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Article ; Online: Oxalic acid activated bone meal for immobilization of Pb and Cd contaminated soils.

Liu, Yi-Zhao / Fan, Ri-Dong / Liu, Song-Yu / He, Huan

Environmental science and pollution research international

2022 Volume 29, Issue 24, Page(s) 36281–36294

Abstract: Bone meal (BM) is a cost-effective and low-carbon material to remediate heavy metal contaminated soils. Moreover, its immobilization efficiency for heavy metals still requires improvement. This study aimed to assess the activation effect of oxalic acid ... ...

Abstract	Bone meal (BM) is a cost-effective and low-carbon material to remediate heavy metal contaminated soils. Moreover, its immobilization efficiency for heavy metals still requires improvement. This study aimed to assess the activation effect of oxalic acid on the BM to develop an oxalic acid-activated bone meal (ABM) for improving immobilization efficiency. Several series of tests, including the available phosphorus content test, toxicity characteristic leaching procedure (TCLP), modified European Community Bureau of Reference (BCR) sequential extraction procedure, and X-ray diffraction (XRD) analysis, are used to investigate the effect of activation on the immobilization ability and chemical speciation of lead (Pb) and cadmium (Cd) in soils and the different mechanisms of Pb/Cd immobilization using the ABM and BM. The results indicate that the ABM possesses a higher solubility than the BM. The activation of BM achieves optimal effect when using 1 mol/L oxalic acid solution with a liquid-solid ratio of 2:1. The TCLP and BCR test results show that the ABM significantly outperforms the BM in terms of Pb immobilization. The leaching concentration of Pb from ABM immobilized soils can meet regulatory limits in China and the USA, and it is also 30 to 75% lower than that from BM immobilized soils. Regarding Cd immobilization, ABM outperforms BM after 90 days of curing. The XRD analysis shows that heavy metal phosphates are the primary products of Pb and Cd immobilized by ABM, whereas heavy metal carbonates are the main products after the immobilization by BM.
MeSH term(s)	Biological Products ; Cadmium/analysis ; Lead/analysis ; Metals, Heavy/analysis ; Minerals ; Oxalic Acid/chemistry ; Soil/chemistry ; Soil Pollutants/analysis
Chemical Substances	Biological Products ; Metals, Heavy ; Minerals ; Soil ; Soil Pollutants ; Cadmium (00BH33GNGH) ; Lead (2P299V784P) ; Oxalic Acid (9E7R5L6H31) ; bone meal (TRS31EO6ZN)
Language	English
Publishing date	2022-01-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-18530-6
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Article: Oxalic acid activated bone meal for immobilization of Pb and Cd contaminated soils

Liu, Yi-Zhao / Fan, Ri-Dong / Liu, Song-Yu / He, Huan

Environmental science and pollution research. 2022 May, v. 29, no. 24

2022

Abstract	Bone meal (BM) is a cost-effective and low-carbon material to remediate heavy metal contaminated soils. Moreover, its immobilization efficiency for heavy metals still requires improvement. This study aimed to assess the activation effect of oxalic acid on the BM to develop an oxalic acid-activated bone meal (ABM) for improving immobilization efficiency. Several series of tests, including the available phosphorus content test, toxicity characteristic leaching procedure (TCLP), modified European Community Bureau of Reference (BCR) sequential extraction procedure, and X-ray diffraction (XRD) analysis, are used to investigate the effect of activation on the immobilization ability and chemical speciation of lead (Pb) and cadmium (Cd) in soils and the different mechanisms of Pb/Cd immobilization using the ABM and BM. The results indicate that the ABM possesses a higher solubility than the BM. The activation of BM achieves optimal effect when using 1 mol/L oxalic acid solution with a liquid–solid ratio of 2:1. The TCLP and BCR test results show that the ABM significantly outperforms the BM in terms of Pb immobilization. The leaching concentration of Pb from ABM immobilized soils can meet regulatory limits in China and the USA, and it is also 30 to 75% lower than that from BM immobilized soils. Regarding Cd immobilization, ABM outperforms BM after 90 days of curing. The XRD analysis shows that heavy metal phosphates are the primary products of Pb and Cd immobilized by ABM, whereas heavy metal carbonates are the main products after the immobilization by BM.
Keywords	X-ray diffraction ; bone meal ; cadmium ; chemical speciation ; cost effectiveness ; heavy metals ; lead ; oxalic acid ; phosphorus content ; pollution ; research ; solubility ; toxicity ; China
Language	English
Dates of publication	2022-05
Size	p. 36281-36294.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-18530-6
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Article ; Online: Relationship between ambient air pollution and preterm birth: a retrospective birth cohort study in Yan'an, China.

He, Jinwei / Cao, Na / Hei, Jiangrong / Wang, Huiling / He, Jinrong / Liu, Yizhao / Ren, Yuanyuan

Environmental science and pollution research international

2022 Volume 29, Issue 48, Page(s) 73271–73281

Abstract: Preterm birth (PTB) has been associated with exposure to air pollution, but it is unclear whether effects might vary among air pollution sources in a valley city, and yet few studies have investigated refined susceptible windows for PTB. We performed a ... ...

Abstract	Preterm birth (PTB) has been associated with exposure to air pollution, but it is unclear whether effects might vary among air pollution sources in a valley city, and yet few studies have investigated refined susceptible windows for PTB. We performed a retrospective birth cohort study in Yan'an city, a typical valley city in the west of China, and analyze the effects of air pollutants on premature delivery, identify critical windows for maternal air pollutants exposure and PTB. The pregnant women who gave birth in the Affiliated Hospital of Yan'an University and Yan'an people's Hospital from January 1, 2018 to December 31, 2019 were selected as the research objects. A questionnaire survey and medical records were conducted. The daily average concentrations of particulate matter with aerodynamic diameters of ≤ 2.5 μm (PM
MeSH term(s)	Air Pollutants/analysis ; Air Pollution/analysis ; Birth Cohort ; China/epidemiology ; Cohort Studies ; Female ; Humans ; Infant, Newborn ; Maternal Exposure ; Nitrogen Dioxide/toxicity ; Ozone/toxicity ; Particulate Matter/analysis ; Pregnancy ; Premature Birth/chemically induced ; Premature Birth/epidemiology ; Retrospective Studies ; Sulfur Dioxide/toxicity
Chemical Substances	Air Pollutants ; Particulate Matter ; Sulfur Dioxide (0UZA3422Q4) ; Ozone (66H7ZZK23N) ; Nitrogen Dioxide (S7G510RUBH)
Language	English
Publishing date	2022-05-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-20852-4
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Article ; Online: Relationship between ambient air pollution and preterm birth: a retrospective birth cohort study in Yan’an, China

He, Jinwei / Cao, Na / Hei, Jiangrong / Wong, Wai-ling / He, Jinrong / Liu, Yizhao / Ren, Yuanyuan

Environ Sci Pollut Res. 2022 Oct., v. 29, no. 48 p.73271-73281

2022

Abstract	Preterm birth (PTB) has been associated with exposure to air pollution, but it is unclear whether effects might vary among air pollution sources in a valley city, and yet few studies have investigated refined susceptible windows for PTB. We performed a retrospective birth cohort study in Yan’an city, a typical valley city in the west of China, and analyze the effects of air pollutants on premature delivery, identify critical windows for maternal air pollutants exposure and PTB. The pregnant women who gave birth in the Affiliated Hospital of Yan’an University and Yan’an people’s Hospital from January 1, 2018 to December 31, 2019 were selected as the research objects. A questionnaire survey and medical records were conducted. The daily average concentrations of particulate matter with aerodynamic diameters of ≤ 2.5 μm (PM₂.₅) and ≤ 10 μm (PM₁₀), nitrogen dioxide (NO₂), sulfur dioxide (SO₂) and ozone (O₃) in Yan’an City from January 1, 2017 to December 31, 2019 were collected. After controlling the confounding factors of PTB by logistic regression model, the effect of air pollutants on preterm birth was analyzed. After controlling the confounding factors such as maternal age, gestational times and gestational hypertension syndrome, PTB was associated with exposure to third trimester PM₁₀ (adjusted odds ratio [aOR] = 1.019, 95% confidence interval [95%CI] = 1.004–1.035). PTB risk increased with second trimester exposure to SO₂ (aOR = 1.039, CI = 1.011–1.068), also with third trimester (aOR = 1.031, CI = 1.010–1.053). PTB was also associated with third trimester O₃ (aOR = 1.023, CI = 1.005–1.041). This study indicates that maternal exposure to PM₁₀, SO₂ and O₃ might lead to increased risk of PTB, and critical exposure windows were inconsistent.
Keywords	aerodynamics ; air ; air pollution ; cohort studies ; confidence interval ; hospitals ; hypertension ; maternal exposure ; nitrogen dioxide ; odds ratio ; ozone ; particulates ; people ; premature birth ; questionnaires ; regression analysis ; risk ; sulfur dioxide ; China
Language	English
Dates of publication	2022-10
Size	p. 73271-73281.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-20852-4
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: An Improved Control Strategy for the Bus Interlinking Converter Based on Three-level Topology in AC-DC Hybrid Microgrid

Ren Yuan / Wang Jinhao / Chang Xiao / Du Yi / Zhang Ying / Liu Yizhao / Wang Gangbin

E3S Web of Conferences, Vol 186, p

2020 Volume 02002

Abstract: Considering the increasing requirements of the AC-DC hybrid microgrid (HMG) for the transmission power capacity and voltage level, the several bus interface converters (BICs) with the two-level PWM converter topology, need to be connected between AC bus ... ...

Abstract	Considering the increasing requirements of the AC-DC hybrid microgrid (HMG) for the transmission power capacity and voltage level, the several bus interface converters (BICs) with the two-level PWM converter topology, need to be connected between AC bus and DC bus in parallel, which could generate circulating current and cycle power. The cost of the modular multilevel converter topology based BIC is too high. Hence, this paper proposes to apply the BIC with three-level topology to the HMG, and a droop control strategy with the midpoint potential hysteresis regulation link is designed, which can effectively suppress the fluctuation of midpoint potential without affecting the normal operation of the BIC in the grid connected or off mode. In addition, the principle of neutral point fluctuation and the process of hysteresis control are introduced, and the detailed design of dual-mode control strategy based on droop curve are also given. Finally, the effectiveness of the improved control strategy is verified by simulation.
Keywords	Environmental sciences ; GE1-350
Subject code	629
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Three-branch and Mutil-scale learning for Fine-grained Image Recognition (TBMSL-Net)

Zhang, Fan / Zhai, Guisheng / Li, Meng / Liu, Yizhao

2020

Abstract: ImageNet Large Scale Visual Recognition Challenge (ILSVRC) is one of the most authoritative academic competitions in the field of Computer Vision (CV) in recent years, but it can not achieve good result to directly migrate the champions of the annual ... ...

Abstract	ImageNet Large Scale Visual Recognition Challenge (ILSVRC) is one of the most authoritative academic competitions in the field of Computer Vision (CV) in recent years, but it can not achieve good result to directly migrate the champions of the annual competition, to fine-grained visual categorization (FGVC) tasks. The small interclass variations and the large intraclass variations caused by the fine-grained nature makes it a challenging problem. The proposed method can be effectively localize object and useful part regions without the need of bounding-box and part annotations by attention object location module (AOLM) and attention part proposal module (APPM). The obtained object images contain both the whole structure and more details, the part images have many different scales and have more fine-grained features, and the raw images contain the complete object. The three kinds of training images are supervised by our three-branch network structure. The model has good classification ability, good generalization and robustness for different scale object images. Our approach is end-to-end training, through the comprehensive experiments demonstrate that our approach achieves state-of-the-art results on CUB-200-2011, Stanford Cars and FGVC-Aircraft datasets.
Keywords	Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Machine Learning ; Electrical Engineering and Systems Science - Image and Video Processing
Subject code	004
Publishing date	2020-03-20
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Discovery of 4-((3,4-dichlorophenyl)amino)-2-methylquinolin-6-ol derivatives as EGFR and HDAC dual inhibitors.

Qian, Yuqing / Zhou, Siyu / Li, Jiayi / Ma, Mingyuan / Chen, Huanwen / Cao, Yin / Zhang, Yuxiang / Sun, Chaoyu / Li, Kang / Liu, Yizhao / Dai, Shutong / Ao, Mingtao / Fang, Meijuan / Wu, Zhen / Li, Mingdong

European journal of pharmacology

2023 Volume 960, Page(s) 176114

Abstract: In patients with non-small cell lung cancer (NSCLC), the standard therapy consists of selective tyrosine kinase inhibitors that target epidermal growth factor receptors (EGFR). Nonetheless, their clinical utility is primarily limited by the development ... ...

Abstract	In patients with non-small cell lung cancer (NSCLC), the standard therapy consists of selective tyrosine kinase inhibitors that target epidermal growth factor receptors (EGFR). Nonetheless, their clinical utility is primarily limited by the development of resistance to drugs. HDAC inhibitors have been shown in studies to reduce the level of EGFR that is expressed and downregulate the EGFR-induced phosphorylation of AKT and ERK. Therefore, dual inhibitors of EGFR and HDAC provide a potential approach as combination treatment synergistically inhibited the growth of NSCLC. Herein, we examined the EGFR inhibition effect of twenty compounds which designed and synthesized by us previously. Among them, compounds 12c and 12d exhibited powerful antiproliferative activity against the NCI-H1975 cell line with IC
MeSH term(s)	Humans ; Animals ; Mice ; ErbB Receptors/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/therapeutic use ; Lung Neoplasms/pathology ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Drug Resistance, Neoplasm ; Cell Line, Tumor ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Cell Proliferation
Chemical Substances	ErbB Receptors (EC 2.7.10.1) ; Histone Deacetylase Inhibitors ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Protein Kinase Inhibitors ; EGFR protein, human (EC 2.7.10.1)
Language	English
Publishing date	2023-10-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2023.176114
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Article ; Online: Plasma miR-15b-5p, miR-338-5p, and miR-764 as Biomarkers for Hepatocellular Carcinoma.

Chen, Yi / Chen, Jin / Liu, Yizhao / Li, Shiliang / Huang, Ping

Medical science monitor : international medical journal of experimental and clinical research

2015 Volume 21, Page(s) 1864–1871

Abstract: Background: Recently, increasing research evidence indicates that miRNA plays important roles in oncogenesis of hepatocellular carcinoma (HCC). The objective of this study was to investigate the potential of plasma miRNAs as biomarkers for HCC ... ...

Abstract	Background: Recently, increasing research evidence indicates that miRNA plays important roles in oncogenesis of hepatocellular carcinoma (HCC). The objective of this study was to investigate the potential of plasma miRNAs as biomarkers for HCC determination. Material and methods: This trial included 4 phases: (i) miRNAs in tumor tissues were screened with a miRNA array for determining candidate miRNAs. (ii) Candidate miRNAs were measured by RT-qPCR in plasma of 10 HCC patients before and after surgery (7-10 days) for target miRNAs that displayed a pattern of postoperative decrease. (iii) Plasma levels of target miRNAs in 37 HCC patients, 29 cirrhosis patients, and 31 healthy controls were measured by RT-qPCR for determining potential biomarkers. (iv) The powers of biomarkers for differentiating HCC were validated and the correlations with clinicopathological variables of HCC patients were analyzed. Results: miRNA array demonstrated an abnormal expression of 92 miRNAs in tumor tissues compared to adjacent non-tumor tissues. Of those molecules with an over-expressed level in tumor tissues and preoperative plasmas, a decrease in postoperative plasma was observed in miR-15b-5p, miR-338-5p, and miR-764. Plasma levels of these miRNAs in HCC patients were higher than in the other 2 groups (P<0.05). Receiver-operator characteristic (ROC) curve analyses suggested these plasma miRNAs could be useful biomarkers for determining HCC. miR-338-5p yielded an area under the ROC curve (AUC) of 0.799 (74.5% sensitivity and 82.8% specificity) and 0.909 (72.3% sensitivity and 99.68% specificity) to discriminate HCC patients from cirrhosis patients and healthy controls, respectively. The expression level of miR-338-5p was negatively correlated with the level of AFP (r=-0.306, P=0.036), and the expression level of miR-764 was positively correlated with the tumor size (r=0.371, P=0.01). Conclusions: Circulating miR-15b-5p, miR-338-5p, and miR-764 may be biomarkers for diagnosis of HCC.
MeSH term(s)	Biomarkers, Tumor/blood ; Carcinoma, Hepatocellular/blood ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/surgery ; Case-Control Studies ; Female ; Gene Expression Profiling ; Humans ; Liver Neoplasms/blood ; Liver Neoplasms/genetics ; Liver Neoplasms/surgery ; Male ; MicroRNAs/blood ; Middle Aged ; Postoperative Period ; Preoperative Period
Chemical Substances	Biomarkers, Tumor ; MicroRNAs
Language	English
Publishing date	2015-06-29
Publishing country	United States
Document type	Journal Article ; Validation Studies
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.893082
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Article: [Effect of flurbiprofen combined different concentrations of ropivacaine local infiltration on postoperative analgesia after laparoscopic cholecystectomy].

Liang, Han-sheng / Feng, Yi / Liu, Yi-zhao / An, Hai-yan / Yang, Ba-xian

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

2011 Volume 43, Issue 5, Page(s) 753–756

Abstract: Objective: To investigate the effects of postoperative analgesia after laparoscopic cholecystectomy using intravenous flurbiprofen combined with different concentrations of ropivacaine incision infiltration.: Methods: Eighty patients who underwent ... ...

Abstract	Objective: To investigate the effects of postoperative analgesia after laparoscopic cholecystectomy using intravenous flurbiprofen combined with different concentrations of ropivacaine incision infiltration. Methods: Eighty patients who underwent traditional laparoscopic cholecystectomy received standard general anesthesia. At the end of surgery, patients were randomly divided into four groups: group Con (control group: no analgesics was administered, n=20); group F (flurbiprofen group: 100 mg of flurbiprofen was given intravenously with no incision infiltration, n=20); group FR(0.25) (100 mg of flurbiprofen was given intravenously, combined with 0.25% ropivacaine incision infiltration, 2 mL per incision, 6 mL in total, n=20) and group FR(0.5) (100 mg of flurbiprofen was given intravenously, combined with 0.5% ropivacaine incision infiltration, 2 mL per incision, 6 mL in total, n=20). The intensity of postoperative pain was evaluated using numeric rating scale (NRS) in a double-blinded manner. Intramuscularly 50 mg of meperidin was administered as rescue medication when NRS was above 4. The NRS and the associated side effects were observed and recorded at the end of 0, 2, 6, 12, 24, and 48 hours postoperatively (T(0 h)h,T(2 h),T(6 h),T(12 h),T(24 h),and T(48 h)). Results: There was no obvious difference among the four groups in respect of gender, age, body weight, baseline blood pressure, heart rate(HR), and total doses of sufentanil and remifentanil during operation and surgical time(P>0.05).There were significant differences among group FR(0.25)(2.34 ± 0.89,3.01 ± 1.27,2.79 ± 0.94), group FR(0.5)(2.42 ± 0.79, 2.69 ± 0.96, 2.03 ± 0.87)and group Con(3.42 ± 1.23, 5.98 ± 1.46, 4.53 ± 0.92)in NRS at T(2 h), T(6 h), and T(12 h)(P<0.05).Systolic blood pressures (SBP) of patients in group FR(0.25) [(114.19 ± .74) mmHg,(108.31 ± 7.62) mmHg) and group FR(0.5) [(115.26 ± 8.95) mmHg,(111.25 ± 9.12) mmHg] were significantly lower than those of patients in group Con [(137.11 ± 8.71) mmHg,(125.16 ± 8.92) mmHg] at T(2 h) and T(6 h)(P<0.05). Compared with group Con [(81.24 ± 6.64) beats/min], heart rate(HR) was also lower in patients of group FR(0.25) [(69.14 ± 5.92) beats/min] and group FR(0.5) [(70.16 ± 5.25) beats/min] at T(6 h)(P<0.05). There was no obvious adverse effect in all the four groups. Conclusion: Intravenous flurbiprofen combined with ropivacaine infiltration could significantly reduce postoperative pain after laparoscopic cholecystectomy, providing more stable hemodynamics. Compared with 0.25% ropivacaine, 0.5% ropivacaine infiltration combined with intravenous flurbiprofen has better and longer analgesic effects.
MeSH term(s)	Aged ; Amides/administration & dosage ; Anesthetics, Local/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Cholecystectomy, Laparoscopic ; Double-Blind Method ; Drug Therapy, Combination ; Female ; Flurbiprofen/administration & dosage ; Humans ; Male ; Middle Aged ; Pain, Postoperative/drug therapy
Chemical Substances	Amides ; Anesthetics, Local ; Anti-Inflammatory Agents, Non-Steroidal ; Flurbiprofen (5GRO578KLP) ; ropivacaine (7IO5LYA57N)
Language	Chinese
Publishing date	2011-10-18
Publishing country	China
Document type	English Abstract ; Journal Article ; Randomized Controlled Trial
ISSN	1671-167X
ISSN	1671-167X
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