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  1. Book ; Thesis: Comprehensive mechanism research of different periods of adipogenic and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs)

    Liu, Yu

    2022  

    Author's details vorgelegt von Yu Liu
    Language English
    Size vi, 100 Seiten, Illustrationen, Diagramme
    Publishing place Aachen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2022
    Note Englische und deutsche Zusammenfassung
    HBZ-ID HT021569916
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 D 65 order for loan Magazin

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  2. Article ; Online: methylClass: an R package to construct DNA methylation-based classification models.

    Liu, Yu

    Briefings in bioinformatics

    2024  Volume 25, Issue 1

    Abstract: DNA methylation profiling is a useful tool to increase the accuracy of a cancer diagnosis. However, a comprehensive R package specially for it is lacking. Hence, we developed the R package methylClass for methylation-based classification. Within it, we ... ...

    Abstract DNA methylation profiling is a useful tool to increase the accuracy of a cancer diagnosis. However, a comprehensive R package specially for it is lacking. Hence, we developed the R package methylClass for methylation-based classification. Within it, we provide the eSVM (ensemble-based support vector machine) model to achieve much higher accuracy in methylation data classification than the popular random forest model and overcome the time-consuming problem of the traditional SVM. In addition, some novel feature selection methods are included in the package to improve the classification. Furthermore, because methylation data can be converted to other omics, such as copy number variation data, we also provide functions for multi-omics studies. The testing of this package on four datasets shows the accurate performance of our package, especially eSVM, which can be used in both methylation and multi-omics models and outperforms other methods in both cases. methylClass is available at: https://github.com/yuabrahamliu/methylClass.
    MeSH term(s) DNA Methylation ; DNA Copy Number Variations ; Protein Processing, Post-Translational ; Support Vector Machine
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2068142-2
    ISSN 1477-4054 ; 1467-5463
    ISSN (online) 1477-4054
    ISSN 1467-5463
    DOI 10.1093/bib/bbad485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: CWGCNA

    Liu, Yu

    NAR genomics and bioinformatics

    2024  Volume 6, Issue 2, Page(s) lqae042

    Abstract: ... ...

    Abstract WGCNA
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article
    ISSN 2631-9268
    ISSN (online) 2631-9268
    DOI 10.1093/nargab/lqae042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Functional cellulose aerogel nanocomposites with enhanced adsorption capability and excellent photocatalytic performance.

    Liu, Yu

    International journal of biological macromolecules

    2023  Volume 231, Page(s) 123393

    Abstract: A novel functional cellulose carbon aerogel@ ... ...

    Abstract A novel functional cellulose carbon aerogel@Na
    MeSH term(s) Cellulose ; Adsorption ; Metals, Heavy ; Nanocomposites/chemistry ; Water Pollutants, Chemical
    Chemical Substances Cellulose (9004-34-6) ; Metals, Heavy ; Water Pollutants, Chemical
    Language English
    Publishing date 2023-01-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.123393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Application of femtosecond laser in anterior segment surgery.

    Liu, Yu-Chi

    Taiwan journal of ophthalmology

    2023  Volume 13, Issue 3, Page(s) 263–264

    Language English
    Publishing date 2023-09-08
    Publishing country India
    Document type Editorial
    ZDB-ID 2652841-1
    ISSN 2211-5072 ; 2211-5072
    ISSN (online) 2211-5072
    ISSN 2211-5072
    DOI 10.4103/tjo.TJO-D-23-00098
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: eClock: An ensemble-based method to accurately predict ages with a biased distribution from DNA methylation data.

    Liu, Yu

    PloS one

    2022  Volume 17, Issue 5, Page(s) e0267349

    Abstract: DNA methylation is closely related to senescence, so it has been used to develop statistical models, called clock models, to predict chronological ages accurately. However, because the training data always have a biased age distribution, the model ... ...

    Abstract DNA methylation is closely related to senescence, so it has been used to develop statistical models, called clock models, to predict chronological ages accurately. However, because the training data always have a biased age distribution, the model performance becomes weak for the samples with a small age distribution density. To solve this problem, we developed the R package eClock, which uses a bagging-SMOTE method to adjust the biased distribution and predict age with an ensemble model. Moreover, it also provides a bootstrapped model based on bagging only and a traditional clock model. The performance on three datasets showed that the bagging-SMOTE model significantly improved rare sample age prediction. In addition to model construction, the package also provides other functions such as data visualization and methylation feature conversion to facilitate the research in relevant areas.
    MeSH term(s) DNA Methylation ; Health Services ; Models, Statistical
    Language English
    Publishing date 2022-05-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0267349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Does COVID-19 impact on financial markets of China-evidence from during and pre-COVID-19 outbreak.

    Liu, Yu

    Environmental science and pollution research international

    2022  Volume 30, Issue 4, Page(s) 10165–10178

    Abstract: During the outbreak of COVID-19, concern significantly influenced our financial system. This new paper's primary assessment of the COVID-19 virus affects the world's major economies and financial markets. This paper utilizes an event analysis approach ... ...

    Abstract During the outbreak of COVID-19, concern significantly influenced our financial system. This new paper's primary assessment of the COVID-19 virus affects the world's major economies and financial markets. This paper utilizes an event analysis approach and a data model to investigate the influence of COVID-19 on the financial market system from three viewpoints: (1) supply chain finance and titles, (2) processing system, and (3) the financial system of the organization. According to data analysis, the model built in this work may properly depict the influence of COVID-19 on the financial market system. The results indicated that the low age coefficient (p-value (p 0.05)) and a higher blocking condition (p-value (p > 0.05)) impact city tourism market system with p-values of 0.002 and 0.004, respectively. Other results show the impact of the Chinese New Year vacations. Since then, the government has slowly stabilized its recovery, with many measures taken to limit the epidemic in February and a series of regulatory measures enacted to stabilize financial markets. These findings show a small but statistically significant degree of stabilization in international financial markets in response to stay-at-home government policies and social distancing measures, which is encouraging for political actors concerned about economic performance during the coronavirus 2019 pandemic response.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Disease Outbreaks ; SARS-CoV-2 ; China/epidemiology ; Pandemics
    Language English
    Publishing date 2022-09-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-22721-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: scDeconv: an R package to deconvolve bulk DNA methylation data with scRNA-seq data and paired bulk RNA-DNA methylation data.

    Liu, Yu

    Briefings in bioinformatics

    2022  Volume 23, Issue 3

    Abstract: Many DNA methylation (DNAm) data are from tissues composed of various cell types, and hence cell deconvolution methods are needed to infer their cell compositions accurately. However, a bottleneck for DNAm data is the lack of cell-type-specific DNAm ... ...

    Abstract Many DNA methylation (DNAm) data are from tissues composed of various cell types, and hence cell deconvolution methods are needed to infer their cell compositions accurately. However, a bottleneck for DNAm data is the lack of cell-type-specific DNAm references. On the other hand, scRNA-seq data are being accumulated rapidly with various cell-type transcriptomic signatures characterized, and also, many paired bulk RNA-DNAm data are publicly available currently. Hence, we developed the R package scDeconv to use these resources to solve the reference deficiency problem of DNAm data and deconvolve them from scRNA-seq data in a trans-omics manner. It assumes that paired samples have similar cell compositions. So the cell content information deconvolved from the scRNA-seq and paired RNA data can be transferred to the paired DNAm samples. Then an ensemble model is trained to fit these cell contents with DNAm features and adjust the paired RNA deconvolution in a co-training manner. Finally, the model can be used on other bulk DNAm data to predict their relative cell-type abundances. The effectiveness of this method is proved by its accurate deconvolution on the three testing datasets here, and if given an appropriate paired dataset, scDeconv can also deconvolve other omics, such as ATAC-seq data. Furthermore, the package also contains other functions, such as identifying cell-type-specific inter-group differential features from bulk DNAm data. scDeconv is available at: https://github.com/yuabrahamliu/scDeconv.
    MeSH term(s) DNA Methylation ; Gene Expression Profiling ; RNA/genetics ; RNA-Seq ; Sequence Analysis, RNA ; Single-Cell Analysis
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2022-05-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2068142-2
    ISSN 1477-4054 ; 1467-5463
    ISSN (online) 1477-4054
    ISSN 1467-5463
    DOI 10.1093/bib/bbac150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online ; E-Book: Advanced Application of Arthroscopy

    Liu, Yu-jie / Xue, Jing / Huang, Chang-ming / Li, Chun-bao

    A Practical Guide with Illustrative Cases

    2020  

    Abstract: This book provides novel arthroscopy techniques and applications to clinical practitioners, including sports medicine therapeutics, orthopaedic surgeons, specialist training candidates, rehabilitation clinicians. Small incisions per minimally invasive ... ...

    Author's details edited by Yu-jie Liu, Jing Xue, Chang-ming Huang, Chun-bao Li
    Abstract This book provides novel arthroscopy techniques and applications to clinical practitioners, including sports medicine therapeutics, orthopaedic surgeons, specialist training candidates, rehabilitation clinicians. Small incisions per minimally invasive surgery using a camera mounted on a thin tube to visualize, repair and reconstruct joint-associated structures are accepted and welcomed by the sports medicine field. Arthroscopy technique as a minimally invasive surgical method, in Orthopeadics is not only for the treatment of intra-articular diseases but also an advanced conception for treatment of extra-articular diseases and peri-articular fractures. After performing years of arthroscopy, authors intend to provide an elite technique demonstration of each procedure, including indications, technique, complications, and results. There are three main parts of the book, including the extra-articular application of arthroscopy techniques, arthroscopic minimally invasive techniques for the treatment of intra-articular fractures, and Innovative technology for repair and reconstruction of bone and joint injuries. Key technical points and experience of arthroscopic repair of joint injuries, dislocation of joints, fixation of the intra-articular fractures, ligament release for limbs are illustrated. Special situations such as congenital torticollis, deltoid contracture, gluteal muscle contracture, bone grafting, removal of locking plate and screw and benign tumors treatment are also included.
    Keywords Orthopedics ; Sports medicine ; Sports Medicine ; Artroscòpia ; Cirurgia ortopèdica ; Medicina esportiva
    Subject code 617.4720597
    Language English
    Size 1 online resource (xxi, 223 pages) :, illustrations
    Edition 1st ed. 2020.
    Publisher Springer Singapore ; Imprint: Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-15-4684-3 ; 981-15-4683-5 ; 978-981-15-4684-6 ; 978-981-15-4683-9
    DOI 10.1007/978-981-15-4684-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  10. Article ; Online: Does COVID-19 impact on financial markets of China—evidence from during and pre-COVID-19 outbreak

    Liu, Yu

    Environ Sci Pollut Res. 2023 Jan., v. 30, no. 4 p.10165-10178

    2023  

    Abstract: During the outbreak of COVID-19, concern significantly influenced our financial system. This new paper’s primary assessment of the COVID-19 virus affects the world’s major economies and financial markets. This paper utilizes an event analysis approach ... ...

    Abstract During the outbreak of COVID-19, concern significantly influenced our financial system. This new paper’s primary assessment of the COVID-19 virus affects the world’s major economies and financial markets. This paper utilizes an event analysis approach and a data model to investigate the influence of COVID-19 on the financial market system from three viewpoints: (1) supply chain finance and titles, (2) processing system, and (3) the financial system of the organization. According to data analysis, the model built in this work may properly depict the influence of COVID-19 on the financial market system. The results indicated that the low age coefficient (p-value (p 0.05)) and a higher blocking condition (p-value (p > 0.05)) impact city tourism market system with p-values of 0.002 and 0.004, respectively. Other results show the impact of the Chinese New Year vacations. Since then, the government has slowly stabilized its recovery, with many measures taken to limit the epidemic in February and a series of regulatory measures enacted to stabilize financial markets. These findings show a small but statistically significant degree of stabilization in international financial markets in response to stay-at-home government policies and social distancing measures, which is encouraging for political actors concerned about economic performance during the coronavirus 2019 pandemic response.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; economic performance ; finance ; markets ; models ; pandemic ; politics ; supply chain ; tourism
    Language English
    Dates of publication 2023-01
    Size p. 10165-10178.
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-22721-6
    Database NAL-Catalogue (AGRICOLA)

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