ED were the two most commonly constructed models of ED in studies. Concerning the types of stem cells, mesenchymal stem cells derived from adipose and bone marrow were most frequently used. Moreover, future research would mainly focus on exosomes, tissue engineering technology, extracorporeal shockwave therapy, and clinical translation.
    Conclusion: The research of SCT for ED will receive increasing global attention in the future. Our study provided bibliometric and visualization analysis of published literature, helping researchers understand the global landscape and frontiers in this field. More preclinical and clinical studies should be conducted to more deeply explore the underlying mechanisms of treatment and promote clinical translation.
    MeSH term(s) Humans ; Male ; Erectile Dysfunction ; Bibliometrics ; China ; Exosomes ; Cell- and Tissue-Based Therapy
    Language English
    Publishing date 2024-03-08
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2451346-5
    ISSN 1177-8881 ; 1177-8881
    ISSN (online) 1177-8881
    ISSN 1177-8881
    DOI 10.2147/DDDT.S448483
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Study on the mechanism of aging-related erectile dysfunction based on bioinformatics and experimental verification.

    Sun, Taotao / Liu, Yipiao / Chen, Yinwei / Xu, Wenchao / Wang, Tao / Liu, Kang / Liu, Jihong

    Translational andrology and urology

    2023  Volume 12, Issue 2, Page(s) 197–208

    Abstract: Background: The incidence of aging-related erectile dysfunction (ED) remains high in the elderly population, and has attracted the attention of the medical community. However, aging-related ED responds poorly to traditional treatments for ED, and its ... ...

    Abstract Background: The incidence of aging-related erectile dysfunction (ED) remains high in the elderly population, and has attracted the attention of the medical community. However, aging-related ED responds poorly to traditional treatments for ED, and its mechanism has not yet been fully clarified. This study sought to explore the potential mechanisms of aging-related ED based on bioinformatics and experimental verification.
    Methods: A bioinformatics analysis was performed on data from the Gene Expression Omnibus database related to ED and aging, and the associated differentially expressed genes (DEGs) and signaling pathways were identified. Young and aged rats (n=8 per group) were included in the experimental verification study. Erectile function was detected by electrical stimulation of the cavernous nerve. The corpus cavernosum was collected for the follow-up experiments.
    Results: A total of 4 hub genes were identified, among which biglycan (BGN) appears to play an important role. The functional enrichment analysis revealed that the extracellular matrix (ECM), especially collagen, related pathways, and the phosphatidylinositol 3‑kinase (PI3K)/protein kinase B (AKT) pathway were enriched, which was also confirmed by the animal experiments. Impaired erectile function in aged rats was associated with the downregulation of the PI3K/AKT pathway, endothelial dysfunction, and increased fibrosis in the penis.
    Conclusions: Erectile function is impaired with aging. The downregulation of the PI3K/AKT pathway, endothelial dysfunction, and increased fibrosis are involved in this process. BGN may be the key gene regulating these changes. Our study extended understandings of the mechanisms of age-related ED and provides new potential treatment ideas.
    Language English
    Publishing date 2023-02-03
    Publishing country China
    Document type Journal Article
    ZDB-ID 2851630-8
    ISSN 2223-4691 ; 2223-4691 ; 2223-4683
    ISSN (online) 2223-4691
    ISSN 2223-4691 ; 2223-4683
    DOI 10.21037/tau-22-511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The role of complement in the clinical course of hepatocellular carcinoma.

    Qian, Xinye / Yang, Zhoujing / Gao, Lu / Liu, Yipiao / Yan, Jun

    Immunity, inflammation and disease

    2021  Volume 10, Issue 3, Page(s) e569

    Abstract: Background: The complement system, an innate immune system, may either play an antitumor role, or promote tumorigenesis and cancer progression in different kinds of cancer. The function of complement in hepatocellular carcinoma (HCC) is unclear.: ... ...

    Abstract Background: The complement system, an innate immune system, may either play an antitumor role, or promote tumorigenesis and cancer progression in different kinds of cancer. The function of complement in hepatocellular carcinoma (HCC) is unclear.
    Methods: The gene expressions of the complement system were based on data obtained from TCGA and GEO. We explored gene expressions, mutation, enrichment analysis, clinicopathology, patients' outcome, and immune infiltration via Gepia2, cBioPortal, Metascape, UALCAN, Kaplan-Meier Plotter, and TIMER 2.
    Results: Five complement genes, including C1R, C6, C7, CFP, and CFHR3, were not only found to be significantly downregulated in HCC samples compared with normal liver samples, but also found to be significantly associated with overall survival, disease-free survival, and progress-free survival in HCC patients. In addition, lower mRNA expression of C1R, C6, C7, and CFHR3 were found correlated with advanced cancer stages and higher tumor grades in HCC patients. Also, the expression levels of CFP were correlated with many sets of immune markers of tumor immune cells, such as those of CD8+ T cells, CD4+ T cells, B cells, M2 macrophages, neutrophils, DCs, Th1 cells, Th2 cells, and T cell exhaustion in HCC. Based on that, we developed a prognostic model for HCC patients-Riskscore = (-0.0053)*C6+(-0.0498)*C7+(-0.1045)*CFHR3.
    Conclusion: C1R, C6, C7, CFP, and CFHR3 could be prognostic biomarkers for patients with HCC.
    MeSH term(s) Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; CD8-Positive T-Lymphocytes ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Prognosis
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2021-11-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2740382-8
    ISSN 2050-4527 ; 2050-4527
    ISSN (online) 2050-4527
    ISSN 2050-4527
    DOI 10.1002/iid3.569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction: Management of esophageal cancer in patients with a right aortic arch or double aortic arch: a case series of 34 cases.

    Zhang, Guoqing / Wang, Zhulin / Jiao, Jia / Liu, Yipiao / Pan, Dabo / Yang, Hang / Zhan, Mengyao / Yan, Fuping / Li, Huijie / Zhang, Yan / Li, Jindong / Li, Xiangnan

    Surgical endoscopy

    2024  Volume 38, Issue 3, Page(s) 1663

    Language English
    Publishing date 2024-01-29
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-024-10711-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2214: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Management of esophageal cancer in patients with a right aortic arch or double aortic arch: a case series of 34 cases.

    Zhang, Guoqing / Wang, Zhulin / Jiao, Jia / Liu, Yipiao / Pan, Dabo / Yang, Hang / Zhan, Mengyao / Yan, Fuping / Li, Huijie / Zhang, Yan / Li, Jindong / Li, Xiangnan

    Surgical endoscopy

    2023  Volume 38, Issue 1, Page(s) 240–252

    Abstract: Background: Few cases describing patients with a right aortic arch (RAA) or double aortic arch (DAA) and esophageal cancer (EC) have been reported.: Methods: We analyzed RAA and DAA cases treated with esophagectomy in our center's database and ... ...

    Abstract Background: Few cases describing patients with a right aortic arch (RAA) or double aortic arch (DAA) and esophageal cancer (EC) have been reported.
    Methods: We analyzed RAA and DAA cases treated with esophagectomy in our center's database and reported in English-language studies until April 1, 2023. Our study assessed the malformation characteristics and surgical details of EC patients with RAA and DAA.
    Results: We extracted data of 24 EC patients with RAAs and 10 EC patients with DAAs. In both groups, the patients were more likely to be Japanese and male, to have squamous cell carcinoma and to have tumors located in the upper thoracic esophagus or middle thoracic esophagus. Left thoracotomy was commonly applied for RAA patients. For DAA patients, the proportions of left-sided and right-sided approaches were similar. Esophagectomy under video-assisted thoracoscopic surgery (VATS) in RAA or DAA patients had been performed on a routine basis in recent years. There were two anastomotic leakages in each group. Specifically, Kommerell diverticulum rupture occurred in 1 RAA patient; gastric tube dilation occurred in 1 DAA patient; and recurrent laryngeal nerve (RLN) injury occurred in 2 RAA patients. The postoperative course was uneventful for most patients in both cohorts.
    Conclusions: Esophageal carcinoma is rarely seen in patients with an RAA or DAA. To adequately dissect superior mediastinal LNs, an auxiliary incision (such as sternotomy), the left door open method or a preceding cervical procedure should be used appropriately. Esophagectomy, whether via thoracotomy or thoracoscopic surgery, can be performed safely for both RAA and DAA.
    MeSH term(s) Humans ; Male ; Vascular Ring/complications ; Vascular Ring/surgery ; Vascular Ring/pathology ; Aorta, Thoracic/surgery ; Aorta, Thoracic/abnormalities ; Aorta, Thoracic/pathology ; Esophageal Neoplasms/surgery ; Esophageal Neoplasms/pathology ; Thoracic Surgery, Video-Assisted ; Carcinoma, Squamous Cell/surgery ; Carcinoma, Squamous Cell/pathology ; Retrospective Studies
    Language English
    Publishing date 2023-11-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-023-10543-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2214: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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